公开(公告)号：US11617774B2

公开(公告)日：2023-04-04

申请号：US15917209

申请日：2018-03-09

申请人： UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY

发明人： Jin Gyu Choi ,  Donghun Lee ,  Juyeon Park ,  Jungbin Song ,  Hocheol Kim

IPC分类号： A61K36/63 ,  A23L33/115 ,  A61K35/60 ,  A61K31/201 ,  A61K31/23 ,  A61K31/685 ,  A23G1/42 ,  A23G4/12 ,  A61K31/047 ,  A61K9/00 ,  A61K36/48

摘要： The present invention relates to a composition for preventing and/or treating a stroke or a degenerative brain disease comprising: at least two substances selected from the group consisting of egg yolk lecithin, glycerol, sodium oleate, medium chain triglyceride and refined fish oil; olive oil; and soybean oil. The composition of the present invention has an excellent neuroprotective effect but no toxicity or side effects, and thus can be effectively and safely used for preventing, treating or ameliorating a stroke or a degenerative brain disease.

公开(公告)号：US20230047565A1

公开(公告)日：2023-02-16

申请号：US17790004

申请日：2019-12-31

申请人： L'OREAL

发明人： Shichen ZHANG ,  Cherry YANG ,  Jessica YUAN

IPC分类号： A61K8/37 ,  A61K31/20 ,  A61K31/23 ,  A61P17/04 ,  A61Q5/12 ,  A61K8/36

摘要： A composition for caring for keratin materials, comprising a fatty acid-ester mixture of a plurality, e.g., at least 3, 4, or 5, of medium chain fatty acids and a plurality, e.g., at least 3, 4, or 5, of monoesters; and a cosmetically or dermatologically acceptable auxiliary agent to assist the delivery of the fatty acid-ester mixture to the keratin materials.

公开(公告)号：US20230015225A1

公开(公告)日：2023-01-19

申请号：US17787187

申请日：2020-12-17

申请人： GLAXOSMITHKLINE CONSUMER HEALTHCARE HOLDINGS (US) LLC

发明人： Pallav Arvind BULSARA ,  David John MOORE ,  Alireza SHALVIRI

IPC分类号： A61K31/23 ,  A61K9/00 ,  A61K31/137 ,  A61K45/06 ,  A61K31/573 ,  A61K31/593 ,  A61K47/10 ,  A61K47/26 ,  A61P31/10

摘要： The present invention relates to topical pharmaceutical compositions for treatment or prophylaxis of onychomycosis, and other fungal conditions caused by Trichophyton rubrum and/or Trichophyton mentagrophytes, comprising an effective amount of an amine-based anti-fungal compound, such as terbinafine or a pharmaceutically acceptable salt thereof, and monocaprin, in certain proportions.

公开(公告)号：US11517551B2

公开(公告)日：2022-12-06

申请号：US16164431

申请日：2018-10-18

申请人： Purac Biochem BV

发明人： Anne Cazemier

IPC分类号： A01N37/00 ,  A61K31/215 ,  A01N37/12 ,  A01N37/44 ,  A61K31/24 ,  A01N25/00 ,  A61K31/23 ,  A23K20/105 ,  A23K50/10 ,  A23K50/75

摘要： The present invention pertains to the use for preventing or treating intestinal infections caused by gram-positive bacteria in animals of an antibacterial compound selected from lactylate in accordance with formula 1, R2—COO—[—CH(CH3)—COO]n—R1  Formula 1 or a Na, K, Ca, Mg, Fe(II), Zn, NH4, or Cu(II) salt thereof, a glycolylate of formula 2, R2—COO—[—CH2—COO]n—R1  Formula 2 or a Na, K, Ca, Mg, Fe(II), Zn, NH4, or Cu(II) salt thereof, a lactate ester of formula 3, HO—CH(CH3)—COO—R22  Formula 3 and/or a glycolic acid ester of formula 4, HO—CH2—COO—R2  Formula 4 wherein R1 is selected from H, n stands for an integer with a value of 1-10, and R2 stands for a C1-C35 alkyl or alkenyl chain which may be branched or unbranched. The compound, which preferably is a lactylate or a Na, K, Ca, Mg, Fe(II), Zn, NH4, or Cu(II) salt thereof, is particularly useful in the treatment or prevention of Clostridia. An animal nutrition composition and a method for preventing or treating infections are also claimed.

公开(公告)号：US20220304986A1

公开(公告)日：2022-09-29

申请号：US17656855

申请日：2022-03-28

申请人： Thomas Winston

发明人： Thomas Winston

IPC分类号： A61K31/436 ,  A61K31/23 ,  A61K31/155 ,  A61K31/352 ,  A61K31/593 ,  A61K31/07 ,  A61K31/519 ,  A61K31/375 ,  A61K31/355 ,  A61K31/122 ,  A61K31/51 ,  A61K31/525 ,  A61K31/455 ,  A61K31/4188 ,  A61K31/197 ,  A61K33/06 ,  A61K33/42 ,  A61K33/18 ,  A61K33/30 ,  A61K33/34 ,  A61K33/04 ,  A61K33/32 ,  A61K33/24

摘要： Disclosed herein are pharmaceutical compositions for the treatment of acquired brain injury (ABI), including traumatic brain injury (TBI) and acute non-traumatic brain injury (ANBI), post-traumatic stress disorder (PTSD), and other degenerative neurological disorders that may or may not be associated with ABI comprising an effective amount of one or more mTOR inhibitors and optionally an effective amount of one or more thyroid hormones. Further disclosed herein are methods of treating, preventing, reducing the intensity of or reducing the severity of ABI and/or PTSD, the method comprising administering an effective amount of one or more mTOR inhibitors and optionally an effective amount of one or more thyroid hormones.

公开(公告)号：US20220226238A1

公开(公告)日：2022-07-21

申请号：US17715612

申请日：2022-04-07

申请人： THE CHILDREN'S MEDICAL CENTER CORPORATION

发明人： Mark PUDER ,  Kathleen Marie GURA

IPC分类号： A61K9/107 ,  A23L33/11 ,  A23L33/115 ,  A23L33/15 ,  A23L33/00 ,  A61K31/202 ,  A61K31/23 ,  A61K31/355 ,  A61K35/60

摘要： Described herein are emulsion compositions comprising fish oil and medium-chain triglycerides (MCT) and/or omega-3 fatty acids and medium-chain triglycerides (MCT). In some embodiments, the compositions further comprise, e.g., alpha-tocopherol, or one or more fatty acids. Further provided herein are methods of using the compositions, e.g., to provide nutrion, e.g., parenteral nutrition to a subject and/or to treat or prevent certain conditions described herein.

公开(公告)号：US20220220412A1

公开(公告)日：2022-07-14

申请号：US17406892

申请日：2021-08-19

申请人： TAKASAGO INTERNATIONAL CORPORATION (USA)

发明人： Rafael Trujillo ,  Raphael K.L. Kang ,  Alba T. Cilia

IPC分类号： C11B9/00 ,  A61Q13/00 ,  A61K8/34 ,  A61K8/35 ,  A61K8/37 ,  A61K8/49 ,  A61K31/045 ,  A61K31/122 ,  A61K31/215 ,  A61K31/23 ,  A61K31/365 ,  A61Q5/02 ,  A61Q15/00 ,  A61K31/12

摘要： A fragrance composition comprising one or more musk or fragrance accords for use in reducing or inhibiting a subject's physiological reaction to stress. The composition can be incorporated into consumer products.

公开(公告)号：US20220211655A1

公开(公告)日：2022-07-07

申请号：US17614294

申请日：2020-05-27

申请人： ALESCO S.R.L. ,  PHARMANUTRA S.P.A.

发明人： Andrea LACORTE ,  Germano TARANTINO ,  Elisa BRILLI

IPC分类号： A61K31/231 ,  A61K31/23 ,  A61K31/122 ,  A61K31/355 ,  A61K31/685 ,  A61K36/537 ,  A61K31/05 ,  A61K47/44 ,  A61P29/00

摘要： A composition is described comprising a mixture of at least one cetylated fatty acid or a mixture of cetylated fatty acids and an antioxidant in reduced percentages by weight, and related methods for treatment of arthritis and of inflammatory joint and musculoskeletal pain. Furthermore a composition is described comprising a mixture of at least one cetylated fatty acid or a mixture of cetylated fatty acids and, optionally, an antioxidant, and related treatment methods for protecting the gastric mucosa and for regulating the blood glucose levels. Additionally, a method is described for preparing the at least one cetylated fatty acid or mixture of cetylated fatty acids and for preparing compositions comprising the cetylated fatty acids and the antioxidant.

公开(公告)号：US20220192191A1

公开(公告)日：2022-06-23

申请号：US17545409

申请日：2021-12-08

申请人： SMITH & NEPHEW, INC.

发明人： Aleksa JOVANOVIC ,  Lei SHI ,  Eric ROCHE ,  Paul RENICK

IPC分类号： A01N37/02 ,  A01N59/12 ,  A01N59/16 ,  A61L31/16 ,  A61K33/18 ,  A61K33/38 ,  A61L27/54 ,  A61L29/16 ,  A61L31/10 ,  A61L27/34 ,  A61L29/08 ,  A01N37/46 ,  A61L26/00 ,  A01N25/30 ,  A61L31/14 ,  A61L29/14 ,  A61L27/52 ,  A61K31/23 ,  A61K47/26 ,  A61K47/38 ,  A61K45/06 ,  A61K47/14 ,  A61K47/10 ,  A61K9/00 ,  A61K31/625 ,  A61P31/04 ,  A01N25/04 ,  A61K9/06 ,  A61K31/25 ,  A61K31/7036 ,  A61K31/79 ,  A61K38/12 ,  A61L27/02 ,  A61L27/04 ,  A61L27/30 ,  A61L29/02 ,  A61L29/10 ,  A61L31/02 ,  A61L31/08

摘要： The compositions of the present invention comprise at least one medium polarity oil and at least one antibacterial agent, the combination of which produces a synergistic antibacterial effect against bacterial biofilms. Methods are disclosed for the reduction of bacteria in and/or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms.

公开(公告)号：US20220184024A1

公开(公告)日：2022-06-16

申请号：US17552967

申请日：2021-12-16

申请人： NEW FRONTIER LABS, LLC

发明人： Robert T. STREEPER ,  Elzbieta IZBICKA

IPC分类号： A61K31/23 ,  A61P39/02

摘要： The disclosure provides compositions and methods of treating diseases and conditions associated with phospholipase D (PLD) toxin. In particular, the methods include administering to a subject in need a pharmaceutical composition comprising a dicarboxylic acid ester.