公开(公告)号：US20210371391A1

公开(公告)日：2021-12-02

申请号：US17396088

申请日：2021-08-06

申请人： DAIKIN INDUSTRIES, LTD. ,  NATIONAL UNIVERSITY CORPORATION SHIZUOKA UNIVERSITY

发明人： Atsushi SHIRAI ,  Yoshichika KUROKI ,  Nobuyuki MASE

IPC分类号： C07D317/16 ,  C07D307/10 ,  C07C31/38 ,  C08L27/12 ,  C08J3/09

摘要： An object of the present disclosure is to provide a method for producing an organic compound, and a composition. The object is achieved by a method for producing a compound represented by formula (1): wherein X represents —O—, an optionally substituted imino group, or —S—, R1 represents a hydrogen atom or a hydrocarbyl group optionally having at least one substituent, and R2 represents a hydrogen atom or a monovalent organic group, or R1 and R2, together with X and one carbon atom respectively adjacent to R1 and R2, may form a heterocyclic ring optionally having at least one substituent, R3 represents a hydrogen atom or a monovalent organic group, and R4 represents —CF2CH3 or —CH2CHF2; the method including step A of reacting a compound represented by formula (2): wherein the alphabetical symbols are as defined above, with vinylidene fluoride under light irradiation.

公开(公告)号：US06951957B2

公开(公告)日：2005-10-04

申请号：US10421924

申请日：2003-04-24

申请人： Takashi Okazoe ,  Kunio Watanabe ,  Shin Tatematsu ,  Hidenobu Murofushi

发明人： Takashi Okazoe ,  Kunio Watanabe ,  Shin Tatematsu ,  Hidenobu Murofushi

IPC分类号： C07C51/58 ,  C07B39/00 ,  C07C51/60 ,  C07C53/50 ,  C07C59/135 ,  C07C67/287 ,  C07C67/307 ,  C07C69/63 ,  C07C69/708 ,  C07D317/16 ,  C07D317/42 ,  C08F16/24

CPC分类号： C07D317/42 ,  C07B39/00 ,  C07C51/60 ,  C07C59/135 ,  C07C67/08 ,  C07C67/11 ,  C07C67/287 ,  C07C69/63 ,  C07C69/708 ,  C07C2601/14 ,  C07C53/50 ,  C07C69/734

摘要： The invention provides a process for producing a fluorine-containing compound from an inexpensive material.Namely, Compound I such as RACH2OH is reacted with Compound II such as XCORB to form Compound III such as RACH2OCORB, followed by fluorination in a liquid phase to form Compound IV such as RAFCF2OCORBF, which is converted to Compound V such as RAFCOF and/or Compound VI such as RBFCOF. RA is an alkyl group or the like, RB is a perhalogenoalkyl group or the like, RAF and RBF are fluorinated RA and RB, and X is halogen.

摘要翻译： 本发明提供从廉价材料制备含氟化合物的方法。 也就是说，将化合物I如R“CH 2 OH与化合物II如XCOR B”反应形成化合物III，例如R SUP 然后在液相中氟化以形成化合物IV，例如R AF AF＆lt; SUB＆gt;＆lt; 将其转化为化合物V，例如R AFFFF和/或化合物VI如R BF BF， 中粮 R A是烷基等，R B是全卤代烷基等，R AF和R BF， R 2是氟化的R A和R B，并且X是卤素。

公开(公告)号：US5969074A

公开(公告)日：1999-10-19

申请号：US64575

申请日：1993-05-21

申请人： William Brown Farnham ,  Mario Joseph Nappa

发明人： William Brown Farnham ,  Mario Joseph Nappa

IPC分类号： C07C43/13 ,  C07C43/17 ,  C07C43/192 ,  C07C43/247 ,  C07D323/00 ,  C07F7/18 ,  C08F20/14 ,  C08F214/18 ,  C08G65/00 ,  C08G65/336 ,  C08G65/34 ,  C08G67/00 ,  C07D317/16 ,  C07D321/00 ,  C07D319/12

CPC分类号： C07C43/17 ,  C07C43/137 ,  C07C43/192 ,  C07C43/247 ,  C07D323/00 ,  C07F7/1852 ,  C08F20/14 ,  C08F214/186 ,  C08G65/007 ,  C08G65/336 ,  C08G65/34 ,  C07C2101/04 ,  C07C2101/06

摘要： A reaction of perfluoroolefins with bis(silyl) ethers to produce novel partially fluorinated and perfluorinated copolymers and macrocyclic compounds is disclosed.

摘要翻译： 公开了全氟烯烃与双（甲硅烷基）醚的反应以产生新的部分氟化和全氟化的共聚物和大环化合物。

公开(公告)号：US5602262A

公开(公告)日：1997-02-11

申请号：US383047

申请日：1995-02-03

申请人： David D. Wirth

发明人： David D. Wirth

IPC分类号： C07D317/20 ,  C07H5/02 ,  C07H9/04 ,  C07D309/10 ,  C07D317/16

CPC分类号： C07H5/02 ,  C07D317/20 ,  C07H9/04

摘要： A process for producing intermediate compounds 2-deoxy 2,2-difluoro-.beta.-D-ribo-pentopyranose (III) from 3,3-difluoro-4,5,6-O-trihydroxy-5,6-O-(1-ethylpropylidene)hexene (I). The process of preparing intermediate compound (I) involves reacting D-glyceraldehyde pentanide with an organometallic complex of 3-bromo-3,3-difluoropropene. The process of preparing intermediate compound (III) involves ozonolysis and then hydrolysis. The intermediate compounds (I) and (III) are used in the preparation of 2'-deoxy-2',2'-difluorocytidine which is an antiviral agent.

摘要翻译： 从3,3-二氟-4,5,6-O-三羟基-5,6-O-（1）中制备中间体化合物2-脱氧的2,2-二氟-β-D-吡喃葡庚糖（III）的方法 乙基亚丙基）己烯（I）。 制备中间体化合物（I）的方法包括使D-甘油醛戊酸酯与3-溴-3,3-二氟丙烯的有机金属络合物反应。 制备中间体化合物（III）的方法包括臭氧分解，然后水解。 中间体化合物（I）和（III）用于制备作为抗病毒剂的2'-脱氧-2'，2'-二氟胞苷。

公开(公告)号：US5426247A

公开(公告)日：1995-06-20

申请号：US161509

申请日：1993-12-06

申请人： Pierre Chabardes

发明人： Pierre Chabardes

IPC分类号： C07C41/48 ,  C07C41/50 ,  C07C43/303 ,  C07C43/313 ,  C07C45/28 ,  C07C45/51 ,  C07C47/277 ,  C07C49/255 ,  C07C403/10 ,  C07C403/14 ,  C07D317/16 ,  C07D317/20 ,  C07D317/26 ,  C07D319/06 ,  C07C35/18

CPC分类号： C07C403/14 ,  C07C43/313 ,  C07C45/28 ,  C07C47/277 ,  C07D317/16 ,  C07D317/20 ,  C07D317/26 ,  C07C2101/16

摘要： A process for the preparation of vitamin A which preferably comprises bringing cyclogeranyl sulphone into contact with a C.sub.10 aldehyde acetal, halogenating the derivative obtained and then removing the halogen group and the sulphone, removing the acetal group and isomerizing the retinal obtained to the desired configuration. Also disclosed are compounds useful as intermediates in the synthesis of vitamin A and processes for preparation of these intermediate compounds.

摘要翻译： 制备维生素A的方法，其优选包括使环丙基甘油基砜与C10醛缩醛接触，卤化得到的衍生物，然后除去卤素基团和砜，除去缩醛基团并将获得的视黄醛异构化至所需的构型。 还公开了可用作合成维生素A的中间体的化合物及其制备方法。

公开(公告)号：US5266592A

公开(公告)日：1993-11-30

申请号：US862851

申请日：1992-04-03

申请人： Helmut Grub ,  Ralf Pelzer ,  Rudolf Hopp ,  Roland Emberger ,  Heinz-Jurgen Bertram

发明人： Helmut Grub ,  Ralf Pelzer ,  Rudolf Hopp ,  Roland Emberger ,  Heinz-Jurgen Bertram

IPC分类号： A61K31/335 ,  A23L27/20 ,  A61K8/49 ,  A61K31/357 ,  A61P1/02 ,  A61P17/00 ,  A61P43/00 ,  A61Q11/00 ,  A61Q19/00 ,  C07D317/12 ,  C07D317/14 ,  C07D317/16 ,  C07D317/20 ,  C07D317/28 ,  C07D317/72 ,  C07D319/04 ,  C07D319/06 ,  C07D319/08 ,  C07D319/12 ,  C07D319/14 ,  C07D321/00 ,  C07D321/06 ,  C07D321/10 ,  C09K3/00

CPC分类号： C07D319/08 ,  A23L27/2052 ,  A61K8/4973 ,  A61K8/498 ,  A61Q11/00 ,  A61Q19/00 ,  C07D317/20 ,  C07D317/72 ,  A61K2800/244 ,  Y10S514/901

摘要： Ketals, preferably glycerol ketals such as, for example, 1-menthone glycerol ketal or 3,3,5-trimethylcyclohexanone glycerol ketal, have a physiological cooling effect and are therefore suitable as active compounds in compositions which are intended to cause a sensation of freshness on human skin or mucous membrane.

摘要翻译： 优选甘油缩酮，例如1-薄荷酮甘油缩酮或3,3,5-三甲基环己酮甘油缩酮的Ketals具有生理冷却效果，因此适合作为旨在引起新鲜感的组合物中的活性化合物 在人的皮肤或粘膜上。

公开(公告)号：US5225576A

公开(公告)日：1993-07-06

申请号：US711775

申请日：1991-06-07

申请人： Walter Navarrini ,  Simonetta Fontana ,  Vittorio Montanari

发明人： Walter Navarrini ,  Simonetta Fontana ,  Vittorio Montanari

IPC分类号： C07D317/16 ,  C07D317/42

CPC分类号： C07D317/42

摘要： This invention relates to a process for preparing 1,3-dioxolanes of formula: ##STR1## wherein; X.sub.1, X.sub.2, X.sub.3 and X.sub.4, like or different from one another, represent F, Cl, Br, I, CF.sub.2 OSO.sub.2 F, SO.sub.2 F, C(O)F, H, perhaloalkyl or oxyperhaloalkyl radicals containing from 1 to 5 carbon atoms,X.sub.5 and X.sub.6, like or different from each other, represent F or CF.sub.3. Said process is characterized in that a bis(fluoroxy)perfluoroalkane is reacted, at a temperature ranging from -140.degree. C. to +60.degree. C., with a halogenated olefin.This invention also relates to new 1,3-dioxolanes of formula (I) belonging to the class defined hereinbefore.

公开(公告)号：US5198556A

公开(公告)日：1993-03-30

申请号：US746241

申请日：1991-08-15

申请人： Ming-Hong Hung ,  Shlomo Rozen

发明人： Ming-Hong Hung ,  Shlomo Rozen

IPC分类号： C07D317/16 ,  C07D317/42 ,  C07D407/14

CPC分类号： C07D407/14 ,  C07D317/16 ,  C07D317/42

摘要： The present invention concerns novel dioxolane containing fluoroepoxides that are useful as curing materials, adhesives lubricants and coatings.

公开(公告)号：US5120864A

公开(公告)日：1992-06-09

申请号：US620854

申请日：1990-12-03

申请人： Pierre F. Charbardes ,  Lucette Duhamel ,  Pierre Duhamel ,  Jerome Guillemont ,  Jean-Marie Poirier

发明人： Pierre F. Charbardes ,  Lucette Duhamel ,  Pierre Duhamel ,  Jerome Guillemont ,  Jean-Marie Poirier

IPC分类号： C07D317/12 ,  B01J27/08 ,  B01J31/02 ,  C07B61/00 ,  C07C45/59 ,  C07C47/24 ,  C07C403/14 ,  C07C403/22 ,  C07D317/16 ,  C07D317/20 ,  C07D319/06 ,  C07D325/00 ,  C07F9/655

CPC分类号： C07C403/14 ,  C07C45/59 ,  C07C47/24 ,  C07D317/20 ,  C07D319/06 ,  C07F9/65515 ,  C07C2101/16

摘要： New intermediates and processes for the preparation of vitamins A and E, which are the acetals of 5,6-dihalo-3-methyl-3-hydroxyhexanal or of 6-halo-3-hydroxy-3-methyl-5-hexenal or 3-methyl-3-hydroxy-5-hexenal, as well as processes for making the intermediates. After dehydrohalogenation and dehydration these intermediates are condensed directly with .beta.-ionone or with 2-methyl-2-heptene-6-one to synthesize vitamins A and E respectively.

摘要翻译： 用于制备维生素A和E的新中间体和方法，其为5,6-二卤代-3-甲基-3-羟基己醛或6-卤代-3-羟基-3-甲基-5-己烯醛或3 3-甲基-3-羟基-5-己烯醛，以及制备中间体的方法。 在脱卤化氢和脱水后，这些中间体直接与β-戊酮或2-甲基-2-庚烯-6-酮缩合以分别合成维生素A和E。

公开(公告)号：US5116402A

公开(公告)日：1992-05-26

申请号：US333737

申请日：1989-03-31

申请人： Ferenc Dutka ,  Tamas Komives ,  Katalin Fodor, nee Csorba ,  Attila Marton ,  Aniko Csikos, nee Gluck ,  Eva Osztheimer ,  Karoly Henger ,  Robert Laborczy ,  Zsuzsanna Reti, nee Bosnyak ,  Dezso Sebok ,  Jozsef Szabolcs ,  Elemer Tomordi

发明人： Ferenc Dutka ,  Tamas Komives ,  Katalin Fodor, nee Csorba ,  Attila Marton ,  Aniko Csikos, nee Gluck ,  Eva Osztheimer ,  Karoly Henger ,  Robert Laborczy ,  Zsuzsanna Reti, nee Bosnyak ,  Dezso Sebok ,  Jozsef Szabolcs ,  Elemer Tomordi

IPC分类号： A01N47/10 ,  A01C1/06 ,  A01N25/32 ,  A01N35/00 ,  A01N35/02 ,  A01N37/42 ,  A01N43/08 ,  A01N43/24 ,  A01N43/48 ,  A01N43/74 ,  A01N47/12 ,  A01N47/28 ,  A01P13/00 ,  C07C43/313 ,  C07C43/315 ,  C07C43/317 ,  C07D233/02 ,  C07D235/10 ,  C07D239/04 ,  C07D263/04 ,  C07D307/46 ,  C07D317/16 ,  C07D317/20 ,  C07D319/06 ,  C07D321/06 ,  C07D327/04 ,  C07H9/04 ,  C09K17/00

CPC分类号： C07D263/04 ,  A01N25/32 ,  C07C323/00 ,  C07C43/313 ,  C07C43/315 ,  C07C43/317 ,  C07D233/02 ,  C07D235/10 ,  C07D239/04 ,  C07D307/46 ,  C07D317/16 ,  C07D317/20 ,  C07D319/06 ,  C07D321/06 ,  C07D327/04 ,  C07H9/04

摘要： The invention relates to a herbicidal composition which contains, besides binding, wetting, dispersing, emulsifying agents, solvents and/or surface-active substances, herbicides as active agent of thiocarbamate, carbamate, acid amide or urea type alone or in a combination, furthermore as antidote a compound of the general formula I ##STR1## wherein R.sup.1 and R.sup.2, independently of each other, are hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.1-4 cyanoalkyl, C.sub.1-6 haloalkyl, phenyl-C.sub.1-4 -haloalkyl, phenyl, halogenphenyl, C.sub.1-4 -alkyl-phenyl, C.sub.1-4 -alkoxyphenyl, furfuryl;R.sup.3 and R.sup.4, independently of each other, are hydrogen, C.sub.1-18 -alkyl, C.sub.2-4 -haloalkyl, C.sub.2-4 -cyanoalkyl, C.sub.1-4 -alkoxy-C.sub.2-4 -alkyl, C.sub.5-6 -cycloalkyl, phenyl-C.sub.1-4 -alkyl, C.sub.3-4 -alkenyl, phenyl-C.sub.3-4 -alkenyl, di-C.sub.1-4 -alkylamino-C.sub.2-4 -alkyl, hydroxy-C.sub.2-6 -alkyl, furfuryl, tetrahydrofurfuryl, C.sub.1-4 -alkoxy-C.sub.2-4 -alkoxy-C.sub.2-4 -alkyl;R.sup.3 and R.sup.4, together, are C.sub.2-4 -alkylene, C.sub.4 -alkenylene, glucofuranosylene, acetoxy-C.sub.3 -alkylene, C.sub.1-4 -alkoxy-C.sub.3 -alkylene, hydroxy-C.sub.3 -alkylene, halogen-C.sub.3 -alkylene; wherein the quantity of the antidote lies between 0.01 and 15 parts by weight referred to 1 part by weight of herbicidal agent, furthermore the composition contains altogether 0.1 to 95 percent by weight of the herbicidal agents and the antidote.

摘要翻译： 本发明涉及一种除草剂除了结合之外还含有除了作为硫代氨基甲酸酯，氨基甲酸酯，酰胺或尿素的单独或组合的活性剂之外的其它润湿剂，分散剂，乳化剂，溶剂和/或表面活性物质，除此之外 作为解毒剂，通式I的化合物其中R 1和R 2彼此独立地为氢，C 1-6烷基，C 2-6烯基，C 1-4氰基烷基，C 1-6卤代烷基，苯基-C 1-4 - 卤代烷基， 苯基，卤素苯基，C 1-4 - 烷基 - 苯基，C 1-4烷氧基苯基，糠基; R 3和R 4彼此独立地是氢，C 1-18 - 烷基，C 2-4 - 卤代烷基，C 2-4 - 氰基烷基，C 1-4 - 烷氧基-C 2-4 - 烷基，C 5-6 - 环烷基， C 1-4 - 烷基，C 3-8 - 烯基，苯基-C 3-4 - 烯基，二-C 1-4 - 烷基氨基-C 2-4 - 烷基，羟基-C 2-6 - 烷基，糠基，四氢糠基， 烷氧基-C 2-4的烷氧基-C 2-4的烷基; R 3和R 4一起是C 2-4亚烷基，C 4 - 亚烯基，呋喃糖基，乙酰氧基-C 3 - 亚烷基，C 1-4 - 烷氧基-C 3 - 亚烷基，羟基-C 3 - 亚烷基，卤素-C 3 - 亚烷基; 其中解毒剂的量介于0.01至15重量份之间，称为除草剂1重量份，此外该组合物含有除草剂和解毒剂重量的0.1-95重量％。