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146 条记录 (耗时 0.025 秒)

    Methods of extraction of nitrosylated or nitrated derivatives of ascorbic acid from Myriciaria dubia and methods of synthesis thereof
    7.
    发明授权
    Methods of extraction of nitrosylated or nitrated derivatives of ascorbic acid from Myriciaria dubia and methods of synthesis thereof 有权

    公开(公告)号：US10780140B2

    公开(公告)日：2020-09-22

    申请号：US15832053

    申请日：2017-12-05

    申请人： John P. Crow, Jr.

    发明人： John P. Crow, Jr.

    IPC分类号： A61K36/61 ,  C07D307/32 ,  C07D307/30

    摘要： The present invention relates to methods and strategies for extracting nitrosylated and/or nitrated derivatives and analogs from Myrciaria dubia fruit and for synthesizing the same. The ascorbic acid derivatives and analogs have the chemical structure of: where R1 is ═O, —ONO, —ONO2, or —NH2; R2 is —OH, —ONO, —ONO2, or —NH2; R3 is —OH, —ONO, —ONO2. The extraction method comprises freeze-drying the Myrciaria dubia fruit, mixing the freeze-dried powder with a solvent and separating and drying the supernatant. The synthetic method comprises derivatizing an ascorbic acid via nitrosylation and/or nitration in a buffered ascorbic acid solution, reducing zero or more nitro groups to an amine group, and purifying the ascorbic acid analog.