公开(公告)号：US11628199B2

公开(公告)日：2023-04-18

申请号：US16641197

申请日：2018-08-17

申请人： SICHUAN JIUZHANG BIOLOGICAL SCIENCE AND TECHNOLOGY CO., LTD

发明人： Jie Zhang ,  Wang Huang ,  Huarong Yang

IPC分类号： A61K31/216 ,  A61K31/565 ,  A61K38/09 ,  A61P35/00

摘要： A medicine for combined use in cancer treatment, comprising chlorogenic acid and a hormone drug which have unit preparations of the same or different specifications and which are administered either together or separately, as well as comprising a pharmaceutically acceptable carrier. The combined use of the chlorogenic acid and hormone drug achieves the effects of synergistic interaction, which thus overcome the defects of single drug treatment, such as a major toxic side effect and a poor treatment outcome and may reverse the drug resistance to hormone drugs and has good prospects for clinical application.

公开(公告)号：US20230070977A1

公开(公告)日：2023-03-09

申请号：US17483199

申请日：2021-09-23

申请人： Millicent Pharma Limited

发明人： Roger M. Boissonneault ,  Ryan Loughlin

IPC分类号： A61K31/565 ,  A61K31/57

摘要： A contraceptive regimen that provides for a reduced level of estrogen. The contraceptive regimen can be used for the treatment of symptoms associated with endometriosis or fibroids.

公开(公告)号：US11590084B2

公开(公告)日：2023-02-28

申请号：US16178324

申请日：2017-04-28

申请人： Roman Bielski ,  Zbigniew Janusz Witczak

发明人： Roman Bielski ,  Zbigniew Janusz Witczak

IPC分类号： C05G3/00 ,  A61K9/50 ,  A61Q19/00 ,  A61K8/11 ,  B01J13/16 ,  A61K31/565

摘要： The present invention relates a microcapsule that comprises an active pharmaceutical ingredient and a polymeric shell comprised of polymeric materials such as polyether, polyester, polyamine, polyamide, polyurea, polyurethane, polythiocarbamate, and polythiocarbonate. The outer surface of shell comprises surface functional groups such as hydroxide, primary amine, carboxylic acid, or protected forms thereof. These surface functional groups may be reacted further with reactants to place specific organic groups on the surface of the microcapsule. Such microcapsules are prepared by a modified interfacial condensation polymerization.

公开(公告)号：US20230055912A1

公开(公告)日：2023-02-23

申请号：US17816084

申请日：2022-07-29

申请人： Regeneron Pharmaceuticals, Inc. ,  The Royal Institution for the Advancement of Learning / McGill University

发明人： Jonas Bovijn ,  Okukayode Sosina ,  Sirui Zhou ,  Luca Andrea Lotta ,  Aris Baras ,  Brent Richards

IPC分类号： C12N15/113 ,  C12Q1/6883 ,  A61K31/663 ,  A61K31/675 ,  A61K38/23 ,  A61K38/29 ,  C07K16/28 ,  A61K31/565 ,  A61K31/57 ,  A61K31/4535

摘要： The present disclosure provides methods of treating a subject having decreased bone mineral density or at risk of developing decreased bone mineral density, and methods of identifying subjects having an increased risk of developing decreased bone mineral density.

公开(公告)号：US11564969B2

公开(公告)日：2023-01-31

申请号：US16479520

申请日：2018-01-19

申请人： ISR IMMUNE SYSTEM REGULATION HOLDING AB (PUBL)

发明人： Ola Winqvist ,  Emma Lindh ,  Robert Wallin ,  Matt Gregory ,  Steven Moss

IPC分类号： C07K7/23 ,  A61K38/09 ,  A61K31/565 ,  A61K31/568 ,  A61K31/573 ,  A61K38/00

摘要： The present invention provides immune stimulating peptides (immunorhelins) capable of activating GnRH receptors when administered to animal or human patients or cells. These immunorhelins have utility in treating intracellular bacterial, fungal, and protozoal infections.

公开(公告)号：US20230016074A1

公开(公告)日：2023-01-19

申请号：US17867431

申请日：2022-07-18

申请人： Wendy Anne Epstein

发明人： Wendy Anne Epstein

IPC分类号： A61K31/353 ,  A61K9/00 ,  A61K31/085 ,  A61K31/565 ,  A61K31/566 ,  A61P15/02 ,  A61K31/355 ,  A61K31/375 ,  A61P43/00 ,  A61P15/00

摘要： The invention provides safe and efficacious treatments for Female Sexual Disorders, genitopelvic pain/penetration disorders; vulvovaginal atrophy, vestibulodynia, dyspareunia, sexual interest/arousal disorder, low female libido, and female orgasmic disorder.

公开(公告)号：US20230000876A1

公开(公告)日：2023-01-05

申请号：US17835827

申请日：2022-06-08

申请人： Nuvation Bio Inc.

发明人： Teeru BIHANI ,  Gary HATTERSLEY ,  Chris P. MILLER ,  Hitisha PATEL ,  Sergey YURASOV ,  Yan ZHANG

IPC分类号： A61K31/538 ,  A61P35/04 ,  A61K31/565 ,  A61K39/395 ,  A61K31/517 ,  A61K31/4166 ,  A61K31/495

摘要： The present disclosure relates to methods of treating cancers, including metastasized cancers by administering a potent CDK 2/4/6 inhibitor of the formula (I), or a pharmaceutically acceptable salt thereof, to a patient in need thereof.

公开(公告)号：US11478434B2

公开(公告)日：2022-10-25

申请号：US16577473

申请日：2019-09-20

申请人： LTS Lohmann Therapie-Systeme AG

发明人： Reinhold Meconi ,  Klaus Schumann

IPC分类号： A61K9/70 ,  A61K31/196 ,  A61K31/21 ,  A61K31/565 ,  A61K31/465

摘要： The present invention is directed to transdermal therapeutic systems that are free of fibrous constituents, as well methods for producing such transdermal therapeutic systems. A preparation containing active substance is applied by a printing method onto the pressure-sensitive adhesive layer of the transdermal therapeutic system. Exemplary printing methods include application methods based upon a distributor plate of an application device.

公开(公告)号：US11419941B2

公开(公告)日：2022-08-23

申请号：US15991870

申请日：2018-05-29

申请人： Brenda K. Mann

发明人： Brenda K. Mann

IPC分类号： A61K47/38 ,  A61K9/00 ,  A61K47/34 ,  A61K45/06 ,  A61P31/04 ,  A61P15/02 ,  A61K47/32 ,  A61K31/565

摘要： The vaginal hydrogel may be a composition which includes a glycosaminoglycan, a reactive molecule, and, in some embodiments, a therapeutic agent. The glycosaminoglycan and the reactive molecule may include either thiol groups or thiol reactive sites and have a pH that is within a range of a normal vaginal environment. Some of the thiol groups may interact with the vaginal mucosa and allow the hydrogel to remain in the vagina for a longer period than existing compounds intended for intravaginal administration. Therapeutic agents may be included in the composition. In these embodiments, the hydrogel acts as a vehicle which delivers the therapeutic agent.

公开(公告)号：US20220259156A1

公开(公告)日：2022-08-18

申请号：US17681634

申请日：2022-02-25

申请人： Lupin Inc.

发明人： Richard John Holl ,  Kurt Nielsen ,  James Garegnani

IPC分类号： C07D233/94 ,  A61K31/4164 ,  A61K31/57 ,  A61K31/565

摘要： The present invention is related to deuterated secnidazole, a prodrug thereof, a hydrate thereof, a solvate thereof, a polymorph thereof, or a pharmaceutically acceptable salt thereof and its use for the treatment of bacterial vaginosis or trichomoniasis in a subject in need thereof. The present invention is also related to pharmaceutical compositions and methods and uses of treating bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, or a combination thereof.