公开(公告)号：US20240082191A1

公开(公告)日：2024-03-14

申请号：US18273694

申请日：2022-01-24

申请人： EGIS GYÓGYSZERGYÁR ZRT.

发明人： Anita GULYÁS ,  Krisztina MÓRICZ ,  Dániel ULEJ ,  Gábor GIGLER ,  Edit PAP ,  Adrienn PÁLVÖLGYI ,  István GACSÁLYI ,  Zoltán VARGA ,  András Ferenc WACHA ,  Attila BÓTA

IPC分类号： A61K31/197 ,  A61K9/00 ,  A61K9/06 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/22 ,  A61K47/30 ,  A61K47/32 ,  A61P25/04

CPC分类号： A61K31/197 ,  A61K9/0014 ,  A61K9/06 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/183 ,  A61K47/22 ,  A61K47/30 ,  A61K47/32 ,  A61P25/04

摘要： The present invention relates to a topical pharmaceutical composition comprising pregabalin and a reduced micellar phospholipid as an active ingredient, which results in a prolonged analgesic effect of pregabalin. The product can reduce neuropathic pain by at least 5 hours.

公开(公告)号：US20230277636A1

公开(公告)日：2023-09-07

申请号：US18316850

申请日：2023-05-12

申请人： GRIFOLS WORLDWIDE OPERATIONS LIMITED

发明人： James REBBEOR ,  Charles MILLER ,  Anthony KLOS ,  Eric ALLGAIER ,  Thomas P. ZIMMERMAN ,  Kevin WEE ,  Michelle StPETER ,  Kelly GLANCY

IPC分类号： A61K38/55 ,  A61K47/12 ,  A61K47/26 ,  A61K47/30

CPC分类号： A61K38/55 ,  A61K47/12 ,  A61K47/26 ,  A61K47/30

摘要： Compositions include highly concentrated Alpha-1 Proteinase Inhibitor (A1PI) in a concentration greater than or equal to 100 mg/ml. Pharmaceutical compositions can be prepared from these compositions. The pharmaceutical compositions can be suitable for subcutaneous administration. The highly concentrated A1PI solutions can be obtained by single-pass tangential flow filtration (SPTFF).

公开(公告)号：US20220378982A1

公开(公告)日：2022-12-01

申请号：US17819220

申请日：2022-08-11

申请人： ANTEROGEN CO., LTD.

发明人： Sung-Koo LEE ,  Mihyung KIM

IPC分类号： A61L27/38 ,  A61K9/70 ,  A61K9/00 ,  A61P17/00 ,  A61K38/39 ,  A61K47/30 ,  A61L27/52 ,  A61L27/54 ,  C12N5/00 ,  C12N5/071 ,  C12N5/0775

摘要： Provided are a composition and a sheet, including a mesenchymal stem cells-hydrogel-biodegradable support or a mesenchymal stem cells-hydrogel-nondegradable support and a preparing method thereof. More specifically, in the sheet including a mesenchymal stem cells-hydrogel-biodegradable support or a mesenchymal stem cells-hydrogel-nondegradable support according to the present invention, the high-active mesenchymal stem cells may be applied to a wounded part of a patient with epidermolysis bullosa as it is without isolation using proteases, and in the culturing, an extracellular matrix such as collagen, laminin, fibronectin, and elastin secreted from the mesenchymal stem cells is wholly present on the hydrogel to have an advantageous effect that skin reproduction and re-epithelization abilities are significantly excellent as compared with conventional dressing agents used for epidermolysis bullosa.

公开(公告)号：US11454861B2

公开(公告)日：2022-09-27

申请号：US16557243

申请日：2019-08-30

申请人： ProLynx LLC

发明人： Gary W. Ashley ,  Daniel V. Santi ,  Jeffrey C. Henise

IPC分类号： A61K47/61 ,  G02F1/361 ,  A61K47/69 ,  A61K47/60 ,  A61L15/44 ,  A61L15/60 ,  A61L15/64 ,  A61L27/54 ,  A61L27/58 ,  C07C317/18 ,  C08J3/075 ,  C09B23/01 ,  A61K47/50 ,  A61K9/06 ,  A61K47/30 ,  A61K47/34 ,  A61L15/26 ,  A61L27/18 ,  A61L27/52 ,  C07C271/08

摘要： Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.

公开(公告)号：US20220226475A1

公开(公告)日：2022-07-21

申请号：US17617785

申请日：2019-06-10

申请人： The Brigham and Women`s Hospital, Inc.

发明人： Yuhan Lee ,  Ali Tavakkoli ,  Jeffrey M. Karp

IPC分类号： A61K47/30 ,  A61K47/36 ,  A61K9/00 ,  A61K45/06

摘要： This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents and one or more biologically active substances to mucosal surfaces within the GI tract and methods for the manufacture and the use of these compositions.

公开(公告)号：US20210369633A1

公开(公告)日：2021-12-02

申请号：US17342368

申请日：2021-06-08

申请人： Massachusetts Institute of Technology

发明人： Eric A. Appel ,  Mark W. Tibbitt ,  Robert S. Langer

IPC分类号： A61K9/51 ,  A61K9/06 ,  A61K47/36 ,  A61K47/38 ,  A61K47/30 ,  A61K47/34

摘要： Network materials which exhibit both shear thinning and self-healing properties are disclosed. The networks contain particles and gel-forming compounds. The networks are useful for a variety of biomedical uses, including drug delivery.

公开(公告)号：US10994016B2

公开(公告)日：2021-05-04

申请号：US15251681

申请日：2016-08-30

申请人： Northwestern University

发明人： Mark C. Hersam ,  Thomas J. Meade ,  Hsiang-Hua Hung

IPC分类号： A61K47/30 ,  A61K49/08 ,  A61K49/12 ,  A61K47/54 ,  A61K47/69 ,  A61K49/10 ,  B82Y5/00

摘要： A method of bioactive molecule delivery includes providing a first aqueous medium comprising native graphene oxide and a second aqueous medium comprising a bioactive molecular component that includes Gd(III)-labeled molecules; mixing said first and second media to form a mixture thereof; co-incubating the mixture for a first period of time for coupling said molecular component on a surface of said native graphene oxide, to provide a co-incubation product; and contacting a cellular medium with said co-incubation product for a second period of time for cellular delivery of said bioactive molecular component.

公开(公告)号：US10683387B2

公开(公告)日：2020-06-16

申请号：US15725036

申请日：2017-10-04

申请人： Massachusetts Institute of Technology

发明人： Jeremiah A. Johnson ,  Qixian Chen ,  Farrukh Vohidov

IPC分类号： C08G61/02 ,  C08G61/08 ,  C08G61/12 ,  A61K9/06 ,  A61K47/30 ,  A61K9/14 ,  A61K31/192 ,  A61K31/5383 ,  A61K31/573

摘要： Materials (e.g., particles, hydrogels) that provide extended release of one or more therapeutic agents are useful platforms for drug delivery. In part, the present invention relates to new triblock (ABC) bottlebrush copolymers which can be used in the formulation of particles and hydrogels for the extended release of therapeutic agents. In certain embodiments, the triblock bottlebrush copolymers, particles, and hydrogels described herein are thermally-responsive and gel at physiological temperature (e.g., upon administration to a subject), providing injectable and/or implantable gels which can be used for extended release drug delivery. The present invention also provides methods for extended release drug delivery, and methods of treating and/or preventing a disease or conditions in a subject, using the inventive copolymers, particles, and hydrogels. In addition, the present invention provides methods of preparing the triblock bottlebrush copolymers described herein.

公开(公告)号：US10596300B2

公开(公告)日：2020-03-24

申请号：US15553509

申请日：2016-02-29

申请人： Wayne State University

发明人： Zhiqiang Cao ,  Wei Wang ,  Zhanguo Yue

IPC分类号： A61K9/00 ,  A61K47/30 ,  A61K47/36 ,  A61K47/56 ,  A61K47/61 ,  A61L27/52 ,  A61K9/06 ,  A61K47/34 ,  A61K9/50 ,  A61L27/54 ,  C12N5/071

摘要： Biocompatible hydrogel compositions according to aspects of the present invention are provided wherein the biocompatible hydrogel composition is or includes a physical hydrogel, a chemical hydrogel or both a physical hydrogel and a chemical hydrogel, along with biocompatible hydrogel compositions encapsulating a therapeutic agent and methods of use thereof.

公开(公告)号：US20200054486A1

公开(公告)日：2020-02-20

申请号：US16487824

申请日：2017-09-26

申请人： Tathagata DUTTA

发明人： Tathagata DUTTA

IPC分类号： A61F9/00 ,  A61K47/30

摘要： A biodegradable intravitreal implant comprising an antioxidant and a biodegradable polymer that releases the antioxidant at a predetermined rate effective to sustain release of an amount of the antioxidant from the implant for a prolonged period of time after the implant is placed into the vitreous of an eye.