公开(公告)号：US12084690B2

公开(公告)日：2024-09-10

申请号：US18488060

申请日：2023-10-17

申请人： LINNO PHARMACEUTICALS INC.

发明人： Zhaozhong Han ,  Hongya Pan ,  Haiyang Li ,  Lingyu Li

IPC分类号： A61K39/395 ,  A61K38/43 ,  A61P25/16 ,  A61P25/28 ,  C07K16/18 ,  C12N9/00 ,  C12N9/16 ,  C12N15/63

CPC分类号： C12N9/16 ,  A61P25/16 ,  A61P25/28 ,  C07K16/18 ,  C12N15/63 ,  C07K2317/565 ,  C07K2317/94

摘要： The present application pertains to a fusion protein, comprising a transferrin-binding protein, and an arylsulfatase A (ARSA) or functionally active fragment thereof, wherein the transferrin-binding protein comprises a peptide, an antibody or an antigen-binding fragment of the antibody capable of binding transferrin. The other aspect of the present application provides the preparing methods and the uses of the fusion protein.

公开(公告)号：US20240082164A1

公开(公告)日：2024-03-14

申请号：US18513988

申请日：2023-11-20

申请人： BIOSPECIFICS TECHNOLOGIES LLC ,  DUKE UNIVERSITY

发明人： Phyllis Carolyn LEPPERT ,  Thomas L. WEGMAN

IPC分类号： A61K9/48 ,  A61K9/00 ,  A61K9/107 ,  A61K38/43 ,  A61K38/48 ,  A61K45/06

CPC分类号： A61K9/48 ,  A61K9/0019 ,  A61K9/0034 ,  A61K9/1075 ,  A61K38/43 ,  A61K38/4886 ,  A61K45/06 ,  C12Y304/24003

摘要： The invention relates to compositions and methods for treating uterine fibroids, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of uterine fibroids is injected or inserted into the uterine fibroid.

公开(公告)号：US11723982B2

公开(公告)日：2023-08-15

申请号：US16985522

申请日：2020-08-05

申请人： The Regents of the University of California

发明人： Kevin E. Healy ,  Eda Isil Altiok ,  David V. Schaffer ,  Wesley M. Jackson

IPC分类号： A61K39/395 ,  A61K47/50 ,  C07K16/22 ,  A61K47/61 ,  A61K9/00 ,  A61K38/16 ,  A61K47/32 ,  A61K47/36 ,  A61K9/06 ,  A61K38/17 ,  A61K47/69 ,  A61K38/43 ,  A61K39/00

CPC分类号： A61K47/61 ,  A61K9/0048 ,  A61K9/06 ,  A61K38/16 ,  A61K38/177 ,  A61K38/179 ,  A61K38/1774 ,  A61K38/43 ,  A61K39/3955 ,  A61K47/32 ,  A61K47/36 ,  A61K47/6903 ,  C07K16/22 ,  A61K2039/505 ,  C07K2317/22 ,  C07K2317/35 ,  C07K2317/622

摘要： The present disclosure provides methods of treating an ocular disease or disorder. The methods involve direct administration into the eye of a conjugate comprising a biologically active polypeptide and a biocompatible polymer.

公开(公告)号：US11690899B2

公开(公告)日：2023-07-04

申请号：US15557296

申请日：2016-03-10

申请人： Micreos Human Health B.V.

发明人： Fritz Eichenseher

IPC分类号： A61K38/43 ,  A61K38/16 ,  A61K31/5383 ,  A61K31/545 ,  A61K31/43 ,  A61K31/7042 ,  A61K31/431 ,  A61K31/4164 ,  A61P31/04

CPC分类号： A61K38/43 ,  A61K31/4164 ,  A61K31/43 ,  A61K31/431 ,  A61K31/5383 ,  A61K31/545 ,  A61K31/7042 ,  A61K38/16 ,  A61P31/04

摘要： The present invention relates to the field of medicine, specifically the field of bacterial infection and treatment thereof.

公开(公告)号：US20230125500A1

公开(公告)日：2023-04-27

申请号：US17937650

申请日：2022-10-03

申请人： The Governors of the University of Alberta

发明人： Paul JURASZ ,  Khaled Barakat ,  Subha Kalyaanamoorthy

IPC分类号： A61K38/43 ,  A61P9/10

摘要： Angiostatin Neutralizing Peptides Derived from ATP Synthase Alpha.

公开(公告)号：US20230032226A1

公开(公告)日：2023-02-02

申请号：US17690437

申请日：2022-03-09

申请人： Selecta Biosciences, Inc.

发明人： Roberto A. Maldonado

IPC分类号： A61K31/436 ,  A61K39/395 ,  A61K38/47 ,  A61K47/69 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  C07K16/18 ,  C07K16/24 ,  C07K16/40 ,  A61K38/19 ,  A61K38/21 ,  A61K38/37 ,  A61K38/43 ,  A61K45/06 ,  A61K31/192

摘要： Disclosed are methods and related compositions for concomitantly, locally administering immunosuppressants and doses of therapeutic macromolecules for reducing Type I and Type IV hypersensitivity.

公开(公告)号：US11524978B2

公开(公告)日：2022-12-13

申请号：US16823356

申请日：2020-03-19

申请人： Academia Sinica

发明人： Han-Chung Wu ,  Yuan-Sung Kuo

IPC分类号： C07K7/06 ,  A61K47/64 ,  A61K38/43

摘要： Disclosed herein is a biomolecule comprising a synthetic peptide for targeting thrombus, a pharmaceutical composition comprising the same, and uses thereof in the treatment of thromboembolism-related diseases. According to embodiments of the present disclosure, the synthetic peptide having the amino acid sequence of SEQ ID NO: 1, 2, or 3 exhibits a binding affinity and specificity to thrombus. Thus, the synthetic peptide may serve as a targeting element for delivering a therapeutic agent (e.g., an anticoagulant agent or a thrombolytic agent) to the thrombus thereby improving the therapeutic safety and efficacy of the therapeutic agent.

公开(公告)号：US20220370503A1

公开(公告)日：2022-11-24

申请号：US17710539

申请日：2022-03-31

申请人： Aelan Cell Technologies, Inc.

发明人： Victoria LUNYAK ,  Meenakshi GAUR

IPC分类号： A61K35/28 ,  A61K38/20 ,  A61K38/43 ,  A61P35/00 ,  C07K16/24 ,  C12N5/00 ,  C12N5/0775 ,  C12Q1/6886 ,  G01N33/574

摘要： Provided herein are methods and devices related to inducing a population of self-renewing or senescent stem cells, to produce one or more beneficial factors for the treatment of a disease or disorder in an individual. Also provided are compositions and methods for inducing senescence, useful for inducing senescence in a population of stem cells, in order to produce one or more beneficial factors for the treatment of a disease or disorder in an individual. Methods and devices to control and customize the production of the beneficial factors for the requirements of a disease or disorder being treated are described. Also provided are factor production units for the production of the beneficial factors, and devices for the delivery of the beneficial factors to an individual in need.

公开(公告)号：US20220331234A1

公开(公告)日：2022-10-20

申请号：US17736579

申请日：2022-05-04

申请人： Vertex Pharmaceuticals Incorporated

发明人： Christopher Thanos ,  Yang Qiu

IPC分类号： A61K9/00 ,  A61K35/39 ,  A61K38/43 ,  A61K38/18 ,  A61K9/70 ,  C12N5/071 ,  A61M31/00

摘要： The present invention provides devices and methods for delivering a population of cells or a therapeutic agent to a subject in need thereof.

公开(公告)号：US20220280603A1

公开(公告)日：2022-09-08

申请号：US17635047

申请日：2020-08-14

申请人： University of Massachusetts

发明人： Claudia Fallini ,  John Landers

IPC分类号： A61K38/17 ,  A61K38/43 ,  C07K14/47

摘要： In some aspects, the disclosure relates to compositions and methods useful for the modulating the function of the nuclear pore and/or nucleocytoplasmic transport (NCT). In some embodiments, the disclosure relates to methods of treatment of a neurodegenerative disease (e.g., amyotrophic lateral sclerosis).