公开(公告)号：US20250060370A1

公开(公告)日：2025-02-20

申请号：US18820811

申请日：2024-08-30

Applicant: TSUTOMU TAKEUCHI ,  KEIKO YOSHIMOTO ,  KOWA COMPANY, LTD.

Inventor： Tsutomu Takeuchi ,  Keiko Yoshimoto

IPC: G01N33/68 ,  A61K39/00 ,  C07K14/705 ,  C07K16/24 ,  G01N33/564 ,  G01N33/74

Abstract: An antibody against a peptide having an amino acid sequence AVQGPEETVT QDC (expressed in single letter amino acid code) as represented by SEQ ID: NO1 corresponding to the 134- to 146-positions in human BAFF (B cell activating factor belonging to the TNF family) protein which is preferably a monoclonal antibody; a method of producing the above antibody; a medicinal composition containing the antibody; utilization of the antibody; and a method of screening an inhibitory effect or an activating effect on BAFF with the use of the antibody.

公开(公告)号：US12222354B2

公开(公告)日：2025-02-11

申请号：US17697813

申请日：2022-03-17

Applicant: Quest Diagnostics Investments LLC

Inventor： Ievgen Motorykin ,  Nigel Clarke ,  Michael J. McPhaul ,  Zengru Wu

IPC: G01N33/68 ,  G01N33/74

Abstract: Methods are provided for detecting insulin-like growth factor-I (IGF-I) variant(s) in a sample. Methods provided herein are further directed to using the detected ion or ions to determine the presence of IGF1 variant(s) in the sample.

公开(公告)号：US12216133B2

公开(公告)日：2025-02-04

申请号：US17218638

申请日：2021-03-31

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christopher Espy ,  Yin Cai

IPC: B01L3/00 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B23Q17/24 ,  C07K14/705 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/686 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N21/64 ,  G01N21/77 ,  G01N21/78 ,  G01N27/414 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/68 ,  G01N33/74 ,  G01N35/00 ,  G01N35/10 ,  G06K7/10 ,  G06K7/14 ,  G06K19/06 ,  G06K19/07 ,  G06T7/00 ,  G06T7/90 ,  H10K10/46 ,  H10K85/00 ,  H10K85/20

Abstract: A sample handling system for handling samples is disclosed. The sample handling system comprises sample holders, each receives a sample container; a sample transport device for moving the sample holders; a control unit for controlling functionality of the sample handling system, and a monitoring system for monitoring the samples during movement. The monitoring system comprises a camera module for continuously capturing images of a part of the sample transport device, wherein the camera module is at a distance from the sample transport device such that the camera module has a free field of view to the sample transport device, and a processor for processing the captured images and determining an item of information about the sample transport device and/or the sample container and/or the sample from the captured images. The control unit retrieves the item of information from the processor. The controlling is based on the retrieved item of information.

公开(公告)号：US20250027942A1

公开(公告)日：2025-01-23

申请号：US18710727

申请日：2023-01-26

Applicant: Université libre de Bruxelles

Inventor： Nathalie DE VOS

IPC: G01N33/569 ,  G01N33/68 ,  G01N33/74

Abstract: A diagnostic based on Angiotensin 1-7 level, possibly in synergy with other blood parameters, to predict the outcome of infected patients by respiratory viral diseases and the corresponding drugs to prevent worsening of the disease for the patients predicted to be at higher risk.

公开(公告)号：US20250012819A1

公开(公告)日：2025-01-09

申请号：US18830867

申请日：2024-09-11

Applicant: Aveta.Life Inc.

Inventor： Lina Freage ,  Henry Grage

IPC: G01N33/74 ,  G01N33/543 ,  G01N33/58

Abstract: Probes that are versatile, easy to use, and provide rapid results for detecting and quantifying levels of small molecules that include steroids, hormones, antibodies, aptamers and enzymes such as various steroidal hormones like estrogen, progesterone and testosterone in samples. This is particularly useful in home and clinical settings. A probe useful in competitive assays includes a competitive ligand bound to a linker molecule bound to a detectable tag. The linker may be chemical, DNA or a combination of both.

公开(公告)号：US20250012818A1

公开(公告)日：2025-01-09

申请号：US18710081

申请日：2022-11-10

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： Kanwaljeet S. Anand ,  Cynthia Rovnaghi ,  Ryan Leib

IPC: G01N33/74 ,  C12Q1/6806 ,  C12Q1/6883 ,  G01N1/34

Abstract: Compositions and methods are provided for identifying and measuring biomarkers in hair. In particular, methods for extracting proteins and RNA species from hair, and for identifying and measuring hair biomarkers are disclosed. Serial segmentation of a hair sample can be used to assess sequential epochs of protein expression, metabolic regulation, and gene expression in the body across different time periods. Use of hair biomarkers provides a non-invasive, pain-free method for diagnosing diseases and identifying individuals at risk for poor health outcomes.

公开(公告)号：US20250009756A1

公开(公告)日：2025-01-09

申请号：US18435166

申请日：2024-02-07

Applicant: Acerus Biopharma Inc.

Inventor： Wayne Kreppner ,  Paul Jose Pierre Marie Maes

IPC: A61K31/568 ,  A61K9/00 ,  A61K9/06 ,  A61K47/02 ,  A61K47/14 ,  A61K47/44 ,  G01N33/74 ,  G16H20/10

Abstract: The present invention relates to pernasal testosterone bio-adhesive gel formulations for intranasal administration and testosterone replacement treatment methods for using the pernasal testosterone bio-adhesive gel formulations for providing sustained intranasal delivery of testosterone to testosterone deficient males to treat, for example, male subjects diagnosed with hypogonadism. The present invention is also concerned with a novel titration method to determine the appropriate daily treatment regimen, i.e., a BID or TID treatment regimen, to administer the intranasal gels of the present invention to treat hypogonadism or TRT.

公开(公告)号：US12188952B2

公开(公告)日：2025-01-07

申请号：US17433090

申请日：2019-12-02

Applicant: Hitachi High-Tech Corporation

Inventor： Kazuhiro Noda ,  Kenta Imai ,  Tatsuki Takakura ,  Nobuhiro Tsukada

IPC: B01L3/00 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B23Q17/24 ,  C07K14/705 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/686 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N21/64 ,  G01N27/414 ,  G01N30/12 ,  G01N30/68 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/68 ,  G01N33/74 ,  G01N35/00 ,  G01N35/10 ,  H10K10/46 ,  H10K85/00 ,  H10K85/20

Abstract: An automatic analysis device including a container filled with a fluid, a pressure source, a probe which separates the fluid within the container, the probe associated with a probe position, a motor which moves the probe, a flow path which connects the probe and the pressure source, the flow path associated with a flow path position, a pressure sensor which measures pressure variations within the flow path corresponding with time series management data, and a sensor which detects a liquid level position within the container. A condition of flow generated within the flow path is estimated based on (i) the time series measurement data and (ii) a reference value of pressure according to fluid pressure based on gravitational acceleration in a position of the pressure sensor calculated based on (a) the probe position or the flow path position and (b) an immersion depth of the probe determined by the sensor.

公开(公告)号：US12174195B2

公开(公告)日：2024-12-24

申请号：US17396836

申请日：2021-08-09

Applicant: Syncerus S.A R.L.

Inventor： Jean-Francois Floch

IPC: G01N33/574 ,  C07K16/26 ,  C07K16/30 ,  G01N33/74

Abstract: The present invention provides a method for evaluating the risk of occurrence of cancer in an individual.

公开(公告)号：US12163966B2

公开(公告)日：2024-12-10

申请号：US16694283

申请日：2019-11-25

Applicant: Mars, Incorporated

Inventor： Janet Alexander ,  Penelope Morris ,  Adrian Hewson-Hughes

IPC: G01N33/74 ,  A23K20/147 ,  A23K20/158 ,  A23K50/42 ,  A23K50/48 ,  A61K9/00 ,  A61K31/198 ,  A61K31/20 ,  A61K31/201 ,  A61K31/202 ,  A61K31/401

Abstract: A method is provided, comprising feeding a cat a foodstuff comprising a protein to fat ratio of 1:0.27 to 1:0.63 on a gram:gram as fed or dry matter basis, and measuring the level of glucose-dependent insulinotropic polypeptide (GIP) in a blood sample from the cat before and after feeding the foodstuff. A reduction in GIP levels and/or maintaining low levels of GIP post-prandially is indicative of a foodstuff useful in preventing accumulation of and/or reducing body fat in a cat and therefore controlling the body weight of a cat.