公开(公告)号：US12173083B2

公开(公告)日：2024-12-24

申请号：US17686453

申请日：2022-03-04

Applicant: Boehringer Ingelheim International GmbH

Inventor： Susanne Hipp ,  Paul Adam ,  Michael Dziegelewski ,  Rajkumar Ganesan ,  Philip Nicholas Gorman ,  Priyanka Gupta ,  Justin Scheer ,  Vladimir H. Voynov ,  Pankaj Gupta

IPC: A61K39/395 ,  A61P35/00 ,  C07K1/14 ,  C07K16/22 ,  C07K16/24 ,  C07K16/28 ,  C07K16/30 ,  C12N5/10 ,  C12N15/63 ,  G01N33/577 ,  A61K39/00 ,  A61K45/06

Abstract: The present invention relates to novel DLL3/CD3 binding proteins. The invention also relates to nucleic acids encoding such proteins; to methods for preparing such proteins; to host cells expressing or capable of expressing such proteins; to compositions comprising such proteins; and to uses of such proteins or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

公开(公告)号：US20240418716A1

公开(公告)日：2024-12-19

申请号：US18755805

申请日：2024-06-27

Applicant: MeMed Diagnotics Ltd.

Inventor： Eran EDEN ,  Kfir OVED ,  Assaf COHEN-DOTAN ,  Roy NAVON ,  Olga BOICO ,  Gali KRONENFELD ,  Meital PAZ ,  Ellen BAMBERGER

IPC: G01N33/569 ,  C07K14/525 ,  C07K14/54 ,  C07K14/555 ,  C07K14/575 ,  C07K16/12 ,  C07K16/18 ,  C07K16/24 ,  C07K16/26 ,  C07K16/28 ,  G01N33/50 ,  G01N33/52 ,  G01N33/53 ,  G01N33/535 ,  G01N33/543 ,  G01N33/547 ,  G01N33/577 ,  G01N33/58 ,  G01N33/60 ,  G01N33/68 ,  G16B20/00 ,  G16B40/00 ,  G16B40/20 ,  G16B40/30

Abstract: Methods of diagnosing infections are disclosed. In one embodiment, the method comprises measuring the amount of each of the polypeptides TRAIL, CRP, IP10 and at least one additional polypeptide selected from the group consisting of IL-6 and PCT.

公开(公告)号：US20240402173A1

公开(公告)日：2024-12-05

申请号：US18699663

申请日：2022-10-14

Applicant: CORNELL UNIVERSITY

Inventor： Bettina WAGNER ,  Elisabeth SIMONIN ,  Susanna BABASYAN

IPC: G01N33/569 ,  G01N33/577 ,  G01N33/68

Abstract: Methods of detecting IgE+ plasmablasts in a mammal are described herein. Also described herein are methods of predicting clinical allergy in a mammal. Additionally, methods of monitoring progression of an allergy along with methods of monitoring efficacy of treatment of an allergy are described.

公开(公告)号：US20240385191A1

公开(公告)日：2024-11-21

申请号：US18570499

申请日：2022-06-18

Applicant: Nordic Bioscience A/S

Inventor： Jeppe Thorlacius-Ussing ,  Nicholas Willumsen ,  Morten Asser Karsdal

IPC: G01N33/574 ,  G01N33/577

Abstract: Described herein are immunoassays for detecting and/or monitoring cancer in a patient, comprising contacting a sample from a patient with a monoclonal antibody that specifically binds to a C-terminus amino acid sequence that corresponds to the C-terminus of type XX collagen. Also described are said monoclonal antibodies and immunoassay kits for use in carrying out said immunoassays.

公开(公告)号：US12123876B2

公开(公告)日：2024-10-22

申请号：US16077911

申请日：2017-01-16

Applicant: Kanagawa Prefectural Hospital Organization ,  The University of Tokyo

Inventor： Shoutaro Tsuji ,  Taihei Kageyama ,  Kota Washimi ,  Makiko Tsuji ,  Rieko Matsuura ,  Mitsuyo Yoshihara ,  Kohzoh Imai

IPC: G01N33/574 ,  A61K39/395 ,  A61K49/00 ,  A61K49/16 ,  A61P35/00 ,  C07K14/705 ,  C07K16/30 ,  C07K16/46 ,  C12N15/09 ,  C12N15/62 ,  G01N33/577 ,  G01N33/68

CPC classification number: G01N33/574 ,  A61K39/395 ,  A61K49/00 ,  A61K49/0058 ,  A61K49/16 ,  A61P35/00 ,  C07K14/705 ,  C07K16/30 ,  C07K16/3092 ,  C07K16/46 ,  C12N15/09 ,  C12N15/62 ,  G01N33/57423 ,  G01N33/68

Abstract: The present invention provides an antibody for detecting mesothelioma and an antibody having high specificity to mesothelioma and high sensitivity thereto. The present invention also provides a method of diagnosis of mesothelioma by using the antibody, a reagent containing the antibody for use in diagnosis of mesothelioma, and a kit comprising the antibody for use in diagnosis of mesothelioma. Further, the present invention provides a marker for use in diagnosis of mesothelioma. Furthermore, the present invention provides a pharmaceutical composition containing the antibody according to the present invention or an antigen-binding fragment thereof for use in treatment of mesothelioma. An antibody that binds to a glycosylated HEG1 protein obtained from mesothelioma.

公开(公告)号：US20240298956A1

公开(公告)日：2024-09-12

申请号：US18588150

申请日：2024-02-27

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Frederick Korley ,  Agim Beshiri ,  Jaime Marino ,  Saul Datwyler

IPC: A61B5/00 ,  C12Q1/6883 ,  G01N33/533 ,  G01N33/543 ,  G01N33/564 ,  G01N33/577 ,  G01N33/68

CPC classification number: A61B5/4064 ,  G01N33/54346 ,  G01N33/54366 ,  G01N33/577 ,  G01N33/6896 ,  C12Q1/6883 ,  G01N33/533 ,  G01N33/564 ,  G01N33/6893 ,  G01N2800/28 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/60

Abstract: Disclosed herein are methods that aid in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or a moderate, severe, or moderate to severe traumatic brain injury (TBI), by detecting levels of cardiac troponin I (cTnI) and one or more early biomarkers which are not cTnI, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof, in biological samples taken from a human subject at time points within about 24 hours of injury after the subject has sustained or may have sustained the injury to the head.

公开(公告)号：US20240294649A1

公开(公告)日：2024-09-05

申请号：US18595973

申请日：2024-03-05

Applicant: Chugai Seiyaku Kabushiki Kaisha

Inventor： Yuu Okura ,  Noriyuki Takahashi

IPC: C07K16/28 ,  A61P1/00 ,  A61P37/06 ,  G01N33/577

CPC classification number: C07K16/2833 ,  A61P1/00 ,  A61P37/06 ,  G01N33/577 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N2800/065

Abstract: The invention provides anti-HLA-DQ2.5/8 antibodies and methods of using the same. The antibodies of the present invention have binding activity to human HLA-DQ2.5/8 and monkey MHC-DQ, but substantially no binding activity to HLA-DR, HLA-DP, or a complex of the invariant chain (CD74) and HLA-DQ2.5/8. The antibodies bind to HLA-DQ2.5/8 in the presence of a gluten peptide such as gliadin, i.e., bind to HLA-DQ2.5/8 forming a complex with the gluten peptide. The antibodies have neutralizing activity against the binding between HLA-DQ2.5/8 and TCR, and thus block the interaction between HLA-DQ2.5/8 and an HLA-DQ2.5/8-restricted CD4+ T cell. The antibodies do not undergo rapid internalization mediated by the invariant chain. These characteristics are particularly useful for treating celiac disease. Thus, the present invention also provides a method of treating celiac disease using the antibodies of the present invention.

公开(公告)号：US20240262894A1

公开(公告)日：2024-08-08

申请号：US18566962

申请日：2022-06-13

Applicant: INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES

Inventor： Fu GAO ,  Lianpan DAI ,  Jian SONG ,  Senyu XU ,  Qihui WANG

IPC: C07K16/10 ,  A61K39/00 ,  G01N33/569 ,  G01N33/577

CPC classification number: C07K16/1027 ,  G01N33/56983 ,  G01N33/577 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/135 ,  G01N2469/10

Abstract: Provided in the present disclosure is an antibody or an antigen-binding fragment thereof that binds to the respiratory syncytial virus F protein. Further provided in the present disclosure is the use of the antibody or the antigen-binding fragment thereof in the preparation of a drug for the treatment and/or prevention of RSV infections.

公开(公告)号：US20240248093A1

公开(公告)日：2024-07-25

申请号：US18289868

申请日：2022-06-03

Applicant: Georgia Tech Research Corporation ,  Emory University

Inventor： Todd Sulchek ,  Ignacio Sanz ,  Frances Eun-Hyung LEE ,  Katily Ramirez

IPC: G01N33/577 ,  C07K16/10

CPC classification number: G01N33/577 ,  C07K16/1018

Abstract: An exemplary embodiment of the present disclosure provides a composition comprising a cell capable of secreting one or more molecules, the cell non-covalently attached to a particle, wherein the particle comprises a first linker linking a collector unit, the collector unit capable of binding to the one or more molecules secreted by the cell, optionally, wherein the one or more molecules secreted by the cell are bound to the first unit. The cell is non-covalently bound to the particle through a targeting unit affixed to the particle via a second linker. Also disclosed are methods of isolating cells with one or more particles comprising the same or different collector units and targeting units.

公开(公告)号：US20240248090A1

公开(公告)日：2024-07-25

申请号：US18443945

申请日：2024-02-16

Applicant: E&S HEALTHCARE CO., LTD.

Inventor： Kyong Hoon SUH ,  Dae Joong KIM ,  Young KIM ,  Mi Kyung KIM ,  Jong Hwan JUNG ,  Ki Se LEE

IPC: G01N33/574 ,  C07K7/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K16/40 ,  G01N33/543 ,  G01N33/577 ,  G01N33/58

CPC classification number: G01N33/57415 ,  C07K7/08 ,  C07K16/40 ,  G01N33/54393 ,  G01N33/577 ,  G01N33/581 ,  C07K7/00 ,  C07K7/06 ,  C07K14/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622

Abstract: The present invention relates to an epitope of a thioredoxin-1 (Trx1) antigen and a use thereof, and more particularly, to the epitope, and an antibody or an antigen-binding fragment binding thereto. The epitope region of the human Trx1 antigen confirmed in the present invention may be effectively used in the development of an improved antibody to enhance the binding affinity of an anti-Trx1 antibody. In addition, the improved antibody of the present invention is effective in improvement of performance of a breast cancer diagnosis kit due to excellent binding affinity for Trx1 and very high sensitivity and specificity, compared to a conventional anti-Trx1 antibody. Further, the accuracy and reliability of breast cancer diagnosis may significantly increase because exceptionally high sensitivity and specificity are exhibited by detecting the monoclonal antibody of the present invention, which specifically binds to Trx1, rather than detecting CA15-3, another conventional breast cancer diagnostic biomarker.