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145 条记录 (耗时 0.036 秒)

    Transfection reagents
    8.
    发明申请
    Transfection reagents 有权

    公开(公告)号：US20050164391A1

    公开(公告)日：2005-07-28

    申请号：US11040687

    申请日：2005-01-21

    申请人： Yongliang Chu ,  Malek Masoud ,  Gulilat Gebeyehu

    发明人： Yongliang Chu ,  Malek Masoud ,  Gulilat Gebeyehu

    IPC分类号： C12N15/09 ,  A61K9/127 ,  A61K31/14 ,  A61K47/16 ,  A61K47/18 ,  A61K47/22 ,  C07C211/21 ,  C07C211/63 ,  C07C211/64 ,  C07C215/18 ,  C07C217/08 ,  C07C229/26 ,  C07C237/10 ,  C07C279/08 ,  C07D211/26 ,  C07D213/38 ,  C07D241/12 ,  C07D273/08 ,  C07D291/02 ,  C12N5/10 ,  C12N15/85 ,  C07C275/14 ,  C07D241/02 ,  C07K14/47

    CPC分类号： A61K47/48046 ,  A61K9/16 ,  A61K31/14 ,  A61K38/28 ,  A61K38/40 ,  A61K47/543 ,  C07C211/21 ,  C07C211/63 ,  C07C211/64 ,  C07C229/26 ,  C07D209/48 ,  C07D241/12 ,  C12N15/88 ,  Y10S435/81

    摘要： Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L′-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wherein at least one of R1, R3, R4 and R6 is a straight chain or branched, cyclic, alkyl, alkenyl, alkynyl or aryl group; and anyone of R1, R3, R4 and/or R6 may optionally be covalently linked with each other, with Y or with L when L is C or CH to form a cyclic moiety; Z is selected from the group consisting of amine, spermiyl, carboxyspermiyl, guanidyl, spermidinyl, putricinyl, diaminoalkyl, pyridyl, piperidinyl, pyrrolidinyl, polyamine, amino acid, peptide, and protein; X1 and X2, independently of one another, are selected from the group consisting of NH, O, S, alkylene, and arylene; L′ is selected from the group consisting of alkylene, alkenylene, alkynylene, arylene, alkylene ether, and polyether; D is Q or a bond; A1 and A2, independently of one another, are selected from the group consisting of CH2O, CH2S, CH2NH, C(O), C{NH), C(S) and (CH2)t; X is a physiologically acceptable anion; m, n, r, s, u, v, w and y are 0 or 1, with the proviso that when both m and n are 0 at least one of r, s, u and y is other than 0; i, j, k, l, p and are integers from 0 to about 100; q is an integer from 1 to about 1000; and a is the number of positive charge divided by the valence of the anion.

    Transfection reagents
    9.
    发明申请
    Transfection reagents 有权

    公开(公告)号：US20050124069A1

    公开(公告)日：2005-06-09

    申请号：US11040562

    申请日：2005-01-21

    申请人： Yongliang Chu ,  Malek Masoud ,  Gulilat Gebeyehu

    发明人： Yongliang Chu ,  Malek Masoud ,  Gulilat Gebeyehu

    IPC分类号： C12N15/09 ,  A61K9/127 ,  A61K31/14 ,  A61K47/16 ,  A61K47/18 ,  A61K47/22 ,  C07C211/21 ,  C07C211/63 ,  C07C211/64 ,  C07C215/18 ,  C07C217/08 ,  C07C229/26 ,  C07C237/10 ,  C07C279/08 ,  C07D211/26 ,  C07D213/38 ,  C07D241/12 ,  C07D273/08 ,  C07D291/02 ,  C12N5/10 ,  C12N15/88 ,  C07D43/02

    CPC分类号： A61K47/48046 ,  A61K9/16 ,  A61K31/14 ,  A61K38/28 ,  A61K38/40 ,  A61K47/543 ,  C07C211/21 ,  C07C211/63 ,  C07C211/64 ,  C07C229/26 ,  C07D209/48 ,  C07D241/12 ,  C12N15/88 ,  Y10S435/81

    摘要： Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i—Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L′-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wherein at least one of R1, R3, R4 and R6 is a straight chain or branched, cyclic, alkyl, alkenyl, alkynyl or aryl group; and anyone of R1, R3, R4 and/or R6 may optionally be covalently linked with each other, with Y or with L when L is C or CH to form a cyclic moiety; Z is selected from the group consisting of amine, spermiyl, carboxyspermiyl, guanidyl, spermidinyl, putricinyl, diaminoalkyl, pyridyl, piperidinyl, pyrrolidinyl, polyamine, amino acid, peptide, and protein; X1 and X2, independently of one another, are selected from the group consisting of NH, O, S, alkylene, and arylene; L′ is selected from the group consisting of alkylene, alkenylene, alkynylene, arylene, alkylene ether, and polyether; D is Q or a bond; A1 and A2, independently of one another, are selected from the group consisting of CH2O, CH2S, CH2NH, C(O), C{NH), C(S) and (CH2)t; X is a physiologically acceptable anion; m, n, r, s, u, v, w and y are 0 or 1, with the proviso that when both m and n are 0 at least one of r, s, u and y is other than 0; i, j, k, l, p and are integers from 0 to about 100; q is an integer from 1 to about 1000; and a is the number of positive charge divided by the valence of the anion.

    Amino thiol compounds and compositions for use in conjunction with cancer therapy
    10.
    发明申请
    Amino thiol compounds and compositions for use in conjunction with cancer therapy 有权
    氨基硫醇化合物和与癌症治疗结合使用的组合物

    公开(公告)号：US20050101676A1

    公开(公告)日：2005-05-12

    申请号：US10915089

    申请日：2004-08-09

    申请人： William Fahl ,  Daniel Peebles ,  Richard Copp

    发明人： William Fahl ,  Daniel Peebles ,  Richard Copp

    IPC分类号： C07C211/14 ,  C07C211/22 ,  C07C215/18 ,  C07C215/24 ,  C07C323/25 ,  C07C323/27 ,  A61K31/14 ,  A61K31/13

    CPC分类号： C07C323/25 ,  C07C211/14 ,  C07C211/22 ,  C07C215/18 ,  C07C215/24 ,  C07C323/27

    摘要： The invention provides novel polyamine and amino thiol compounds and pharmaceutical compositions for administration in conjunction with cancer chemotherapy or radiation therapy. The compounds are administered locally to provide protection against the adverse side-effects of chemotherapy or radiation therapy, such as alopecia, mucositis and dermatitis. Pharmaceutical preparations comprising one or more chemoprotective polyamines or amino thiols formulated for topical or local delivery to epithelial or mucosal cells are disclosed. Methods of administering the pharmaceutical preparations are also disclosed.

    摘要翻译： 本发明提供新的多胺和氨基硫醇化合物和用于与癌症化学疗法或放射治疗相结合的药物组合物。 化合物在局部施用以提供防止化学疗法或放射治疗（例如秃发，粘膜炎和皮炎）的不良副作用的保护。 公开了包含一种或多种配制用于局部或局部递送至上皮或粘膜细胞的化学保护性多胺或氨基硫醇的药物制剂。 还公开了施用药物制剂的方法。