公开(公告)号：US20250060386A1

公开(公告)日：2025-02-20

申请号：US18722268

申请日：2021-12-29

Applicant: TECAN GENOMICS, INC.

Inventor： Sebastian Georg RAMMENSEE ,  Michael Roy FAIRS

IPC: G01N35/10

Abstract: A liquid handling unit comprising: a sample unit (5) with a carrier (560) for laboratory containers (561), a liquid transfer unit (3,4) for dispensing liquid into some off the laboratory containers (561) and/or for extracting liquid from the laboratory containers (561), wherein the liquid transfer unit (3,4) being arranged above the sample unit (5) and having a holder (41) for dispensing means (43) and/or extracting means that can be raised and lowered, wherein positioning pins (46,47) being arranged on the holder (41) and positioning holes (54,55) being formed in the carrier (560), wherein with raised holder (41), the carrier (560) can pass freely below the positioning pins (46,47) in a horizontal direction and wherein with lowered holder (41), the positioning pins (46,47) can be arranged fittingly in the positioning holes (54,55).

公开(公告)号：US20250060291A1

公开(公告)日：2025-02-20

申请号：US18940745

申请日：2024-11-07

Applicant: Ventana Medical Systems, Inc.

Inventor： Kayla Capps ,  Henning Groll ,  Brian Howard Kram ,  Matthew Mette ,  Ali Mousavi ,  Christine Tse ,  Glen Ward ,  Daniel O'Connor ,  Troy Paluszcyk ,  Benjamin David Randall ,  Ken Stumpe

IPC: G01N1/31 ,  G01N35/00 ,  G01N35/10

Abstract: Automated system configured to perform and methods for performing one or more slide processing operations on slides bearing biological samples. The system and methods enable high sample throughput while also minimizing or limiting the potential for cross-contamination of slides. The automated systems can include features that facilitate consistency, controllability of processing time, and/or processing temperature.

公开(公告)号：US12228584B2

公开(公告)日：2025-02-18

申请号：US17506600

申请日：2021-10-20

Applicant: XCella Biosciences, Inc.

Inventor： Bob Chen

IPC: G01N35/10 ,  B01J19/00 ,  B01L3/00 ,  B01L9/00 ,  C12N15/10 ,  C12Q1/6851 ,  C40B60/02 ,  G01N15/14 ,  G01N15/1433 ,  G01N21/75 ,  G01N33/543 ,  G01N15/10 ,  G01N21/03 ,  G01N21/64 ,  G01N21/77 ,  G01N35/00

Abstract: Multi-stage sample-recovery systems, including automated 2-stage and 3-stage sample-recovery systems, are provided. Such systems enable the rapid screening and recovery of samples, including viable cell-based samples, from high-throughput screening systems, including systems utilizing large-scale arrays of microcapillaries. In specific screening systems, each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be identified and recovered using the multi-stage systems disclosed herein.

公开(公告)号：US12222360B2

公开(公告)日：2025-02-11

申请号：US17603725

申请日：2020-02-26

Applicant: Hitachi High-Tech Corporation

Inventor： Yoshihiro Kabe ,  Takenori Okusa

IPC: G01N35/10 ,  G01N35/00 ,  G01N35/02 ,  G01N35/08 ,  G01N35/04

Abstract: An automatic analyzer includes a flow cell detector, a nozzle that is connected to the flow cell detector by a flow path and aspirates or discharges liquid, a reservoir that is provided with a table and a table driving mechanism that rotates or moves the table up and down, and a cleaning tank that is disposed on the table. A position of the nozzle is fixed, and a cleaning water discharge port discharges cleaning water used for cleaning the nozzle at an angle φ with respect to a plane perpendicular to a central axis of the nozzle. An upper part of a side wall of the cleaning tank is continuous with an upper discharge unit at a side facing a discharge outlet provided in the reservoir and a spatula-shaped part projects outward of the cleaning tank at a side facing the upper discharge unit.

公开(公告)号：US20250044311A1

公开(公告)日：2025-02-06

申请号：US18717570

申请日：2022-11-15

Applicant: Hitachi High-Tech Corporation

Inventor： Kenshiro SAKATA ,  Yoichiro SUZUKI ,  Tetsuji KAWAHARA ,  Takuya TAKAHASHI

IPC: G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

Abstract: Provided is an automatic analyzer that detects an abnormality of an electrode constituting a stirring mechanism with high accuracy and suppresses decline in processing capability. The automatic analyzer comprises: a sample dispensing mechanism that dispenses a sample into a reaction container; a reagent dispensing mechanism that dispenses a reagent into the reaction container; a stirring mechanism that has an electrode; a reaction disk that rotates and stops the reaction container; and a control unit that, when the reaction container containing a mixture of the sample and the reagent is stopped at a stirring position, applies a voltage to the electrode and irradiates the mixture with ultrasonic waves. The control unit applies a voltage to the electrode and measures an electric impedance when, during operation, the reaction container into which a liquid has been dispensed by the reagent dispensing mechanism in an empty state is stopped at the stirring position.

公开(公告)号：US20250034554A1

公开(公告)日：2025-01-30

申请号：US18782679

申请日：2024-07-24

Applicant: The Regents of the University of California

Inventor： Amy Yi-Tyng Chang ,  Eric D. Chow ,  Brandon Kwan-Leong

IPC: C12N15/10 ,  C12M1/12 ,  C12M1/30 ,  C12M1/36 ,  C40B60/00 ,  G01N35/00 ,  G01N35/10

Abstract: Provided are methods and compositions for creating an arrayed library of cells. In particular, the methods and compositions provided herein improve the selection and transfer of cells by reducing contamination, increasing throughput, and improving consistency of transfer. Such methods and compositions include automated colony selection employing a solid barrier mounted on an automated apparatus for automatic handling of one or more pick tools. The solid barrier is configured to prevent undesired transfer of cells from a pick tool into the destination receptacle. Such methods and compositions also include acoustic transfer of cells in a high-density media by an acoustic liquid handler. The methods and compositions further include pooling the cells using a bitcode sample pooling scheme for high-throughput sequencing and deconvoluting the obtained nucleic acid sequences to identify the cells from which the sequences originated.

公开(公告)号：US12210028B2

公开(公告)日：2025-01-28

申请号：US17608745

申请日：2020-04-29

Applicant: GEN-PROBE INCORPORATED

Inventor： Rolf Silbert ,  HongRan Peng ,  David Aaron Buse ,  David H. Combs

IPC: B65G47/90 ,  B01L3/00 ,  B01L9/06 ,  B65G43/08 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10

Abstract: A receptacle delivery system includes a carriage configured to move from a first to a second location of an instrument. The carriage may be configured to removably support a receptacle and may include a receptacle clamping mechanism. The receptacle mechanism may be configured to apply a clamping force to the receptacle as the carriage moves from the first to the second location and release the clamping force as the carriage moves from the second to the first location.

公开(公告)号：US20250027964A1

公开(公告)日：2025-01-23

申请号：US18850600

申请日：2023-04-06

Applicant: Hitachi High-Tech Corporation

Inventor： Fuyuki MUKAI ,  Chie YABUTANI

IPC: G01N35/02 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10

Abstract: Provided is an automatic analysis device having an incubation function. An example of the automatic analysis device includes: a reaction vessel storage section where a reaction vessel storage container that stores reaction vessels is installed; and a dispensing mechanism that dispenses specimens or reagents into a reaction vessel which was removed from the reaction vessel storage container. The reaction vessel storage section has a temperature-controlled area where at least a portion of the storage section is adjusted to a prescribed temperature. The reaction vessel into which a specimen or a reagent is dispensed by the dispensing mechanism is placed in a reaction vessel storage container installed in the temperature-controlled area for a prescribed period.

公开(公告)号：US12203951B2

公开(公告)日：2025-01-21

申请号：US17294029

申请日：2019-11-22

Applicant: Hitachi High-Tech Corporation

Inventor： Takumi Yamada

IPC: B01L3/00 ,  A61L27/16 ,  A61L27/56 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B01L7/00 ,  B01L9/00 ,  B23Q17/24 ,  C07K14/705 ,  C08F220/56 ,  C08L33/26 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/6844 ,  C12Q1/686 ,  G01N1/31 ,  G01N15/00 ,  G01N15/02 ,  G01N21/17 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N21/64 ,  G01N21/77 ,  G01N21/78 ,  G01N27/10 ,  G01N27/414 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/68 ,  G01N33/74 ,  G01N35/00 ,  G01N35/10 ,  G06T7/00 ,  G06T7/90 ,  H10K10/46 ,  H10K85/00 ,  H10K85/20

Abstract: Since the measurement start timings for a plurality of specimens in different test fields deviate from one another, the measurement results are not coordinated, leading to a delay in reporting. When determining an order for measuring a newly recognized specimen using an automated analysis device capable of performing measurements in a plurality of test fields, the measurement order for specimens waiting to be measured is changed to minimize the time difference between measurement result output timings for a plurality of specimens for the same patient, with reference to specimen information such as urgent test information, a measurement completion time, and an earliest measurement completion time for other specimens, relating to the patient's other specimens having the same patient number in the specimen information.

公开(公告)号：US12203907B2

公开(公告)日：2025-01-21

申请号：US17738116

申请日：2022-05-06

Applicant: SHIMADZU CORPORATION

Inventor： Tomoyuki Yamazaki ,  Tatsuya Obe

IPC: G01N30/32 ,  G01N1/14 ,  G01N30/24 ,  G01N35/10 ,  G01N35/00

Abstract: A sampling needle (2) having a suction port at a tip, a movement mechanism (4) that moves the needle (2) at least in a vertical direction while holding the needle (2) in a state where the suction port faces vertically downward, a suction mechanism (6) for sucking liquid through the needle (2), a controller (10) configured to control operation of the movement mechanism (4) and the suction mechanism (6) are included. In sampling of liquid from a container (16) whose upper surface is opened, the controller (10) is configured to execute an inserting step of inserting the tip of the needle (2) into the liquid in the container (16) by lowering the needle (2) from above the container (16), a sucking step of sucking a predetermined amount of the liquid from the suction port of the needle (2) after the inserting step is completed, a pulling up step of pulling up the needle (2) from the liquid to position the suction port above a liquid level of the liquid after the sucking step is completed, and a shaking-off step of repeating shaking-off operation of lowering and suddenly stopping the needle (2) a plurality of times with standby time in which the needle (2) is completely stopped or raised in between while maintaining a state where the suction port is positioned above the liquid level after the pulling up step is completed.