公开(公告)号：US20240360075A1

公开(公告)日：2024-10-31

申请号：US18640931

申请日：2024-04-19

申请人： ALCON INC.

发明人： Heeren M. Gordhan ,  Mitchell A. deLong ,  Jill M. Sturdivant ,  David Archer Ellis ,  Cynthia L. Lichorowic

IPC分类号： C07C233/60 ,  A61K9/00 ,  A61K31/16 ,  A61K31/165 ,  A61K31/167 ,  A61K31/175 ,  A61K31/192 ,  A61K31/27 ,  A61K31/277 ,  A61K31/337 ,  A61K31/341 ,  A61K31/343 ,  A61K31/351 ,  A61K31/382 ,  A61K31/397 ,  A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/4465 ,  A61K31/495 ,  A61K31/5375 ,  A61K31/69 ,  A61K47/12 ,  A61K47/18 ,  A61K47/38 ,  C07C231/02 ,  C07C233/58 ,  C07C233/59 ,  C07C233/62 ,  C07C233/63 ,  C07C235/14 ,  C07C235/56 ,  C07C237/24 ,  C07C271/20 ,  C07C271/24 ,  C07C279/22 ,  C07C315/04 ,  C07C317/30 ,  C07D205/04 ,  C07D207/09 ,  C07D209/54 ,  C07D211/58 ,  C07D213/75 ,  C07D213/79 ,  C07D231/40 ,  C07D239/42 ,  C07D263/04 ,  C07D263/56 ,  C07D265/36 ,  C07D275/03 ,  C07D277/46 ,  C07D295/088 ,  C07D295/135 ,  C07D295/32 ,  C07D305/06 ,  C07D305/08 ,  C07D305/14 ,  C07D307/22 ,  C07D307/94 ,  C07D309/14 ,  C07D311/58 ,  C07D335/02 ,  C07F5/02

CPC分类号： C07C233/60 ,  A61K9/0048 ,  A61K31/16 ,  A61K31/165 ,  A61K31/167 ,  A61K31/175 ,  A61K31/192 ,  A61K31/27 ,  A61K31/277 ,  A61K31/337 ,  A61K31/341 ,  A61K31/343 ,  A61K31/351 ,  A61K31/382 ,  A61K31/397 ,  A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/4465 ,  A61K31/495 ,  A61K31/5375 ,  A61K31/69 ,  A61K47/12 ,  A61K47/183 ,  A61K47/186 ,  A61K47/38 ,  C07C231/02 ,  C07C233/58 ,  C07C233/59 ,  C07C233/62 ,  C07C233/63 ,  C07C235/14 ,  C07C235/56 ,  C07C237/24 ,  C07C271/20 ,  C07C271/24 ,  C07C279/22 ,  C07C315/04 ,  C07C317/30 ,  C07D205/04 ,  C07D207/09 ,  C07D209/54 ,  C07D211/58 ,  C07D213/75 ,  C07D213/79 ,  C07D231/40 ,  C07D239/42 ,  C07D263/04 ,  C07D263/56 ,  C07D265/36 ,  C07D275/03 ,  C07D277/46 ,  C07D295/088 ,  C07D295/135 ,  C07D295/32 ,  C07D305/06 ,  C07D305/08 ,  C07D305/14 ,  C07D307/22 ,  C07D307/94 ,  C07D309/14 ,  C07D311/58 ,  C07D335/02 ,  C07F5/025 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/18 ,  C07C2602/38 ,  C07C2602/42 ,  C07C2602/50

摘要： Described herein are modified monoterpene TRPM8 activating compounds. In particular, provided herein are compounds that affect the function of ion channels in a cell, and are useful as therapeutic agents or with therapeutic agents. The compounds provided herein are useful in the treatment of a variety of diseases and conditions including inflammatory eye diseases such as uveitis, cardiovascular diseases, inflammatory diseases, and diseases characterized by abnormal growth, such as cancers.

公开(公告)号：US12083114B2

公开(公告)日：2024-09-10

申请号：US17413689

申请日：2019-12-18

申请人： Disarm Therapeutics, Inc.

发明人： Todd Bosanac ,  Rajesh Devraj ,  Thomas Engber ,  Robert Owen Hughes ,  Raul Eduardo Krauss

IPC分类号： A61K31/472 ,  A61K31/416 ,  A61K31/425 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4985 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/519

CPC分类号： A61K31/472 ,  A61K31/416 ,  A61K31/425 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4985 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/519

摘要： The present disclosure relates to methods of treating neurodegeneration and neurodegenerative diseases comprising administering to a subject in need thereof a combination of a SARM1 inhibitor and a neuroprotective agent.

公开(公告)号：US20240208959A1

公开(公告)日：2024-06-27

申请号：US18553831

申请日：2022-04-04

申请人： INIPHARM, INC.

发明人： Joshua ODINGO ,  Sampath Kumar ANANDAN ,  Heather Kay Webb HSU ,  Vincent FLORIO ,  Subramanyam Janardhan TANTRY ,  Athisayamani Jeyaraj DURAISWAMY ,  Bharathi Mohan KUPPUSAMY

IPC分类号： C07D417/12 ,  A61K31/425 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/501 ,  C07D275/03 ,  C07D277/56

CPC分类号： C07D417/12 ,  A61K31/425 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/501 ,  C07D275/03 ,  C07D277/56

摘要： Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASHI, or drug induced liver injury (DILI).

公开(公告)号：US20220401391A1

公开(公告)日：2022-12-22

申请号：US17610025

申请日：2020-05-08

申请人： Apkarian Technologies LLC

发明人： A. Vania APKARIAN

IPC分类号： A61K31/167 ,  A61K31/425 ,  A61K31/198 ,  A61K31/192 ,  A61P29/00

摘要： The present disclosure features combinations of dopaminergic agents and analgesic agents useful for treating pain. In particular, the combinations feature a low ratio of dopaminergic agent to analgesic agent. The dopaminergic agent can be an agonist of the dopamine receptor D1-like family or the dopamine receptor D2-like family. Such combinations potentiate analgesia to 1) alleviate acute pain, 2) prevent the transition from acute pain to chronic pain, and 3) manage chronic pain.

公开(公告)号：US11505547B2

公开(公告)日：2022-11-22

申请号：US16767379

申请日：2018-11-30

申请人： STEP PHARMA S.A.S.

发明人： Andrew Novak ,  Geraint Jones ,  Joseph Wrigglesworth ,  Lorna Duffy ,  Louise Birch ,  Pascal George

IPC分类号： C07D241/12 ,  C07D401/12 ,  C07D417/12 ,  C07D417/14 ,  C07D277/52 ,  C07D213/22 ,  C07D213/38 ,  A61K31/425 ,  A61P35/00 ,  A61P37/00

摘要： Compounds of formula (I) and related aspects.

公开(公告)号：US20220257771A1

公开(公告)日：2022-08-18

申请号：US17610962

申请日：2020-05-20

申请人： DOUGLAS PHARMACEUTICALS LIMITED

发明人： Ian Hampson ,  Lynne Hampson ,  Fergus Cameron Binnie ,  Peter Surman

IPC分类号： A61K47/44 ,  A61K31/505 ,  A61K31/425 ,  A61K9/00 ,  A61K9/06 ,  A61K9/107 ,  A61K45/06 ,  A61P31/22

摘要： Provided herein are methods and compositions for treating and/or inhibiting the development or progression of conditions caused by, or associated with, Herpes Simplex Virus (HSV)infection. In particular, provided are compositions comprising lopinavir alone, or lopinavir and ritonavir, methods for their manufacture; and the use of said pharmaceutical compositions as a medicament. In particular, pharmaceutical compositions are provided for use in treating and/or inhibiting the progression of HSV related conditions.

公开(公告)号：US20220125924A1

公开(公告)日：2022-04-28

申请号：US17571084

申请日：2022-01-07

申请人： Argenta Innovation Limited

发明人： Douglas Robert Cleverly ,  Debashis Mukhopadhyay

IPC分类号： A61K45/06 ,  A61K9/00 ,  A61K31/4184 ,  A61K9/16 ,  A61K31/425

摘要： The present invention relates to anthelmintic compositions comprising two or more anthelmintic active agents selected from one or more of the following groups; imidazothiazoles such as levamisole, benzimidazoles such as oxfendazole, or fenbendazole, macrocylic lactones such as ivermectin or avermectin, salicylanilides, and praziquantel. The composition being in the form of stable granules that are readily dispersible in water so as to provide a homogenous mixture of the anthelmintic agents suitable for administration. Methods of preparing the composition are also described.

公开(公告)号：US11266632B1

公开(公告)日：2022-03-08

申请号：US17380325

申请日：2021-07-20

申请人： King Abdulaziz University

发明人： Raya Soltane ,  Hani Abdullah Alhadrami ,  Ahlam Alasiri ,  Hichem Ben Jannet ,  Karim Chouaib ,  Amani Chrouda ,  Ahmed Mostafa ,  Rami Adel Pashameah

IPC分类号： A61K31/21 ,  A61K31/425 ,  A61K31/42 ,  A61P31/14 ,  A61K31/215 ,  A61K31/4192

摘要： Provided are methods of using oleanolic acid and derivatives for treating coronavirus infection. The method includes using propargyl-moiety containing oleanolic acid derivatives for inhibiting coronavirus growth by impairing the viral replication of SARS-CoV-2 through inhibition of the viral function of SARS-CoV-2 main protease.

公开(公告)号：US11214538B2

公开(公告)日：2022-01-04

申请号：US16872985

申请日：2020-05-12

申请人： Metacrine, Inc.

发明人： Nicholas D. Smith ,  Steven P. Govek ,  Johnny Y. Nagasawa

IPC分类号： C07C233/80 ,  C07C233/63 ,  A61K31/167 ,  A61K31/216 ,  C07D333/32 ,  C07D239/34 ,  C07D241/18 ,  C07D263/32 ,  C07D205/04 ,  C07D207/27 ,  C07D275/03 ,  C07D277/34 ,  C07D213/65 ,  A61K45/06 ,  C07D207/12 ,  C07D213/75 ,  C07D207/08 ,  C07D213/68 ,  C07D211/42 ,  C07D211/46 ,  C07D213/40 ,  C07D213/64 ,  C07D213/80 ,  C07C271/20 ,  C07C237/22 ,  C07C237/42 ,  C07C233/59 ,  C07C233/62 ,  A61K31/381 ,  A61K31/397 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/421 ,  A61K31/425 ,  A61K31/426 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/4965 ,  A61K31/505 ,  C07D207/24 ,  C07D211/94

摘要： Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.

公开(公告)号：US20210308126A1

公开(公告)日：2021-10-07

申请号：US16949571

申请日：2020-11-04

申请人： Otsuka Pharmaceutical Co., Ltd.

发明人： Tetsuro Kikuchi ,  Taro Iwamoto ,  Tsuyoshi Hirose

IPC分类号： A61K31/496 ,  A61K31/19 ,  A61K31/195 ,  A61K31/425 ,  A61K31/4704 ,  A61K31/497 ,  A61K31/55 ,  A61K31/7008 ,  A61K33/00 ,  A61K33/14 ,  A61K45/06 ,  A61K31/357 ,  A61K31/4015 ,  A61K31/423 ,  A61K31/53 ,  A61K31/5513

摘要： The pharmaceutical composition of the present invention comprises a carbostyril derivative which is a dopamine-serotonin system stabilizer and a mood stabilizer in a pharmaceutically acceptable carrier. The carbostyril derivative may be aripiprazole or a metabolite thereof. The mood stabilizer may include but is not limited to lithium, valproic acid, divalproex sodium, carbemazapine, oxcarbamazapine, zonisamide, lamotragine, topiramate, gabapentin, levetiracetam or clonazepam. These compositions are used to treat patients with mood disorders, particularly bipolar disorder with or without psychotic features, manta or mixed episodes. Methods are provided for separate administration of a carbostyril derivative and a mood stabilizer to a patient with a mood disorder.