公开(公告)号：US10776461B2

公开(公告)日：2020-09-15

申请号：US16246614

申请日：2019-01-14

申请人： The University of Toledo

发明人： Bruce E. Heck ,  Dong Hyun Kim ,  Paul W. Erhardt ,  Brian J. Kress

IPC分类号： C07D277/20 ,  C07D277/22 ,  C07D277/28 ,  G06F21/31 ,  H04W12/06 ,  A61K45/06 ,  A61K31/426 ,  A61K31/5575 ,  C07D277/30 ,  C07D277/24 ,  H04W12/04 ,  H04W12/08

摘要： Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.

公开(公告)号：US10413527B2

公开(公告)日：2019-09-17

申请号：US16178277

申请日：2018-11-01

申请人： New York Blood Center, Inc. ,  The United States of America, as Represented by the Secretary, Department of Health and Human Services

发明人： Asim Kumar Debnath ,  Francesca Curreli ,  Peter D. Kwong ,  Young Do Kwon

IPC分类号： C07D207/30 ,  A61K31/40 ,  C07D403/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14 ,  C07D207/34 ,  C07C25/00 ,  C07C233/01 ,  C07D277/20 ,  A61P31/18

摘要： Substituted phenylpyrrolecarboxamide compounds such as those represented by Formula A can be used in the treatment of HIV infection and related conditions.

公开(公告)号：US20190070146A1

公开(公告)日：2019-03-07

申请号：US16178277

申请日：2018-11-01

申请人： New York Blood Center, Inc. ,  The United States of America, as Represented by the Secretary, Department of Health and Human Serv

发明人： Asim Kumar Debnath ,  Francesca Curreli ,  Peter D. Kwong ,  Young Do Kwon

IPC分类号： A61K31/40 ,  C07C233/01 ,  C07C25/00 ,  C07D207/30 ,  C07D417/14 ,  C07D277/20 ,  C07D403/12 ,  C07D405/14 ,  C07D417/12 ,  C07D207/34 ,  A61P31/18

CPC分类号： A61K31/40 ,  A61P31/18 ,  C07C25/00 ,  C07C233/01 ,  C07D207/30 ,  C07D207/34 ,  C07D277/20 ,  C07D403/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14

摘要： Substituted phenylpyrrolecarboxamide compounds such as those represented by Formula A can be used in the treatment of HIV infection and related conditions.

公开(公告)号：US10155754B2

公开(公告)日：2018-12-18

申请号：US15314067

申请日：2015-05-28

申请人： UNIVERSITAT BERN

发明人： Jean-Louis Reymond ,  Simon Nicolussi ,  Jurg Gertsch

IPC分类号： C07D277/20 ,  C07D417/06 ,  C07D277/54

摘要： The invention relates to a compound comprising the following general formula (1): and said compound for use as a medicament, in particular for use in the treatment psychiatric or neurological disorders and inflammation, in particular neuroinflammation: (formula 1) wherein each of R1, R2 and R3 are selected independently from each other from alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, aryl, heterocycle, or heteroaryl.

公开(公告)号：US10112957B2

公开(公告)日：2018-10-30

申请号：US15518541

申请日：2015-10-22

申请人： Dana-Farber Cancer Institute, Inc.

发明人： Nathanael S. Gray ,  Sara Jean Buhrlage ,  Steven P. Treon ,  Hwan Geun Choi ,  Yuan Xiong ,  Guang Yang

IPC分类号： C07D277/20 ,  C07D277/56 ,  C07D417/12 ,  C07D513/04 ,  C07D417/04 ,  C07D417/14

摘要： The present disclosure provides thiazolyl-containing compounds of Formula (I), (II), or (III). The compounds described herein may be able to inhibit protein kinases (e.g., Src family kinases (e.g., hemopoietic cell kinase (HCK)), Bruton's tyrosine kinase (BTK)) and may be useful in treating and/or preventing proliferative diseases (e.g., myelodysplasia, leukemia, lymphoma (e.g., Waldenström's macroglobulinemia)) and in inducing apoptosis in a cell (e.g., malignant blood cell). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.

公开(公告)号：US10098885B2

公开(公告)日：2018-10-16

申请号：US15517951

申请日：2015-09-22

申请人： GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD

发明人： Lingyun Wu ,  Chaofeng Long ,  Peng Zhang ,  Xiaoxin Chen ,  Li Zhang ,  Zhuowei Liu ,  Jian Li ,  Shuhui Chen

IPC分类号： A61K31/522 ,  C07D473/04 ,  C07D241/10 ,  C07D277/20 ,  C07D261/06

摘要： Hydroxyl purine compounds represented by formula (I), tautomers or pharmaceutically acceptable salts thereof, and applications thereof as PDE2 or TNF-α inhibitors.

公开(公告)号：US10081610B2

公开(公告)日：2018-09-25

申请号：US15509722

申请日：2015-09-10

申请人： ARIAGEN, INC.

发明人： Jiasheng Song ,  Suoming Zhang ,  Guodong Li ,  Luquing Yang

IPC分类号： C07D277/20 ,  C07D209/12 ,  C07D417/06 ,  C07B43/08 ,  C07C67/47

CPC分类号： C07D277/20 ,  C07B43/08 ,  C07C67/47 ,  C07D209/12 ,  C07D417/06

摘要： Methods of synthesizing 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) and structural analogs thereof. The methods include condensation reactions or condensation and oxidation reactions to form the thiazoline or thiazole moiety of ITE or its structural analogs.

公开(公告)号：US20170326149A1

公开(公告)日：2017-11-16

申请号：US15517951

申请日：2015-09-22

申请人： GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD ,  MEDSHINE DISCOVERY INC.

发明人： Lingyun WU ,  Chaofeng LONG ,  Peng ZHANG ,  Xiaoxin CHEN ,  Li ZHANG ,  Zhuowei LIU ,  Jian LI ,  Shuhui CHEN

IPC分类号： A61K31/522 ,  C07D241/10 ,  C07D261/06 ,  C07D277/20

CPC分类号： A61K31/522 ,  A61K31/52 ,  C07D241/10 ,  C07D261/06 ,  C07D277/20 ,  C07D473/30

摘要： Hydroxyl purine compounds represented by formula (I), tautomers or pharmaceutically acceptable salts thereof, and applications thereof as PDE2 or TNF-α inhibitors.

公开(公告)号：US09777096B2

公开(公告)日：2017-10-03

申请号：US14437748

申请日：2013-10-16

申请人： ZEON CORPORATION

发明人： Kei Sakamoto ,  Satoshi Kiriki ,  Kumi Okuyama

IPC分类号： C08F28/06 ,  C07D277/00 ,  C08F222/24 ,  C07D277/20 ,  C07D277/50 ,  C08F222/10 ,  G02B5/30 ,  G02B1/04 ,  G02B1/08 ,  G02F1/13363

CPC分类号： C08F222/24 ,  C07D277/20 ,  C07D277/50 ,  C08F222/1006 ,  G02B1/04 ,  G02B1/08 ,  G02B5/3016 ,  G02F2001/133633

摘要： The present invention pertains to: a polymerizable compound represented by a formula (I); a polymerizable composition comprising the polymerizable compound and an initiator; a polymer obtained by polymerizing the polymerizable compound or the polymerizable composition; and an optically anisotropic article comprising the polymer. The present invention provides a polymerizable compound, a polymerizable composition, and a polymer that have a practical low melting point, exhibit excellent solubility in a general-purpose solvent, can be produced at low cost, and can produce an optical film that achieves uniform conversion of polarized light over a wide wavelength band, and also provide an optically anisotropic article.

公开(公告)号：US09725438B2

公开(公告)日：2017-08-08

申请号：US14956240

申请日：2015-12-01

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Shigeo Yamanoi ,  Hidenori Namiki ,  Yuichi Ochiai ,  Madoka Hoshino ,  Koji Matsumoto

IPC分类号： C07D403/12 ,  C07D401/14 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07D249/06 ,  C07D257/04 ,  C07D263/32 ,  C07D271/06 ,  C07D277/20 ,  C07D277/30 ,  A61K31/421 ,  A61K31/4439

CPC分类号： C07D403/12 ,  A61K31/421 ,  A61K31/4439 ,  C07D249/06 ,  C07D257/04 ,  C07D263/32 ,  C07D271/06 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D417/12

摘要： Compounds are provided having an excellent hypoglycemic effect and β cell- or pancreas-protecting effects, or pharmaceutically acceptable salts thereof, and a pharmaceutical composition having an excellent therapeutic effect and/or prophylactic effect on type 1 diabetes, type 2 diabetes, and the like, which cause hyperglycemia due to abnormal glucose metabolism. A compound represented by general formula (I), or a pharmaceutically acceptable salt thereof, is disclosed.