公开(公告)号：US20240133986A1

公开(公告)日：2024-04-25

申请号：US18379387

申请日：2023-10-12

申请人： Emory University

发明人： Phillip Zhe Sun

IPC分类号： G01R33/485 ,  G01R33/44

CPC分类号： G01R33/485 ,  G01R33/448

摘要： The devices, systems, and methods can overcome the impact of scan protocols on experimental measurements to reconstruct the CEST equilibrium effect and can therefore improve the quantification of the underlying CEST contrast mechanism. The methods may include determining a spinlock relaxation rate for each RF offset for at least the first signal average so that the normalized spectrum for each RF offset and each slice first signal average corresponds to at least each transient state associated with each saturated slice readout normalized by at least each control state associated with each control slice readout based on the spinlock relaxation rate. The method may further include reconstructing CEST equilibrium effect for each RF offset using the respective spinlock relaxation rate for the RF offset. The method may include determining one or more quantitative information using the CEST equilibrium effect.

公开(公告)号：US20240094321A1

公开(公告)日：2024-03-21

申请号：US18521825

申请日：2023-11-28

申请人： Purdue Research Foundation

发明人： Uzay Emir ,  Mark Chiew

IPC分类号： G01R33/483 ,  A61B5/055 ,  G01R33/48 ,  G01R33/485

CPC分类号： G01R33/4835 ,  A61B5/055 ,  G01R33/4824 ,  G01R33/4828 ,  G01R33/485

摘要： A method of performing magnetic resonance spectroscopic imaging (MRSI) includes transmitting a multi-slice excitation pulse through tissue, the multi-slice excitation pulse configured to generate multi-slice MRSI signals. The method also includes performing density weighted concentric ring acquisition on the multi-slice MRSI signals. The method further includes receiving the generated multi-slice MRSI signals in a plurality of sensors disposed in various locations around the tissue. Imaging data is reconstructed based on the acquired imaging signals. A representation of the data is displayed.

公开(公告)号：US20230236272A1

公开(公告)日：2023-07-27

申请号：US18102249

申请日：2023-01-27

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Shreyas S. Vasanawala ,  Yan Wu

IPC分类号： G01R33/485 ,  G06T11/00 ,  G01R33/48

CPC分类号： G01R33/485 ,  G01R33/4828 ,  G06T11/008

摘要： A method for magnetic resonance imaging performs chemical shift encoded imaging to produce complex dual-echo images which are then applied (with imaging parameters) as input to a deep neural network to produce as output water-only and fat-only images. The deep neural network can be trained with ground truth water/fat images derived from chemical shift encoded images using a conventional water-fat separation algorithm such as projected power approach, IDEAL, or VARPRO. The chemical shift encoded imaging comprises performing an image acquisition with the MRI scanner via a spoiled-gradient echo sequence or a spin-echo sequence.

公开(公告)号：US20230095599A1

公开(公告)日：2023-03-30

申请号：US17489698

申请日：2021-09-29

申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION

发明人： Nathan Tibbitts Roberts

IPC分类号： G01R33/485 ,  G01R33/48 ,  G01R33/56 ,  G01R33/385 ,  G01R33/44 ,  G01R33/565

摘要： A system and method are provided for magnetic resonance imaging (MRI) and/or image reconstruction that includes acquiring multi-pass, chemical shift-encoded (CSE)-MRI imaging data of a subject. The method further includes performing a complex, joint estimation of phase terms in the imaging data for each pass of the multi-pass, CSE-MRI imaging data to account for concomitant gradient (CG)-induced phase errors of different passes. The method also includes generating at least one of a proton density fat fraction (PDFF) estimate or an R*2 estimate that is unbiased by CG-induced phase errors using the phase terms and communicating a report that includes at least one of the PDFF estimate or the R*2 estimate.

公开(公告)号：US20220317214A1

公开(公告)日：2022-10-06

申请号：US17712548

申请日：2022-04-04

申请人： Xiamen University

发明人： Yuqing Huang ,  Zhong Chen ,  Cunyuan Gao ,  Haolin Zhan

IPC分类号： G01R33/485 ,  G01R33/46

摘要： A method for acquiring nuclear magnetic resonance (NMR) phase-sensitive two-dimensional (2D) J-resolved spectrum by suppressing strong coupling spurious peaks, comprising: 1) placing a sample, collecting a conventional one-dimensional (1D) spectrum of the sample, and measuring a time width (pw) of a 90° pulse, wherein the conventional 1D spectrum provides J coupling information and chemical shift information of the sample; and 2) introducing a pulse sequence for suppressing strong coupling, setting parameters of a chirp sweep frequency pulse, a pure shift yielded by chirp excitation (PSYCHE) module, and a J sampling module, and collecting and saving data of a spectrum.

公开(公告)号：US20220214414A1

公开(公告)日：2022-07-07

申请号：US17607774

申请日：2020-04-30

申请人： Purdue Research Foundation

发明人： Uzay Emir ,  Mark Chiew

IPC分类号： G01R33/483 ,  G01R33/48 ,  G01R33/485 ,  A61B5/055

摘要： A method of performing magnetic resonance spectroscopic imaging (MRSI) measures neurochemical profiles over larger regions non-invasively. The method includes transmitting a multi-slice excitation pulse through tissue, the multi-slice excitation pulse configured to generate multi-slice MRSI signals. The method also includes performing density weighted concentric ring acquisition on the multi-slice MRSI signals. The method further includes receiving the generated multi-slice MRSI signals in a plurality of sensors disposed in various locations around the tissue. Imaging data is reconstructed based on the acquired imaging signals. A representation of the data is displayed.

公开(公告)号：US11237239B2

公开(公告)日：2022-02-01

申请号：US16762917

申请日：2019-09-03

申请人： ZHEJIANG UNIVERSITY

发明人： Yi Zhang ,  Ruibin Liu ,  Hongxi Zhang ,  Dan Wu

IPC分类号： G01R33/485 ,  G01R33/54 ,  G01R33/565 ,  G01R33/56

摘要： A magnetic resonance CEST imaging sequence and device based on a frequency stabilization module are provided. It includes following steps: first, in the frequency stabilization module, exciting a target slice with a small-flip-angle radio frequency pulse, and collecting three lines of non-phase-encoded k-space data; second, obtaining an estimated value of the frequency drift of the main magnetic field by calculating the phase difference between the three lines of non-phase encoded k-space data; third, adjusting a center frequency of the radio frequency pulse based on the calculation result of the frequency drift of the main magnetic field, to realize a real-time correction of the frequency drift of the main magnetic field; and fourth, performing conventional magnetic resonance CEST imaging.

公开(公告)号：US11071470B2

公开(公告)日：2021-07-27

申请号：US15304878

申请日：2015-04-22

申请人： UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Wen Ling ,  Tao Jin ,  Kyongtae Ty Bae

IPC分类号： A61B5/055 ,  G01R33/485 ,  G01R33/56 ,  A61B5/00

摘要： A method of measuring a tissue parameter such as proteoglycan content and other relevant tissue parameters, e.g. tissue pH, in a tissue or an organ of a subject includes generating first and second frequency magnetic resonance data using T1ρ scans at different frequencies, wherein the frequencies are symmetric. The method also includes combining the first frequency magnetic resonance data and the second frequency magnetic resonance data to remove a number of contributions from a number of relaxation mechanisms other than chemical exchange, thereby obtaining chemical exchange-specific magnetic resonance data indicative of the tissue parameter in the tissue or the organ. The chemical exchange-specific magnetic resonance data may be used to measure the proteoglycan content in the tissue or organ.

公开(公告)号：US10955506B2

公开(公告)日：2021-03-23

申请号：US16293718

申请日：2019-03-06

申请人： KONINKLIJKE PHILIPS N.V.

发明人： Johannes Martinus Peeters ,  Elwin De Weerdt

IPC分类号： G01V3/00 ,  G01R33/561 ,  G01R33/34 ,  G01R33/56 ,  G01R33/485 ,  G01R33/44 ,  A61B5/055 ,  G01R33/48 ,  G01R33/24 ,  G01R33/563

摘要： A magnetic resonance (MR) imaging technique enables parallel imaging in combination with fat suppression at an increased image quality, notably in combination with EPI. The method includes acquiring reference MR signal data from the object in a pre-scan and acquiring imaging MR signal data from the object in parallel via one or more receiving coils having different spatial sensitivity profiles. The MR signal data are acquired with sub-sampling of k-space and with spectral fat suppression and an MR image is reconstructed from the imaging MR signal data. Sub-sampling artefacts are eliminated using sensitivity maps indicating the spatial sensitivity profiles of the two or more RF receiving coils. A B0 map is derived from the reference MR signal data and the spatial dependence of the effectivity of the spectral fat suppression is determined using the Bo map. In the image reconstruction step, signal contributions from water and fat are separated using regularisation taking the spatial dependence of the effectivity of the spectral fat suppression into account.

公开(公告)号：US10429473B2

公开(公告)日：2019-10-01

申请号：US15067507

申请日：2016-03-11

申请人： Icahn School of Medicine at Mount Sinai

发明人： Hadrien Dyvorne ,  Priti Balchandani

IPC分类号： G01R33/56 ,  G01R33/54 ,  G01R33/483 ,  G01R33/563 ,  G01R33/485

摘要： A method, magnetic resonance imaging computing device, and a non-transitory computer readable medium for producing a slice-selective adiabatic magnetization T2 preparation pulse for magnetic resonance imaging. A pulse control signal including an adiabatic half passage pulse control signal, an adiabatic full passage pulse control signal, and a reverse adiabatic half passage pulse control signal is generated. A plurality of slice-selective linear phase subpulse control signals are generated. The pulse control signal is sampled using the plurality of slice-selective linear phase subpulse control signals to generate a slice-selective adiabatic magnetization T2 preparation control signal. The slice-selective adiabatic magnetization T2 preparation control signal is output to a waveform generator to produce the slice-selective adiabatic magnetization T2 preparation pulse.