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公开(公告)号：US20250029825A1
公开(公告)日：2025-01-23
申请号：US18715324
申请日：2022-12-01
Applicant: YOUNG IN ACE Co., Ltd.
Inventor： Sungwon Kang , Hun Lee , Yoon Jin Jeong , Ju Woo , Hyun-sang Lee , Jingeun Rhee
Abstract: The present invention provides a mass spectrometer includes a sample introduction part, an ionization part connected to the sample introduction part and configured to ionize the sample introduced from the sample introduction part, an ion lens part including an extraction lens structure adjacent to the ionization part and first and second guiding lenses configured to guide an ion beam extracted from the extraction lens structure, and a detection part configured to detect the ion beam, wherein a central axis of the extraction lens structure is a first axis extending in a first direction, a central axis of the first guiding lens is a second axis spaced a first distance from the first axis, and a central axis of the second guiding lens is a third axis spaced a second distance from the second axis.
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公开(公告)号：US20250029824A1
公开(公告)日：2025-01-23
申请号：US18715315
申请日：2022-12-01
Applicant: YOUNG IN ACE Co., Ltd.
Inventor： Sungwon Kang , Hun Lee , Yoon Jin Jeong , Ju Woo , Hyun-sang Lee , Jingeun Rhee
Abstract: The present invention provides a mass spectrometer including a sample introduction part, an ionization part connected to the sample introduction part and configured to ionize the sample introduced from the sample introduction part, an ion lens part including an extraction lens adjacent to the ionization part and a guiding lens configured to guide ion beam extracted from the extraction lens, an interface part between the ionization part and the ion lens part, and a detection part configured to detect the ion beam, wherein the extraction lens includes a first extraction lens adjacent to the interface part and a second extraction lens between the first extraction lens and the guiding lens, each of the first and second extraction lenses has a hollow cone shape, the first extraction lens includes a protrusion protruding from an outer sidewall thereof to the interface part, and an internal space of the second extraction lens includes a first space having a pillar shape and a second space having a cone shape and extending from the first space.
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公开(公告)号：US12205808B2
公开(公告)日：2025-01-21
申请号：US17777191
申请日：2020-11-20
Applicant: THE TRUSTEES OF INDIANA UNIVERSITY
Inventor： Nicholas Edward Manicke , Brandon John Bills
Abstract: Disclosed herein are mass spectrometry sample substrates. Also disclosed herein are mass spectrometry sample strips and cartridges that include a solid phase extraction (SPE) element. The mass spectrometry sample substrates, sample strips, and cartridges can be used in paper spray mass spectrometry to detect and quantify one or more analytes present in a biological sample. Also disclosed are methods for collecting and concentrating one or more analytes from a biological sample, as well as for storing a biological sample that includes one or more analytes. Methods for analyzing the one or more analytes from the biological sample are also provided.
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公开(公告)号：US12188943B2
公开(公告)日：2025-01-07
申请号：US18465292
申请日：2023-09-12
Applicant: Quest Diagnostics Investments Incorporated
Inventor： Nigel Clarke , Zhaohui Chen
IPC: G01N33/68 , G01N30/72 , G01N33/487 , G01N33/74 , H01J49/04 , G01N30/02 , H01J49/00 , H01J49/16 , H01J49/40
Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
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公开(公告)号：US12181454B2
公开(公告)日：2024-12-31
申请号：US17557698
申请日：2021-12-21
Applicant: DIONEX CORPORATION
Inventor： Brandon Howard Robson , Xuefei Sun , Carla Marie Medlin , Shane Bechler
Abstract: An integrated system for liquid separation and electrospray ionization includes an emitter-enabled capillary column including an emitter portion and a column portion; and a retractable protective sleeve for covering and/or supporting the emitter portion along at least a portion of its axis. The protective sleeve is mounted around the emitter-enabled capillary column. The retractable protective sleeve is moveable to an extended position wherein a tip of the emitter portion is covered by the protective sleeve. A resilient member is provided to bias the protective sleeve towards the extended position. The protective sleeve is enclosed and moveable within an outer electrically conductive sheath adapted for insertion within a holder having a high-voltage contact point. The sheath is adapted to contact the high-voltage contact point and provide an electrical connection to enable the emitter-enabled capillary column to receive a high voltage. The sheath has a recess to receive the high-voltage contact point.
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Patent Agency Ranking
公开(公告)号：US20240420941A1
公开(公告)日：2024-12-19
申请号：US18744388
申请日：2024-06-14
Inventor： Jan Fietzke
Abstract: The invention relates to a temperature control plasma source analyzer arrangement (1) comprising a plasma source (3), at least one preheating device (2), preferably comprising a temperature control means (21) for heating and/or cooling at least one gas flow of the plasma source (3) relative to room temperature, of, and an analyzer (4); wherein the at least one gas flow comprises a sample gas flow (5) with a sample aerosol (15), the plasma source (3) is configured to ionize the sample aerosol (15) of the sample gas flow (5), and the analyzer (4) is configured to analyze the ionized sample aerosol (15); wherein the preheating device (2) is configured to increase temperature of the at least one gas flow; the preheating device (2) is located in front of the plasma source (3) so that the at least one gas flow reaches the plasma source (3) only after leaving the preheating device (2); the preheating device (2) is configured to controllably increase the temperature of the at least one gas flow; and the arrangement (1) is designed as a modular system, wherein the preheating device (2) is constructed as a separate module
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公开(公告)号：US20240395530A1
公开(公告)日：2024-11-28
申请号：US18693796
申请日：2022-09-20
Applicant: Micromass UK Limited
Inventor： Andrew Whatley
Abstract: An ion source assembly comprising: a target plate for holding a sample to be analysed; a laser for ionising the sample on the target plate so as to form analyte ions; one or more optical elements; an ion guide for guiding the analyte ions; a first gas port arranged to supply a first gas stream so as to urge material generated at the target plate away from the one or more optical element; and a second, different gas port arranged to supply a second gas stream that urges ions from the target plate, towards and into the ion guide.
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公开(公告)号：US20240395525A1
公开(公告)日：2024-11-28
申请号：US18322251
申请日：2023-05-23
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Michael KNIERMAN , Stephen ZANON
Abstract: In some examples, a three-dimensional printed nanospray interface for mass spectrometry may include a body including a sheath inlet connected to a sheath outlet for passage of sheath liquid to an emitter. The emitter may include a sidewall including a stepped texture on an inner surface of the sidewall.
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公开(公告)号：US20240377344A1
公开(公告)日：2024-11-14
申请号：US18643765
申请日：2024-04-23
Inventor： Xiaoxiao LING , Yu LIU , Xianhua LI , Hongxia MA
IPC: G01N23/2258 , G01N33/24 , H01J49/00 , H01J49/04 , H01J49/14
Abstract: A method for accurately correcting the age of columbite-tantalite by using double-reference-material includes: using at least two kinds of columbite-tantalite with known ages as reference materials; determining the positive correlation between the lead-uranium ion ratio and the uranium ion ratio of the columbite-tantalite based on test results of a lead-uranium ion ratio ( 206 Pb + 238 U 16 O + ) Cstd 1 and a uranium ion ratio ( 238 U 16 O 2 + 238 U 16 O + ) Cstd 1 of the reference material 1, correcting the correlation by reference material 2; calculating the lead-uranium mass ratio ( 206 Pb 238 U ) un of the columbite-tantalite sample to be tested by using the corrected correlation; finally, determining the uranium-lead age UPbtun of the columbite-tantalite sample to be tested based on the lead-uranium mass ratio ( 206 Pb 238 U ) un . The method is fast and reliable, and greatly increases the accuracy in calculating the age of columbite-tantalite, and the method represents the latest international test design and calibration method in this field, and is of great practical value.
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公开(公告)号：US20240363322A1
公开(公告)日：2024-10-31
申请号：US18686595
申请日：2022-08-31
Applicant: Micromass UK Limited
Inventor： Suloke Mathai , Ian David Trivett
IPC: H01J49/04 , G01N27/623 , H01J49/16
CPC classification number: H01J49/045 , H01J49/167 , G01N27/623
Abstract: A nebuliser outlet assembly comprises an inlet end and an outlet end, and a first channel (24) arranged between the inlet end and the outlet end, wherein the first channel is configured to receive a capillary. The nebuliser outlet assembly comprises a first part (40) and one or more second parts (50), wherein the one or more second parts are removably attachable to the first part. The nebuliser outlet assembly is configured such that the first channel is formed from the first part and the one or more second parts when the one or more second parts are attached to the first part. The first part comprises an open-sided channel that corresponds to the first channel for at least some of its length. The nebuliser outlet assembly is configured such that when the one or more second parts are removed from the first part, said open-sided channel is exposed.
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