公开(公告)号：US20240279665A1

公开(公告)日：2024-08-22

申请号：US18468043

申请日：2023-09-15

申请人： The Trustees of the University of Pennsylvania

发明人： Yangbing Zhao ,  Jiangtao Ren ,  Xiaojun Liu ,  Carl H. June

IPC分类号： C12N15/113 ,  A61K35/17 ,  A61K35/26 ,  A61K39/00 ,  A61P35/00 ,  A61P37/06 ,  C12N15/85

CPC分类号： C12N15/1138 ,  A61K35/17 ,  A61K35/26 ,  A61K39/001102 ,  A61P35/00 ,  A61P37/06 ,  C12N15/85 ,  A61K2039/5156 ,  A61K2039/5158 ,  C12N2310/10 ,  C12N2310/20 ,  C12N2501/48 ,  C12N2501/515 ,  C12N2501/599 ,  C12N2501/998 ,  C12N2510/00

摘要： The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of TCR α chain, TCR β chain, beta-2 microglobulin, a HLA molecule, CTLA-4, PD1, and FAS and further comprising a nucleic acid encoding a modified T cell receptor (TCR) comprising affinity for a surface antigen on a target cell or an electroporated nucleic acid encoding a chimeric antigen receptor (CAR). Also included are methods and pharmaceutical compositions comprising the modified T cell for adoptive therapy and treating a condition, such as an autoimmune disease.

公开(公告)号：US12064452B2

公开(公告)日：2024-08-20

申请号：US17486045

申请日：2021-09-27

申请人： Duke University

发明人： Mary Louise Markert

IPC分类号： A61K38/13 ,  A01N1/02 ,  A61K9/00 ,  A61K31/343 ,  A61K31/436 ,  A61K31/573 ,  A61K35/26 ,  A61K35/34 ,  A61K38/17 ,  A61K39/00 ,  A61K39/395 ,  A61L27/38 ,  A61P37/06 ,  C07K16/28 ,  G01N33/50 ,  A61K35/12

CPC分类号： A61K35/26 ,  A01N1/0284 ,  A61K9/0019 ,  A61K31/343 ,  A61K31/436 ,  A61K31/573 ,  A61K35/34 ,  A61K38/13 ,  A61K38/1722 ,  A61K39/0008 ,  A61K39/3955 ,  A61L27/3804 ,  A61L27/3895 ,  A61P37/06 ,  C07K16/2893 ,  G01N33/5047 ,  A61K2035/122 ,  A61L2430/20 ,  A61L2430/40 ,  C07K2317/24 ,  G01N2800/245

摘要： Methods and compositions for promoting donor-specific tolerance and immunocompetence to a recipient of a solid organ transplant, by implanting an allogeneic solid organ in a recipient in need of a solid organ transplant and further comprising surgical implantation of a tissue-engineered allogeneic cultured postnatal thymus tissue product in the recipient of a solid organ from a donor.

公开(公告)号：US20240122986A1

公开(公告)日：2024-04-18

申请号：US18543191

申请日：2023-12-18

申请人： MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

发明人： Shikhar MEHROTRA ,  Shilpak CHATTERJEE

IPC分类号： A61K35/17 ,  A61K9/00 ,  A61K35/26 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  C07K16/24 ,  C07K16/28 ,  C07K16/30 ,  C12N5/0783

CPC分类号： A61K35/17 ,  A61K9/0019 ,  A61K35/26 ,  A61K39/39558 ,  A61K45/06 ,  A61P35/00 ,  C07K16/249 ,  C07K16/2896 ,  C07K16/30 ,  C12N5/0636 ,  C12N5/0638 ,  C07K2317/55 ,  C07K2317/76 ,  C12N2501/15 ,  C12N2501/2301 ,  C12N2501/2306 ,  C12N2501/2312 ,  C12N2501/2323 ,  C12N2501/599

摘要： The present disclosure provides methods of producing hybrid Th1/Th17 cells. Also provided herein are methods of treating cancer comprising targeting the CD38-mediated metabolic axis.

公开(公告)号：US11883430B2

公开(公告)日：2024-01-30

申请号：US16347743

申请日：2017-11-08

申请人： MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

发明人： Shikhar Mehrotra ,  Shilpak Chatterjee

IPC分类号： A61K35/17 ,  A61P35/00 ,  A61K35/26 ,  C07K16/24 ,  C12N5/0783 ,  A61K45/06 ,  A61K9/00 ,  C07K16/28 ,  C07K16/30 ,  A61K39/395

CPC分类号： A61K35/17 ,  A61K9/0019 ,  A61K35/26 ,  A61K39/39558 ,  A61K45/06 ,  A61P35/00 ,  C07K16/249 ,  C07K16/2896 ,  C07K16/30 ,  C12N5/0636 ,  C12N5/0638 ,  C07K2317/55 ,  C07K2317/76 ,  C12N2501/15 ,  C12N2501/2301 ,  C12N2501/2306 ,  C12N2501/2312 ,  C12N2501/2323 ,  C12N2501/599 ,  A61K39/39558 ,  A61K2300/00

摘要： The present disclosure provides methods of producing hybrid Th1/Th17 cells. Also provided herein are methods of treating cancer comprising targeting the CD38-mediated metabolic axis.

公开(公告)号：US11693000B2

公开(公告)日：2023-07-04

申请号：US15776463

申请日：2016-11-14

申请人： OBERON SCIENCES ILAN LTD.

发明人： Yaron Ilan

IPC分类号： A61B5/00 ,  G01N33/50 ,  G16B45/00 ,  A61K35/26 ,  G06F3/01 ,  A61K31/00 ,  A61B5/24

CPC分类号： G01N33/5091 ,  A61B5/24 ,  A61B5/486 ,  A61K31/00 ,  A61K35/26 ,  G06F3/011 ,  G16B45/00 ,  G01N2800/52 ,  G06F2203/011

摘要： The invention provides methods and systems for the treatment and diagnosis of pathologic disorders by modulating a physiological state of a target biological entity via exposure of the target entity to a single or a plurality of triggered entities and for transferring of information in a non-direct way and as part of virtual reality interactive environment.

公开(公告)号：US20220288127A1

公开(公告)日：2022-09-15

申请号：US17514136

申请日：2021-10-29

申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Eric Lagasse

IPC分类号： A61K35/26 ,  A61K35/22 ,  A61K35/55 ,  A61K35/42 ,  A61K35/30 ,  A61K35/38 ,  A61K35/39

摘要： The present invention relates to methods and compositions for transplanting non-lymphoid tissues into lymphoid organs. It may be used to cultivate organ tissues including for the purpose of supplementing or reconstituting organ function. Tissues that may be propagated in this manner include but are not limited to lung, kidney, thyroid, intestine, and brain.

公开(公告)号：US20220265728A1

公开(公告)日：2022-08-25

申请号：US17740026

申请日：2022-05-09

申请人： International Stem Cell Corporation

发明人： Elena S. Revazova ,  Marina V. Pryzhkova ,  Leonid N. Kuzmichev ,  Jeffrey D. Janus

IPC分类号： A61K35/39 ,  C12N15/877 ,  C12N5/075 ,  C12N5/0735 ,  A61K35/15 ,  A61K35/26 ,  A61K35/30 ,  A61K35/32 ,  A61K35/34 ,  A61K35/35 ,  A61K35/36 ,  C12N9/12

摘要： Methods of producing human stem cells are disclosed for parthenogenetically activating human oocytes by manipulation of O2 tension, including manipulation of Ca2+ under high O2 tension and contacting oocytes with serine threonine kinase inhibitors under low O2 tension, isolating inner cell masses (ICMs) from the activated oocytes, and culturing the cells of the isolated ICMs under high O2 tension. Moreover, methods are described for the production of stems cells from activated oocytes in the absence of non-human animal products, including the use of human feeder cells/products for culturing ICM/stem cells. Stem cells produced by the disclosed methods are also described.

公开(公告)号：US11324777B2

公开(公告)日：2022-05-10

申请号：US15825275

申请日：2017-11-29

申请人： Yeda Research and Development Co. Ltd.

发明人： Yair Reisner ,  Yaki Eidelstein ,  Eran Ophir ,  Assaf Lask ,  Ran Afik ,  Noga Or-Geva ,  Esther Bachar-Lustig

IPC分类号： A61K35/17 ,  A61K39/00 ,  C12N5/0783 ,  A61K35/22 ,  A61K35/26 ,  A61K35/28 ,  A61K35/34 ,  A61K35/36 ,  A61K35/38 ,  A61K35/39 ,  A61K35/407 ,  A61K35/42 ,  A61K35/12

摘要： A method of generating an isolated population of cells comprising anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance-inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) contacting peripheral blood mononuclear cells (PBMC) with a third party antigen or antigens in the presence of IL-21 so as to allow enrichment of antigen reactive cells; and (b) culturing the cells resulting from step (a) in the presence of IL-21, IL-15 and IL-7 in an antigen free environment so as to allow proliferation of cells comprising the central memory T-lymphocyte (Tcm) phenotype.

公开(公告)号：US20220125849A1

公开(公告)日：2022-04-28

申请号：US17441613

申请日：2020-03-20

申请人： ALBANY MEDICAL COLLEGE

发明人： Qi YANG

IPC分类号： A61K35/26 ,  A61K9/00 ,  A61K38/20 ,  A61K38/19 ,  A61K31/5575 ,  A61K39/395 ,  A61K31/202 ,  A61K35/741 ,  A61P25/28

摘要： The present disclosure relates to a method of improving cognitive function in a subject. The method includes implanting group-2 innate lymphoid cells (ILC2) in a cranium of a subject, where the ILC2 was treated with an ILC2 activator. The present disclosure further relates to a method including selecting a subject having aging-associated cognitive decline and administering to the subject an activator of innate lymphoid cell activity under conditions effective to promote innate lymphoid cell activity. The present disclosure further relates to a method of improving cognition in a subject. The method includes selecting a subject having aging-associated cognitive decline and administering to the subject a cytokine selected from the group consisting of IL-33, IL-5, IL-7, IL-25, and thymic stromal lymphopoietin.

公开(公告)号：US20220110977A1

公开(公告)日：2022-04-14

申请号：US17556650

申请日：2021-12-20

申请人： Reza Saadat Niaki Moghaddam ,  Jayesh Arvind Desai

发明人： Reza Saadat Niaki Moghaddam ,  Jayesh Arvind Desai

IPC分类号： A61K35/26 ,  A61K36/481 ,  A61K35/28 ,  A61K36/9066 ,  A61K35/20 ,  A61K31/375 ,  A61K36/07 ,  A61K36/254 ,  A61K36/185 ,  A61K36/74 ,  A61K38/40 ,  A61K36/484 ,  A61K36/63 ,  A61K36/19 ,  A61K36/81 ,  A61K35/644 ,  A61K36/074 ,  A61K36/738 ,  A61K31/715 ,  A61K31/706 ,  A61K38/38 ,  A61K36/28 ,  A61K36/04 ,  A61K36/537 ,  A61K36/14 ,  A61K31/716 ,  A61K31/355 ,  A61K36/489 ,  A61K36/53 ,  A61K31/4045 ,  A61K33/06 ,  A61K31/7076 ,  A61K35/76 ,  A61K31/01 ,  A61K31/593 ,  A61K31/07 ,  A61K33/04 ,  A61K31/714 ,  A61K45/06 ,  A61K33/30 ,  A61K38/47 ,  A61K38/17 ,  A61P37/04

摘要： A pretreatment herbal composition comprises Andrographis paniculata, Eleuthero roots, and resistant potato starch. A treatment herbal composition comprises cannabidiol, bee pollen, and coconut oil, and in some embodiments, additionally comprises hemp seed oil. A fortifying herbal composition comprises many ingredients. A method comprises the steps of providing a dose of apitoxin at least once a day for at least one day, providing a dose of a glucosamine product at least once a day for at least one day, and providing a dose of a treatment herbal composition at least once a day for at least one day. In some embodiments, the method additionally comprises the step of providing a dose of a pretreatment herbal composition at least once a day for at least one day. In further embodiments, the method additionally comprises the step of providing a dose of a fortifying herbal composition.