公开(公告)号：US12237162B2

公开(公告)日：2025-02-25

申请号：US17371899

申请日：2021-07-09

Applicant: Duke University ,  Coldquanta, Inc.

Inventor： Jungsang Kim ,  Geert Vrijsen ,  Ismail Inlek ,  Tom Noel ,  Megan Ivory ,  Alexander Kato ,  Steve Hughes

IPC: H01J49/42 ,  H01J49/16 ,  H01J49/24

Abstract: Aspects of the present disclosure describe systems, methods, and structures that enable a compact, UHV ion trap system that can operate at temperatures above cryogenic temperatures. Ion trap systems in accordance with the present disclosure are surface treated and sealed while held in a UHV environment, where disparate components are joined via UHV seals, such as weld joints, compressible metal flanges, and UHV-compatible solder joints. As a result, no cryogenic pump is required, thereby enabling an extremely small-volume system.

公开(公告)号：US12205807B2

公开(公告)日：2025-01-21

申请号：US17301385

申请日：2021-03-31

Applicant: Milan Pophristic

Inventor： Milan Pophristic

IPC: H01J49/04 ,  G01N27/623 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  H01J49/24

Abstract: An ionizing system includes a flange device for connection to a mass spectrometer or ion mobility spectrometer having the property of providing a barrier between the lower pressure region of the spectrometer and a higher pressure region substantially at atmospheric pressure, and a channel therethrough providing fluid communication between the higher and lower pressure regions. A plate device independent of the flange device which can accommodate multiple samples, such as a sample plate device, when placed over the channel in the flange device substantially seals the channel Sliding the sample plate device while in intimate contact with the flange device provides a means to sequentially and rapidly expose said samples to the opening of the channel and thus the lower pressure region. Samples are ionized when exposed to the lower pressure region in as little as one sample per second using multiple ionization methods.

公开(公告)号：US12176199B2

公开(公告)日：2024-12-24

申请号：US17616495

申请日：2020-05-11

Applicant: Leybold GmbH

Inventor： Yessica Brachthaeuser ,  Thorsten Benter ,  Marco Thinius ,  Michel Aliman

IPC: H01J49/24 ,  H01J27/20 ,  H01J49/06 ,  H01J49/14 ,  H01J49/02 ,  H01J49/26

Abstract: The invention relates to an ionization device with an ionization space formed in a container, an inlet system for supplying a gas to be ionized to the ionization space, an electron source having at least one filament for supply of an electron beam to the ionization space, and an outlet system for letting the ionized gas out of the ionization space. Electron optics having at least two electrodes are disposed between the filament and the ionization space.

公开(公告)号：US20240355608A1

公开(公告)日：2024-10-24

申请号：US18641183

申请日：2024-04-19

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Jan-Peter HAUSCHILD ,  Tobias WOERNER ,  Kyle FORT ,  Alexander MAKAROV ,  Konstantin AIZIKOV

IPC: H01J49/24 ,  G01N30/72 ,  H01J49/00 ,  H01J49/26

CPC classification number: H01J49/24 ,  G01N30/72 ,  H01J49/0009 ,  H01J49/26

Abstract: Mass spectrometry systems for performing mass analysis on ion samples include a vacuum region comprising a mass analyser configured to provide a detection signal for the ion sample. A turbomolecular pump is configured to maintain the vacuum region at a vacuum pressure and a controller is configured to control the pressure within the mass analyser to control the rate of decay over time of the detection signal for the ion sample by: controlling a pumping speed of the turbomolecular pump. The turbomolecular pump can be configured to maintain the vacuum region at a first pressure when the mass analyser is being operated in a mass analysis mode of operation and a second pressure when the mass analyser is being operated in a collision cross section analysis mode of operation, wherein the second pressure is greater than the first pressure.

公开(公告)号：US20240242952A1

公开(公告)日：2024-07-18

申请号：US18514444

申请日：2023-11-20

Applicant: Institute of Geology and Geophysics, CAS

Inventor： Ziheng Liu ,  Jiannan Li ,  Fei Su ,  Huaiyu He

IPC: H01J49/04 ,  H01J49/24 ,  H01J49/42

CPC classification number: H01J49/0459 ,  H01J49/0468 ,  H01J49/0495 ,  H01J49/24 ,  H01J49/4205

Abstract: A water-containing simulated lunar soil preparation and water content measurement system and method is provided. The system includes a water-containing simulated lunar soil preparation unit, a low-pressure environment simulation unit, and a water content analysis unit. The water-containing simulated lunar soil preparation unit includes a preparation pipeline, a low-temperature lunar soil cold trap, and a low-temperature water ice cold trap. Both ends of the preparation pipeline are connected with the low-temperature lunar soil cold trap and the low-temperature water ice cold trap through a first opening and closing valve and a second opening and closing valve, respectively. The low-pressure environment simulation unit includes a low-pressure pipeline provided with a vacuum pump. Both ends of the low-pressure pipeline are connected with the preparation pipeline and the water content analysis unit through a first pneumatic valve and a second pneumatic valve, respectively.

公开(公告)号：US20240234122A9

公开(公告)日：2024-07-11

申请号：US18047801

申请日：2022-10-19

Applicant: Thermo Finnigan LLC

Inventor： Scott T. Quarmby ,  Joshua T. Maze

IPC: H01J49/24 ,  H01J49/42

CPC classification number: H01J49/24 ,  H01J49/421

Abstract: A mass spectrometer includes a vacuum chamber, a pump for maintaining a vacuum chamber at an operating vacuum pressure, an ion source, a first mass filter configured to select precursor ions, a collision/reaction cell pressurized with a collision or reaction gas and configured to generate a plurality of product ions from the precursor ions by colliding or reacting the precursor ions with one or more gas particles, and a second mass filter configured to select target ions from the product ions. Also provided are entrance and exit lenses between the collision/reaction cell and the first and second mass filters, respectively, each of which include axially-spaced ion lenses and evacuation chambers between adjacent ion lenses. A plenum fluidly connects the evacuation chambers to the pump inlet to facilitate evacuation of collision or reaction gas escaping the collision/reaction cell to the pump away from the first and second mass filters.

公开(公告)号：US20240213011A1

公开(公告)日：2024-06-27

申请号：US18508669

申请日：2023-11-14

Applicant: SHIMADZU CORPORATION

Inventor： Xiaoqiang ZHANG ,  Zhi Geng ,  Wenjian Sun

IPC: H01J49/06 ,  H01J49/24

CPC classification number: H01J49/063 ,  H01J49/24

Abstract: The technical solution of the present disclosure provides an ion source apparatus and a mass spectrometer. According to the ion source apparatus, the axial ion guide assembly includes the plurality of multipole segments extending axially, the transmission path of axial ions is straight, and the ion transmission efficiency is substantially unaffected when the axial ion source is used alone. Further, since the ion outlet of the lateral ion guide assembly faces a gap between two adjacent segmented multipoles, the lateral ion guide assembly does not affect axial field, thereby integrating the multiple ion sources while ensuring the ion transmission efficiency and ion constraining of the axial ion source.

公开(公告)号：US20240177987A1

公开(公告)日：2024-05-30

申请号：US18282841

申请日：2021-11-18

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Leigh BEDFORD ,  Thomas R. COVEY ,  James HAGER ,  Bradley B. SCHNEIDER

IPC: H01J49/42 ,  G01N33/02 ,  G01N33/483 ,  H01J49/24

CPC classification number: H01J49/4215 ,  G01N33/02 ,  G01N33/4833 ,  H01J49/24

Abstract: In one aspect, a method of performing mass spectrometric analysis of a sample, e.g. a food-based sample, is disclosed, which comprises ionizing the sample to generate a plurality of ions, introducing the plurality of ions into a mass filter configured to provide a high m/z cutoff greater than a maximum m/z ratio of ions associated with one or more analytes of interest in the sample so as to allow passage of the analyte ions while inhibiting passage of ions having m/z ratios above said high m/z cutoff, and performing a mass analysis of ions passing through said mass filter. In a related aspect, a mass spectrometer is disclosed, which comprises an atmospheric pressure ion source, a first mass filter, a user interface and a controller.

公开(公告)号：US20240145225A1

公开(公告)日：2024-05-02

申请号：US18382955

申请日：2023-10-23

Applicant: SHIMADZU CORPORATION

Inventor： Tomoyoshi MATSUSHITA

IPC: H01J49/04 ,  H01J49/10 ,  H01J49/24

CPC classification number: H01J49/0495 ,  H01J49/105 ,  H01J49/24

Abstract: Provided is a mass spectrometer including a vacuum chamber containing a cell used for causing ions originating from a sample to come in contact with a predetermined gas supplied from a gas supplier (20), which includes a three-way valve (204) configured to selectively send the gas into either a first passage (22) for sending the predetermined gas to the cell or a second passage (23) for discharging the gas into vacuum state. The mass spectrometer also includes a controller configured to control the three-way valve so as to send the gas into the second passage during an analysis period in which ions are not caused to come in contact with the gas within the cell and/or during a non-analyzing period, as well as to send the gas into the first passage during an analysis period in which ions are caused to come in contact with the gas within the cell.

公开(公告)号：US20240136171A1

公开(公告)日：2024-04-25

申请号：US18047801

申请日：2022-10-18

Applicant: Thermo Finnigan LLC

Inventor： Scott T. Quarmby ,  Joshua T. Maze

IPC: H01J49/24 ,  H01J49/42

CPC classification number: H01J49/24 ,  H01J49/421

Abstract: A mass spectrometer includes a vacuum chamber, a pump for maintaining a vacuum chamber at an operating vacuum pressure, an ion source, a first mass filter configured to select precursor ions, a collision/reaction cell pressurized with a collision or reaction gas and configured to generate a plurality of product ions from the precursor ions by colliding or reacting the precursor ions with one or more gas particles, and a second mass filter configured to select target ions from the product ions. Also provided are entrance and exit lenses between the collision/reaction cell and the first and second mass filters, respectively, each of which include axially-spaced ion lenses and evacuation chambers between adjacent ion lenses. A plenum fluidly connects the evacuation chambers to the pump inlet to facilitate evacuation of collision or reaction gas escaping the collision/reaction cell to the pump away from the first and second mass filters.