公开(公告)号：US20250011288A1

公开(公告)日：2025-01-09

申请号：US18701270

申请日：2022-10-28

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Adam James Clarke ,  Todd J. Friends ,  Arvind Mathur ,  Michael C. Myers ,  Jianqing Li ,  Donald J. P. Pinto ,  Kumar Balashanmuga Pabbisetty ,  Shun Su ,  Benjamin P. Vokits ,  Durga Buchi Raju Barre ,  Leon M. Smith, II ,  Michael J. Orwat ,  Scott A. Shaw ,  Sreekantha Ratna Kumar ,  Hima Kiran Potturi

IPC: C07D213/82 ,  A61K31/343 ,  A61K31/353 ,  A61K31/381 ,  A61K31/415 ,  A61K31/416 ,  A61K31/42 ,  A61K31/423 ,  A61K31/424 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/47 ,  A61K31/4704 ,  A61K31/496 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/505 ,  A61K31/5383 ,  A61K31/541 ,  C07D215/54 ,  C07D217/02 ,  C07D217/04 ,  C07D217/08 ,  C07D231/18 ,  C07D231/22 ,  C07D231/54 ,  C07D237/24 ,  C07D239/34 ,  C07D241/24 ,  C07D261/04 ,  C07D307/00 ,  C07D311/24 ,  C07D333/38 ,  C07D401/06 ,  C07D405/12 ,  C07D413/04 ,  C07D417/14 ,  C07D471/04 ,  C07D491/107 ,  C07D498/04

Abstract: The disclosure relates to compounds of Formula (I), which arm RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such as lung disease (e.g., idiopathic pulmonary fibrosis), kidney disease (e.g., chronic kidney disease), or hepatic disease (e.g., non-alcoholic steatohepatitis and portal hypertension). Formula (I)

公开(公告)号：US20230266666A1

公开(公告)日：2023-08-24

申请号：US17896138

申请日：2022-08-26

Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED

Inventor： Katsuhiro KOMURO ,  Saki KATO ,  Koji ICHIKAWA

IPC: G03F7/004 ,  C07D307/00 ,  C07D333/76 ,  C07D321/10 ,  C07D409/12 ,  C08F220/18

CPC classification number: G03F7/0045 ,  C07D307/00 ,  C07D321/10 ,  C07D333/76 ,  C07D409/12 ,  C08F220/1808 ,  C08F220/1818

Abstract: Disclosed are a salt represented by formula (I), an acid generator, and a resist composition including the same:





wherein R4 to R9 each represent a halogen atom, a haloalkyl group, etc., A1, A2 and A3 each represent a hydrocarbon group which may have a substituent, —CH2— included in the group may be replaced by —O—, —CO—, —S—, etc., X4, X5 and X6 each represent —O— or —S—, m1 and m7 represent an integer of 0 to 5, m2, m3, m8 and m9 represent an integer of 0 to 4, m4 to m6 represent an integer of 0 to 3, 0 ≤ m1 + m7 ≤ 5, 0 ≤ m2 + m8 ≤ 4, 0 ≤ m3 + m9 ≤ 4, one or more of m1, m2 and m3 represent an integer of 1 or more, X7 represents a single bond, —CH2—, —O—, —S—, etc., and Al— represents an organic anion.

公开(公告)号：US20230004084A1

公开(公告)日：2023-01-05

申请号：US17730603

申请日：2022-04-27

Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED

Inventor： Katsuhiro KOMURO ,  Koji ICHIKAWA

IPC: G03F7/004 ,  C07D307/00 ,  C07D333/76 ,  C07D321/10 ,  C07D409/12 ,  C07D493/10

Abstract: Disclosed are a salt represented by formula (I), an acid generator, and a resist composition: wherein R1, R2 and R3 each represent a hydroxy group, *—O—R10, *—O-L10-CO—O—R10, etc.; L10 represents an alkanediyl group; R10 represents an acid-labile group; R4 to R9 each represent a halogen atom, a haloalkyl group, etc.; A1, A2 and A3 each represent a hydrocarbon group, etc.; m1 and m7 represent an integer of 0 to 5, m2 to m6, m8 and m9 represent an integer of 0 to 4, 0≤m1+m7≤5, 0≤m2+m8≤4, 0≤m3+m9≤4, and at least one of m1, m2 and m3 represents an integer of 1 or more; X4 represents a single bond, —CH2—, etc.; and Al− represents an organic anion.

公开(公告)号：US20220299873A1

公开(公告)日：2022-09-22

申请号：US17829531

申请日：2022-06-01

Applicant: JSR CORPORATION

Inventor： Ryuichi NEMOTO ,  Ryotaro TANAKA ,  Taiichi FURUKAWA ,  Katsuaki NISHIKORI ,  Hiromitsu NAKASHIMA

IPC: G03F7/039 ,  G03F7/038 ,  C07C69/734 ,  C07D307/00 ,  C07C69/736 ,  C07C69/96 ,  C08F220/28 ,  C08F220/38 ,  C08F220/36 ,  C08F212/14 ,  C08F220/30

Abstract: A radiation-sensitive resin composition includes: a first polymer including a structural unit including an acid-labile group; a second polymer including a structural unit represented by formula (1); and a radiation-sensitive acid generator. In the formula (1), A represents an oxygen atom or a sulfur atom; a sum of m and n is 2 or 3, wherein m is 1 or 2, and n is 1 or 2; X represents a single bond or a divalent organic group having 1 to 20 carbon atoms; and R1 represents a monovalent organic group including a fluorine atom.

公开(公告)号：US10927090B2

公开(公告)日：2021-02-23

申请号：US16344026

申请日：2018-04-18

Applicant: Beijing Union Pharmaceutical Factory

Inventor： Bo Song

IPC: A61P25/00 ,  C07D307/00 ,  A61K47/32

Abstract: A method suitable for large-scale production of buagafuran active pharmaceutical ingredient. A buagafuran active pharmaceutical ingredient (API) with a high purity prepared by the method includes an active ingredient of buagafuran, an impurity A, and an impurity B. In the buagafuran API, a content of the active ingredient of buagafuran is higher than 97.5%, and a total content of the impurity A and the impurity B is less than 0.04%. The buagafuran API can be applied to new drug development processes such as clinical research, pharmaceutical research and quality control research.

公开(公告)号：US10890591B2

公开(公告)日：2021-01-12

申请号：US16167993

申请日：2018-10-23

Applicant: Synapse Biosciences, LLC

Inventor： Robert Anthony Millet, Jr. ,  Philip T. Radford ,  Ashwin Anand Patkar

IPC: G01N33/94 ,  G01N33/493 ,  C07D307/00 ,  C07D277/00 ,  A61K31/10 ,  A61K31/075 ,  A61K31/13 ,  A61B5/00

Abstract: Provided herein are methods and dose packs for the monitoring of medication adherence. In one aspect, the dose pack comprises comprise a multiplicity of doses of an agent and a multiplicity of doses of a marker and be configured to isolate a pair of at least one of the multiplicity of doses of the agent and at least one of the multiplicity of doses of the marker for co-administration of the pair to the subject according to the dosing schedule. In another aspect, the method comprises obtaining a sample from the subject subsequent to the conclusion of a monitoring window and analyzing the sample for the presence or absence of a marker or a degradation product thereof.

公开(公告)号：US10710969B2

公开(公告)日：2020-07-14

申请号：US16334152

申请日：2017-09-07

Applicant: BASF Agro B.V.

Inventor： Stefan Benson ,  Michael Rack ,  Bernd Wolf ,  Roland Goetz ,  Joachim Gebhardt ,  Helmut Kraus

IPC: C07D307/00

Abstract: This invention relates to a process for preparing (±)-2-exo-(2-Methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (I) any of its individual enantiomers or any non-racemic mixture thereof, comprising the steps of (a) reacting (±)-2-exo-hydroxy-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (II) any of its individual enantiomers or any non-racemic mixture thereof with a 2-Methylbenzyl compound of the formula (III) wherein X is a leaving group in the presence of at least one base capable of forming water or a C1-C4 alkyl alcohol under the reaction conditions, and at least one inert organic solvent, and (b) simultaneously removing water, the C1-C4 alkyl alcohol or any mixture thereof from the reaction mixture.

公开(公告)号：US10538470B2

公开(公告)日：2020-01-21

申请号：US15571987

申请日：2016-04-22

Applicant: BASF Agro B.V.

Inventor： Bernd Wolf ,  Michael Rack ,  Stefan Benson ,  Helmut Kraus ,  Roland Goetz ,  Sukunath Narayanan ,  Chidambaram Rishinaradamangalam

IPC: C07D307/00 ,  C07C29/56 ,  C07C29/17 ,  C07D493/08

Abstract: The present invention relates to a process for the preparation of limonene-4-ol by an epoxide ring opening isomerization of terpinolene epoxide.

公开(公告)号：US10221131B2

公开(公告)日：2019-03-05

申请号：US15167223

申请日：2016-05-27

Applicant: Rohm and Haas Electronic Materials LLC

Inventor： Irvinder Kaur ,  Cong Liu ,  Cheng-Bai Xu

IPC: G03F7/004 ,  C07C309/17 ,  C07D307/00 ,  C07D493/18 ,  C07C381/12 ,  H01L21/027 ,  C07C309/01 ,  G03F7/039

Abstract: Acid generator compounds are provided that are particularly useful as a photoresist composition component. In one preferred aspect, acid generators are provided that comprise one or more hydrophilic moieties.

公开(公告)号：US10195592B2

公开(公告)日：2019-02-05

申请号：US15584933

申请日：2017-05-02

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Young Kyu Hwang ,  Jong San Chang ,  Do Young Hong ,  Dong Won Hwang ,  U Hwang Lee ,  Kyung Ho Cho ,  Anil Haribhau Valekar ,  Su Kyung Lee

IPC: C07D307/00 ,  B01J27/20 ,  B01J37/03 ,  B01J37/06 ,  B01J31/26 ,  B01J35/00 ,  B01J35/10

Abstract: The present invention relates to a catalyst for transfer hydrogenation, which is formed of a metal-organic framework having an MOF-808 based X-ray diffraction pattern.A high crystalline porous MOF-808 based metal-organic framework exhibits excellent performance in the transfer hydrogenation of ethyl levulinate (EL) at high and low temperature.