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公开(公告)号:US20240361584A1
公开(公告)日:2024-10-31
申请号:US18645424
申请日:2024-04-25
发明人: Gabriel SIRAT , Tom SPERBER , Lionel MOISAN , Marcus DYBA
IPC分类号: G02B21/06 , G01N15/1434 , G02B21/16 , G02B21/36
CPC分类号: G02B21/06 , G01N15/1434 , G02B21/16 , G02B21/365
摘要: A single-particle localization microscope includes a light source configured to generate illumination light for illuminating a sample region, and an optical illumination system configured to shape the illumination light into a localizing light distribution having a substantially zero intensity minimum at a target point within the sample region. The localizing light distribution is adapted to cause a single particle in a fluorescent state located in the sample region outside the intensity minimum to emit fluorescent light. The optical illumination system is further configured to shape the illumination light into an auxiliary light distribution having a non-zero intensity at the target point such that the auxiliary light distribution is defined in a spatial extent and/or in its shape by the localizing light distribution.
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公开(公告)号:US12130417B2
公开(公告)日:2024-10-29
申请号:US17511485
申请日:2021-10-26
申请人: Evident Corporation
摘要: Provided is an optical signal detection device that includes: an objective; a holding member provided between the objective and a sample to hold the sample; and a gel member that fills a space between the objective and the holding member. The gel member has ¼ scale penetration indicating a value of 44 to 111, both inclusive, measured based on a penetration test using a ¼ scale cone of JIS K 2220.
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公开(公告)号:US20240337982A1
公开(公告)日:2024-10-10
申请号:US17797120
申请日:2021-06-09
发明人: Xuhui ZHANG , Wenjing SHEN
CPC分类号: G03H1/0005 , G02B21/361 , G03H1/0443 , G03H1/0866 , G03H2001/005
摘要: A transflective digital holographic microscope system belongs to the technical field of microscopes, includes a reflection-type digital holographic microscope light path and a transmission-type digital holographic microscope light path, wherein the reflection-type digital holographic microscope light path is as follows: a first light beam is changed in polarization direction through a first polarizer, and is divided into two light waves with vertical polarization states; wherein the transmission-type digital holographic microscope light path is as follows: a second light beam is changed in polarization direction through a second polarizer, and is divided into two light waves with vertical polarization states, so that the thickness information and surface contour information of the sample can be tested at the same time.
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4.
公开(公告)号:US20240331100A1
公开(公告)日:2024-10-03
申请号:US18625768
申请日:2024-04-03
发明人: Tobias SCHILLING , Mathias KATZER
CPC分类号: G06T5/50 , G02B21/26 , G02B21/367 , H04N23/56 , G06T2207/10024 , G06T2207/10056 , G06T2207/10064 , G06T2207/10152 , G06T2207/20221
摘要: A method for recording a merged microscope image of a sample includes a microscopic capturing of at least a first fused image and a second fused image. According to the method, there is capturing a first image in which the sample is illuminated in a structured manner; capturing a second image in which the sample is uniformly illuminated; fusing the first image and the second image; and merging the first fused image and the second fused image into the merged microscope image. The first image is used for low-frequency image information located in the focus and the second image is used for high-frequency image information located in the focus. The second fused image depicts a different position on the sample than the first fused image. A microscope system can be used with a computer program product to perform the method.
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5.
公开(公告)号:US20240329383A1
公开(公告)日:2024-10-03
申请号:US18610320
申请日:2024-03-20
发明人: Sebastian TILLE
CPC分类号: G02B21/368 , G02B21/244
摘要: A computer-implemented method for manual focus adjustment of a microscope includes obtaining information about a manually adjusted focus relative to a sample in a microscope, determining information about a proposed focus for the sample, determining a difference between the adjusted focus and the proposed focus, and providing information about a signal to a user based on the determined difference.
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公开(公告)号:US12105273B2
公开(公告)日:2024-10-01
申请号:US18079930
申请日:2022-12-13
申请人: cytena GmbH
发明人: Agnes Johansson , Nathanael Dögel , David Rauch , Lena Lautscham
CPC分类号: G02B21/362 , G02B21/26 , G02B21/34
摘要: A microscope comprises a housing having a receiving portion for receiving at least one biological sample, an optics module comprising several objectives and an illumination system for illuminating at least one biological sample and/or an acquiring system for acquiring light coming from at least one biological sample, wherein the optics module is arranged in an inner space of the housing. The microscope is characterized in that the microscope comprises a replacement system for replacing an objective by one of the other objectives wherein the replacement system is configured to replace the objective by means of moving the optics module relative to the housing and/or by means of moving the housing relative to the optics module.
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公开(公告)号:US12099177B2
公开(公告)日:2024-09-24
申请号:US17913958
申请日:2020-04-08
申请人: BGI SHENZHEN
发明人: Qing Xie , Wei-Mao Wang , Wen-Wei Zhang , Mengzhe Shen
CPC分类号: G02B21/361 , G02B21/367 , G03H1/0443 , G03H2001/005
摘要: A lens-free microscopic imaging system (11), which is used to image microbeads (15) with pattern codes, includes an illumination system (11a) and an imaging system (11b). The illumination system (11a) includes an illumination light source (111) and an excitation light source (112). The imaging system (11b) includes an image sensor (113). The illumination light source (111) is used to emit illumination light to irradiate the microbeads (15), causing the irradiated microbeads (15) to be imaged on the image sensor. The excitation light source (112) is used to emit excitation light to excite the microbeads (15) to generate specific signals. The image sensor (113) is used to collect the images of the microbeads (15) and the specific signals to generate images. The imaging system (11) does not require a lens system. The present disclosure improves a detection efficiency of the microbeads (15).
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公开(公告)号:US12099012B2
公开(公告)日:2024-09-24
申请号:US17738251
申请日:2022-05-06
发明人: Victoria Ly , Pierre Baudin , Pattawong Pansodtee , Erik Jung , Robert Currie , David Haussler , Mircea Teodorescu
IPC分类号: G06T7/00 , C12M1/12 , G01N21/64 , G02B21/36 , G06T7/571 , H04N5/265 , H04N23/62 , H04N23/66 , H04N23/90
CPC分类号: G01N21/6458 , C12M25/06 , G01N21/6486 , G02B21/365 , G06T7/571 , H04N5/265 , H04N23/62 , H04N23/66 , H04N23/90 , G01N2201/021 , G01N2201/062 , G06T2207/10056 , G06T2207/10148 , G06T2207/30024 , G06T2207/30072
摘要: An imaging system includes an imaging device having a holder configured to hold a cell culture plate with a plurality of wells. The imaging device also includes an imaging assembly having a plurality of imaging units, each of which is configured to image one well of the plurality of wells. The imaging system also includes a storage platform in communication with the imaging device configured to receive a plurality of images from the imaging device. The system further includes a computer in communication with the imaging device and the storage platform. The computer is configured to control the imaging device and to display at least one image of the plurality of images.
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9.
公开(公告)号:US20240310617A1
公开(公告)日:2024-09-19
申请号:US18575708
申请日:2022-06-30
申请人: CytoVeris Inc.
发明人: David Fournier , Alan Kersey
CPC分类号: G02B21/16 , G01N21/6458 , G01N21/6486 , G02B21/06 , G02B21/361
摘要: A system and method for imaging a tissue sample is provided. The system includes a dome, at least one excitation light source, and at least one light detector. The dome is configured to surround at least a portion of a tissue sample. The dome has interior surfaces that define a dome interior cavity. The excitation light source is configured to produce light at one or more wavelengths. The excitation light source is in photometric communication with the dome. The dome interior surfaces are configured to reflect the light at the one or more predetermined wavelengths. The dome is configured to cause the light at the one or more predetermined wavelengths to be incident to the exposed surface of the tissue sample in a substantially uniform manner. The light detector is in photometric communication with the dome and configured to detect light emitted or reflected from the tissue sample.
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公开(公告)号:US20240310585A1
公开(公告)日:2024-09-19
申请号:US18674871
申请日:2024-05-26
申请人: Kevin B. LARKIN
发明人: Kevin B. LARKIN
CPC分类号: G02B6/385 , G02B6/3809 , G02B6/3898 , G02B21/0004 , G02B21/362 , G01M11/30
摘要: The purpose of this continuation is to increase the viewing magnification of the already issued patent U.S. Pat. No. 11,385,412 B2. By the addition of a module housing that has the capability of allowing for additional magnification, lighting and focusing capabilities. A module housing case is described. The modular housing case includes a fiber optic component housing defined as a cavity and or cavities that are sized to receive a fiber optic connector and or connectors. Within the cavity or cavities is a ferrule guide or ferrule guides. The module housing case also has an internal cavity that is at least partially enclosed. Components to assist in magnification may be disposed at least partially or fully within the internal cavity. Those components can range from a lighting system powered by internal electronics or a system that relies on the cell phone camera flash and or flashlight LED for internal fiber end face lighting. Finally, the module housing case employs a camera lens alignment feature that can be adjusted manually to increase magnification of the field of view by the raising and or lowering of the module housing case.
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