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    Five-membered cyclocarbonate polysiloxane compound and process for preparation of same
    2.
    发明授权
    Five-membered cyclocarbonate polysiloxane compound and process for preparation of same 有权
    五元环碳酸酯聚硅氧烷化合物及其制备方法

    公开(公告)号：US08975420B2

    公开(公告)日：2015-03-10

    申请号：US13503936

    申请日：2010-10-07

    申请人： Kazuyuki Hanada ,  Kazuya Kimura ,  Kenichi Takahashi ,  Osamu Kawakami ,  Manabu Uruno

    发明人： Kazuyuki Hanada ,  Kazuya Kimura ,  Kenichi Takahashi ,  Osamu Kawakami ,  Manabu Uruno

    IPC分类号： C07D307/04 ,  C07D307/77

    CPC分类号： C08G77/458 ,  C07F7/0838 ,  C08G77/14 ,  C08G77/38 ,  C09D183/10

    摘要： A 5-membered cyclic carbonate polysiloxane compound is represented by the below-described formula (1), and is produced by a process that reacts an epoxy-modified polysiloxane compound with carbon dioxide. wherein A means in which R1 means an alkylene group which has from 1 to 12 carbon atoms and may be linked via an element of O, S or N and/or —(C2H4O)b—, R2 means a direct bond or an alkylene group having from 2 to 20 carbon atoms, R2 may be linked to an alicyclic group or aromatic group, b stands for a number of from 1 to 300, and a stands for a number of from 1 to 300.

    摘要翻译： 5元环状碳酸酯聚硅氧烷化合物由下述式（1）表示，通过使环氧改性聚硅氧烷化合物与二氧化碳反应的方法制造。 其中A表示其中R1表示具有1至12个碳原子并可以通过O，S或N和/或 - （C 2 H 4 O）b - 的元素连接的亚烷基，R 2表示直接键或亚烷基 具有2至20个碳原子，R 2可以连接到脂环族基团或芳族基团，b代表1至300个数，a代表1至300个数。

    Preparation of aminomethyl furans and alkoxymethyl furan derivatives from carbohydrates
    3.
    发明授权
    Preparation of aminomethyl furans and alkoxymethyl furan derivatives from carbohydrates 有权
    从碳水化合物制备氨基甲基呋喃和烷氧基甲基呋喃衍生物

    公开(公告)号：US08901326B2

    公开(公告)日：2014-12-02

    申请号：US14085080

    申请日：2013-11-20

    申请人： Archer Daniels Midland Company

    发明人： Stephen Howard ,  Alexandra Sanborn

    IPC分类号： C07D307/04 ,  C07D307/34 ,  C07D307/42 ,  C07D307/14 ,  C07D307/12 ,  C07D307/44 ,  C07D307/52

    CPC分类号： C07D307/12 ,  C07D307/14 ,  C07D307/42 ,  C07D307/44 ,  C07D307/52

    摘要： Described herein are single step methods of making various classes of alkylamine derivatives of furan and tetrahydrofuran by simultaneous contact of a sugar with H2, an acid catalyst and hydrogenation catalyst in the presence of an alkylamide solvent. The hydrogenation catalyst is a heterogeneous catalyst comprising a metal selected from the group consisting of Pt, Pd, and nickel. The acid catalysts may be homogeneous mineral acid or a heterogeneous acid catalyst on substrate. In a preferred practice the two catalysts are provided on a common heterogeneous bifunctional support. Using similar combinations of acid and hydrogenation catalysts, there is also described single step methods for making furandimethanol by simultaneously contacting a hexose with the two separate catalysts in the presence of H2 in an aprotic solvent, such as dimethylformamide. With the same catalyst system and similar reaction conditions, 2, 5 furan dialkylethers can also be made in a single step when the solvent includes an ROH alcohol.

    摘要翻译： 本文描述了通过在烷基酰胺溶剂存在下，通过糖与H 2，酸催化剂和氢化催化剂的同时接触来制备呋喃和四氢呋喃的各种类型的烷基胺衍生物的单步方法。 氢化催化剂是包含选自Pt，Pd和镍的金属的多相催化剂。 酸催化剂可以是基质上均相无机酸或多相酸催化剂。 在优选的实践中，两种催化剂提供在共同的异构双功能载体上。 使用酸和氢化催化剂的类似组合，还描述了通过在非质子溶剂如二甲基甲酰胺中在H 2存在下同时使己糖与两种分离的催化剂接触来制备呋喃二甲醇的单步方法。 在相同的催化剂体系和类似的反应条件下，当溶剂包括ROH醇时，也可以在一个步骤中制备2,5,5-呋喃二烷基醚。

    Liquid crystal compounds, and liquid crystal displays and photochromic materials comprising the liquid crystal compounds
    4.
    发明授权
    Liquid crystal compounds, and liquid crystal displays and photochromic materials comprising the liquid crystal compounds 有权
    液晶化合物，液晶显示器和含有液晶化合物的光致变色材料

    公开(公告)号：US08481129B2

    公开(公告)日：2013-07-09

    申请号：US13340206

    申请日：2011-12-29

    申请人： Yi-Rong Wang ,  Chih-Lung Chin ,  Wan-Chi Chen ,  Kung-Lung Cheng ,  Shih-Hsien Liu

    发明人： Yi-Rong Wang ,  Chih-Lung Chin ,  Wan-Chi Chen ,  Kung-Lung Cheng ,  Shih-Hsien Liu

    IPC分类号： C09K19/32 ,  C09K19/30 ,  C09K19/34 ,  C09K19/20 ,  C07C69/78 ,  C07D307/04

    CPC分类号： C07D307/54 ,  C09K19/32 ,  Y10T428/10

    摘要： A liquid crystal compound of Formula (I) is provided. In Formula (I), A is benzene, naphthalene, pyridine, furan, thiophene or a single bond, D is benzene, naphthalene, pyridine, furan, thiophene or a single bond, R1 and R2 are C1-10 alkyl, C1-10 alkoxy, fluoro or trifluoro methyl, E is benzene, naphthalene, pyridine, furan, thiophene or a single bond, W is —CO—O—, —O—CO—, —O—, —CH2—CH2—, —CH═CH—, —CH2—O— or a single bond, Z is benzene, naphthalene, pyridine, furan, thiophene or a single bond, Y is hydrogen, methyl, ethyl or propyl, m is 0, 1 or 2, p is 0, 1 or 2, r is 0, 1 or 2, q is 0, 1 or 2, and n is 0, 1, 2 or 3. The invention also provides a liquid crystal display and photochromic material including the compound.

    摘要翻译： 提供式（I）的液晶化合物。 在式（I）中，A为苯，萘，吡啶，呋喃，噻吩或单键，D为苯，萘，吡啶，呋喃，噻吩或单键，R1和R2为C1-10烷基，C1-10 烷氧基，氟或三氟甲基，E是苯，萘，吡啶，呋喃，噻吩或单键，W是-CO-O-，-O-CO-，-O-，-CH2-CH2-，-CH = CH-，-CH 2 -O-或单键，Z为苯，萘，吡啶，呋喃，噻吩或单键，Y为氢，甲基，乙基或丙基，m为0,1或2，p为0 ，1或2，r为0,1或2，q为0,1或2，n为0,1,2或3.本发明还提供了包含该化合物的液晶显示器和光致变色材料。

    Amines that inhibit a mammalian anandamide transporter, and methods of use thereof
    8.
    发明授权
    Amines that inhibit a mammalian anandamide transporter, and methods of use thereof 有权
    抑制哺乳动物anandamide转运蛋白的胺及其使用方法

    公开(公告)号：US07671087B2

    公开(公告)日：2010-03-02

    申请号：US12392981

    申请日：2009-02-25

    申请人： Brian M. Aquila ,  Seth C. Hopkins ,  Curtis A. Lockshin ,  Fengjiang Wang

    发明人： Brian M. Aquila ,  Seth C. Hopkins ,  Curtis A. Lockshin ,  Fengjiang Wang

    IPC分类号： A61K31/34 ,  A61K31/135 ,  C07D307/04 ,  C07C211/03

    CPC分类号： C40B40/04 ,  C07C217/58 ,  C07C2601/02 ,  C07D307/14 ,  C40B20/08 ,  C40B30/04 ,  C40B40/00 ,  C40B50/14

    摘要： One aspect of the present invention relates to amines. A second aspect of the present invention relates to the use of the amines as inhibitors of a mammalian anandamide transporter. The compounds of the present invention will also find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to asthma, neuropathic pain, persistent pain, inflammatory pain, hyperactivity, hypertension, brain ischemia, Parkinson's disease, spasticity, Tourette's syndrome, schizophrenia, hemorrhagic shock, septic shock, cardiac shock, migrane, Horton's headache, multiple sclerosis, anorexia, AIDS wasting syndrome, organ rejection, autoimmune diseases, allergy, arthritis, Crohn's disease, malignant gliomas, neurodegenerative diseases, Huntington's chorea, glaucoma, nausea, anxiety, psychosis, attention deficit hyperactivity disorder, premature ejaculation, and stroke. Another aspect of the present invention relates to combinatorial libraries of amines, and methods for preparing the libraries.

    摘要翻译： 本发明的一个方面涉及胺。 本发明的第二方面涉及胺作为哺乳动物安非他明转运蛋白的抑制剂的用途。 本发明的化合物还可用于治疗影响哺乳动物的许多疾病，病症和疾病，包括但不限于哮喘，神经性疼痛，持续性疼痛，炎性疼痛，多动症，高血压，脑缺血，帕金森病， 痉挛性，Tourette综合征，精神分裂症，出血性休克，败血性休克，心脏休克，偏头痛，霍顿头痛，多发性硬化症，厌食症，艾滋病综合征，器官排斥反应，自身免疫性疾病，变态反应，关节炎，克罗恩病，恶性胶质瘤，神经变性疾病，亨廷顿舞蹈病 舞蹈病，青光眼，恶心，焦虑，精神病，注意力缺陷多动障碍，早泄和中风。 本发明的另一方面涉及胺的组合文库，以及制备文库的方法。