公开(公告)号：US12103881B2

公开(公告)日：2024-10-01

申请号：US17648442

申请日：2022-01-20

申请人： ECOLAB USA INC.

发明人： Ashish Dhawan ,  Carter M. Silvernail

IPC分类号： C02F5/12 ,  C07C231/12 ,  C07C237/06 ,  C07F9/54 ,  C11D1/62 ,  C11D3/386 ,  C11D7/32 ,  C23F11/10 ,  C23F11/14 ,  C02F1/68

CPC分类号： C02F5/12 ,  C07C231/12 ,  C07C237/06 ,  C07F9/5407 ,  C11D1/62 ,  C11D3/386 ,  C11D7/3254 ,  C11D7/3263 ,  C23F11/10 ,  C23F11/141 ,  C23F11/149 ,  C02F1/683 ,  C02F2303/08 ,  C02F2305/04 ,  C07C231/12 ,  C07C237/10

摘要： A novel class of compounds is described here. The disclosed novel compounds have one hydrophilic group and two identical hydrophilic ionic groups. The two hydrophilic groups of the disclosed compounds contain or end with a cationic or anionic charged group. The disclosed novel compounds herein can be used as surfactants in an article, product, or composition, or for some other purposes. A method to synthesize the disclosed novel compounds is also described.

公开(公告)号：US20240246900A1

公开(公告)日：2024-07-25

申请号：US18625045

申请日：2024-04-02

申请人： Io Therapeutics, Inc.

发明人： Vidyasagar Vuligonda

IPC分类号： C07C233/66 ,  A61K31/196 ,  C07C231/02 ,  C07C231/12 ,  C07C231/24 ,  C07C235/66

CPC分类号： C07C233/66 ,  A61K31/196 ,  C07C231/02 ,  C07C231/12 ,  C07C231/24 ,  C07C235/66

摘要： Provided herein are compounds and synthetic methods useful for preparing tetrahydronaphthalenol derivatives, and uses of the compounds prepared.

公开(公告)号：US11981688B2

公开(公告)日：2024-05-14

申请号：US17841046

申请日：2022-06-15

申请人： IMMUNOGEN, INC.

发明人： Michael Reardon ,  Richard A. Silva

IPC分类号： C07D487/04 ,  C07C231/12 ,  C07C233/07 ,  C07C319/20 ,  C07C321/20 ,  C07D519/00

CPC分类号： C07D519/00 ,  C07C231/12 ,  C07C233/07 ,  C07C319/20 ,  C07C321/20 ,  C07D487/04

摘要： The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.

公开(公告)号：US11938101B2

公开(公告)日：2024-03-26

申请号：US17692133

申请日：2022-03-10

申请人： PTC Therapeutics, Inc.

发明人： Paul Mollard ,  Peter Giannousis ,  Shazad Suchit ,  Mahmoud Mirmehrabi ,  Christopher R. Cornell ,  Kieron E. Wesson

IPC分类号： C07C235/78 ,  A61K31/122 ,  A61K31/164 ,  C07B57/00 ,  C07C215/08 ,  C07C215/28 ,  C07C215/30 ,  C07C231/12 ,  C07D215/28

CPC分类号： A61K31/122 ,  A61K31/164 ,  C07B57/00 ,  C07C215/08 ,  C07C215/28 ,  C07C215/30 ,  C07C231/12 ,  C07C235/78 ,  C07B2200/13 ,  C07C2601/16 ,  C07C231/12 ,  C07C235/78

摘要： Disclosed herein are polymorphic and amorphous forms of anhydrate, hydrate, and solvates of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide and methods of using such compositions for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging. Further disclosed are methods of making such polymorphic and amorphous forms.

公开(公告)号：US20240082418A1

公开(公告)日：2024-03-14

申请号：US18381450

申请日：2023-10-18

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Yoshio NISHI ,  Kohei SAKANISHI ,  Shigeru NOGUCHI ,  Tadahiro TAKEDA

IPC分类号： A61K47/68 ,  C07C231/12 ,  C07C233/15 ,  C07C233/33 ,  C07C233/54 ,  C07D491/22 ,  C07K5/103 ,  C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  C07K16/32

CPC分类号： A61K47/6889 ,  A61K47/6803 ,  C07C231/12 ,  C07C233/15 ,  C07C233/33 ,  C07C233/54 ,  C07D491/22 ,  C07K5/1008 ,  C07K16/00 ,  C07K16/28 ,  C07K16/2827 ,  C07K16/30 ,  C07K16/32

摘要： A method for producing a compound represented by formula (C) wherein R1 represents an amino group protected with a protecting group, the method comprising a step of subjecting a compound represented by formula (B) wherein R1 represents the same meaning as above, to intramolecular cyclization to convert the compound into the compound represented by formula (C).

公开(公告)号：US20230373900A1

公开(公告)日：2023-11-23

申请号：US18198423

申请日：2023-05-17

申请人： FUNDACIÓ INSTITUT CATALÀ D'INVESTIGACIÓ QUÍMICA

发明人： Marcos GARCÍA SUERO ,  Hangfei TU ,  Aliénor JEANDIN

IPC分类号： C07C69/743 ,  C07D209/08 ,  C07D209/38 ,  C07D333/24 ,  C07D307/80 ,  C07D213/69 ,  C07D223/24 ,  C07D495/04 ,  C07D295/088 ,  C07J51/00 ,  C07D405/12 ,  C07D239/04 ,  C07F5/02 ,  C07D213/64 ,  C07C67/00 ,  C07D207/22 ,  C07D209/26 ,  C07C233/15 ,  C07C231/12

CPC分类号： C07C69/743 ,  C07D209/08 ,  C07D209/38 ,  C07D333/24 ,  C07D307/80 ,  C07D213/69 ,  C07D223/24 ,  C07D495/04 ,  C07D295/088 ,  C07J51/00 ,  C07D405/12 ,  C07D239/04 ,  C07F5/022 ,  C07D213/64 ,  C07C67/00 ,  C07D207/22 ,  C07D209/26 ,  C07C233/15 ,  C07C231/12 ,  C07C2601/02

摘要： The present invention relates to a cyclopropenium salt bearing an electron withdrawing group suitable for use as a reagent in cyclopropenylation reactions of formula (I). The invention also relates to a process for their preparation, the use thereof as cyclopropenylation reagent, to an electrophilic aromatic substitution process of cyclopropenylation, and to a process for cyclopropenylation of organometallic substrates using said reagents.

公开(公告)号：US20230339840A1

公开(公告)日：2023-10-26

申请号：US18025397

申请日：2021-08-04

申请人： BEIJING HONGHUI MEDITECH CO., LTD

发明人： Pingping ZHANG ,  Ye LIU ,  Guokun YU ,  Qiangfeng ZHAO

IPC分类号： C07C205/22 ,  C07C213/02 ,  C07C231/12 ,  C07C303/30

CPC分类号： C07C205/22 ,  C07C213/02 ,  C07C231/12 ,  C07C303/30

摘要： The present disclosure provides preparation method for water-soluble magnolol derivatives and honokiol derivatives and intermediates thereof, and related monohydroxy protection intermediates. The nitrification intermediate has a structure shown in Formula I. Formula I is




R2 is a hydroxyl, and R3 is H; or, R2 is H, and R3 is a hydroxyl; and R1 and R4 are independently selected from C1˜C12 electron donor groups. The preparation method includes the following steps: performing monohydroxy protection on a compound A




with a hydroxy protection reagent in the presence of an acid binding agent to form a monohydroxy protection compound, herein R1, R2, R3 and R4 in the compound A have the same definition as above, and the hydroxy protection reagent is p-toluenesulfonyl chloride and 1-hydroxybenzotriazole; and performing a nitrification reaction and a deprotection reaction on the monohydroxy protection compound successively to obtain the nitrification intermediate.

公开(公告)号：US11667600B2

公开(公告)日：2023-06-06

申请号：US17042377

申请日：2019-03-29

申请人： DAIKIN INDUSTRIES, LTD. ,  SAGA UNIVERSITY

发明人： Masahiro Higashi ,  Yosuke Kishikawa ,  Tsugio Kitamura

IPC分类号： C07C67/307 ,  C07C231/12 ,  C07C51/363 ,  C07C45/63 ,  C07C51/62 ,  C07C17/02

CPC分类号： C07C67/307 ,  C07C17/02 ,  C07C45/63 ,  C07C51/363 ,  C07C51/62 ,  C07C231/12 ,  C07C67/307 ,  C07C69/62 ,  C07C67/307 ,  C07C69/738

摘要： An object of the present invention is to provide a method for producing a fluorinated organic compound, whereby an iodosylbenzene derivative can be easily separated and recovered. The above object can be achieved by a method for producing a fluorinated organic compound, comprising step A of fluorinating an organic compound (1) by reaction with a fluorine source (3) in the presence of a hypervalent iodine aromatic ring compound (2a), or in the presence of an iodine aromatic ring compound (2b) and an oxidant (2bo); wherein the fluorine source (3) is a fluorine source (3a) represented by formula: MFn, wherein M is H, a metal of Group 1 of the periodic table, or a metal of Group 2 of the periodic table; and n is 1 or 2; and step B of separating the iodine aromatic ring compound from a reaction liquid after step A is started.

公开(公告)号：US20230113948A1

公开(公告)日：2023-04-13

申请号：US17787089

申请日：2020-12-17

申请人： ARBUTUS BIOPHARMA CORPORATION

发明人： Mahesh PALLERLA ,  Ganapati Reddy PAMULAPATI ,  Jan SPINK

IPC分类号： A61K47/54 ,  C07D491/048 ,  C07D207/08 ,  C07C213/08 ,  C07H1/00 ,  C07H15/08 ,  C07C231/12 ,  C07C231/02 ,  C07D207/46 ,  C07C201/12 ,  C07C227/04 ,  C07C231/10 ,  C07C237/06 ,  C07C237/16 ,  C12N15/113 ,  A61K45/06

摘要： The invention provides synthetic processes and synthetic intermediate compounds that can be used to prepare therapeutic conjugates. The invention also provides methods for treating HBV and/or HDV infection in a human by administering a therapeutic conjugate prepared by the synthetic methods of the invention.

公开(公告)号：US20230098716A1

公开(公告)日：2023-03-30

申请号：US17800989

申请日：2021-02-24

申请人： Osaka Gas Chemicals Co., Ltd.

发明人： Yuki OUCHI

IPC分类号： C07C233/11 ,  C07C231/12 ,  C08K5/20

摘要： The fluorene derivative of the present disclosure is represented by the following formula (1): Wherein R1 represents a substituent, k denotes an integer of 0 to 8, R2a, R2b, R2c, and R2d each represent a hydrogen atom or a substituent, R3a and R3b each represent a hydrogen atom or a substituent, and X1a and X1b each represent a group defined in the following formula (X1): wherein R4 and R5 each represent a hydrogen atom or an aliphatic hydrocarbon group, provided that the case where both R4 and R5 are a hydrogen atom is excluded; or R4 and R5 bond together to form a heterocyclic ring containing the nitrogen atom adjacent to R4 and R5. The present disclosure provides a novel fluorene derivative useful as an additive for improving the properties of a resin, a method for producing the same and a use thereof.