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1.发明公开公开(公告)号：US20240350608A1
公开(公告)日：2024-10-24
申请号：US18634326
申请日：2024-04-12
申请人： Pfizer Inc.
发明人： Bishwa Raj Bhetuwal , Kaushik Dutta , Jianxin Gu , Sunayana Kapil , Jin-Hwan Kim , Justin Keith Moran , Suddham Singh , YuYing Yang
IPC分类号： A61K39/09 , A61K39/00 , A61K39/385 , A61K47/64
CPC分类号： A61K39/092 , A61K47/646 , A61K39/385 , A61K2039/55516
摘要： The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates), kits comprising said immunogenic compositions and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.
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公开(公告)号：US20240342263A1
公开(公告)日：2024-10-17
申请号：US18757757
申请日：2024-06-28
发明人： Jitin Bajaj , Michael Albert Winters , Emily Wen , Jian He
IPC分类号： A61K39/09 , A61K39/385 , A61K39/00
CPC分类号： A61K39/092 , A61K39/385 , A61K2039/6037 , A61K2039/62
摘要： The present invention provides methods for making polysaccharide-protein conjugates in which polysaccharides, typically from bacteria, are conjugated to a carrier protein by reductive amination under conditions which improve conjugation reaction consistency, increase consumption of protein during conjugation reaction, generate conjugates of higher molecular weight, and/or reduce the levels of free cyanide in the conjugate reaction product. The polysaccharide-protein conjugates obtained using these methods are useful for inclusion in multivalent vaccines.
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3.发明公开公开(公告)号：US20240325515A1
公开(公告)日：2024-10-03
申请号：US18621962
申请日：2024-03-29
申请人： Pfizer Inc.
发明人： Kaushik Dutta , Caitlyn Gallagher , Isis Kanevsky , Jin-hwan Kim , Justin Keith Moran , Suddham Singh , Abhishek Ravindra Vartak
CPC分类号： A61K39/092 , A61K47/42 , A61P31/04 , A61K2039/55505
摘要： The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates), kits comprising said immunogenic compositions and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.
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公开(公告)号：US20240238399A1
公开(公告)日：2024-07-18
申请号：US18419900
申请日：2024-01-23
发明人： Kyungjun AN , Dongsoo HAM , Hun KIM , Sunghyun KIM , Jinhwan SHIN , Robert HOPFER , Richard D. KENSINGER , Moe KYAW , Philippe TALAGA
CPC分类号： A61K39/092 , A61K9/0019 , A61K2039/6031 , A61K2039/70
摘要： Provided are mixed carrier, multivalent pneumococcal conjugate compositions comprising 21 different pneumococcal capsular polysaccharide-protein conjugates, wherein each of the conjugates includes a capsular polysaccharide from a different serotype of Streptococcus pneumoniae conjugated to either tetanus toxoid (TT) or CRM197, wherein the Streptococcus pneumoniae serotypes are selected from 1, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F, where the capsular polysaccharides of two of serotypes 1, 3, and 5 and one or both of serotypes 15B and 22F are conjugated to TT and the remaining capsular polysaccharides are conjugated to CRM197. Also provided are methods of producing the mixed carrier, multivalent pneumococcal conjugate compositions and methods of using the same for prophylaxis against Streptococcus pneumoniae infection or disease in a subject.
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公开(公告)号：US20240216491A1
公开(公告)日：2024-07-04
申请号：US18433142
申请日：2024-02-05
申请人： KORANEX CAPITAL
发明人： Tze Chieh SHIAO , Serge MOFFETT , Serge MIGNANI , Rene ROY
IPC分类号： A61K39/00 , A61K39/09 , A61K39/095 , A61K39/145 , A61K39/215 , A61K39/385 , A61K39/39
CPC分类号： A61K39/001169 , A61K39/092 , A61K39/095 , A61K39/145 , A61K39/215 , A61K39/385 , A61K39/39 , A61K39/00117 , A61K39/001172 , A61K2039/575 , A61K2039/6031 , A61K2039/6037 , A61K2039/6056 , A61K2039/627 , A61K2039/70
摘要： Neoglycoconjugates as immunogens and therapeutic/diagnostic tools are described herein. The neoglycoconjugates are produced by conjugating a carbohydrate antigen intermediate to a free amine group of a carrier material (e.g., carrier protein). The intermediate comprises a linker having a first end and a second end, the first end being conjugated to a carbohydrate antigen via a thio ether bond and the second end comprising a functional group reactable with a free amine group. Following coupling, the carbohydrate antigen becomes covalently bound to the carrier material via an amide, a carbamate, a sulfonamide, a urea, or a thiourea bond, thereby producing the neoglycoconjugate. Applications of the neoglycoconjugates as antigens, immunogens, vaccines, and in diagnostics are also described. Specifically, the use of (neo)glycoconjugates as vaccine candidates and other therapeutic tools against cancers, viruses such as SARS-CoV-2, and other diseases characterized by expression of aberrant glycosylation are also described.
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公开(公告)号：US12005108B2
公开(公告)日：2024-06-11
申请号：US17643942
申请日：2021-12-13
发明人： Do-Hyung Kim , Thanh Luan Nguyen , Nam-Eun Kim
IPC分类号： A61K35/744 , A23K10/18 , A23K50/80 , A61K39/02 , A61K39/09 , C12N1/20 , A61K39/106
CPC分类号： A61K39/092 , A23K10/18 , A23K50/80 , A61K35/744 , A61K39/025 , A61K39/09 , C12N1/20 , A23V2400/231 , A61K2039/106
摘要： The present invention provides a Lactococcus lactis subspecies lactis isolate WFLU-12 with the accession number o KCTC 13180BP, and a use thereof.
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7.发明公开公开(公告)号：US20240181043A1
公开(公告)日：2024-06-06
申请号：US18440735
申请日：2024-02-13
申请人： nference, Inc.
IPC分类号： A61K39/215 , A61K39/00 , A61K39/09 , A61K39/116 , A61K39/145 , A61K39/25 , A61K39/29 , A61K39/295 , A61P31/14 , A61P37/04
CPC分类号： A61K39/215 , A61K39/092 , A61K39/116 , A61K39/145 , A61K39/25 , A61K39/29 , A61K39/292 , A61K39/295 , A61P31/14 , A61P37/04 , A61K2039/55
摘要： This application relates to methods for assessing patient populations and determining subpopulations vulnerable to viral infection, methods of reducing the risk of infection and/or inducing heterologous immunity to said viral infection.
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公开(公告)号：US11998599B2
公开(公告)日：2024-06-04
申请号：US15859251
申请日：2017-12-29
申请人： Vaxcyte, Inc.
发明人： Jeffery Fairman , Jon H. Heinrichs , Wei Chan
CPC分类号： A61K39/385 , A61K39/092 , A61K47/6415 , A61K47/646 , A61P29/00 , A61P31/04 , A61P37/00 , A61K2039/575 , A61K2039/6037 , A61K2039/627
摘要： Methods for the production of immunogenic compositions containing a non-natural amino acid are disclosed. The non-natural amino acid can be a site for attachment of antigens, such as bacterial capsular polysaccharides, to make immunogenic conjugates. Bio-orthogonal attachment chemistry incorporated into the non-natural amino acids allows for more efficient and potent antigen presentation to the immune system, simplified purification, and more well-defined structure of these semi-synthetic immunogens.
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公开(公告)号：US11981708B2
公开(公告)日：2024-05-14
申请号：US16945714
申请日：2020-07-31
发明人： Richard Malley , Yingjie Lu , Fan Zhang
IPC分类号： C07K14/31 , A61K39/085 , A61K39/09 , A61K39/385 , A61K47/54 , A61K47/55 , A61K47/61 , A61P31/04 , A61K39/00
CPC分类号： C07K14/31 , A61K39/092 , A61K39/385 , A61K47/543 , A61K47/557 , A61K47/61 , A61P31/04 , A61K2039/55505 , A61K2039/6031 , A61K2039/6093 , A61K2039/625 , A61K2039/627 , A61K2039/645 , A61K2039/70 , C07K2319/00 , C07K2319/20 , Y02A50/30
摘要： The present embodiments provide for an immunogenic multiple antigen presenting system comprising a polymer to which antigens are associated by complementary affinity molecules. For example, the polymer can be a polysaccharide, or antigenic polysaccharide, to which protein or peptide antigens from the same or different pathogens are indirectly linked. The present immunogenic compositions can elicit both humoral and cellular immune responses to one or multiple antigens at the same time.
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公开(公告)号：US20240148847A1
公开(公告)日：2024-05-09
申请号：US18414392
申请日：2024-01-16
发明人： Heli Salmela , Dalial Freitak
CPC分类号： A61K39/0208 , A61K39/02 , A61K39/09 , A61K2039/54
摘要： The present invention relates to animals and more specifically to insects. In more details the invention relates to an edible composition or insect artificial diet comprising bacteria, fungi or any fragment or spore thereof for use as a vaccine in preventing a microbial disease or infection in an insect. Still, the present invention relates to preventive methods and different uses relating to said compositions or bacteria, fungi or fragments or spores thereof.
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