SINGLE-PARTICLE LOCALIZATION MICROSCOPE
    1.
    发明公开

    公开(公告)号:US20240361584A1

    公开(公告)日:2024-10-31

    申请号:US18645424

    申请日:2024-04-25

    摘要: A single-particle localization microscope includes a light source configured to generate illumination light for illuminating a sample region, and an optical illumination system configured to shape the illumination light into a localizing light distribution having a substantially zero intensity minimum at a target point within the sample region. The localizing light distribution is adapted to cause a single particle in a fluorescent state located in the sample region outside the intensity minimum to emit fluorescent light. The optical illumination system is further configured to shape the illumination light into an auxiliary light distribution having a non-zero intensity at the target point such that the auxiliary light distribution is defined in a spatial extent and/or in its shape by the localizing light distribution.

    TRANSFLECTIVE DIGITAL HOLOGRAPHIC MICROSCOPE SYSTEM

    公开(公告)号:US20240337982A1

    公开(公告)日:2024-10-10

    申请号:US17797120

    申请日:2021-06-09

    摘要: A transflective digital holographic microscope system belongs to the technical field of microscopes, includes a reflection-type digital holographic microscope light path and a transmission-type digital holographic microscope light path, wherein the reflection-type digital holographic microscope light path is as follows: a first light beam is changed in polarization direction through a first polarizer, and is divided into two light waves with vertical polarization states; wherein the transmission-type digital holographic microscope light path is as follows: a second light beam is changed in polarization direction through a second polarizer, and is divided into two light waves with vertical polarization states, so that the thickness information and surface contour information of the sample can be tested at the same time.

    Microscope having movable multi-objective optics module

    公开(公告)号:US12105273B2

    公开(公告)日:2024-10-01

    申请号:US18079930

    申请日:2022-12-13

    申请人: cytena GmbH

    IPC分类号: G02B21/36 G02B21/26 G02B21/34

    摘要: A microscope comprises a housing having a receiving portion for receiving at least one biological sample, an optics module comprising several objectives and an illumination system for illuminating at least one biological sample and/or an acquiring system for acquiring light coming from at least one biological sample, wherein the optics module is arranged in an inner space of the housing. The microscope is characterized in that the microscope comprises a replacement system for replacing an objective by one of the other objectives wherein the replacement system is configured to replace the objective by means of moving the optics module relative to the housing and/or by means of moving the housing relative to the optics module.

    Lens-free microscopic imaging system and method, and biochemical substance detection system and method

    公开(公告)号:US12099177B2

    公开(公告)日:2024-09-24

    申请号:US17913958

    申请日:2020-04-08

    申请人: BGI SHENZHEN

    IPC分类号: G02B21/36 G03H1/04 G03H1/00

    摘要: A lens-free microscopic imaging system (11), which is used to image microbeads (15) with pattern codes, includes an illumination system (11a) and an imaging system (11b). The illumination system (11a) includes an illumination light source (111) and an excitation light source (112). The imaging system (11b) includes an image sensor (113). The illumination light source (111) is used to emit illumination light to irradiate the microbeads (15), causing the irradiated microbeads (15) to be imaged on the image sensor. The excitation light source (112) is used to emit excitation light to excite the microbeads (15) to generate specific signals. The image sensor (113) is used to collect the images of the microbeads (15) and the specific signals to generate images. The imaging system (11) does not require a lens system. The present disclosure improves a detection efficiency of the microbeads (15).

    METHOD AND APPARATUS FOR MITIGATING SPECULAR HIGHLIGHTS IN IMAGING OF BIOLOGICAL TISSUE

    公开(公告)号:US20240310617A1

    公开(公告)日:2024-09-19

    申请号:US18575708

    申请日:2022-06-30

    申请人: CytoVeris Inc.

    摘要: A system and method for imaging a tissue sample is provided. The system includes a dome, at least one excitation light source, and at least one light detector. The dome is configured to surround at least a portion of a tissue sample. The dome has interior surfaces that define a dome interior cavity. The excitation light source is configured to produce light at one or more wavelengths. The excitation light source is in photometric communication with the dome. The dome interior surfaces are configured to reflect the light at the one or more predetermined wavelengths. The dome is configured to cause the light at the one or more predetermined wavelengths to be incident to the exposed surface of the tissue sample in a substantially uniform manner. The light detector is in photometric communication with the dome and configured to detect light emitted or reflected from the tissue sample.

    FIBER INSPECTION TOOL WITH MANUAL ADJUSTMENT
    10.
    发明公开

    公开(公告)号:US20240310585A1

    公开(公告)日:2024-09-19

    申请号:US18674871

    申请日:2024-05-26

    申请人: Kevin B. LARKIN

    发明人: Kevin B. LARKIN

    摘要: The purpose of this continuation is to increase the viewing magnification of the already issued patent U.S. Pat. No. 11,385,412 B2. By the addition of a module housing that has the capability of allowing for additional magnification, lighting and focusing capabilities. A module housing case is described. The modular housing case includes a fiber optic component housing defined as a cavity and or cavities that are sized to receive a fiber optic connector and or connectors. Within the cavity or cavities is a ferrule guide or ferrule guides. The module housing case also has an internal cavity that is at least partially enclosed. Components to assist in magnification may be disposed at least partially or fully within the internal cavity. Those components can range from a lighting system powered by internal electronics or a system that relies on the cell phone camera flash and or flashlight LED for internal fiber end face lighting. Finally, the module housing case employs a camera lens alignment feature that can be adjusted manually to increase magnification of the field of view by the raising and or lowering of the module housing case.