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公开(公告)号:US20230126280A1
公开(公告)日:2023-04-27
申请号:US18075316
申请日:2022-12-05
发明人: Mark Spyvee , Pravin S. Shirude
IPC分类号: C07D233/74 , C07F9/6506 , A61K31/4015 , C07D211/88 , C07D207/40 , A61P35/00 , C07D401/12 , C07D403/12 , C07D405/12 , C07D487/04 , C07D207/36 , C07D207/404 , C07D233/46 , C07D239/22 , C07D241/08 , C07D249/12 , C07D251/10 , C07D263/44 , C07D277/34
摘要: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
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公开(公告)号:US11629304B2
公开(公告)日:2023-04-18
申请号:US17525105
申请日:2021-11-12
申请人: ECOLAB USA INC.
IPC分类号: C10L1/232 , C07D207/404 , C10L10/04 , C10L10/08
摘要: Lubricity additives for hydrocarbon fuels are provided according to formula I: wherein n is 1 or 0; each Q is independently selected from oxygen and sulfur; each R is independently selected from C8-C60 alkenyl groups which are substituted or unsubstituted; and L is a linking group comprising 0-20 carbons which may be substituted or unsubstituted and may optionally comprise catenary heteroatoms. Fuel mixtures comprising a hydrocarbon fuel; and a lubricity additive according to the present disclosure are also provided. Methods of making lubricity additives comprise reacting an alkenyl succinic anhydrides (ASA's) with certain bisamides or bisthioamides.
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公开(公告)号:US11584723B2
公开(公告)日:2023-02-21
申请号:US17320650
申请日:2021-05-14
发明人: Mark Spyvee , Pravin S. Shirude
IPC分类号: A61K31/4015 , C07D233/74 , C07F9/6506 , C07D211/88 , C07D207/40 , A61P35/00 , C07D401/12 , C07D403/12 , C07D405/12 , C07D487/04 , C07D207/36 , C07D207/404 , C07D233/46 , C07D239/22 , C07D241/08 , C07D249/12 , C07D251/10 , C07D263/44 , C07D277/34
摘要: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
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公开(公告)号:US20220154089A1
公开(公告)日:2022-05-19
申请号:US17525105
申请日:2021-11-12
申请人: ECOLAB USA INC.
IPC分类号: C10L1/232 , C07D207/404 , C10L10/04 , C10L10/08
摘要: Lubricity additives for hydrocarbon fuels are provided according to formula I: wherein n is 1 or 0; each Q is independently selected from oxygen and sulfur; each R is independently selected from C8-C60 alkenyl groups which are substituted or unsubstituted; and L is a linking group comprising 0-20 carbons which may be substituted or unsubstituted and may optionally comprise catenary heteroatoms. Fuel mixtures comprising a hydrocarbon fuel; and a lubricity additive according to the present disclosure are also provided. Methods of making lubricity additives comprise reacting an alkenyl succinic anhydrides (ASA's) with certain bisamides or bisthioamides.
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公开(公告)号:US20220153694A1
公开(公告)日:2022-05-19
申请号:US17593974
申请日:2020-04-16
发明人: Krzysztof KAMINSKI , Michal ABRAM , Marcin JAKUBIEC , Anna RAPACZ , Szczepan MOGILSKI , Gniewomir LATACZ , Marta STRUGA
IPC分类号: C07D207/27 , A61P25/28 , C07D207/404 , C07D207/416
摘要: 2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2-oxopyrrolidin-1-yl)propanamide derivatives with R-configuration at the stereogenic center are disclosed, showing broad-spectrum protective activity in animal models of epileptic seizures, pain, depression and anxiety that are simultaneously devoid of undesirable sedative effects. Additionally, the disclosed derivatives have neuroprotective effects in the in vitro and in vivo studies.
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公开(公告)号:US20220033355A1
公开(公告)日:2022-02-03
申请号:US17487106
申请日:2021-09-28
发明人: Guobin REN , Dongxu YI , Weijie JI , Jiajun HUANG
IPC分类号: C07D207/404
摘要: A crystal form A of 2-(2, 5-dioxopyrrolidin-1yl)ethyl methyl fumarate has a good light irradiation stability, high-temperature stability and high-humidity stability.
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公开(公告)号:US11104649B2
公开(公告)日:2021-08-31
申请号:US16789687
申请日:2020-05-04
发明人: Mark Spyvee , Pravin S. Shirude
IPC分类号: A61K31/4015 , C07D233/74 , C07F9/6506 , C07D211/88 , C07D207/40 , A61P35/00 , C07D401/12 , C07D403/12 , C07D405/12 , C07D487/04 , C07D207/36 , C07D207/404 , C07D233/46 , C07D239/22 , C07D241/08 , C07D249/12 , C07D251/10 , C07D263/44 , C07D277/34
摘要: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
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公开(公告)号:US20210179920A1
公开(公告)日:2021-06-17
申请号:US17099432
申请日:2020-11-16
发明人: Dirk Leinweber , Zachary Thomas Ward , Felix Hoevelmann , Jonathan James Wylde , Matthias Krull
IPC分类号: C09K8/52 , C10L3/10 , C07D207/404
摘要: The present disclosure relates to a gas hydrate inhibitor composition comprising an amphiphile having a hydrophobic tail linked to a hydrophilic head group by a linking moiety, the amphiphile having the general formula (1) [R5-L-N(R1)(R2)(R3)]+X− (1) wherein each of R1 and R2 is independently an alkyl group having from 1 to 5 carbon atoms; or wherein the nitrogen atom and the R1 and R2 groups together form a substituted or unsubstituted heterocyclic group; R3 is present or not as hydrogen or an alkyl group having from 1 to 8 carbon atoms which optionally bears a hydroxy group or a carboxy group in the 2-position; L is a linking moiety comprising an optionally substituted hydrocarbyl group having at least 2 adjacent carbon atoms, at least one heteroatom selected from nitrogen and oxygen, and optionally one or more further heteroatoms; R5 is a hydrocarbyl group having from 6 to 22 carbon atoms; and X− is present as an anion when R3 is present; and a nonionic surfactant which is selected from alkoxylated C8-C18 fatty alcohols, alkoxylated C8-C18 fatty amines, alkoxylated C8-C18 fatty acids and alkoxylated C8-C18 fatty acid amides and a method of using the gas hydrate inhibitor composition.
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公开(公告)号:US20210002222A1
公开(公告)日:2021-01-07
申请号:US16988332
申请日:2020-08-07
申请人: 3R VALO, S.E.C.
IPC分类号: C07D207/452 , C07D207/404 , C07D207/456 , A61P35/00 , C07D209/48
摘要: There are provided compounds of formula (I) in which R2, R2, R3, R4 and Q can represent various different possibilities. These compounds can be useful as anticancer agents as well as anti-inflammatory agents, anti-proliferative agents and/or anti-metastatic agents.
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公开(公告)号:US10562860B2
公开(公告)日:2020-02-18
申请号:US15914958
申请日:2018-03-07
发明人: Mark Spyvee , Pravin S. Shirude
IPC分类号: C07D233/74 , C07D207/40 , C07D211/88 , C07D401/12 , C07D403/12 , C07D405/12 , C07D487/04 , C07D207/36 , C07D207/404 , C07D233/46 , C07D239/22 , C07D241/08 , C07D249/12 , C07D251/10 , C07D263/44 , C07D277/34 , C07F9/6506 , A61K31/4015 , A61P35/00
摘要: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
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