公开(公告)号：US12109259B2

公开(公告)日：2024-10-08

申请号：US16326833

申请日：2017-09-01

申请人： GLAXOSMITHKLINE BIOLOGICALS, S.A.

发明人： Mariagrazia Pizza ,  Steven B. Black

IPC分类号： A61K39/095 ,  A61K39/116 ,  A61K39/39 ,  A61K47/64 ,  C07K14/22 ,  C07K16/12 ,  A61K39/00

CPC分类号： A61K39/095 ,  A61K39/116 ,  A61K39/39 ,  A61K47/646 ,  C07K14/22 ,  C07K16/1217 ,  A61K2039/54 ,  A61K2039/55 ,  A61K2039/55505 ,  A61K2039/58 ,  C07K2317/33

摘要： A method for immunizing a subject in need thereof against Neisseria gonorrhoeae by administering an immunogenic composition comprising meningococcal outer membrane vesicles (OMVs).

公开(公告)号：US20240293524A1

公开(公告)日：2024-09-05

申请号：US18620109

申请日：2024-03-28

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Renzo ALFINI ,  Roberta Di Benedetto ,  Francesca Micoli ,  Allan James Saul

IPC分类号： A61K39/095 ,  A61K35/74 ,  A61K39/00 ,  A61K39/108 ,  A61K47/69

CPC分类号： A61K39/095 ,  A61K35/74 ,  A61K39/0258 ,  A61K47/6911 ,  A61K2039/6018 ,  A61K2039/6087 ,  A61K2039/627

摘要： The present invention is in the field of conjugating native, non-detergent extracted, outer membrane vesicles (nOMV) to multiple antigens to form multi functionalized nOMV-antigen conjugated derivatives, which are particularly useful for immunogenic compositions and immunisation; processes for the preparation and use of such conjugates are also provided.

公开(公告)号：US20230355735A1

公开(公告)日：2023-11-09

申请号：US18338961

申请日：2023-06-21

申请人： PFIZER INC.

发明人： Jianxin Gu ,  Jin-hwan Kim ,  Avvari Krishna Prasad ,  Yu-ying Yang

IPC分类号： A61K39/095 ,  A61K47/64 ,  A61K39/09 ,  A61K45/06

CPC分类号： A61K39/095 ,  A61K47/646 ,  A61K47/64 ,  A61K39/092 ,  A61K45/06 ,  A61K47/6415 ,  A61K2039/6068

摘要： The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.

公开(公告)号：US20230346904A1

公开(公告)日：2023-11-02

申请号：US17988688

申请日：2022-11-16

申请人： ORBIS HEALTH SOLUTIONS LLC

发明人： Thomas E. Wagner

IPC分类号： A61K39/095 ,  A61K39/12

CPC分类号： A61K39/095 ,  A61K39/12 ,  A61K2039/523

摘要： The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making bacterial and viral vaccines

公开(公告)号：US20230241196A1

公开(公告)日：2023-08-03

申请号：US17790360

申请日：2021-01-26

申请人： Oregon State University ,  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc

发明人： Aleksandra E. Sikora ,  Ryszard A. Zielke ,  Ann E. Jerse

IPC分类号： A61K39/095 ,  A61P31/04

CPC分类号： A61K39/095 ,  A61P31/04 ,  A61K2039/55561

摘要： Methods are disclosed for inducing an immune response to Neisseria gonorrhoeae in a mammalian subject. These methods include administering to the mammalian subject an effective amount of a MetQ protein and an effective amount of a K-type CpG oligodeoxynucleotide, thereby inducing the immune response. Also disclosed are immunogenic compositions including an effective amount of a MetQ protein and an effective amount of a K-type CpG oligodeoxynucleotide.

公开(公告)号：US11707514B2

公开(公告)日：2023-07-25

申请号：US17468989

申请日：2021-09-08

申请人： Sanofi Pasteur Inc.

发明人： Richard David Kensinger, Jr. ,  Steven L. Hauser

IPC分类号： A61K39/095 ,  A61K47/65 ,  A61K47/64 ,  A61K47/18 ,  A61K47/36 ,  A61K39/00

CPC分类号： A61K39/095 ,  A61K47/18 ,  A61K47/36 ,  A61K47/6415 ,  A61K47/65 ,  A61K2039/55583 ,  A61K2039/6037 ,  A61K2039/70 ,  Y02A50/30

摘要： Provided herein are compounds, compositions, formulations, kits, uses, and methods for vaccinating a subject against Neisseria meningitidis.

公开(公告)号：US20230203091A1

公开(公告)日：2023-06-29

申请号：US18176631

申请日：2023-03-01

申请人： Pfizer Inc.

发明人： Mingming Han ,  Rajesh Kumar Kainthan ,  Jin-Hwan Kim ,  Avvari Krishna Prasad

IPC分类号： C07K1/107 ,  C07K14/34 ,  C07K14/22 ,  C07K14/315 ,  A61K39/095 ,  A61K39/09 ,  A61K47/64 ,  C07H3/06

CPC分类号： C07K1/1077 ,  C07K14/34 ,  C07K14/22 ,  C07K14/315 ,  A61K39/095 ,  A61K39/092 ,  A61K47/646 ,  A61K47/6415 ,  A61K39/09 ,  C07H3/06 ,  A61K2039/6037

摘要： The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related agent/oxidant as an oxidizing agent, to immunogenic compositions comprising such glycoconjugates, and to methods for the use of such glycoconjugates and immunogenic compositions.

公开(公告)号：US20230019488A1

公开(公告)日：2023-01-19

申请号：US17929415

申请日：2022-09-02

申请人： THE U.S.A, as represented by the Secretary, Department of Health and Human Services

发明人： Margaret Bash ,  Kathryn Matthias

IPC分类号： A61K39/095 ,  C12N1/20 ,  C07K14/22

摘要： Immunogenic compositions are disclosed that include Neisseria meningitidis microvesicles, such as outer membrane vesicles (OMV) and/or blebs, from PorA−PorB− Neisseria, such as PorA−PorB−ampM− Neisseria meningitidis. These immunogenic compositions are of use to induce an immune response to Neisseria, including Neisseria meningitidis and Neisseria gonorrhea.

公开(公告)号：US11547755B2

公开(公告)日：2023-01-10

申请号：US16379049

申请日：2019-04-09

申请人： BIOSYNTH S.R.L.

发明人： Massimo Porro

IPC分类号： A61K39/385 ,  A61K39/09 ,  A61K39/095 ,  A61K39/102 ,  A61K39/00

摘要： The present invention refers to new conjugate antigens expressing built-in multiple epitopes and to polyvalent glycoconjugate vaccines and formulations containing the same. In addition, the present invention concerns the use of these vaccines in particular for the protection of the human population, and in particular for the protection of the paediatric population from pulmonary and systemic infections due to S. pneumoniae, N. meningitidis, H. influenzae, K. pneumoniae, M. tuberculosis, S. aereus, or from intestinal infections due to S. typhi, V. cholerae and E. coli. The present invention additionally refers to new polyvalent glycoconjugate vaccines for the protection from C. albicans and E. coli systemic and genitourinary infections or for the protection from M. bovis infections in veterinary medicine.

公开(公告)号：US11541109B2

公开(公告)日：2023-01-03

申请号：US16955735

申请日：2019-01-08

申请人： KOREA ATOMIC ENERGY RESEARCH INSTITUTE

发明人： Ho-Seong Seo ,  Sang-Yong Lim ,  Jong-Hyun Jung

IPC分类号： A61K39/112 ,  A61K39/02 ,  A61K39/00 ,  A61K41/17 ,  A61K39/108 ,  A61K39/04 ,  A61K39/085 ,  A61K39/09 ,  A61K39/095

摘要： The present invention relates to a method of preparing a live attenuated vaccine by irradiation and a live attenuated vaccine composition prepared by the same, and more particularly, a method of preparing a live attenuated vaccine by irradiation including irradiating a pathogenic microorganism with a dose of 0.5 to 2 kGy of radiation per single radiation six to fifteen times; and a live attenuated vaccine composition including a pathogenic microorganism attenuated to not be revertant to a wild type by generation of at least one mutation of nucleotide insertion and nucleotide deletion by irradiation.