公开(公告)号：US20230134557A1

公开(公告)日：2023-05-04

申请号：US18046719

申请日：2022-10-14

申请人： DESIGNED CELLS CO.,LTD.

发明人： Yun Bae KIM ,  Ehn Kyoung CHOI ,  Tae Myoung KIM

IPC分类号： A61K35/50 ,  A61K9/127 ,  A61P27/06 ,  A61P27/02 ,  C12N5/073 ,  A23L33/10

摘要： Disclosed herein is a pharmaceutical composition comprising at least one selected from the group consisting of a stem cell-conditioned medium and an exosome isolated therefrom as an active ingredient for prevention or treatment of an ocular disease. Containing exosomes, growth factors and neurotrophic factors at high levels and functioning to: promote retinal cell proliferation and wound recovery; protect retinal cells against oxidative stress or hypoxia; lower the increased intraocular pressure and restore the atrophy of the retinal layer and the retinal ganglion cell layer to normal levels in the glaucoma animal model; and have a protective effect on retinal ganglion cells and nerve cells, the stem cell-conditioned medium according to the present disclosure can find advantageous applications in the therapy of an ocular disease.

公开(公告)号：US20230092739A1

公开(公告)日：2023-03-23

申请号：US17951082

申请日：2022-09-22

申请人： AVITA INTERNATIONAL LTD. ,  FUNDAÇÃO BUTANTAN

发明人： Irina Kerkis

IPC分类号： C12N5/0775 ,  C12N5/073 ,  A61K35/12 ,  A61K35/50 ,  A61K35/51

摘要： The present method relates to methods of expanding or increasing stem cell production obtained from donor samples. The methods preferably including the steps of harvesting cells from minimally manipulated tissue using multiply harvesting cycles to increase the number of obtained stem cells.

公开(公告)号：US11590175B2

公开(公告)日：2023-02-28

申请号：US16640699

申请日：2018-08-23

申请人： MERAKRIS THERAPEUTICS INC.

发明人： Thomas Christopher Broderick ,  William Samuel Fagg, IV

IPC分类号： A61K35/50 ,  A61P17/02 ,  A01N1/02 ,  A61K8/67 ,  A61K8/98 ,  A61K9/00 ,  A61K31/355 ,  A61K31/455 ,  A61K35/51 ,  A61L27/36 ,  A61L27/54 ,  A61Q19/00 ,  A61Q19/08 ,  C12N5/073 ,  C12N5/0775 ,  A61K8/99 ,  A01N63/10

摘要： Compositions are provided that contain biologically active components of amniotic fluid including growth factors and other proteins, carbohydrates, lipids, and metabolites. The compositions containing biologically active components of amniotic fluid can be useful for a range of therapeutic treatments including joint and soft tissue repair, regulation of skin condition, and for use in organ preservation, such as for use in organ transplant procedures. Advantages of the compositions include that they can be reproducibly produced, without the inherent variability of amniotic fluid from individual donors, and that they are free of fetal waste.

公开(公告)号：US11590172B2

公开(公告)日：2023-02-28

申请号：US16296463

申请日：2019-03-08

申请人： Osiris Therapeutics, Inc.

发明人： Samson Tom ,  Alla Danilkovitch ,  Dana YOo ,  Timothy Jansen ,  Jin-Qiang Kuang ,  Jennifer Michelle Marconi

IPC分类号： A61K35/50 ,  A01N1/02 ,  A61K38/57 ,  A61K35/28 ,  A61K38/18 ,  A61K38/39 ,  C12N5/073

摘要： Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.

公开(公告)号：US20230021803A1

公开(公告)日：2023-01-26

申请号：US17778333

申请日：2020-11-13

申请人： Bioventus, LLC ,  Musculoskeletal Transplant Foundation

发明人： Alessandra PAVESIO ,  Carl FLANNERY ,  Scott SEAMAN ,  Michael A. NASERT ,  Eric J. SEMLER ,  Marc LONG

IPC分类号： A61K35/50 ,  A61K35/51 ,  A61K38/17 ,  A61K38/18 ,  A61K38/20 ,  A61K38/39 ,  A61K38/57 ,  A61K9/00 ,  A61P19/02

摘要： Provided herein are compositions containing dehydrated placental tissue particulates, methods of making the compositions and methods for treating various musculoskeletal disorders and other conditions using such compositions, including osteoarthritis (OA), degenerative disc disease, tendonitis, plantar fasciitis, and pain associated therewith.

公开(公告)号：US20230014529A1

公开(公告)日：2023-01-19

申请号：US17952593

申请日：2022-09-26

申请人： Babak Ghalili ,  Craig M Siegler ,  Keyon Janani ,  Peter Scherp ,  John Borja

发明人： Babak Ghalili ,  Craig M Siegler ,  Keyon Janani ,  Peter Scherp ,  John Borja

IPC分类号： A61K9/127 ,  A61K35/50 ,  A61K47/34 ,  A61K47/02 ,  A61K47/20

摘要： The aspects of the disclosed embodiments relate to exosome systems and compositions and preservative systems and compositions including systems and compositions including diatomic oxygen as well as methods of use and methods of manufacturing of them.

公开(公告)号：US20220401496A1

公开(公告)日：2022-12-22

申请号：US17832997

申请日：2022-06-06

申请人： Hilltop BioSciences, Inc.

发明人： Terrell Suddarth ,  Amanda Drobnis ,  Bruce Werber ,  David Dutton

IPC分类号： A61K35/50 ,  A61K35/51

摘要： A method for a therapeutic compound from a plurality of birth tissues for the treatment of at least breathing and inflammation ailments. The method includes receiving a plurality of birth tissues from a mammalian donner. Each received birth tissue is processes to provide a refined material. This refined material is evaluated to determine at least a concentrate of at least one constituent. Portions of the processed birth tissues are then mixed to provide an initial blend of materials having a predetermined ration of the constituents to provide the therapeutic compound.

公开(公告)号：US11529376B2

公开(公告)日：2022-12-20

申请号：US16610859

申请日：2018-05-04

申请人： Capricor, Inc.

发明人： Luis Rodriguez-Borlado ,  Houman Hemmati ,  Kiel A. Peck ,  Linda Marban ,  Jennifer J. Moseley

IPC分类号： A61K35/14 ,  A61K35/00 ,  A61K35/50 ,  A61P37/06 ,  A61K9/00 ,  A61K35/28 ,  A61K35/34 ,  A61K35/51 ,  A61K35/545

摘要： The present invention relates to a method of treating acute or chronic systemic graft-versus-host disease (GVHD) with extracellular vesicles, e.g., exosomes obtained from human cardiospheres or cardiosphere-derived cells (CDCs), wherein systemic GVHD involves, e.g., at least two organs selected from the group consisting of the skin, mucosa, gastrointestinal tract, liver, lungs, joints and fascia, genitalia, and eyes. The present invention also provides a pharmaceutical formulation comprising extracellular vesicles, e.g., exosomes obtained from human cardiospheres or CDCs, for systemic administration, e.g., intravenous infusion, to a human subject in need of treatment of systemic GVHD.

公开(公告)号：US11524036B2

公开(公告)日：2022-12-13

申请号：US16639319

申请日：2018-08-16

申请人： SUNGKWANG MEDICAL FOUNDATION

发明人： He Len Lew ,  Mi Ra Park ,  Gi Jin Kim

IPC分类号： A61K35/50 ,  A23L33/10 ,  A61K9/00 ,  C12N5/0775

摘要： Provided is a composition including mesenchymal stem cells as an effective ingredient for prevention, alleviation, or treatment of thyroid-associated ophthalmopathy. A pharmaceutical composition including mesenchymal stem cells as an effective ingredient for treatment of thyroid-associated ophthalmopathy allows patients with thyroid-associated ophthalmopathy to recover from an abnormal increase in hyaluronic acid production in orbital fibroblasts, increased adipocyte differentiation, and increased lipid accumulation, and thus may be useful for the treatment of thyroid-associated ophthalmopathy.

公开(公告)号：US20220387516A1

公开(公告)日：2022-12-08

申请号：US17755275

申请日：2020-11-02

申请人： FIGENE, LLC

发明人： Pete O'HEERON ,  Thomas ICHIM

IPC分类号： A61K35/33 ,  A61K35/17 ,  A61K35/545 ,  A61K35/50 ,  A61K39/00 ,  A61P35/00

摘要： Described are means of generating immunological compositions that are universally applicable for induction of immunity to neoplasia regardless of histological origin of tissue. Certain methods concern fibroblasts that are manipulated or dedifferentiated in a manner to induce expression of tumor associated antigens including cancer testis antigens. These cells are used as a source of antigenic stimuli for creation of a cellular vaccine, and/or an exosome vaccine, and/or a lysate-based vaccine.