公开(公告)号：US11975013B2

公开(公告)日：2024-05-07

申请号：US17901284

申请日：2022-09-01

Applicant: SHORLA PHARMA LTD.

Inventor： Sharon Cunningham ,  Orlaith Ryan ,  Johannes Jan Platteeuw

IPC: A01N43/00 ,  A01N43/46 ,  A61K9/08 ,  A61K31/55 ,  A61K31/675 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/20 ,  A61K47/22

CPC classification number: A61K31/675 ,  A61K9/08 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/20 ,  A61K47/22

Abstract: The present disclosure provides pharmaceutical compositions comprising thiotepa and one selected from PEG, such as PEG400 or PEG600, and DMSO, and optionally water or an aqueous saline solution and thiosulfate. The composition is free or substantially free of impurities. Also provided is a method for treating cancer in a subject, or myeloablation prior to bone marrow transplantation using the composition. A method for enhancing the stability of a thiotepa formulation is also contemplated.

公开(公告)号：US11938118B2

公开(公告)日：2024-03-26

申请号：US18171431

申请日：2023-02-20

Applicant: SHANGHAI RUIHUKANG PHARMACEUTICAL PARTNERSHIP (LIMITED PARTNERSHIP)

Inventor： Changgeng Peng ,  Liting Sun ,  Ruilong Xia

IPC: A01N43/00 ,  A01N43/46 ,  A61K31/4164 ,  A61K31/427 ,  A61K31/55 ,  A61K47/02 ,  A61K47/36 ,  A61P25/04

CPC classification number: A61K31/427 ,  A61K31/4164 ,  A61K47/02 ,  A61K47/36 ,  A61P25/04

Abstract: An analgesic and antipruritic pharmaceutical composition, including PF-05089771 shown as




and PF-04885614 shown as





An application of the analgesic and antipruritic pharmaceutical composition in the treatment of a disease in which both a voltage-gated sodium channel 1.7 (Nav1.7) and a voltage-gated sodium channel 1.8 (Nav1.8) are involved.

公开(公告)号：US11744247B2

公开(公告)日：2023-09-05

申请号：US16855907

申请日：2020-04-22

Applicant: Neogen Corporation

Inventor： Martin Donnelly

IPC: A01N43/00 ,  A01N43/46 ,  A61K31/55 ,  A01N43/50 ,  A01N37/08 ,  A61K9/00 ,  A61K31/4439 ,  A61K31/215 ,  A61K9/08 ,  A61K47/20 ,  A61K31/4402 ,  A61K47/22

CPC classification number: A01N43/50 ,  A01N37/08 ,  A61K9/0017 ,  A61K9/08 ,  A61K31/215 ,  A61K31/4402 ,  A61K31/4439 ,  A61K47/20 ,  A61K47/22 ,  A61K31/4439 ,  A61K2300/00 ,  A61K31/215 ,  A61K2300/00 ,  A61K31/4402 ,  A61K2300/00

Abstract: Disclosed herein are veterinary compositions including imidacloprid or an analogue thereof; a pyrethroid; a solvent selected from the group consisting of N-methyl pyrrolidone, N-ethyl pyrrolidone and mixtures thereof; and dimethyl sulfoxide. The veterinary compositions of the invention are useful in methods of controlling parasites on or within warm-blooded domesticated animals.

公开(公告)号：US11632953B2

公开(公告)日：2023-04-25

申请号：US16348236

申请日：2017-11-13

Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

Inventor： Daniel R. Swale ,  Lane D. Foil

IPC: A01N43/00 ,  A01N43/40 ,  A01N43/38 ,  A01N43/56 ,  A01N43/90

Abstract: Modulation of inward potassium ion conductance with structurally diverse small-molecules in the arthropod salivary gland induces arthropod salivary gland failure that results in a reduction or elimination in the ability of the arthropod to feed. Administering Kir channel inhibitors reduces food intake, increases feeding time, reduces salivary gland secretion, induces mortality, and reduces transmission of vector-borne pathogens. Kir channel inhibitors induce these adverse effects in ticks, mosquitoes, horn flies, and aphids.

公开(公告)号：US11357744B2

公开(公告)日：2022-06-14

申请号：US17217311

申请日：2021-03-30

Applicant: ANTECIP BIOVENTURES II LLC

Inventor： Herriot Tabuteau

IPC: A01N43/00 ,  A01N43/46 ,  A61K31/55 ,  A61K31/137 ,  A61K31/485 ,  A61K31/135 ,  A61K31/15 ,  A61K31/381

Abstract: Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.

公开(公告)号：US11234905B2

公开(公告)日：2022-02-01

申请号：US12172039

申请日：2008-07-11

Applicant: Stacy Averic Mundschau ,  Scott W. Wenzel ,  Lisa Ann Flugge-Berendes ,  Debra Hartley Durrance ,  Jonathan Kyle Arendt ,  Kroy Donald Johnson

Inventor： Stacy Averic Mundschau ,  Scott W. Wenzel ,  Lisa Ann Flugge-Berendes ,  Debra Hartley Durrance ,  Jonathan Kyle Arendt ,  Kroy Donald Johnson

IPC: A01N43/00 ,  A01N43/46 ,  A61K31/55 ,  A61K8/02 ,  A61K8/891 ,  A61K8/37 ,  A61Q19/00

Abstract: Nonwoven and elastomeric substrates having formulations disposed thereon, wherein the formulations have improved compatibility with the substrate, are disclosed herein. More particularly, the formulations can be applied on the substrates without compromising the elastomeric properties and overall integrity of the substrate. Laminated articles using one or more of the nonwoven and elastomeric substrates having the formulations disposed thereon are further disclosed.

公开(公告)号：US10813999B2

公开(公告)日：2020-10-27

申请号：US15721259

申请日：2017-09-29

Applicant: Bernhard Gunther ,  Bastian Theisinger ,  Sonja Theisinger ,  Dieter Scherer

Inventor： Bernhard Gunther ,  Bastian Theisinger ,  Sonja Theisinger ,  Dieter Scherer

IPC: A01N43/00 ,  A01N43/46 ,  A61K31/55 ,  A61K45/06 ,  A61K9/08 ,  A61K31/355 ,  A61K9/00 ,  A61K9/107 ,  A61K47/06 ,  A61K31/436

Abstract: The invention provides liquid or semi-solid pharmaceutical compositions for topical administration comprising a semifluorinated alkane. The compositions are useful for the delivery of active ingredients into the deep layers of the skin or skin appendages. Various active ingredients may be incorporated, such as immunosuppressants, antiinfectives, antifungal agents, antiinflammatory agents, and retinoids.

公开(公告)号：US10786571B2

公开(公告)日：2020-09-29

申请号：US15761623

申请日：2016-09-20

Applicant: Zimmer Biotech GmbH

Inventor： Andre Solioz ,  Frank Stowasser ,  Armin Zimmer

IPC: A01N43/00 ,  A01N43/46 ,  A61K31/55 ,  A61K41/00 ,  A61K9/00 ,  A61K9/06 ,  A61K47/36 ,  A61P17/00 ,  A61K31/198 ,  A61K47/22

Abstract: The present invention relates to a pharmaceutical topical gel solution that contains 5-aminolevulinic acid (5-ALA) and an aqueous low viscous gel matrix. This invention also relates to a pharmaceutical preparation containing this composition. The formulation of this type can be used in photodynamic therapy as well as in the photodynamic detection of abnormally proliferating cells.

公开(公告)号：US10786525B2

公开(公告)日：2020-09-29

申请号：US15000727

申请日：2016-01-19

Applicant: Hibernation Therapeutics, A KF, LLC

Inventor： Geoffrey Phillip Dobson

IPC: A01N43/00 ,  A01N43/46 ,  A61K31/55 ,  A61K31/7076 ,  A61K31/167 ,  A61K45/06 ,  A61K9/00 ,  A61K31/519 ,  A61K31/7004 ,  A61K47/26 ,  A61K33/06 ,  A61K31/194 ,  A61K9/08 ,  A61K31/05 ,  A61K31/19

Abstract: The invention relates to a composition and method for increasing blood pressure, including a low pain or analgesic state or hypotensive anaesthesia in a subject that has suffered a life threatening hypotension or shock or reducing hypofusion in the whole body of a subject. The composition comprises (i) a compound selected from at least one of a potassium channel opener, a potassium channel agonist and an adenosine receptor agonist; and (ii) an antiarrhythmic agent or a local anaesthetic.

公开(公告)号：US10721930B2

公开(公告)日：2020-07-28

申请号：US14809030

申请日：2015-07-24

Applicant: Martin Donnelly

Inventor： Martin Donnelly

IPC: A01N43/00 ,  A01N43/46 ,  A61K31/55 ,  A01N43/50 ,  A01N37/08 ,  A61K9/00 ,  A61K31/4439 ,  A61K31/215 ,  A61K9/08 ,  A61K47/20 ,  A61K31/4402 ,  A61K47/22

Abstract: Disclosed herein are veterinary compositions including imidacloprid or an analogue thereof; a pyrethroid; a solvent selected from the group consisting of N-methyl pyrrolidone, N-ethyl pyrrolidone and mixtures thereof; and dimethyl sulfoxide. The veterinary compositions of the invention are useful in methods of controlling parasites on or within warm-blooded domesticated animals.