公开(公告)号：US20220132844A1

公开(公告)日：2022-05-05

申请号：US17577564

申请日：2022-01-18

申请人： FMC Corporation

发明人： Andrew Duncan Satterfield ,  Thomas Paul Selby

IPC分类号： A01N43/36 ,  C07D207/22 ,  C07D207/277

摘要： Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof: wherein R1, R2, R3, R4, R5, R6, Q1, Q2, Y1, and Y2 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.

公开(公告)号：US20210107869A1

公开(公告)日：2021-04-15

申请号：US16880443

申请日：2020-05-21

申请人： Kyorin Pharmaceutical Co. Ltd.

发明人： Hiroyasu Takahashi ,  Yoshifumi Saito ,  Kosuke Tsuda ,  Mitsuhito Shibasaki ,  Kohei Ohata

IPC分类号： C07D207/273 ,  C07D403/12 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D209/54 ,  C07D405/14 ,  C07D413/14 ,  C07D401/06 ,  C07D403/04 ,  C07D409/14 ,  C07D413/06 ,  C07D207/22

摘要： Provided is a compound having a formyl peptide receptor like 1 (FPRL1) agonist effect.
The present invention relates to a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing the compound represented by the general formula (I) or a pharmacologically acceptable salt thereof.

公开(公告)号：US10370388B2

公开(公告)日：2019-08-06

申请号：US15425375

申请日：2017-02-06

申请人： NOVARTIS AG

发明人： Thomas David McCarthy ,  Alan Naylor

IPC分类号： A61K31/4439 ,  A61K31/40 ,  C07D498/10 ,  C07D403/04 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D205/04 ,  C07D207/16 ,  C07D207/22 ,  C07D209/18 ,  C07D209/42 ,  C07D209/94 ,  C07D401/04 ,  C07D401/12 ,  C07D409/04 ,  C07D498/04 ,  C07D207/14 ,  C07D413/04

摘要： The present invention relates to heterocyclic compounds useful for antagonizing angiotensin II Type 2 (AT2) receptor. More particularly the invention relates to pyrrolidine and azetidine compounds, compositions containing them and their use in methods of treating or preventing disorders or diseases associated with AT2 receptor function including neuropathic pain, inflammatory pain, conditions associated with neuronal hypersensitivity, impaired nerve conduction velocity, cell proliferation disorders, disorders associated with an imbalance between bone resorption and bone formation and disorders associated with aberrant nerve regeneration.

公开(公告)号：US10226045B2

公开(公告)日：2019-03-12

申请号：US15956847

申请日：2018-04-19

申请人： BASF SE

发明人： Pascal Bindschaedler ,  Wolfgang Von Deyn

IPC分类号： A01N43/80 ,  A01N43/40 ,  C07D417/12 ,  C07D413/12 ,  C07D409/12 ,  C07D401/12 ,  C07D263/16 ,  C07D261/04 ,  A01N43/36 ,  C07D207/20 ,  A01N43/82 ,  A01N43/54 ,  C07D207/22 ,  A01N43/78

摘要： The present invention relates to azoline compounds of formula I wherein A, B1, B2, B3, G1, G2, X1, R1, R3a, R3b, Rg1 and Rg2 are as defined in the claims and the description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

公开(公告)号：US09822069B2

公开(公告)日：2017-11-21

申请号：US15039964

申请日：2014-11-27

申请人： KYORIN PHARMACEUTICAL CO. LTD.

发明人： Hiroyasu Takahashi ,  Yoshifumi Saito ,  Kosuke Tsuda ,  Mitsuhito Shibasaki ,  Kohei Ohata

IPC分类号： C07D207/273 ,  C07D209/54 ,  C07D417/12 ,  C07D207/22 ,  C07D409/04 ,  C07D401/04 ,  C07D413/12 ,  C07D413/14 ,  C07D403/12 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12 ,  C07D405/14 ,  C07D401/06 ,  C07D403/04 ,  C07D409/14 ,  C07D413/06

CPC分类号： C07D207/273 ,  C07D207/22 ,  C07D209/54 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： Provided is a compound having a formyl peptide receptor like 1 (FPRL1) agonist effect.The present invention relates to a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing the compound represented by the general formula (I) or a pharmacologically acceptable salt thereof.

公开(公告)号：US20170066718A1

公开(公告)日：2017-03-09

申请号：US15039964

申请日：2014-11-27

申请人： KYORIN PHARMACEUTICAL CO., LTD

发明人： Hiroyasu Takahashi ,  Yoshifumi Saito ,  Kosuke Tsuda ,  Mitsuhito Shibasaki ,  Kohei Ohata

IPC分类号： C07D207/273 ,  C07D401/04 ,  C07D409/04 ,  C07D405/12 ,  C07D417/12 ,  C07D403/12 ,  C07D401/12 ,  C07D409/12 ,  C07D413/12 ,  C07D409/14 ,  C07D209/54 ,  C07D401/06 ,  C07D413/06 ,  C07D413/14 ,  C07D207/22 ,  C07D405/14 ,  C07D405/04

CPC分类号： C07D207/273 ,  C07D207/22 ,  C07D209/54 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： Provided is a compound having a formyl peptide receptor like 1 (FPRL1) agonist effect.The present invention relates to a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing the compound represented by the general formula (I) or a pharmacologically acceptable salt thereof.

摘要翻译： 提供具有甲酰基肽受体1（FPRL1）激动剂作用的化合物。 本发明涉及由通式（I）表示的化合物或其药理学上可接受的盐。 本发明还涉及含有由通式（I）表示的化合物或其药理学上可接受的盐的药物组合物。

公开(公告)号：US09527811B2

公开(公告)日：2016-12-27

申请号：US14570996

申请日：2014-12-15

申请人： AbbVie Deutschland GmbH & Co. KG ,  AbbVie Inc.

发明人： Helmut Mack ,  Andreas Kling ,  Katja Jantos ,  Achim Moeller ,  Wilfried Hornberger ,  Charles W. Hutchins

IPC分类号： C07D207/26 ,  C07D207/28 ,  C07D401/12 ,  C07D233/34 ,  C07D239/10 ,  C07D207/22 ,  C07D211/78 ,  C07D211/76 ,  C07D233/32 ,  C07D275/03 ,  C07D401/06 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D213/81

CPC分类号： C07D207/22 ,  C07D207/26 ,  C07D207/28 ,  C07D211/76 ,  C07D211/78 ,  C07D213/81 ,  C07D233/32 ,  C07D233/34 ,  C07D239/10 ,  C07D275/03 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

摘要： The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity.The carboxamide compounds are compounds of the general formula I in which R1, R2, R3a, R3b, R4, Q, Y, A and X have the meanings mentioned in the claims and the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula Ia and Ib in which R1, r, R2b, R3a, R3b, R4, Y and X have the meanings mentioned in the claims, including the tautomers thereof and the pharmaceutically suitable salts thereof. Of these compounds those are preferred wherein Y is a moiety CH2—CH2, CH2—CH2—CH2, N(Ry#)—CH2, N(Ry#)—CH2—CH2 or CH═CH—CH═, each optionally having 1 or 2H-atoms replaced with identical or different radicals Ry, wherein Ry and Ry# have the meanings mentioned in the claims.

公开(公告)号：US20160221944A1

公开(公告)日：2016-08-04

申请号：US14917847

申请日：2014-07-25

申请人： ObsEva S.A.

发明人： Andre CHOLLET

IPC分类号： C07D207/22

摘要： The present invention relates to a compound of formula (3Z,5S)-5-(hydroxymethyl)-1-[(2′-methyl-1,1′-biphenyl-4-yl)carbonyl]pyrrolidin-3-one O-methl9243yloxime, and/or an active metabolite thereof having antagonist action at the oxytocin receptor and/or vasopressin V1a receptor, to processes for their preparation, pharmaceutical compositions containing them and their use.

摘要翻译： 本发明涉及式（3Z，5S）-5-（羟甲基）-1 - [（2'-甲基-1,1'-联苯-4-基）羰基]吡咯烷-3-酮O- 甲基9243肟，和/或其在催产素受体和/或加压素V1a受体上具有拮抗作用的活性代谢物，其制备方法，含有它们的药物组合物及其用途。

公开(公告)号：US20160145208A1

公开(公告)日：2016-05-26

申请号：US14898465

申请日：2014-06-23

申请人： ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD.

发明人： Bin ZHANG ,  Yuanqiang LI ,  Daqing CHE ,  Lingfeng QIAN ,  Guoliang ZHU ,  Wenfa YE

IPC分类号： C07D207/22

CPC分类号： C07D207/22 ,  C07D207/16 ,  Y02P20/55

摘要： The present invention relates to the field of medical synthesis, in particular to a preparation method for pyrrolidine-2-carboxylic acid derivatives. The present invention adopts the following technical solution: providing a compound having a structure of formula (E), wherein R is R1 or R2, R1 is C1-C6 an alkyl, benzyl, p-methoxybenzyl, or p-nitrobenzyl group, and R2 is hydrogen; R3 is a protecting group of the carboxyl group; and P1 is a protecting group on nitrogen.

摘要翻译： 本发明涉及医学合成领域，特别涉及吡咯烷-2-羧酸衍生物的制备方法。 本发明采用以下技术方案：提供具有式（E）结构的化合物，其中R为R 1或R 2，R 1为C 1 -C 6烷基，苄基，对甲氧基苄基或对硝基苄基，R2为 是氢; R3是羧基的保护基; P1是氮的保护基。

公开(公告)号：US20160130240A1

公开(公告)日：2016-05-12

申请号：US14899260

申请日：2014-06-16

申请人： BAYER CROPSCIENCE AKTIENGESELLSCHAFT

发明人： Bernd ALIG ,  Silvia CEREZO-GALVEZ ,  Reiner FISCHER ,  Adeline KOEHLER ,  Julia Johanna HAHN ,  Angela BECKER ,  Kerstin ILG ,  Arnd VOERSTE ,  Daniela PORTZ

IPC分类号： C07D277/54 ,  A01N43/36 ,  C07D233/32 ,  A01N43/50 ,  A01N43/78 ,  C07D233/74 ,  C07D207/404 ,  C07D249/12 ,  A01N43/653 ,  C07D233/96 ,  C07D263/20 ,  A01N43/76 ,  C07D263/44 ,  C07D231/34 ,  A01N43/56 ,  C07D207/22

CPC分类号： C07D277/54 ,  A01N43/36 ,  A01N43/50 ,  A01N43/56 ,  A01N43/653 ,  A01N43/76 ,  A01N43/78 ,  C07D207/22 ,  C07D207/404 ,  C07D231/34 ,  C07D233/32 ,  C07D233/34 ,  C07D233/74 ,  C07D233/96 ,  C07D249/12 ,  C07D263/20 ,  C07D263/44

摘要： The present invention relates to aryl sulfoxide derivatives, to the use thereof as acaricides and insecticides for controlling animal pests and to processes and intermediates for preparation thereof. The aryl sulfide and aryl sulfoxide derivatives have the general structure (I) in which the respective radicals are as defined in the description.

摘要翻译： 本发明涉及芳基亚砜衍生物，其用作杀螨剂和用于防治动物害虫的杀虫剂及其制备方法和中间体。 芳基硫醚和芳基亚砜衍生物具有通式（I），其中各个基团如说明书中所定义。