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公开(公告)号：US20230150922A1
公开(公告)日：2023-05-18
申请号：US17919848
申请日：2021-04-21
发明人： Pedro Brugarolas , YuPeng Zhou
IPC分类号： C07C229/32 , C07B39/00 , C07C235/14 , C07D209/54 , C07B59/00 , A61K51/04
CPC分类号： C07C229/32 , C07B39/00 , C07C235/14 , C07D209/54 , C07B59/001 , C07B59/002 , A61K51/0402 , A61K51/0446 , C07B2200/05
摘要： Described herein are fluorinated derivatives of gabapentin and methods of synthesis and methods of use thereof, e.g., in imaging and therapy.
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公开(公告)号：US20230059463A1
公开(公告)日：2023-02-23
申请号：US17438826
申请日：2020-03-09
发明人： Guido BOJACK , Alfred ANGERMANN , Estella BUSCATO ARSEQUELL , Andreas REMBIAK , Stefan LEHR , Elmar GATZWEILER , Anu Bheemaiah MACHETTIRA , Elisabeth ASMUS , Dirk SCHMUTZLER
IPC分类号： A01N43/38 , C07D209/54 , A01P13/00
摘要： The present invention relates to novel herbicidally active 3-(2-bromo-4-alkynyl-6-alkoxyphenyl)-substituted pyrrolin-2-ones of the general formula (I) or agrochemically acceptable salts thereof and to their use for controlling broad-leaved weeds and weed grasses in crops of useful plants.
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公开(公告)号：US20220177428A1
公开(公告)日：2022-06-09
申请号：US17437996
申请日：2020-03-09
发明人： Alfred ANGERMANN , Guido BOJACK , Estella BUSCATO ARSEQUELL , Hartmut AHRENS , Elisabeth ASMUS , Elmar GATZWEILER
IPC分类号： C07D209/54 , A01N43/38 , A01P13/00
摘要： The present invention relates to novel herbicidally active 3-phenylpyrrolin-2-ones of the general formula (I) or agrochemically acceptable salts thereof and to their use for controlling broad-leaved weeds and weed grasses in crops of useful plants.
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4.发明授权公开(公告)号：US11344872B2
公开(公告)日：2022-05-31
申请号：US16959880
申请日：2019-01-02
发明人： Sukbok Chang , Seung Youn Hong , Yoon Su Park , Yeongyu Hwang , Yeong Bum Kim
IPC分类号： C07F15/06 , C07F17/02 , B01J31/22 , C07D207/267 , C07D209/46 , C07D209/52 , C07D209/54 , C07D209/56 , C07D209/70 , C07D403/04 , C07D405/04 , C07D409/04 , C07J43/00
摘要： The present invention relates to a novel metal complex, a method for producing same, and a method for producing a gamma-lactam compound using same, and the metal complex according to the present invention is used as a catalyst for producing a gamma-lactam compound and can efficiently produce a gamma-lactam compound with an excellent yield and excellent selectivity.
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公开(公告)号：US20210171521A1
公开(公告)日：2021-06-10
申请号：US16629882
申请日：2018-07-11
发明人： Michael Bruno Plewe , Kenneth McCormack , Gregory Henkel , Nadezda V. Sokolova , Eric Brown , Vidyasagar Reddy Gantla
IPC分类号： C07D471/10 , C07D211/58 , C07D471/08 , C07D205/12 , C07C235/40 , C07D295/192 , C07D209/54 , C07D487/04 , A61K45/06
摘要： The compounds of the invention as shown by general structure I, as shown below, are effective in treating filovirus infections. X is selected from the group consisting of O and H; R1 is selected from (C6 to C10) aryl and (C2 to C9) heteroaryl, and R2 is selected from (C1 to C10) alkyl, (C1 to C10) alkenyl, (C1 to C10) alkynyl, (C3 to C10) cycloalkyl, and (C5 to C10) cycloalkenyl, and NR3aR3b is defined in the specification. These compounds are effective in treating filovirii infections including Ebolavirus and Marburg virus.
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公开(公告)号：US20210107869A1
公开(公告)日：2021-04-15
申请号：US16880443
申请日：2020-05-21
IPC分类号： C07D207/273 , C07D403/12 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D209/54 , C07D405/14 , C07D413/14 , C07D401/06 , C07D403/04 , C07D409/14 , C07D413/06 , C07D207/22
摘要： Provided is a compound having a formyl peptide receptor like 1 (FPRL1) agonist effect.
The present invention relates to a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing the compound represented by the general formula (I) or a pharmacologically acceptable salt thereof.-
公开(公告)号：US10899709B2
公开(公告)日：2021-01-26
申请号：US15738292
申请日：2016-06-20
发明人： Alfred Angermann , Stefan Lehr , Hendrik Helmke , Reiner Fischer , Guido Bojack , Christopher Hugh Rosinger , Elmar Gatzweiler , Hansjörg Dietrich
IPC分类号： C07D209/54 , A01N43/38 , A01N47/06 , A01N55/00 , A01C1/08 , A01N25/02 , A01G7/06 , A01N25/32
摘要： Novel alkynyl-substituted 3-phenylpyrrolidine-2,4-diones and use thereof as herbicides
The present invention relates to novel effective alkynyl-substituted 3-phenylpyrrolidine-2,4-diones according to the general formula (I) or agrochemically acceptable salts thereof, where X═C1-C4-alkyl, C1-C4-haloalkyl or C3-C6-cycloalkyl; Y═C1-C4-alkyl or C3-C6-cycloalkyl; n=1, 2 or 3; m=1 or 2; R1=C1-C6-alkyl, or C3-C6-cycloalkyl; R2=hydrogen or methyl; R3═C1-C3-alkoxy-C1-C3-alkyl, or a saturated five- or six-membered heterocycle with an oxygen or sulphur atom; G=hydrogen, a cleavable group L or a cation E.
The invention also relates to the use of the compounds according to the invention for controlling weeds and weed grasses in crops of useful plants.-
公开(公告)号：US20200079744A1
公开(公告)日：2020-03-12
申请号：US16688469
申请日：2019-11-19
发明人： Jennifer Lee , Nicholas Barczak , Jaime A. Escobedo , Chiara Conti , Bingsong Han , David R. Lancia, JR. , Cuixian Liu , Matthew W. Martin , Pui Yee Ng , Aleksandra Rudnitskaya , Jennifer R. Thomason , Xiaozhang Zheng
IPC分类号： C07D263/58 , A61P35/00 , A61K31/403 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/4192 , A61K31/422 , A61K31/423 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/435 , A61K31/437 , A61K31/438 , A61K31/4439 , A61K31/4709 , A61K31/4985 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07C53/06 , C07D209/40 , C07D209/54 , C07D221/20 , C07D235/30 , C07D277/82 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D473/00 , C07D487/04 , C07D491/056 , C07D491/107 , C07D498/04
摘要： The present invention provides methods and uses of inhibitors of histone deacetylase 11 (HDAC11) in the treatment of diseases and/or disorders, such as, for example, cell proliferative diseases.
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公开(公告)号：US10555935B2
公开(公告)日：2020-02-11
申请号：US16309980
申请日：2017-06-16
IPC分类号： A61K31/438 , C07D401/04 , C07D221/20 , C07D401/06 , C07D209/54 , A61P25/14 , A61P25/28 , A61P35/00 , A61K31/407
摘要： The present invention is directed to inhibitors of histone deacetylases (HDACs) such as HDAC6, and their use in the treatment of diseases such as cell proliferative diseases (e.g., cancer), neurological (e.g., neurodegenerative disease or neurodevelopmental disease), inflammatory or autoimmune disease, infection, metabolic disease, hematologic disease, or cardiovascular disease.
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公开(公告)号：US20190174758A1
公开(公告)日：2019-06-13
申请号：US15765769
申请日：2016-10-04
发明人： Alfred ANGERMANN , Stefan LEHR , Reiner FISCHER , Guido BOJACK , Hendrik HELMKE , Dirk SCHMUTZLER , Hansjörg DIETRICH , Elmar GATZWEILER , Christopher Hugh ROSINGER
IPC分类号： A01N43/38 , C07D209/54
摘要： The present invention relates to novel effective alkynyl-substituted N-phenylpyrrolidine-2,4-diones according to the general formula (I) or agrochemically acceptable salts thereof, where X=C1-C4-alkyl, C1-C4-haloalkyl or C3-C6-cycloalkyl, Y=C1-C4-alkyl or C3-C6-cycloalkyl, R1=hydrogen, C1-C6-alkyl, or C3-C6-cycloalkyl, R2=hydrogen or methyl, R3=C1-C6-alkyl or C1-C6-alkoxy-C2-C6-alkyl, G=hydrogen, a cleavable group L or a cation E. The invention further relates to a herbicidal composition comprising a compound of the general formula (I) and to the use of the compounds according to the invention for controlling weeds and weed grasses in crops of useful plants.
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