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117 条记录 (耗时 0.041 秒)

    Fused ring thrombin receptor antagonists
    3.
    发明授权
    Fused ring thrombin receptor antagonists 有权
    融合环凝血酶受体拮抗剂

    公开(公告)号：US08003803B2

    公开(公告)日：2011-08-23

    申请号：US11734057

    申请日：2007-04-11

    申请人： Yan Xia ,  Samuel Chackalamannil

    发明人： Yan Xia ,  Samuel Chackalamannil

    IPC分类号： C07D263/00 ,  C07D413/00

    CPC分类号： C07D405/06 ,  C07D498/04

    摘要： Fused-ring, heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein   represents an optional double bond, and wherein An, En, Mn, Gn, Jn, R3, n7, R8, R9, R10, R11, R32, R33, X, Y, B and Het are herein defined and the remaining substituents are as defined in the specification, are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.

    摘要翻译： 具有下式的稠环，杂环取代的三环或所述化合物的药学上可接受的盐或溶剂合物，异构体或外消旋混合物，其中表示任选的双键，并且其中An，En，Mn，Gn，Jn，R 3，n 7，R 8 本文定义了R9，R10，R11，R32，R33，X，Y，B和Het，其余取代基如说明书中所定义，以及含有它们的药物组合物以及治疗与 血栓形成，动脉粥样硬化，再狭窄，高血压，心绞痛，心律失常，心力衰竭和癌症。 还要求与其它心血管药物联合治疗。

    Photochromic compound and optical functional material
    6.
    发明申请
    Photochromic compound and optical functional material 有权
    光致变色化合物和光学功能材料

    公开(公告)号：US20080006797A1

    公开(公告)日：2008-01-10

    申请号：US11723668

    申请日：2007-03-21

    申请人： Tsuyoshi Kawai ,  Takuya Nakajima ,  Shigekazu Kawai

    发明人： Tsuyoshi Kawai ,  Takuya Nakajima ,  Shigekazu Kawai

    IPC分类号： G02B5/23 ,  C07D207/00 ,  C07D209/04 ,  C07D233/54 ,  C07D263/00 ,  C07D275/00 ,  C07D333/00

    CPC分类号： G02B5/23 ,  C07D417/14

    摘要： The present invention provides a photochromic compound that is colored when irradiated with visible light and quickly faded when set in a dark place. The photochromic compound according to the present invention is expressed by the following general formula (I): where each of A1, A2 and A3 is a five-member rings forming a 6π-electron system, the three rings being identical, partially identical or totally different from each other, and each ring may have a substituent; B1 and B2 are functional groups, each having an atomic number of five or larger, including a ring compound, and bonded to the 2-carbon of each of A2 and A3, respectively; and R1, R2 and R3 are substituents identical to or different from each other. This compound is highly colorable and durable even when it is dispersed into plastic macromolecular materials. Therefore, it is suitable as a dye material for sunglasses or similar products.

    摘要翻译： 本发明提供一种当用可见光照射时着色的光致变色化合物，并且当设置在黑暗处时迅速褪色。 根据本发明的光致变色化合物由以下通式（I）表示：其中A 1，A 2和A 3中的每一个 2和A 3 <3; 和R 1，R 2和R 3是彼此相同或不同的取代基。 该化合物即使分散在塑料大分子材料中也具有高度着色和耐用性。 因此，它适用于太阳镜或类似产品的染料。

    Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
    7.
    发明申请
    Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof 失效
    环丙基取代的恶唑烷酮类抗生素及其衍生物

    公开(公告)号：US20050038092A1

    公开(公告)日：2005-02-17

    申请号：US10878637

    申请日：2004-06-29

    申请人： Yasumichi Fukuda

    发明人： Yasumichi Fukuda

    IPC分类号： A61K31/422 ,  A61P31/04 ,  C07D263/00 ,  C07D413/02 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14 ,  C07D487/08

    CPC分类号： C07D413/10 ,  C07D413/14 ,  C07D417/14

    摘要： This invention relates to new oxazolidinones having a cyclopropyl moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, streptococci and enterococci, Bacteroides spp., Clostridia spp. species, as well as acid-fast organisms such as Mycobacterium tuberculosis and other mycobacterial species. The compounds are represented by structural formula I: its enantiomer, diastereomer, or pharmaceutically acceptable salt or ester thereof.

    摘要翻译： 本发明涉及具有环丙基部分的新的恶唑烷酮，其对有氧和厌氧性病原体有效，例如多重耐药性葡萄球菌，链球菌和肠球菌，拟杆菌属，梭菌属（Clostridia spp。 物种，以及耐酸菌，如结核分枝杆菌和其他分枝杆菌物种。 化合物由结构式I表示：其对映异构体，非对映异构体或其药学上可接受的盐或酯。