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公开(公告)号：US12128114B2
公开(公告)日：2024-10-29
申请号：US16980252
申请日：2019-03-07
发明人： Guillermina Ferro Flores , Blanca Elí Ocampo García , Myrna Alejandra Luna Gutiérrez , Clara Leticia Santos Cuevas , Erika Patricia Azorín Vega , Nallely Patricia Jiménez Mancilla , Tania Hernández Jiménez , Flor de María Ramírez De La Cruz
CPC分类号： A61K51/041
摘要： The invention relates to a new lutetium-177 therapeutic radiopharmaceutical as an inhibitor of prostate-specific membrane antigen (iPSMA), wherein 1,4,7,10-tetraazacyclododecane-N,N′,N″,N″″-tetraacetic acid (DOTA) bonded to the heterocyclic molecule hydrazinonicotinamide (HYNIC), generates a rigid chemical structure that minimises the number of conformers and intramolecular hydrogen bonds, thereby producing a favourable spatial orientation of the active site (Lys(Nal)-NH—CO—NH-Glu) in the molecule, for biological recognition by the PSMA protein. The new 177Lu-DOTA-HYNIC-iPSMA radiopharmaceutical accumulates, with high affinity in vivo, in tumours that overexpress the PSMA protein, acting as a radiotherapeutic agent. The purpose of the invention is to provide a new specific radiopharmaceutical (molecular target radiopharmaceutical) for the treatment of tumours with PSMA overexpression.
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公开(公告)号：US12053532B2
公开(公告)日：2024-08-06
申请号：US17114195
申请日：2020-12-07
CPC分类号： A61K49/0052 , A61B5/0071 , A61K49/0032 , G01N33/57411 , G01N33/57415 , G01N33/57423 , G01N33/57426 , G01N33/57449 , G01N33/582
摘要： The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for incorporating the compounds as used for the targeted imaging of tumors. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.
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公开(公告)号：US12016937B2
公开(公告)日：2024-06-25
申请号：US17295609
申请日：2020-09-15
IPC分类号： A61K51/00 , A61K9/00 , A61K9/14 , A61K51/12 , A61P35/00 , G21G1/00 , G21G1/06 , G21G4/08 , B82Y5/00
CPC分类号： A61K51/1244 , A61K9/0019 , A61K9/141 , A61P35/00 , G21G1/0005 , G21G1/06 , G21G4/08 , B82Y5/00
摘要： The present disclosure provides a composition that includes a mixture of (i) radioactive microparticles; and (ii) non-radioactive microparticles. The radioactive microparticles may be suitable to treat a vascularized tumour, such as a liver tumour or a metastasized liver tumour. The radioactive microparticles and the non-radioactive microparticles may have substantially the same resistance when flowing in a liquid through a conduit. The present disclosure also provides methods of making and methods of using mixtures of microparticles.
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公开(公告)号：US11977084B2
公开(公告)日：2024-05-07
申请号：US17005892
申请日：2020-08-28
IPC分类号： G01N33/68 , A61K31/165 , A61K31/69 , A61K38/05 , A61K51/00 , G01N30/72 , G01N30/88 , G01N33/50
CPC分类号： G01N33/6896 , A61K31/165 , A61K31/69 , A61K38/05 , A61K51/00 , G01N30/72 , G01N33/5023 , G01N33/5058 , G01N2030/8831 , G01N2333/47 , G01N2800/2821
摘要： The inventors surprisingly found that neural stimulation caused the synthesis and degradation of proteins into peptides which were then secreted into the cell media within minutes of stimulation by a novel neural-specific and membrane bound proteasome (neuronal membrane proteasome or NMP) that is transmembrane in nature. These secreted, activity-induced, proteasomal peptides (SNAPPs) range in size from about 500 Daltons to about 3000 Daltons. Surprisingly none of the peptides appear to be those previously known to have any neuronal function. Moreover, these SNAPPs have stimulatory activity and are heretofore a new class of signaling molecules. Moreover, the NMP appears to play a highly significant role in aspects of neuronal signaling known to be critical for neuronal function. The inventors have gone on to develop all tools to study this novel mechanisms including protocols and practice for generation and purification of SNAPPs as well as a new and specific inhibitor of the NMP allowing for selective control of this process in the nervous system. The present invention provides methods of making and using these SNAPPs for both laboratory and clinical purposes, the screening for molecules which modulate NMP function in vivo and in vitro, and methods for diagnosis of NMP related diseases.
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公开(公告)号：US20240108574A1
公开(公告)日：2024-04-04
申请号：US18526765
申请日：2023-12-01
CPC分类号： A61K9/0046 , A61K9/0048 , A61K33/14 , A61K33/18 , A61K33/20 , A61K33/40 , A61K45/06 , A61K51/00 , A61K9/00 , A61K9/0012 , A61K9/0043 , A61K9/06
摘要： The invention is directed to a method for preventing nasolacrimal duct obstruction (NLDO) in a patient receiving high dose radioactive iodine for treatment of cancer. The method includes administering an effective amount of perchlorate anion to the eyes of the patient.
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6.发明授权公开(公告)号：US11938201B2
公开(公告)日：2024-03-26
申请号：US18354282
申请日：2023-07-18
CPC分类号： A61K51/0485 , A61K47/545 , A61K51/0478 , A61K51/0482
摘要： Imaging and radiotherapeutics agents targeting fibroblast-activation protein-α (FAP-α) and their use in imaging and treating FAP-α related diseases and disorders are disclosed.
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公开(公告)号：US11904027B2
公开(公告)日：2024-02-20
申请号：US16827606
申请日：2020-03-23
发明人： Francesco de Palo , Lorenza Fugazza , Donato Barbato , Maurizio Mariani , Daniela Chicco , Giovanni Tesoriere , Clementina Brambati
CPC分类号： A61K51/048 , A61K33/24 , C22B59/00 , A61K51/0482
摘要： The present invention relates to radionuclide complex solutions of high concentration and of high chemical stability, that allows their use as drug product for diagnostic and/or therapeutic purposes. The stability of the drug product is achieved by at least one stabilizer against radiolytic degradation. The use of two stabilizers introduced during the manufacturing process at different stages was found to be of particular advantage.
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公开(公告)号：US11865209B2
公开(公告)日：2024-01-09
申请号：US16371440
申请日：2019-04-01
IPC分类号： A01N59/08 , A61K33/14 , A61K9/00 , A61K33/18 , A61K33/40 , A61K45/06 , A61K51/00 , A61K33/20 , A61K9/06 , A61K9/08 , A61K47/02
CPC分类号： A61K9/0046 , A61K9/0048 , A61K33/14 , A61K33/18 , A61K33/20 , A61K33/40 , A61K45/06 , A61K51/00 , A61K9/00 , A61K9/0012 , A61K9/0043 , A61K9/06 , A61K9/08 , A61K47/02
摘要： The invention is directed to a method for preventing nasolacrimal duct obstruction (NLDO) in a patient receiving high dose radioactive iodine for treatment of cancer. The method includes administering an effective amount of perchlorate anion to the eyes of the patient.
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公开(公告)号：US11813339B2
公开(公告)日：2023-11-14
申请号：US16484706
申请日：2018-02-06
申请人： IGL Pharma, Inc.
发明人： Jaime Simon , R. Keith Frank
CPC分类号： A61K51/0482 , A61K51/0478 , A61P35/00 , A61P7/00 , A61P19/08 , A61P35/04 , G21G1/02
摘要： This invention relates to radioactive, bone-seeking, pharmaceutical compositions that are administered multiple times to a patient, have a lower impurity profile, a longer shelf life, and are less expensive to prepare.
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公开(公告)号：US20230250160A1
公开(公告)日：2023-08-10
申请号：US17997270
申请日：2021-04-29
申请人： Hober Biotech AB
发明人： Sophia Hober , Sarah Lindbo , Emma von Witting
IPC分类号： C07K16/18 , C07K16/24 , C07K16/30 , C07K16/28 , C07K16/22 , C07K16/26 , A61K39/395 , A61K51/00 , A61K31/7048
CPC分类号： C07K16/18 , C07K16/241 , C07K16/3069 , C07K16/2818 , C07K16/22 , C07K16/26 , A61K39/3955 , A61K51/00 , A61K31/7048 , C07K2317/31
摘要： The present disclosure provides for a bispecific protein that enables simultaneous binding of both albumin and a desired target to an ADAPT (ABD Derived Affinity ProTeins) molecule. The present disclosure provides for an ADAPT molecule wherein the proposed binding surface of the desired target is located on helix 1 and helix 2 of the ADAPT molecule.
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