公开(公告)号：US20240350519A1

公开(公告)日：2024-10-24

申请号：US18615236

申请日：2024-03-25

申请人： Quicksilver Scientific, Inc.

发明人： Christopher W. Shade ,  Steven Tieu ,  James R Huey ,  David Durkee ,  Michelle Schwenk

IPC分类号： A61K31/00 ,  A23G3/34 ,  A23G3/36 ,  A23G3/40 ,  A23G3/42 ,  A23G3/44 ,  A23G3/48 ,  A61K9/00 ,  A61K9/107 ,  A61K31/01 ,  A61K31/015 ,  A61K31/045 ,  A61K31/07 ,  A61K31/122 ,  A61K31/197 ,  A61K31/198 ,  A61K31/205 ,  A61K31/355 ,  A61K31/375 ,  A61K31/593 ,  A61K33/30 ,  A61K36/185 ,  A61K36/539 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26 ,  A61K47/42 ,  A61K47/44

CPC分类号： A61K31/658 ,  A23G3/0019 ,  A23G3/368 ,  A23G3/40 ,  A23G3/42 ,  A23G3/44 ,  A23G3/48 ,  A61K9/0056 ,  A61K9/1075 ,  A61K31/01 ,  A61K31/015 ,  A61K31/045 ,  A61K31/07 ,  A61K31/122 ,  A61K31/197 ,  A61K31/198 ,  A61K31/205 ,  A61K31/355 ,  A61K31/375 ,  A61K31/593 ,  A61K33/30 ,  A61K36/185 ,  A61K36/539 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26 ,  A61K47/42 ,  A61K47/44

摘要： Microemulsions incorporated into gummy confections are described where hydrophobic liquid droplets are distributed in a continuous hydrophilic liquid phase. In relation to conventional oil-in-water (OIW) microemulsions, prior to incorporation into the gummy confections the described microemulsions may be thought of as modified oil-in-water (MOIW) microemulsions, where both the “oil” and “water” phases of the microemulsion are modified. The oil phase droplets of the MOIW microemulsion are modified with alcohol and can better deliver oil-soluble species to the bloodstream than can oil blends or the oil phases of conventional oil-in-water (OIW) microemulsions. The polar continuous “water” phase of the MOIW microemulsion is modified with a sugar or sugar alcohol. The modified oil phase droplets disperse into the modified polar continuous phase of the MOIW microemulsion prior to incorporation into the gummy confection.

公开(公告)号：US20240350413A1

公开(公告)日：2024-10-24

申请号：US18686065

申请日：2022-08-24

申请人： GENNOVA BIOPHARMACEUTICALS LTD.

发明人： Swarnendu KAVIRAJ ,  Sanjay SINGH ,  Sunil RAUT ,  Pavan KARDILE ,  Ajay SINGH

IPC分类号： A61K9/19 ,  A61K9/107 ,  A61K9/14 ,  A61K39/00 ,  A61K39/215 ,  A61P31/14

CPC分类号： A61K9/19 ,  A61K9/1075 ,  A61K9/145 ,  A61K39/215 ,  A61P31/14 ,  A61K2039/51 ,  A61K2039/552 ,  A61K2039/55555 ,  C12N2770/20034

摘要： Lyophilised formulations of mRNA adsorbed onto lipid nano-emulsion particles. The present invention relates to lyophilised formulations of mRNA adsorbed onto lipid nano-emulsion particles. It particularly provides a method for lyophilisation of liquid 5 formulations of mRNA adsorbed onto lipid nano-emulsion particles under the conditions that maintain the integrity and pharmaceutical properties of resultant lyophilised formulations for the extended periods at storage temperature of about 5° C.

公开(公告)号：US20240342087A1

公开(公告)日：2024-10-17

申请号：US18731681

申请日：2024-06-03

申请人： Northwestern University

发明人： Joshua N. Leonard ,  Michelle E. Hung

IPC分类号： A61K9/107 ,  A61K9/00 ,  A61K31/713 ,  A61K47/46 ,  C07K14/705 ,  C12N15/88

CPC分类号： A61K9/1075 ,  A61K9/0019 ,  A61K31/713 ,  A61K47/46 ,  C07K14/70596 ,  C12N15/88 ,  C07K2319/03 ,  C07K2319/06 ,  C07K2319/74 ,  C07K2319/85 ,  C07K2319/91 ,  C12N2740/16043 ,  C12N2810/6081

摘要： Disclosed are extracellular vesicles comprising an engineered targeting protein for targeting the extracellular vesicles to target cells. The targeting protein is a fusion protein that includes a ligand, an engineered glycosylation site, and an exosome-targeting domain. Exemplary extracellular vesicles may include but are not limited to exosomes.

公开(公告)号：US20240342086A1

公开(公告)日：2024-10-17

申请号：US18683943

申请日：2021-10-06

申请人： SUN PHARMACEUTICAL INDUSTRIES LIMITED

发明人： Ajay Jaysingh KHOPADE ,  Arindam HALDER

IPC分类号： A61K9/107 ,  A61K9/00 ,  A61K38/13 ,  A61K47/02 ,  A61K47/10 ,  A61K47/32 ,  A61K47/44

CPC分类号： A61K9/1075 ,  A61K9/0048 ,  A61K38/13 ,  A61K47/02 ,  A61K47/10 ,  A61K47/32 ,  A61K47/44

摘要： A stable nanomicellar ophthalmic solution comprising cyclosporine and a method of preparing the nanomicellar solution. The present invention further relates to the stable nanomicellar solution comprising cyclosporine form with characteristic XRD peaks at 2-theta (deg.) 6.9, 7.8, 9.4 and 15.9 or amorphous cyclosporine. The present invention also relates to use of this stable nanomicellar L ophthalmic solution in dry eye.

公开(公告)号：US20240342085A1

公开(公告)日：2024-10-17

申请号：US18580272

申请日：2022-07-17

申请人： RAMOT AT TEL-AVIV UNIVERSITY LTD.

发明人： Roey Jacob AMIR ,  Gadi SLOR ,  Shahar TEVET

IPC分类号： A61K9/107 ,  A61K8/02 ,  A61K8/81 ,  A61K47/32

CPC分类号： A61K9/1075 ,  A61K8/0291 ,  A61K8/8164 ,  A61K47/32

摘要： The present invention provides a stimuli-induced delivery system comprising self¬assembled amphiphilic tri-block copolymers in the form of micelles. The delivery system enables the release of a cargo from within the micelles following a transition to di-block copolymers micelles and subsequent activation by a protein to induce disassembly of the micelles.

公开(公告)号：US12115221B2

公开(公告)日：2024-10-15

申请号：US17216771

申请日：2021-03-30

申请人： Jiangnan University

发明人： Liuping Fan ,  Yang Ni ,  Jinwei Li

IPC分类号： A61K47/38 ,  A23D7/005 ,  A23D7/04 ,  A23G9/32 ,  A61K9/107 ,  C08B1/00 ,  C08B15/08 ,  C09K23/00 ,  C09K23/56

CPC分类号： A61K47/38 ,  A23D7/0053 ,  A23D7/04 ,  A23G9/327 ,  A61K9/1075 ,  C08B1/003 ,  C08B15/08 ,  C09K23/00 ,  C09K23/56 ,  A23V2002/00

摘要： The disclosure discloses a Pickering emulsion stabilized by cellulose from ginkgo seed shells and a preparation method thereof, and belongs to the fields of preparation methods of biomass materials and food chemical industry. The disclosure uses ginkgo seed shells as a raw material to obtain high-purity cellulose through hot alkali treatment and sodium chlorite bleaching. After the cellulose is dried, the cellulose is hydrolyzed with sulfuric acid to obtain a cellulose nanocrystal suspension. The suspension is mixed with an oil phase, and the Pickering emulsion is obtained through high-speed shearing and homogeneous emulsification. The disclosure can prepare cellulose nanocrystals with different aspect ratios by adjusting the parameters of high-speed shearing and homogeneous emulsification according to actual production needs. Cellulose nanocrystals with high aspect ratio can be used to prepare stable Pickering emulsions with high oil phase and high viscosity, which can be applied to the fields of food, cosmetics and the like; and cellulose nanocrystals with low aspect ratio can be used to prepare Pickering emulsions with low viscosity and high fluidity, which can to be applied to the fields of food and medicine.

公开(公告)号：US20240335508A1

公开(公告)日：2024-10-10

申请号：US18627146

申请日：2024-04-04

申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA

发明人： Priyabrata MUKHERJEE ,  Joshua SEABERG ,  Resham BHATTACHARYA

IPC分类号： A61K38/17 ,  A61K9/107 ,  A61K9/51 ,  A61K31/704 ,  A61P35/00

CPC分类号： A61K38/1758 ,  A61K9/1075 ,  A61K9/5115 ,  A61K31/704 ,  A61P35/00

摘要： Provided herein are gold nanoparticles (AuNPs) and therapeutics agents co-encapsulated within non-ionic surfactant vehicles (AuNSVs) as well as therapeutic methods of using AuNSVs. Also provided herein are a millifluidic synthesis apparatus and process using ultrasonic mixing for producing AuNSVs encapsulating therapeutic or diagnostic agents, such as chemotherapeutics and/or mRNA.

公开(公告)号：US20240316136A1

公开(公告)日：2024-09-26

申请号：US18679405

申请日：2024-05-30

申请人： Shanghai Ocean University

发明人： Jing XIE ,  Jie CAO ,  Jinfeng WANG ,  Jun MEI ,  Zhaoyang DING ,  Weiqiang QIU

IPC分类号： A61K36/54 ,  A61K9/107 ,  A61K47/10 ,  A61K47/26 ,  A61P23/00

CPC分类号： A61K36/54 ,  A61K9/107 ,  A61K47/10 ,  A61K47/26 ,  A61P23/00

摘要： An anesthetic method of the spotted seabass with a plant essential oil includes the following steps. (1) Spotted seabass is acclimated in a water tank for 24 h before anesthesia. The metabolic wastes of the spotted seabass were discharged during acclimatization period. (2) Cinnamomum camphora essential oil, ethanol, and Tween-80 are mixed and dissolved to obtain an emulsified essential oil. (3) The emulsified essential oil is respectively added into a plurality of aquariums. The spotted seabass is transferred into the plurality of aquariums. Concentrations of Cinnamomum camphora essential oils in the plurality of aquariums and anesthesia time of the spotted seabass are recorded. (4) The spotted seabass are captured and placed into an aquarium containing clean water for recovery when the spotted seabass enter the deep anesthesia period. The resuscitation time is recorded when the spotted seabass have no flopping, and swim normally and is active.

公开(公告)号：US12091486B2

公开(公告)日：2024-09-17

申请号：US17810591

申请日：2022-07-01

申请人： The Board of Regents of The University of Texas System

发明人： Jinming Gao ,  David Boothman ,  Kejin Zhou ,  Xiaonan Huang ,  Yiguang Wang

IPC分类号： C08F293/00 ,  A61K9/107 ,  A61K9/127 ,  A61K9/50 ,  A61K31/337 ,  A61K31/352 ,  A61K31/704 ,  A61K47/58 ,  A61K47/62 ,  A61K47/68 ,  A61K47/69 ,  A61K49/00 ,  A61P35/00 ,  C07D311/92 ,  C08F299/02 ,  C08G81/02 ,  G01N33/58

CPC分类号： C08F293/005 ,  A61K9/1075 ,  A61K9/1273 ,  A61K9/5031 ,  A61K31/337 ,  A61K31/352 ,  A61K31/704 ,  A61K47/58 ,  A61K47/62 ,  A61K47/6811 ,  A61K47/6845 ,  A61K47/6907 ,  A61K49/0032 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/0082 ,  A61P35/00 ,  C07D311/92 ,  C08F299/024 ,  C08G81/025 ,  G01N33/582 ,  A61K49/005 ,  C08F2438/01

摘要： Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises




wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US12090203B2

公开(公告)日：2024-09-17

申请号：US17595709

申请日：2020-05-29

申请人： Drexel University ,  Thomas Jefferson University

发明人： Margaret A. Wheatley ,  John Robert Eisenbrey ,  Brian E. Oeffinger ,  Purva Vaidya

IPC分类号： A61K41/00 ,  A61K9/107 ,  A61K31/416 ,  A61K47/14 ,  A61K47/18 ,  A61K47/22 ,  A61K49/00

CPC分类号： A61K41/0033 ,  A61K9/1075 ,  A61K31/416 ,  A61K47/14 ,  A61K47/186 ,  A61K47/22 ,  A61K49/0082

摘要： The present invention provides methods for preparing acoustically-sensitive microbubbles. The method includes the steps of: i) preparing a first surfactant solution comprising a first micelle-forming surfactant at a concentration above the critical micelle concentration (CMC); ii) adding one or more pharmaceutical compounds in a solvent to the first surfactant solution, thereby loading the micelles with the one or more pharmaceutical compounds; iii) preparing a second surfactant solution comprising a second surfactant, wherein the second surfactant comprises one or more matrix forming surfactants; iv) adding heat to the second surfactant solution to melt the surfactant and allowing the mixture to cool under rapid stirring; v) combining the second surfactant solution with the loaded micelles; vi) purging the surfactant mixture with a purging gas; vii) agitating the purged mixture under a constant stream of the purging gas; and, viii) separating the formed microbubbles by size.