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公开(公告)号:US20230048972A1
公开(公告)日:2023-02-16
申请号:US17792170
申请日:2020-03-12
申请人: SHIMADZU CORPORATION
发明人: Hidenori TAKAHASHI
IPC分类号: G01N27/623 , G01N27/626 , H01J49/14
摘要: An ion analysis device 1 configured to generate and analyze product ions from precursor ions derived from a sample component includes: a reaction chamber 132 into which the precursor ions are introduced; a radical emitter 134 made of a predetermined kind of metal and disposed in the reaction chamber or a space communicating with the reaction chamber, at least a part of a surface of the radical emitter being oxidized or nitrided; a heating unit 20 configured to heat the radical emitter to a predetermined temperature; and separation detection units 135 and 136 configured to separate and detect, according to at least one of a mass-to-charge ratio and an ion mobility, product ions generated from the precursor ions by a reaction with radicals emitted from the radical emitter heated to the predetermined temperature.
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公开(公告)号:US11574803B2
公开(公告)日:2023-02-07
申请号:US17531490
申请日:2021-11-19
申请人: Micromass UK Limited
发明人: Zoltán Takáts , Frances Bolt , Tamás Karancsi , Emrys Jones , Keith Richardson , Lajos Godorhazy , Daniel Szalay , Julia Balog , Steven Derek Pringle , Daniel Simon
IPC分类号: H01J49/10 , H01J49/04 , A61B10/02 , A61B17/32 , A61B18/00 , A61B18/14 , A61B18/20 , G01N3/00 , G01N9/00 , G01N33/68 , H01J49/00 , H01J49/06 , H01J49/16 , G01N27/623 , A61B90/13 , A61B1/04 , A61B1/273 , A61B5/00 , A61B5/01 , A61B5/0507 , A61B5/055 , A61B6/03 , A61B8/13 , A61B10/00 , A61B17/00 , A61B18/04 , A61B18/18 , A61F13/38 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N27/624 , G01N30/72 , G01N33/487 , G01N33/92 , H01J49/02 , H01J49/14 , H01J49/24 , H01J49/26 , G16B20/00 , G16H10/40 , G16H15/00 , G16H50/20 , A61B1/00 , A61B1/31 , A61B5/145
摘要: A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed. The method comprises: using a first device to generate smoke, aerosol or vapour from a target comprising or consisting of a microbial population; mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and analysing said spectrometric data in order to analyse said microbial population.
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公开(公告)号:US11549954B2
公开(公告)日:2023-01-10
申请号:US17700320
申请日:2022-03-21
发明人: Brett Holmquist , Nigel Clarke
摘要: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.
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公开(公告)号:US20220344138A1
公开(公告)日:2022-10-27
申请号:US17763294
申请日:2020-10-02
摘要: Disclosed herein are specimen imaging systems, comprising: a sample stage in a vacuum environment, the sample stage configured to support a specimen; an electron beam generator configured to focus an electron beam on a first predetermined location on the specimen; a nanospray dispenser configured to dispense a nanospray onto a second predetermined location on the specimen; a mass spectrometer; and an extraction conduit configured to extract a plume of charged particles generated as a result of contact between the nanospray and the specimen and deliver the charged particles to the mass spectrometer. The system can create a topological and chemical map of the specimen by analyzing at least a portion of the specimen with a mass spectrometer to determine a chemical composition of the specimen at the second predetermined location and analyzing at least a portion of the specimen with the electron beam to determine a surface topology.
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公开(公告)号:US20220318988A1
公开(公告)日:2022-10-06
申请号:US17597614
申请日:2021-07-13
发明人: Gaofeng XU
摘要: The present disclosure provides a wafer sample analysis method and device. The method is applied to a secondary-ion-mass spectroscope (Sims) and includes: providing a wafer sample, the wafer sample at least including a slope configured to expose a substrate, a first protective layer and a first doped layer on a same surface, the first protective layer being formed on the substrate, and the first doped layer being formed on the first protective layer; and acquiring and analyzing a slope image of the slope to obtain a doping depth and a doping concentration of elements in the wafer sample in the slope image.
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6.
公开(公告)号:US11335545B2
公开(公告)日:2022-05-17
申请号:US15555818
申请日:2016-03-07
申请人: Micromass UK Limited
发明人: Emrys Jones , Steven Derek Pringle , Zoltan Takats
IPC分类号: H01J49/04 , A61B90/13 , A61B1/04 , A61B1/273 , A61B5/00 , A61B5/01 , A61B5/0507 , A61B5/055 , A61B6/03 , A61B8/13 , A61B10/00 , A61B10/02 , A61B17/00 , A61B17/32 , A61B18/00 , A61B18/04 , A61B18/14 , A61B18/18 , A61B18/20 , A61F13/38 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N3/00 , G01N9/00 , G01N27/622 , G01N27/624 , G01N30/72 , G01N33/487 , G01N33/68 , G01N33/92 , H01J49/00 , H01J49/02 , H01J49/06 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/24 , H01J49/26 , G16H10/40 , G16H15/00 , G16H50/20 , G16B20/00 , A61B1/00 , A61B1/31 , A61B5/145
摘要: A method of ion imaging is disclosed that includes automatically sampling a plurality of different locations on a sample using a front device which is arranged and adapted to generate aerosol, smoke or vapour from the sample. Mass spectral data and/or ion mobility data corresponding to each location is obtained and the obtained mass spectral data and/or ion mobility data is used to construct, train or improved a sample classification model.
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7.
公开(公告)号:US11309174B2
公开(公告)日:2022-04-19
申请号:US16348935
申请日:2016-11-18
申请人: SHIMADZU CORPORATION
发明人: Kenichi Taniguchi , Takeshi Uchida , Hiroto Itoi
摘要: Provided is an ionization method for ionizing a sample 21 adhered to a tip of a probe 11 that is electrically conductive, by applying an ionization voltage to the probe 11 to electrically charge the sample 21. The ionization method includes: subjecting the probe 11 to treatment to make a surface of the probe 11 homogenous; causing adhesion of the sample 21 to the tip of the probe 11; and ionizing the sample 21 by applying the ionization voltage to the probe 11 to electrically charge the sample 21. The treatment for making the surface of the probe 11 homogenous can be implemented by, for example, causing corona discharge at the probe 11.
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公开(公告)号:US11282691B2
公开(公告)日:2022-03-22
申请号:US16956809
申请日:2018-12-21
申请人: Micromass UK Limited
发明人: Stevan Bajic , David S. Douce
摘要: A method of ionizing a sample is disclosed that comprises heating a sample so that analyte is released from the sample, producing charged particles such as charged droplets downstream of the sample, and using the charged particles to ionize at least some of the analyte released from the sample so as to produce analyte ions.
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公开(公告)号:US11264224B2
公开(公告)日:2022-03-01
申请号:US16232475
申请日:2018-12-26
发明人: Puneet Chhabra , Andrew Tipier
IPC分类号: B01D53/04 , B01J20/20 , H01J49/04 , G01N27/622 , G01N27/626 , G01N27/64 , H01J49/14
摘要: A drying device comprising a regenerable desiccant medium that is effective to adsorb water without absorption of gaseous analyte species in an introduced ambient air stream is described. The drying device can be used with a thermal desorption device to remove water vapor from gaseous analyte species prior to analysis of the gaseous analyte species. Systems including a drying device are also described.
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公开(公告)号:US11145502B2
公开(公告)日:2021-10-12
申请号:US16721517
申请日:2019-12-19
申请人: Thermo Finnigan LLC
摘要: An ion source assembly is described that includes an electron source configured to inject electrons into an ion volume to ionize an atom or molecule in the ion volume, wherein the electron source includes a filament. A lens electrode is positioned adjacent the electron source and includes an opening configured to pass electrons therethrough from the electron source into the ion volume. A supply voltage source is coupled to the filament and configured to supply a first voltage to the filament, wherein the first voltage is operable to ionize the molecules in the ion volume. Further, a bias voltage source is coupled to the supply voltage source and configured to supply a bias voltage to the lens electrode. Electrons striking the lens electrode are thereafter returned to the filament.
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