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    Process for the preparation of $g(e)-caprolactam
    4.
    发明申请
    Process for the preparation of $g(e)-caprolactam 失效
    制备$ g（e） - 己内酰胺的方法

    公开(公告)号：US20040132999A1

    公开(公告)日：2004-07-08

    申请号：US10473077

    申请日：2004-02-27

    发明人： Wim Buijs ,  Henricus Franciscus Wilhelmus

    IPC分类号： C07D201/02

    CPC分类号： C08G69/16 ,  C07D201/08

    摘要： The invention relates to a process for the preparation of null-caprolactam starting from 6-aminocapronitrile by hydrolysis/oligomerisation followed by de-oligomerisation/cyclisation using superheated steam characterized in that the hydrolysis/oligomerisation is performed with superheated steam converting 6-aminocapronitrile into a molten phase and a gas phase comprising ammonia, ammonia is continuously separated off and the de-oligomerisation/cyclisation is performed by treating the molten phase further with superheated steam. The invention also relates to a process for the preparation of null-caprolactam starting from 6-aminocapronitrile by hydrolysis/oligomerisation followed by de-oligomerisation/cyclisation characterized in that the preparation is performed in a horizontal scraped-surface reactor, the hydrolysis/oligomerisation is performed with superheated steam converting 6-aminocapronitrile into a molten phase and a gas phase comprising ammonia, ammonia is continuously separated off and the de-oligomerisation/cyclisation is performed by treating the molten phase further with superheated steam.

    摘要翻译： 本发明涉及一种从6-氨基己腈开始通过水解/低聚制备ε-己内酰胺的方法，然后使用过热蒸汽进行脱低聚/环化，其特征在于水解/低聚反应用过热蒸汽将6-氨基己腈转化成 熔融相和包含氨的气相，氨被连续分离，并且通过用过热蒸汽进一步处理熔融相进行脱低聚/环化。 本发明还涉及从6-氨基己腈开始制备ε-己内酰胺的方法，其通过水解/低聚，接着进行脱低聚/环化，其特征在于制备在水平刮面反应器中进行，水解/低聚是 使用过热蒸汽将6-氨基己腈转化成熔融相和包含氨的气相，连续分离氨，通过用过热蒸汽进一步处理熔融相进行脱低聚/环化。

    Method for the production of caprolactam
    5.
    发明申请
    Method for the production of caprolactam 有权
    生产己内酰胺的方法

    公开(公告)号：US20030153749A1

    公开(公告)日：2003-08-14

    申请号：US10297209

    申请日：2002-12-04

    发明人： Frank Ohlbach ,  Andreas Ansmann ,  Rolf-Hartmuth Fischer ,  Johann-Peter Melder

    IPC分类号： C07D201/02

    CPC分类号： C07D201/08 ,  Y02P20/52

    摘要： A process is provided for the preparation of caprolactam from a compound of formula (I): NCnull(CH2)5nullCOnullRnullnull(I)in which R is a carboxamide, carboxylic acid or carboxylic acid ester group, wherein a) a compound (I) or a mixture of such compounds, in the presence of ammonia and optionally a liquid diluent (VI), is hydrogenated with hydrogen in the presence of a catalyst (II) to give a mixture (III), b) the hydrogen and the catalyst (II) are separated from the mixture (III) to give a mixture (IV), and c) the mixture (IV), optionally in the presence of a liquid diluent (VII), is converted to caprolactam in the presence of a catalyst (V).

    摘要翻译： 提供了从式（I）化合物制备己内酰胺的方法：NC-（CH 2）5 -CO-R（I），其中R是羧酰胺，羧酸或羧酸酯基，其中a） 在氨和任选的液体稀释剂（VI）存在下，化合物（I）或这些化合物的混合物在氢气存在下在催化剂（II）的存在下氢化，得到混合物（III），b）氢 并将催化剂（II）与混合物（III）分离，得到混合物（Ⅳ），和c）任选在液体稀释剂（Ⅶ）存在下，混合物（Ⅳ）在存在下转化为己内酰胺 的催化剂（V）。

    Method for producing caprolactam on the basis of 6-aminocapronitrile and subsequent purification by crystallization
    6.
    发明申请
    Method for producing caprolactam on the basis of 6-aminocapronitrile and subsequent purification by crystallization 有权
    基于6-氨基己腈生产己内酰胺的方法，随后通过结晶进行纯化

    公开(公告)号：US20030105322A1

    公开(公告)日：2003-06-05

    申请号：US10258941

    申请日：2002-10-29

    发明人： Peter Bassler ,  Dieter Baumann ,  Rolf-Hartmuth Fischer ,  Eberhard Fuchs ,  Johann-Peter Melder ,  Frank Ohlbach

    IPC分类号： C07D201/02

    CPC分类号： C07D201/08

    摘要： A process for the preparation of caprolactam is provided, wherein a) a mixture (I) containing 6-aminocapronitrile and water is reacted in the gas phase, in the presence of a catalyst, to give a mixture (II) containing caprolactam, ammonia, water, high-boiling components and low-boiling components, b) ammonia is then removed from the mixture (II) to give a mixture (III) containing caprolactam, water, high-boiling components and low-boiling components, c) water is then removed from the mixture (III) to give a mixture (IV) containing caprolactam, high-boiling components and low-boiling components, and d) a solid (V) containing caprolactam is then obtained from the mixture (IV) by crystallization, the proportion by weight of caprolactam in the solid (V) being greater than in the mixture (IV).

    摘要翻译： 提供了制备己内酰胺的方法，其中a）含有6-氨基己腈和水的混合物（I）在气相中在催化剂存在下反应，得到含有己内酰胺，氨， 水，高沸点组分和低沸点组分，b）然后从混合物（II）中除去氨，得到含有己内酰胺，水，高沸点组分和低沸点组分的混合物（III），c）水是 然后从混合物（III）中取出，得到含己内酰胺，高沸点成分和低沸点组分的混合物（Ⅳ），然后通过结晶从混合物（Ⅳ）中获得含有己内酰胺的固体（Ⅴ） 固体（V）中己内酰胺的重量比例大于混合物（IV）中的比例。

    Copper catalyzed process for producing 4-substituted azetidinone derivatives
    7.
    发明授权
    Copper catalyzed process for producing 4-substituted azetidinone derivatives 失效
    用于生产4-取代的氮杂环丁酮衍生物的铜催化方法

    公开(公告)号：US5808055A

    公开(公告)日：1998-09-15

    申请号：US498499

    申请日：1995-07-05

    申请人： Masashi Nakajima, deceased ,  Yasuharu Kimura ,  Kiyohito Imai

    发明人： Masashi Nakajima, deceased ,  Yasuharu Kimura ,  Kiyohito Imai

    IPC分类号： C07D201/02 ,  C07D205/09 ,  C07D403/12 ,  C07D405/12 ,  C07F7/18

    CPC分类号： C07D403/12 ,  C07D201/02 ,  C07D205/09 ,  C07D405/12

    摘要： A process for producing a 4-substituted azetidinone derivative represented by the following general formula �III!: ##STR1## (wherein OR is a protected hydroxy group, Y is an alkyl group, an alkoxy group, a silyloxy group, a carbamoyloxy group, an amino group, a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group, and n is an integer of 0 or 1, provided that n does not represent 0 when Y is an alkoxy group, silyloxy group, carbamoyloxy group or amino group), characterized in that a 2-azetidinone derivative represented by the following general formula �I!: ##STR2## (wherein OR is as defined above, and X is an alkyl group or a substituted or unsubstituted aromatic group) is reacted with thiocarboxylic acid represented by the following general formula �II!: HSCO--(CH.sub.2).sub.n --Y �II! (wherein Y and n are respectively as defined above) in an organic solvent in the presence of copper compounds.

    摘要翻译： 用于制备由以下通式[III]表示的4-取代的氮杂环丁酮衍生物的方法：其中OR为被保护的羟基，Y为烷基，烷氧基，甲硅烷氧基， 氨基甲酰氧基，氨基，取代或未取代的芳基或取代或未取代的杂环基，并且n为0或1的整数，条件是当Y为烷氧基时，n不为0，甲硅烷氧基，氨基甲酰氧基 或氨基），其特征在于由以下通式[I]表示的2-氮杂环丁酮衍生物：其中OR如上所定义，X为烷基或取代或未取代的芳族基团 ）与铜化合物存在下的有机溶剂中由以下通式[II]表示的硫代羧酸反应：HSCO-（CH 2）n Y [II]（其中Y和n分别如上定义）。

    Process of synthesizing N-acyl auxiliaries
    8.
    发明授权
    Process of synthesizing N-acyl auxiliaries 失效
    合成N-酰基助剂的方法

    公开(公告)号：US5594134A

    公开(公告)日：1997-01-14

    申请号：US414541

    申请日：1995-03-31

    申请人： Guo-Jie Ho ,  David J. Mathre

    发明人： Guo-Jie Ho ,  David J. Mathre

    IPC分类号： C07D201/02 ,  C07D205/04 ,  C07D207/12

    CPC分类号： C07D201/02

    摘要： A process of synthesizing N-acyl auxiliary compounds is disclosed. A compound of the formula: ##STR1## is reacted with an anhydride in the presence of a lithium salt and an amine base to produce the N-acylated auxiliary.

    摘要翻译： 公开了合成N-酰基辅助化合物的方法。 在锂盐和胺碱的存在下，使下式的化合物与一种酸酐反应得到N-酰化的辅助物。

    Preparation of 5-membered ring heterocycles
    9.
    发明授权
    Preparation of 5-membered ring heterocycles 失效
    五元环杂环的制备

    公开(公告)号：US5453516A

    公开(公告)日：1995-09-26

    申请号：US165463

    申请日：1993-12-13

    申请人： Rolf Fischer ,  Rolf Pinkos

    发明人： Rolf Fischer ,  Rolf Pinkos

    IPC分类号： C07D201/02 ,  C07D207/26 ,  C07D207/267 ,  C07D307/33 ,  C07D315/00 ,  C07D207/27 ,  C07D307/28

    CPC分类号： C07D201/02 ,  C07D207/267 ,  C07D307/33 ,  C07D315/00

    摘要： A process for preparing 5-membered ring heterocycles of the general formula I ##STR1## where R.sup.1 is methyl or hydroxyethyl,R.sup.2,R.sup.3,R.sup.4,R.sup.5 and R.sup.6 are hydrogen, C.sub.1 - to C.sub.12 -alkyl, C.sub.2 - to C.sub.12 -alkenyl, aryl, C.sub.3 - to C.sub.8 -cycloalkyl, C.sub.1 - to C.sub.12 -alkoxy, halogen, C.sub.2 - to C.sub.20 -alkoxycarbonylalkyl, C.sub.2 - to C.sub.20 -alkylcarbonyloxy, formyl, C.sub.2 - to C.sub.20 -formylalkyl, benzoyl or --CH(OR.sup.3)(OR.sup.5), or R.sup.3 and R.sup.5 together are a C.sub.2 - to C.sub.7 -alkylene chain which is unsubstituted or monosubstituted to pentasubstituted by R.sup.4 or a .dbd.CH--CH.dbd.CH--CH.dbd. unit which is unsubstituted or monosubstituted to tetrasubstituted by R.sup.4,X is oxygen or N--R.sup.4by reacting 5-membered ring heterocycles of the general formula II ##STR2## where R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and X have the abovementioned meanings and Y is hydrogen, acetyl or C.sub.2 - to C.sub.20 -alkoxycarbonyl, with dimethyl or ethylene carbonate in the presence of a nitrogen-containing base at from 50.degree. to 300.degree. C. and from 0.01 to 50 bar is described.

    摘要翻译： 其中R 1是甲基或羟乙基，R 2，R 3，R 4，R 5和R 6是氢，C 1 -C 12 - 烷基，C 2 -C 12的通式I（I）的五元环杂环的制备方法 - 烯基，芳基，C 3 -C 8 - 环烷基，C 1 -C 12 - 烷氧基，卤素，C 2 -C 20 - 烷氧基羰基烷基，C 2 -C 20 - 烷基羰氧基，甲酰基，C 2 -C 20甲酰烷基，苯甲酰基或-CH ）（OR 5）或R 3和R 5一起是未被取代或单取代以被R4或a = CH-CH = CH-CH =未被R4单取代或单取代的单元的C2至C7-亚烷基链， X是通过使通式II的5-元环杂环（II）其中R 2，R 3，R 4，R 5，R 6和X具有上述含义并且Y是氢，乙酰基或C 2 - 在含有50〜300℃的含氮碱和0.01〜50巴的存在下，与二甲基或碳酸亚乙酯进行反应。