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公开(公告)号:US11639351B2
公开(公告)日:2023-05-02
申请号:US17183401
申请日:2021-02-24
发明人: Jean-Christophe Andrez , Kristen Nicole Burford , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Qi Jia , Verner Alexander Lofstrand , Shaoyi Sun , Steven Sigmund Wesolowski , Michael Scott Wilson , Alla Yurevna Zenova
IPC分类号: A61K31/4436 , A61K31/444 , C07D417/14 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/08
摘要: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.
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公开(公告)号:US11638706B2
公开(公告)日:2023-05-02
申请号:US17093194
申请日:2020-11-09
发明人: Suresh Babu , Anuradha Bhattacharyya , Seongwoo Hwang , Minakshi Jani , Young-choon Moon , Nadiya Sydorenko
IPC分类号: C07D417/14 , A61K31/4468 , A61K31/506 , A61K31/433 , C07D403/14 , C07D405/14 , C07D401/12 , C07D417/04 , C07D487/04 , C07D401/04 , C07D409/14 , C07D487/10 , C07D237/20 , C07D471/10 , C07D413/14 , C07D487/08 , C07D405/12 , C07D403/10 , C07D471/08 , C07D403/12 , C07D417/10 , C07D401/14 , C07D417/12 , A61K31/50 , A61K31/415 , A61P25/28 , A61K31/4439 , A61K31/4709 , A61K31/501 , A61K31/517 , A61K31/5377 , A61K31/5513 , G01N33/68
摘要: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号:US20230126252A1
公开(公告)日:2023-04-27
申请号:US18048079
申请日:2022-10-20
发明人: Alex J. Buckmelter , Justin Andrew Caravella , Hongbin Li , Matthew W. Martin , Steven Mischke , David James Richard , Angela V. West
IPC分类号: C07D471/18 , C07D403/12 , C07D471/08 , C07D487/08 , C07D487/18 , C07D491/107
摘要: The disclosure relates to USP30 Inhibitor Compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, and medical uses involving same.
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公开(公告)号:US20230115836A1
公开(公告)日:2023-04-13
申请号:US17817865
申请日:2022-08-05
IPC分类号: C07D403/04 , C07D233/90 , C07D403/14 , A61P13/12 , A61P11/00 , C07D487/08
摘要: The disclosure provides TNIK and/or MAP4K4 kinases inhibitors for the treatment of disease. In one aspect, disclosed herein are kinase inhibitors having a structure of Formula (A), (A*), (I), (IIA), or (IIB). Further described herein are pharmaceutical composition comprising these compounds and methods of using these compounds. In one aspect, disclosed herein are methods of treating a disease or condition by administering the kinases inhibitors described herein.
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公开(公告)号:US20230100516A1
公开(公告)日:2023-03-30
申请号:US17934625
申请日:2022-09-23
发明人: Christian Andreas Kuttruff , Tom Bretschneider , Cédrickx Godbout , Hannes Fiepko Koolman , Domnic Martyres , Gerald Juergen Roth
IPC分类号: C07D401/14 , C07D405/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , A61P11/00 , A61K31/501
摘要: The present invention relates to novel pyridazines, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of diseases and disorders mediated by Autotaxin.
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公开(公告)号:US20230079045A1
公开(公告)日:2023-03-16
申请号:US17636977
申请日:2020-08-24
发明人: Yao Li , Lei Chen , Guobiao Zhang , Wenjing Wang , Zongjun Shi , Gang Hu , Haitao Huang , Haodong Wang , Bo Xu , Xiaobo Zhang , Guoliang LIU , Dengyu Zheng , Shilin Huang , Jianfei Zhao , Changwei Song , Chen Zhang , Fei Ye , Jia Ni , Pangke Yan
IPC分类号: C07D413/14 , C07D451/02 , C07D487/08 , C07D471/10 , C07D487/10 , C07D471/08 , C07D401/14 , C07D417/14 , C07D405/14 , A61P31/16
摘要: Provided are a compound of formula (I-a), an isomer thereof or a pharmaceutically acceptable salt thereof as a Hemagglutinin inhibitor, and a preparation method thereof. The compound is useful for preparing a medicament for treating a disease related to Hemagglutinin.
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公开(公告)号:US20230075198A1
公开(公告)日:2023-03-09
申请号:US17268151
申请日:2019-08-14
申请人: EPIZYME, INC.
发明人: John LAMPE , John CAMPBELL , Kenneth DUNCAN , Megan Alene Cloonan FOLEY , Darren Martin HARVEY , Michael John MUNCHHOF , Michael THOMENIUS , Lawrence Alan REITER
IPC分类号: C07D403/12 , C07D487/04 , C07D401/12 , C07D471/10 , C07D471/04 , C07D403/14 , C07D413/12 , C07D209/08 , C07D413/14 , C07D487/08 , C07D471/08 , C07D491/107 , C07D405/12 , C07D417/12 , C07D409/12 , C07D498/10 , C07D487/10 , C07D513/10 , C07D401/14 , C07D491/08 , C07D417/14 , C07D498/08 , A61P35/00
摘要: The present disclosure provides substituted indole compounds of Formula I: (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R1a, R1e, G1, G2, Q1, Q2, Q3, and (II) are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disease, disorder, or condition such as cancer in a subject.
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公开(公告)号:US20230072658A1
公开(公告)日:2023-03-09
申请号:US17596488
申请日:2020-06-10
发明人: Nan JI , Yi ZHANG , Matthew M. WEISS , Paul R. Fleming
IPC分类号: C07D487/08 , C07D401/14 , C07D413/14 , C07D417/14 , C07D237/20 , C07D403/04 , C07D471/10
摘要: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same for the modulation of one or more SWI/SNF-related matrix associated actin dependent regulator of chromatin subfamily A (SMARCA) and/or polybromo-1 (PB-1) protein via ubiquitination and/or degradation by compounds. The compounds are bifunctional molecules that link a cereblon-binding moiety to a ligand that binds SMARCA and/or PB1 proteins.
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公开(公告)号:US11591344B2
公开(公告)日:2023-02-28
申请号:US17043348
申请日:2019-03-29
发明人: Kenji Uchida , Ryohei Kawai , Keisuke Yamamoto , Toshimi Kanai , Hideo Ikota , Takashi Imaeda , Kei Yoshida
IPC分类号: C07D215/44 , C07D215/46 , C07D401/12 , C07D487/04 , C07D487/08 , C07D495/14 , C07D519/00 , A61K31/4709 , A61K31/4985 , A61K31/551 , A61P35/00 , C07D209/08 , C07D261/08
摘要: A compound having anticancer activity, or a pharmaceutically acceptable salt thereof is provided. Used is a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: (wherein, L1 and L2 are the same or different and each represents a group represented by one formula selected from the group consisting of formulas (A) to (F), and S represents a group represented by one formula selected from the group consisting of formulas (S1) to (S18)).
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公开(公告)号:US20230059865A1
公开(公告)日:2023-02-23
申请号:US17502824
申请日:2021-10-15
发明人: MICHAEL LUZZIO , Kathleen MCCARTHY , William HANEY
IPC分类号: C12N15/113 , C07D401/14 , C07D491/08 , C07D451/04 , C07D471/04 , C07D471/10 , C07D487/08 , C07D471/08 , C07D451/14 , C07D403/14 , C07D451/02
摘要: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
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