公开(公告)号：US11629165B2

公开(公告)日：2023-04-18

申请号：US17259088

申请日：2019-07-08

申请人： Immagina Biotechnology S.r.l.

发明人： Massimiliano Clamer ,  Luca Minati

IPC分类号： C07H19/16 ,  G01N33/68 ,  C07D473/34

摘要： Molecule having the structural formula (I): (I) for use as targeting probe of translating ribosomes and ribosome-interacting proteins.

公开(公告)号：US20220411425A1

公开(公告)日：2022-12-29

申请号：US17335145

申请日：2021-06-01

申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED ,  VIIV HEALTHCARE COMPANY

发明人： Martha Alicia DE LA ROSA ,  John F. MILLER ,  B. Narasimhulu NAIDU ,  Vicente SAMANO ,  David TEMELKOFF ,  Emile Johann VELTHUISEN

IPC分类号： C07D473/34 ,  A61K9/00 ,  A61K45/06

摘要： The invention relates to a compound having the structure: or a pharmaceutically acceptable salt thereof, along with pharmaceutical compositions and therapeutic methods thereof.

公开(公告)号：US11446306B2

公开(公告)日：2022-09-20

申请号：US16940785

申请日：2020-07-28

申请人： ZENITH EPIGENETICS LTD.

发明人： John Frederick Quinn ,  Bryan Cordell Duffy ,  Shuang Liu ,  Ruifang Wang ,  May Xiaowu Jiang ,  Gregory Scott Martin ,  Gregory Steven Wagner ,  Peter Ronald Young

IPC分类号： A61K31/5377 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/517 ,  A61K31/52 ,  A61K45/06 ,  C07D413/04 ,  C07D471/04 ,  C07D473/34 ,  A61P1/16 ,  A61P11/00 ,  A61P1/00 ,  A61P1/02 ,  A61P1/04 ,  A61P1/18 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P3/12 ,  A61P5/14 ,  A61P5/50 ,  A61P7/04 ,  A61P7/06 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/14 ,  A61P11/02 ,  A61P11/16 ,  A61P13/10 ,  A61P13/12 ,  A61P15/16 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P19/06 ,  A61P19/08 ,  A61P21/00 ,  A61P21/04 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P27/02 ,  A61P27/04 ,  A61P27/16 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P31/14 ,  A61P31/18 ,  A61P31/20 ,  A61P35/00 ,  A61P35/02 ,  A61P37/00 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00

摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.

公开(公告)号：US11420970B1

公开(公告)日：2022-08-23

申请号：US17327226

申请日：2021-05-21

申请人： NOVARTIS AG

发明人： Haibing Deng ,  Jinbiao Liu ,  Counde Oyang ,  Ce Wang ,  Qitao Xiao ,  Guoliang Xun ,  Haiqiang Zeng

IPC分类号： C07D473/34

摘要： The present invention provides a compound of Formula (I): or an enantiomer, an enantiomeric mixture, or a pharmaceutically acceptable salt thereof; wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating a disease or condition mediated by nuclear SET domain-containing protein 2 (NSD2).

公开(公告)号：US20220235052A1

公开(公告)日：2022-07-28

申请号：US17460922

申请日：2021-08-30

申请人： JANSSEN SCIENCES IRELAND UNLIMITED COMPANY

发明人： Jean-François BONFANTI ,  Frédéric Marc Maurice DOUBLET ,  Werner EMBRECHTS ,  Jérôme Michel Claude FORTIN ,  David Craig MC GOWAN ,  Philippe MULLER ,  Pierre Jean-Marie Bernard RABOISSON

IPC分类号： C07D473/34 ,  C07D519/00 ,  C07D473/16 ,  C07F9/6561

摘要： The present invention relates to purine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

公开(公告)号：US20220177474A1

公开(公告)日：2022-06-09

申请号：US17679627

申请日：2022-02-24

申请人： ONO PHARMACEUTICAL CO., LTD.

发明人： Shingo YAMAMOTO ,  Toshio YOSHIZAWA

IPC分类号： C07D473/34 ,  A61K31/522 ,  C07D473/00

摘要： The purinone derivative 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride has Btk-selective inhibitory activity and, in addition to having excellent metabolic stability, it is a compound that exhibits a high level of solubility and absorption with respect to the free base and can be crystallized, hence it can serve as a therapeutic agent for diseases involving B cells and mast cells.

公开(公告)号：US20220135584A1

公开(公告)日：2022-05-05

申请号：US17310930

申请日：2020-03-02

申请人： Revolution Medicines, Inc.

发明人： Andreas BUCKL ,  James Joseph CREGG ,  Naing AAY ,  Arlyn A. TAMBO-ONG ,  Elena S. KOLTUN ,  Adrian Liam GILL ,  Severin THOMPSON ,  Micah J Gliedt

IPC分类号： C07D495/04 ,  C07D487/04 ,  C07D471/04 ,  C07D473/34

摘要： The present disclosure is directed to modulators of SOS1 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

公开(公告)号：US20220135573A1

公开(公告)日：2022-05-05

申请号：US17574132

申请日：2022-01-12

申请人： Dana-Farber Cancer Institute, Inc. ,  The Scripps Research Institute

发明人： Nathanael S. GRAY ,  Jianming ZHANG ,  Barun OKRAM ,  Xianming DENG ,  Jae Won CHANG ,  Amy WOJCIECHOWSKI

IPC分类号： C07D487/04 ,  A61K31/517 ,  C07D471/04 ,  C07D239/42 ,  C07D403/06 ,  A61K31/519 ,  A61P35/02 ,  C07D473/34 ,  C07D495/04 ,  A61P35/00 ,  A61K45/06 ,  A61P17/00 ,  A61K31/7076 ,  C07D403/12 ,  C07D239/94 ,  C07D403/04 ,  A61P19/00 ,  A61K31/52 ,  A61K31/5377 ,  C07H19/16 ,  A61P9/00 ,  C07D417/04

摘要： The present disclosure provides novel heteroaryl compounds of formula (VII). Such compounds are useful for the treatment of cancers.

公开(公告)号：US20220127301A1

公开(公告)日：2022-04-28

申请号：US17465238

申请日：2021-09-02

申请人： WAVE LIFE SCIENCES LTD.

发明人： Mamoru Shimizu ,  Takeshi Wada

IPC分类号： C07H23/00 ,  C07D405/04 ,  C07D473/18 ,  C07D473/34 ,  C07B53/00 ,  C07H19/11 ,  C07H19/213 ,  C07H21/04 ,  C07D207/08 ,  C07F7/08 ,  C07H1/00 ,  C07H19/10 ,  C07H19/207

摘要： To provide a chiral reagent or a salt thereof.
The chiral reagent has following chemical formula (I). In the formula (I), G1 and G2 are independently a hydrogen atom, a nitro group (—NO2), a halogen atom, a cyano group (—CN), a group of formula (II) or (III), or both G1 and G2 taken together to form a group of formula (IV).

公开(公告)号：US11312718B2

公开(公告)日：2022-04-26

申请号：US16734135

申请日：2020-01-03

申请人： Infinity Pharmaceuticals, Inc.

发明人： Pingda Ren ,  Michael Martin ,  Paul Isbester ,  Benjamin S. Lane ,  Jason Kropp

IPC分类号： C07D473/34 ,  A61K31/52 ,  A61P35/00 ,  A61P37/00 ,  A61P11/06 ,  A61P29/00

摘要： Polymorphs of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein. Also provided herein are processes for preparing compounds, polymorphs thereof, and pharmaceutical compositions thereof.