公开(公告)号：US20250042891A1

公开(公告)日：2025-02-06

申请号：US18460207

申请日：2023-09-01

Applicant: SHANGHAI YINGLI PHARMACEUTICAL CO., LTD

Inventor： Zusheng XU ,  Yangtong LOU ,  Tiegang XIE ,  Linlin XU ,  Li CHEN ,  Yanhang LIU ,  Qingrui SUN

IPC: C07D417/04 ,  A61P35/00 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/044 ,  C07F9/24

Abstract: Disclosed is a compound containing structure of a heteroaromatic ring, pharmaceutical composition thereof and application thereof. The present disclosure provides a compound containing structure of a heteroaromatic ring represented by formula I, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, an isomer thereof or an isotopic compound thereof. The compound containing structure of a heteroaromatic ring is expected to treat and/or prevent various PARG-related diseases.

公开(公告)号：US20240368176A1

公开(公告)日：2024-11-07

申请号：US18647107

申请日：2024-04-26

Applicant: Enanta Pharmaceuticals, Inc.

Inventor： Adam SZYMANIAK ,  Kevin McGRATH ,  Jianming YU ,  Tyler J. MANN ,  Long NGUYEN ,  Kaicheng ZHU ,  In Jong KIM ,  Yat Sun OR

IPC: C07D491/052 ,  C07D471/04 ,  C07D491/044 ,  C07D491/048

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US12071403B2

公开(公告)日：2024-08-27

申请号：US18462578

申请日：2023-09-07

Applicant: Boehringer Ingelheim International GmbH

Inventor： Kai Gerlach ,  Christian Eickmeier ,  Jan Magnus Kriegl ,  Lothar Kussmaul ,  Klaus Rudolf ,  Bernhard Schmid

IPC: C07D207/38 ,  C07D403/04 ,  C07D471/08 ,  C07D491/044 ,  C07D498/10

CPC classification number: C07D207/38 ,  C07D403/04 ,  C07D471/08 ,  C07D491/044 ,  C07D498/10

Abstract: The present invention describes compounds modulating the function of mitochondrial complex I (NADH-quinone oxidoreductase) having formula (I)

公开(公告)号：US20240245658A1

公开(公告)日：2024-07-25

申请号：US18285975

申请日：2022-04-08

Applicant: Sunovion Pharmaceuticals Inc.

Inventor： Kevin Julian Hodgetts ,  Linghong Xie

IPC: A61K31/4353 ,  A61K31/335 ,  A61K45/06 ,  C07D313/12 ,  C07D491/044

CPC classification number: A61K31/4353 ,  A61K31/335 ,  A61K45/06 ,  C07D313/12 ,  C07D491/044

Abstract: Provided herein is a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., R1, R2, X1, X2, Y1, Y2, Y3, Y4, Y5, Y6, Y7, and Y8) are as disclosed herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of using the compounds, pharmaceutically acceptable salts thereof and pharmaceutical compositions of the foregoing, e.g., to treat a neurological or psychiatric disease or disorder.

公开(公告)号：US20240189287A1

公开(公告)日：2024-06-13

申请号：US18549193

申请日：2022-03-10

Applicant: BIONANOSIM (BNS) LTD

Inventor： Simon BENITA ,  Joseph TAM ,  Taher NASSAR ,  Noam FREEMAN

IPC: A61K31/4196 ,  A61K31/4162 ,  A61K31/4178 ,  A61K31/4406 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/506 ,  A61P3/04 ,  C07D491/044

CPC classification number: A61K31/4196 ,  A61K31/4162 ,  A61K31/4178 ,  A61K31/4406 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/506 ,  A61P3/04 ,  C07D491/044

Abstract: Provided is a class of compounds generally referred to as peripherally restricted CB1 receptor blockers. Further provided are the structural and functional properties of these compounds, and their specific applications to various clinical disorders and subclinical conditions.

公开(公告)号：US12006326B2

公开(公告)日：2024-06-11

申请号：US17894412

申请日：2022-08-24

Applicant: Enanta Pharmaceuticals, Inc.

Inventor： Adam Szymaniak ,  Kevin McGrath ,  Jianming Yu ,  Tyler Mann ,  Long Nguyen ,  Kaicheng Zhu ,  In Jong Kim ,  Yat Sun Or

IPC: C07D491/052 ,  C07D471/04 ,  C07D491/044 ,  C07D491/048

CPC classification number: C07D491/052 ,  C07D471/04 ,  C07D491/044 ,  C07D491/048

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof:




which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US20240172752A1

公开(公告)日：2024-05-30

申请号：US18280604

申请日：2022-03-10

Applicant: Nippon Soda Co., Ltd.

Inventor： Ken MIHARA ,  Yoji IKEDA ,  Humberto Mitio HORIKOSHI ,  Kazushige KATO ,  Jun INAGAKI ,  Masahiro HORI ,  Hirotaka SUGIYAMA

IPC: A01N43/90 ,  A01P13/00 ,  C07D491/044 ,  C07D519/00

CPC classification number: A01N43/90 ,  A01P13/00 ,  C07D491/044 ,  C07D519/00

Abstract: A compound represented by a formula (I) or a salt thereof; and a herbicide containing at least one selected from them as an active ingredient:




wherein R1 represents a substituted or unsubstituted C1-6 alkyl group or the like, R2 represents a substituted or unsubstituted C1-6 alkyl group or the like, R3 represents a hydrogen atom, a substituted or unsubstituted C1-6 alkyl group or the like, and Q represents a substituted or unsubstituted 5- to 10-membered heterocyclyl group.

公开(公告)号：US11970504B1

公开(公告)日：2024-04-30

申请号：US18386560

申请日：2023-11-02

Applicant: KING FAISAL UNIVERSITY

Inventor： Hany Mohamed Abd El-Lateef Ahmed ,  Mai Mostafa Khalaf Ali ,  Antar Ahmed Abdelhamid Ahmed

IPC: A61K31/365 ,  A61P31/04 ,  A61P31/10 ,  C07D491/044

CPC classification number: C07D491/044 ,  A61K31/365 ,  A61P31/04 ,  A61P31/10

Abstract: An 2-benzo-[3,4-b]quinolino-[b,g]indeno[1′,2′:3,4]fluoreno-[1,2-d]oxonine-5,11,16,21-tetraone compound, its synthesis, and its use as an antimicrobial agent.

公开(公告)号：US11958830B2

公开(公告)日：2024-04-16

申请号：US17215313

申请日：2021-03-29

Applicant: WESTLAKE PHARMACEUTICALS (HANGZHOU) CO., LTD.

Inventor： Hongtao Yu ,  Qi Hu ,  Jing Huang ,  Tingliang Wang ,  Ningke Hou ,  Lijing Zhang ,  Wenyi Zhang ,  Qiaozhu Tan

IPC: C07D401/06 ,  C07D217/26 ,  C07D401/12 ,  C07D471/10 ,  C07D491/044

CPC classification number: C07D401/06 ,  C07D217/26 ,  C07D401/12 ,  C07D471/10 ,  C07D491/044

Abstract: The disclosure provides at compounds of Formula I, compositions comprising the same, and methods of using the same, including use in treating a disease and/or a symptom of a disease caused by a coronavirus.

公开(公告)号：US11923508B2

公开(公告)日：2024-03-05

申请号：US18349264

申请日：2023-07-10

Applicant: SK On Co., Ltd. ,  SK Innovation Co., Ltd.

Inventor： Ki Sung Park ,  Myoung Lae Kim

IPC: H01M10/0567 ,  C07D491/044 ,  C07F9/6571 ,  H01M10/052 ,  H01M10/0569

CPC classification number: H01M10/0567 ,  C07D491/044 ,  C07F9/657163 ,  H01M10/052 ,  H01M10/0569 ,  H01M2300/004

Abstract: Provided is an electrolyte solution for a lithium secondary battery and a lithium secondary battery including the electrolyte solution. The electrolyte solution includes an additive represented by a specific chemical formula, an organic solvent and a lithium salt. The lithium secondary battery including the electrolyte solution provide enhanced high-temperature properties.