公开(公告)号：US20240241195A1

公开(公告)日：2024-07-18

申请号：US18582293

申请日：2024-02-20

申请人： NVISION IMAGING TECHNOLOGIES GMBH ,  UNIVERSITÄT ULM

发明人： Ilai SCHWARTZ ,  Michael KEIM ,  Martin PLENIO ,  Benedikt TRATZMILLER

IPC分类号： G01R33/28 ,  A61K49/10 ,  C07C67/14 ,  C07C67/293 ,  C07C69/716 ,  C07F7/08 ,  G01R33/46 ,  G01R33/44

CPC分类号： G01R33/282 ,  A61K49/10 ,  C07C67/14 ,  C07C67/293 ,  C07C69/716 ,  C07F7/081 ,  C07F7/083 ,  G01R33/4608 ,  C07B2200/05 ,  G01R33/445

摘要： A method for preparing an NMR material, comprising generating parahydrogen in gas or liquid form at a first location; transporting the parahydrogen away from the first location; mixing a precursor compound including a metabolite component with a catalyst for hydrogenation; hydrogenating the precursor compound using the parahydrogen; transferring polarization in the precursor compound to a nuclear spin of the metabolite component; cleaving a side arm of the precursor compound in a chemical reaction, with the metabolite molecule being one of the products of the reaction; separating the metabolite molecule from the catalyst for hydrogenation and other products of the reaction; and generating metabolite molecules for use in an MRI scanner by extracting a sample of the metabolite molecule having at least 5% polarization.

公开(公告)号：US20240228451A1

公开(公告)日：2024-07-11

申请号：US18556727

申请日：2022-04-21

申请人： Panafina, Inc.

发明人： Zeeshan Kamal ,  Apparao Bokka ,  Gopalakrishna Akurathi ,  Gary Richard Lee

IPC分类号： C07D305/12 ,  C07C51/347 ,  C07C51/487 ,  C07C67/14 ,  C07C67/31 ,  C07C67/313 ,  C07D309/30 ,  C07D309/32

CPC分类号： C07D305/12 ,  C07C51/347 ,  C07C51/487 ,  C07C67/14 ,  C07C67/31 ,  C07C67/313 ,  C07D309/30 ,  C07D309/32

摘要： Provided according to embodiments of the invention are methods of forming a lipstatin derivative, (S)-1-((2S,3S)-3-ethyl-4-oxooxetan-2-yl) tridecan-2-yl formyl-L-alaninate. Such methods include one or more reaction steps that include the Mitsunobu coupling of N-formyl L-alanine in the presence of di-t-butyl azodicarboxylate (DBAD) and triphenylphosphine. Compounds formed by a method of the invention, compositions that include a compound formed by a method of the invention, and methods of inhibiting lipase activity and/or treating pancreatitis using a compound formed by a method of the invention are also provided.

公开(公告)号：US11940510B2

公开(公告)日：2024-03-26

申请号：US17995232

申请日：2021-03-31

申请人： NVISION IMAGING TECHNOLOGIES GMBH ,  UNIVERSITÄT ULM

发明人： Ilai Schwartz ,  Michael Keim ,  Martin Plenio ,  Benedikt Tratzmiller

IPC分类号： G01R33/28 ,  A61K49/10 ,  C07C67/14 ,  C07C67/293 ,  C07C69/716 ,  C07F7/08 ,  G01R33/46 ,  G01R33/44

CPC分类号： G01R33/282 ,  A61K49/10 ,  C07C67/14 ,  C07C67/293 ,  C07C69/716 ,  C07F7/081 ,  C07F7/083 ,  G01R33/4608 ,  C07B2200/05 ,  G01R33/445

摘要： A method for preparing an NMR material, comprising generating parahydrogen in gas or liquid form at a first location; transporting the parahydrogen away from the first location; mixing a precursor compound including a metabolite component with a catalyst for hydrogenation; hydrogenating the precursor compound using the parahydrogen; transferring polarization in the precursor compound to a nuclear spin of the metabolite component; cleaving a side arm of the precursor compound in a chemical reaction, with the metabolite molecule being one of the products of the reaction; separating the metabolite molecule from the catalyst for hydrogenation and other products of the reaction; and generating metabolite molecules for use in an MRI scanner by extracting a sample of the metabolite molecule having at least 5% polarization.

公开(公告)号：US20240074958A1

公开(公告)日：2024-03-07

申请号：US18112411

申请日：2023-02-21

申请人： Board of Trustees of Northern Illinois University ,  Fona Technologies, Inc.

发明人： Douglas A. Klumpp ,  Rachel A. Klumpp ,  Zachary Liveris ,  Michael Stentzel ,  Robert M. Sobel ,  Smaro G. Kokkinidou

IPC分类号： A61K8/37 ,  A01N37/44 ,  A23L2/56 ,  A23L27/20 ,  A61Q9/02 ,  A61Q11/00 ,  A61Q19/00 ,  C07C67/14 ,  C07C227/08 ,  C07C229/28

CPC分类号： A61K8/37 ,  A01N37/44 ,  A23L2/56 ,  A23L27/203 ,  A61Q9/02 ,  A61Q11/00 ,  A61Q19/00 ,  C07C67/14 ,  C07C227/08 ,  C07C229/28 ,  A23V2002/00

摘要： A compound that includes a menthol glycinate. The menthol glycinate includes a menthol connected to a glycine or glycine derivative, via an ester linkage. The groups on the N atom are referred to as R1 and R2, and R1 and R2 are independently selected from the group consisting of: alkyl and R1 and R2 together with the N atom to which they are attached form a 4-8-member ring. R1 and R2 each contain at most 20 carbon atoms.

公开(公告)号：US20220259137A1

公开(公告)日：2022-08-18

申请号：US17736541

申请日：2022-05-04

申请人： MEXICHEM FLUOR S.A. DE C.V.

发明人： Andrew Paul SHARRATT ,  Robert Elliott LOW ,  Emma Jane HODGSON

IPC分类号： C07C69/63 ,  C09K5/04 ,  C10M171/00 ,  C10M105/54 ,  C07C67/14 ,  C10M105/18 ,  C10M105/38

摘要： A compound of formula (I): wherein W is independently selected from the group consisting of H, F, Cl, Br, and I; X is independently selected from the group consisting of H, F, Cl, Br, and I; Y is independently selected from the group consisting of F, Cl, Br, and I; Z is independently selected from the group consisting of H, F, Cl, Br, and I; n is an integer from 1 to 8; and n′ is an integer from 1 to 12.

公开(公告)号：US20210403410A1

公开(公告)日：2021-12-30

申请号：US17318581

申请日：2021-05-12

申请人： WESTERN SYDNEY UNIVERSITY

发明人： Thomas Millar ,  Burkhardt Schuett

IPC分类号： C07C69/533 ,  A61K31/23 ,  A61K31/231 ,  C07C69/587 ,  A61K9/00 ,  A61K9/06 ,  A61K9/08 ,  A61K9/107 ,  A61K31/232 ,  A61K47/14 ,  A61K47/38 ,  C07C67/14 ,  C07C69/26 ,  C07C69/58 ,  C07C69/22

摘要： Disclosed herein is an ophthalmic formulation comprising a compound of formula (I) wherein le is a linear or branched C9-C33 alkyl or a linear or branched C9-C33 alkenyl with 1 to 4 double bonds; R2 is a linear or branched C9-C19 alkyl or a linear or branched C9-C19 alkenyl with 1 to 4 double bonds; and an ophthalmologically acceptable carrier.

公开(公告)号：US20210130722A1

公开(公告)日：2021-05-06

申请号：US17094457

申请日：2020-11-10

申请人： Polnox Corporation

发明人： Ashok L. Cholli ,  Murat Tonga

IPC分类号： C10L10/04 ,  C10M129/72 ,  C07C69/604 ,  C23F11/12 ,  C07C67/08 ,  C07C67/14 ,  C10M169/04 ,  C10L1/198 ,  C10L1/19 ,  C11D3/00 ,  A23D7/00 ,  A23D9/00 ,  C11C3/00

摘要： Disclosed are multifunctional compounds represented by structural formula (I): methods of producing compounds represented by structural formula (I) and their use in inhibiting corrosion in corrodible material.

公开(公告)号：US20210130271A1

公开(公告)日：2021-05-06

申请号：US17123365

申请日：2020-12-16

申请人： NEONC Technologies, Inc.

发明人： Thomas CHEN ,  Daniel LEVIN ,  Satish PUPPALI

IPC分类号： C07C29/92 ,  A61K31/045 ,  C07C201/16 ,  C07C201/12 ,  C07C67/14 ,  C07C29/88 ,  C07C29/86 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/78

摘要： The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

公开(公告)号：US20210093531A1

公开(公告)日：2021-04-01

申请号：US17037180

申请日：2020-09-29

申请人： Board of Trustees of Northern Illinois University ,  Fona Technologies, Inc.

发明人： Douglas A. Klumpp ,  Rachel A. Klumpp ,  Zachary Liveris ,  Michael Stentzel ,  Robert M. Sobel ,  Smaro G. Kokkinidou

IPC分类号： A61K8/37 ,  A01N37/44 ,  A61Q9/02 ,  A61Q19/00 ,  C07C67/14 ,  C07C227/08 ,  A61Q11/00 ,  C07C229/28 ,  A23L27/20 ,  A23L2/56

摘要： A compound that includes a menthol glycinate. The menthol glycinate includes a menthol connected to a glycine or glycine derivative, via an ester linkage. The groups on the N atom are referred to as R1 and R2, and R1 and R2 are independently selected from the group consisting of: H, alkyl and R1 and R2 together with the N atom to which they are attached form a 4-8-member ring. R1 and R2 each contain at most 20 carbon atoms.

公开(公告)号：US10899691B2

公开(公告)日：2021-01-26

申请号：US16575587

申请日：2019-09-19

申请人： NEONC Technologies, Inc.

发明人： Thomas Chen ,  Daniel Levin ,  Satish Puppalli

IPC分类号： C07C29/92 ,  C07C67/14 ,  C07C201/12 ,  A61K31/045 ,  C07C29/78 ,  C07C29/88 ,  C07C201/16 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/86

摘要： The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.