公开(公告)号：US20250069880A1

公开(公告)日：2025-02-27

申请号：US18810129

申请日：2024-08-20

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Hamish Stewart

IPC: H01J49/42

Abstract: Ions are separated according to their mass-to-charge ratios. A separation region receives the ions, extending in a first direction and a second direction that is different to the first direction. An electrode arrangement confines the ions in the separation region. The electrode arrangement is configured to apply a time-varying potential in the separation region to cause the ions to move in the first direction and configured to apply a potential gradient in the separation region, the potential gradient opposing the time-10 varying potential, such that the ions are separated at different positions in the first direction according to the mass-to-charge ratios of the ions. A force is applied in the second direction to the ions to cause the ions to move in the second direction.

公开(公告)号：US12198918B2

公开(公告)日：2025-01-14

申请号：US17783008

申请日：2021-02-04

Applicant: YOUNG IN ACE Co., Ltd.

Inventor： Sung Won Kang ,  Hun Lee ,  Yoon Jin Jeong

IPC: H01J49/04 ,  H01J49/00 ,  H01J49/10 ,  H01J49/42

Abstract: Provided is a mass spectrometer including: an ion generation unit configured to provide an ion generation path; an ion selection unit configured to provide an ion selection path connected to the ion generation path; a reaction unit configured to provide a reaction path connected to the ion selection path; a second ion selection unit configured to provide a second ion selection path connected to the reaction path; and an ion detection unit coupled to the second ion selection unit. The ion selection path and the reaction path extend in a first direction, and the reaction unit includes: a reaction pipe extending in the first direction to define the reaction path; and a sample inflow pipe coupled to the reaction pipe. The sample inflow pipe provides a sample inflow path connected to the reaction path, and the sample inflow path includes an inclined path. The inclined path extends to form an acute angle (α) with respect to the first direction.

公开(公告)号：US12191130B2

公开(公告)日：2025-01-07

申请号：US18495237

申请日：2023-10-26

Applicant: Micromass UK Limited

Inventor： Keith Richardson ,  Jeffery Mark Brown ,  David J. Langridge

IPC: H01J49/00 ,  H01J49/06 ,  H01J49/42

Abstract: Disclosed herein are various methods and apparatus for performing charge detection mass spectrometry (CDMS). In particular, techniques are disclosed for monitoring a detector signal from a CDMS device to determine how many ions are present in the ion trap (10) of the CDMS device. For example, if no ions are present the measurement can then be terminated early. Similarly, if more than one ion is present, the measurement can be terminated early, or ions can be removed from the trap (10) until only a single ion remains. Techniques are also provided for increasing the probability of there being a single ion in the trap (10). A technique for attenuating an ion beam is also provided.

公开(公告)号：US20240385152A1

公开(公告)日：2024-11-21

申请号：US18287424

申请日：2022-06-28

Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH ,  Shimadzu Corporation

Inventor： Koji UEDA ,  Yoshimi HAGA ,  Masaki YAMADA

IPC: G01N30/72 ,  C12Q1/34 ,  G01N30/02 ,  G01N30/88 ,  H01J49/42

Abstract: A sugar chain analysis method is a method for analyzing a sugar chain structure bound to an antibody, the method including: a releasing step of adding a sugar cleavage enzyme to a sample containing an antibody, so that a sugar chain bound to the antibody is specifically released to obtain a free sugar chain; a recovery step of recovering the free sugar chain by affinity purification; a hydrophobization step of hydrophobizing the free sugar chain to obtain a hydrophobized sugar chain; and a measurement step of performing supercritical liquid chromatography and tandem mass spectrometry in this order on the hydrophobized sugar chain.

公开(公告)号：US12148605B2

公开(公告)日：2024-11-19

申请号：US17441857

申请日：2020-03-26

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Mikhail Belov ,  Lothar Rottman

IPC: H01J49/10 ,  H01J49/00 ,  H01J49/42

Abstract: A method of operating a collision cell (10) in a mass spectrometer is disclosed. The collision cell comprises an entrance aperture (116), an exit aperture (117) and electrodes (113, 114) for producing electric fields. The method comprises feeding ions in a forward axial direction (LD) through the entrance aperture into the collision cell, producing a first electric field to trap ions, and subsequently producing a second electric field to accelerate trapped ions in the forward axial direction. The method further comprises producing a gas flow (G1) which is, at least at the entrance aperture (116) of the collision cell, contrary to the forward axial direction (LD), so as to reduce the kinetic energy of ions in dependence on their collisional cross sections. A collision cell arranged for carrying out the method is also disclosed, as well as a mass spectrometer comprising such a collision cell.

公开(公告)号：US20240355611A1

公开(公告)日：2024-10-24

申请号：US18685534

申请日：2022-08-23

Applicant: DH Technologies Development Pte. Ltd.

Inventor： David M. COX ,  Mircea GUNA ,  Yang KANG ,  Mircea MANOLESCU ,  Andrei SONOC

IPC: H01J49/42

CPC classification number: H01J49/421

Abstract: An ion mass filter for use in a mass spectrometer is disclosed, which includes a plurality of rods arranged in a multipole configuration to provide a passageway through which ions can travel, said plurality of rods being configured for application of RF voltages thereto to generate an electromagnetic field within the passageway for providing radial confinement of the ions and further configured for application of a DC voltage thereto, and at least two pairs of auxiliary electrodes interspersed between the plurality of multipole rods, where one pair forms a first pole of the auxiliary electrodes and the other pair forms a second pole of the auxiliary electrodes. A controller can provide one or more control signals to the DC voltage source so as to switch the polarity of the DC voltage differential between the two poles according to a predefined criterion.

公开(公告)号：US20240347334A1

公开(公告)日：2024-10-17

申请号：US18035331

申请日：2022-05-18

Applicant: NINGBO UNIVERSITY

Inventor： Fu-Xing Xu ,  Li Ding

IPC: H01J49/42

CPC classification number: H01J49/4245

Abstract: The invention relates to an electrostatic ion trap having a central axis and a central symmetrical plane perpendicular to the central axis. The electrostatic ion trap comprises an inner electrode group arranged along the central axis and a pair of outer electrode groups arranged on two sides of the central symmetry plane along the central axis. Each outer electrode group comprises a plurality of electrode plates. The plurality of electrode plates are circumferentially distributed around a periphery of the inner electrode group and centered on the central axis. At least two electrode plates in the same outer electrode group are electrically connected. A potential difference is formed when voltages are respectively applied to the inner electrode group and the outer electrode groups, thereby forming a space for trapping ions between the inner electrode group and the outer electrode groups.

公开(公告)号：US12112936B2

公开(公告)日：2024-10-08

申请号：US17760501

申请日：2020-09-22

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： Martin F. Jarrold ,  Aaron A. Todd

IPC: H01J49/42 ,  H01J49/40

CPC classification number: H01J49/4245 ,  H01J49/406 ,  H01J49/4265

Abstract: A charge detection mass spectrometer includes an ion trap configured to receive and store ions therein and to selectively release stored ions therefrom, and an electrostatic linear ion trap (ELIT) spaced apart from the ion trap, the ELIT including first and second ion mirrors and a charge detection cylinder positioned therebetween, and means for selectively controlling the ion trap to release at least some of the stored ions therefrom to travel toward and into the ELIT, and for controlling the first and second ion mirrors in a manner which traps in the ELIT a single one of the ions traveling therein and causes the trapped ion to oscillate back and forth between the first and second ion mirrors each time passing through and inducing a corresponding charge on the charge detection cylinder.

公开(公告)号：US20240304434A1

公开(公告)日：2024-09-12

申请号：US18630314

申请日：2024-04-09

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Dalton Snyder

IPC: H01J49/42 ,  G01N33/68 ,  H01J49/02

CPC classification number: H01J49/4225 ,  G01N33/6848 ,  H01J49/025 ,  H01J49/429

Abstract: The invention generally relates to mass spectrometry via frequency tagging.

公开(公告)号：US12087567B2

公开(公告)日：2024-09-10

申请号：US18339510

申请日：2023-06-22

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Henning Wehrs ,  Johannes Schwieters ,  Gerhard Jung

IPC: H01J49/06 ,  F16K1/20 ,  H01J49/00 ,  H01J49/02 ,  H01J49/10 ,  H01J49/42

CPC classification number: H01J49/063 ,  F16K1/2007 ,  H01J49/005 ,  H01J49/0077 ,  H01J49/022 ,  H01J49/065 ,  H01J49/067 ,  H01J49/068 ,  H01J49/105 ,  H01J49/421 ,  H01J49/4215

Abstract: An ion optical arrangement (1) for use in a mass spectrometer comprises electrodes (11, 12, 14) comprising a multipole arrangement defining an ion optical axis, and a voltage source for providing voltages to the electrodes to produce electric fields. The ion optical arrangement is configured for producing a radio frequency electric focusing field for focusing ions on the ion optical axis. The radio frequency electric focusing field has a varying frequency so as to reduce any mass dependence of ion trajectories through the ion optical arrangement. The ion optical arrangement may further be configured for producing a static electric field in response to a DC bias voltage applied to the multipole arrangement. A superimposed varying electric field may be produced by superimposing an AC voltage upon the DC bias voltage.