公开(公告)号：US20230130357A1

公开(公告)日：2023-04-27

申请号：US17918024

申请日：2021-04-30

申请人： BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

发明人： Mark A. CARLSON ,  Jingwei XIE

IPC分类号： A61F2/00 ,  A61L31/04 ,  A61L31/16 ,  A61L31/10

摘要： Hernia meshes are provided as well as methods of use thereof and methods of making.

公开(公告)号：US20230119445A1

公开(公告)日：2023-04-20

申请号：US17916716

申请日：2021-04-01

申请人： TRACTIVUS SL

发明人： Robert TEXIDÓ BARTES ,  Joan GILABERT PORRES ,  Salvador BORRÓS GÓMEZ

IPC分类号： A61L29/10 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16

摘要： The present invention relates to a coating for a device, wherein the coating comprises a polymeric film, wherein the polymeric film comprises a polymerisation product formed from a polymerisation solution comprising dopamine, or a salt thereof, and at least one amino acid, or a salt thereof; and a metallic layer formed on the polymeric film.

公开(公告)号：US20230118531A1

公开(公告)日：2023-04-20

申请号：US18067588

申请日：2022-12-16

申请人： Syntach AG

发明人： Zhihao Yang ,  Richard Cornelius ,  Paige Hastings ,  Bodo Quint ,  Gerd Siebold ,  Ib Erling Joergensen ,  Stevan Nielsen

IPC分类号： A61L31/10 ,  A61L27/30 ,  A61L27/44 ,  A61L27/54 ,  A61L27/58 ,  A61L31/08 ,  A61L31/14

摘要： The present invention generally relates to the use of small particles, such as micro particles or nanoparticles, to produce a therapeutic scar such as “trans-mural” scarring or other desired “deep tissue” scarring. In one preferred embodiment, these particles can be delivered to a target location by an implant. More specifically, these particles can be incorporated into the structure of implants or into the coatings on implants. In another preferred embodiment, these small particles can be delivered directly with a catheter by electrophoresis or hydraulic pressure.

公开(公告)号：US20230077402A1

公开(公告)日：2023-03-16

申请号：US17473123

申请日：2021-09-13

申请人： MEDTRONIC INC.

发明人： JONATHAN T. GOODMAN ,  Sean Chen ,  Kasyap V. Seethamraju ,  Charlene X. Yuan ,  Raman V. Bahulekar ,  Joseph L. Kalscheuer

IPC分类号： A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61K31/196 ,  A61K31/496 ,  A61K31/65

摘要： A surgical device includes a substrate and a first coating that covers at least a portion of the substrate. The first coating includes a first polymer. The first coating having antibiotics dispersed in the first polymer such that the first polymer releases the antibiotics as the first polymer degrades. A second coating covers at least a portion of the first coating. The second coating includes a second polymer. The second polymer includes an alginate. The second coating has a hemostatic agent dispersed in the second polymer such that the second polymer releases the hemostatic agent as the second polymer degrades. The hemostatic agent is selected from epinephrine, tranexamic acid, chitosan and oxidized regenerated cellulose. In some embodiments, systems and methods are disclosed.

公开(公告)号：US11602578B2

公开(公告)日：2023-03-14

申请号：US16761202

申请日：2018-11-02

申请人： Université de Strasbourg ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  PROTIP MEDICAL

发明人： Philippe Lavalle ,  Pierre Schaaf ,  Nihal Engin Vrana ,  Angela Mutschler ,  Cynthia Calligaro ,  Lorène Tallet

IPC分类号： A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16

摘要： The present invention concerns a polyelectrolyte coating comprising at least one polycationic layer consisting of at least one polycation consisting of n repetitive units having the formula (1) and at least one polyanionic layer consisting of hyaluronic acid. The polyelectrolyte coating has a biocidal activity and the invention thus further refers to the use of said polyelectrolyte coating for producing a device, in particular a bacteriostatic medical device, more particularly an implantable device, comprising said polyelectrolyte coating, and a method for preparing said device and a kit.

公开(公告)号：US11590267B2

公开(公告)日：2023-02-28

申请号：US16589816

申请日：2019-10-01

申请人： MicroVention, Inc.

发明人： Aaron Baldwin ,  Xinping Wu ,  Bryan Fiamengo ,  Garrett Ulrich ,  John Belletto

IPC分类号： A61L33/06 ,  A61L31/10 ,  B05D3/14 ,  B05D7/16 ,  A61L31/02

摘要： Described are medical devices including expandable tubular bodies configured to be implanted into a lumen, wherein the outer surface of the expandable tubular bodies are coupled to a polymer(s).

公开(公告)号：US20230049289A1

公开(公告)日：2023-02-16

申请号：US17904763

申请日：2021-02-19

申请人： KEYRON LTD

发明人： Giorgio CASTAGNETO GISSEY

IPC分类号： A61F5/00 ,  A61L31/18 ,  A61L31/10 ,  A61L31/00 ,  A61L31/04 ,  A61L31/14

摘要： The present invention relates to an orally administrable intragastric balloon encapsulated so that, once it is in the stomach, the capsules dissolves and increases its volume thanks to the presence, inside thereof, of a superabsorbent edible polymer able of absorbing the water contained in the stomach.

公开(公告)号：US11577003B2

公开(公告)日：2023-02-14

申请号：US17308383

申请日：2021-05-05

申请人： Hothouse Medical Limited

发明人： David Granville Stevenson ,  Timothy Rawden Ashton ,  Lindsey Calcutt ,  Paul Van Hulle ,  James Wade Curlee

IPC分类号： A61L27/50 ,  A61L27/34 ,  A61L27/48 ,  A61L27/52 ,  A61L31/10 ,  A61L31/12 ,  A61L31/14 ,  A61L27/56 ,  A61F2/07

摘要： A method of detecting the presence or absence of a sealant applied to a textile graft includes the steps of: providing a textile graft having a first surface and an opposed second surface; providing a water soluble masking agent; applying the water soluble masking agent to at least a portion of the first surface of the textile graft; providing a sealant solution; providing a visual indicator; applying the water insoluble sealing agent and the visual indicator to the second surface of the textile graft; and removing the water soluble masking agent after the step of applying sealing solution. The second surface has visual indication of the visual indicator and the first surface is substantially free of visual indication of the visual indicator. An implantable textile graft includes the selectively applied visual indicator.

公开(公告)号：US11540909B2

公开(公告)日：2023-01-03

申请号：US16639818

申请日：2018-08-21

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO

发明人： Devatha Nair ,  Robert Mcleod ,  Sean Shaheen ,  Gannon Kehe ,  Michael Schurr ,  Ram Nagaraj

IPC分类号： B05D3/02 ,  B05D1/40 ,  C08F2/46 ,  C08F2/50 ,  C08G61/04 ,  A61C13/087 ,  C08J7/04 ,  A61L15/24 ,  A61L31/10 ,  B29C71/02 ,  C09D133/14 ,  C08J7/043

摘要： Disclosed methods include formulating azobenzene-based polymer networks to induce a modulus change in a highly crosslinked polymer, in vivo, with no external heat requirement and using a benign light as the source of stimuli. A modulus change can be achieved via a coating on the substrate and within the bulk of the substrate via photoexposure. The azobenzene-based polymer network can be formed as a coating or in the bulk of a material from either a glassy composition comprising methyl methacrylate (MMA), poly (methyl methacrylate) (PMMA), and triethylene glycol dimethacrylate (TEGDMA) or a soft material comprising of long-chain difunctional acrylates. The disclosed technology also includes methods of biofilm disruption and removal from the surface of a substrate, and includes methods of inhibiting biofilm growth and cell attachment to a substrate.

公开(公告)号：US20220411681A1

公开(公告)日：2022-12-29

申请号：US17781314

申请日：2020-11-30

申请人： CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST

发明人： Andrew Hindmarsh ,  Alex Skordos ,  Nandita Rahatekar ,  Vijay Kumar Thakur

IPC分类号： C09J167/04 ,  C09J4/06 ,  A61L31/10 ,  A61L24/04

摘要： An adhesive composition comprising a cyanoacrylate and a solidifying polymer. The composition may further comprise a hydrophilic material, e.g. silica particles, and/or one or more polymerisation inhibitors. The adhesive composition may be disposed on a surgical mesh. The surgical mesh carrying the adhesive composition may be used for hernia repair.