公开(公告)号：US20240060128A1

公开(公告)日：2024-02-22

申请号：US18361434

申请日：2023-07-28

Applicant: IsoPlexis Corporation

Inventor： Steven GORDON ,  Jerzy OLEJNIK

IPC: C12Q1/6869 ,  C07H19/00 ,  C12Q1/6874 ,  G01N21/05 ,  G01N21/64

CPC classification number: C12Q1/6869 ,  C07H19/00 ,  C12Q1/6874 ,  G01N21/05 ,  G01N21/6428 ,  G01N21/645 ,  C12Q2535/101 ,  G01N2021/0346 ,  G01N2021/058 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6471

Abstract: The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.

公开(公告)号：US20230407384A1

公开(公告)日：2023-12-21

申请号：US18325668

申请日：2023-05-30

Applicant: IsoPlexis Corporation

Inventor： Steven GORDON ,  Jerzy OLEJNIK

IPC: C12Q1/6869 ,  G01N21/64 ,  C12Q1/6874 ,  C07H19/00 ,  G01N21/05 ,  G01N21/03

CPC classification number: C12Q1/6869 ,  G01N21/6428 ,  C12Q1/6874 ,  G01N21/645 ,  C07H19/00 ,  G01N21/05 ,  G01N2201/062 ,  G01N2201/0627 ,  G01N2021/058 ,  G01N2021/6421 ,  G01N2021/0346 ,  G01N2201/12 ,  G01N2021/6417 ,  G01N2021/6471 ,  C12Q2535/101 ,  G01N2021/6441 ,  G01N2021/6439 ,  G01N2021/6419

Abstract: The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.

公开(公告)号：US20230348519A1

公开(公告)日：2023-11-02

申请号：US18099477

申请日：2023-01-20

Applicant: Gilead Sciences, Inc.

Inventor： Katrien Brak ,  Ernest A. Carra ,  Lars V. Heumann ,  Nate Larson

IPC: C07H19/00 ,  A61P31/14 ,  C07F9/6561

CPC classification number: C07H19/00 ,  A61P31/14 ,  C07F9/6561 ,  C07B2200/13

Abstract: The present invention relates to novel salts and crystalline forms of (S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate for use in treating viral infections. In some embodiments, the viral infection is caused by a virus selected from the group consisting of Arenaviridae, Coronaviridae, Filoviridae, Flaviviridae, and Paramyxoviridae.

公开(公告)号：US11466097B2

公开(公告)日：2022-10-11

申请号：US15766674

申请日：2016-10-06

Applicant: City of Hope

Inventor： Saul J. Priceman ,  Christine E. Brown ,  Stephen J. Forman

IPC: A61P35/00 ,  C07K16/30 ,  A61P35/04 ,  A61K35/17 ,  C07K14/725 ,  C07K14/73 ,  C07K14/705 ,  C12N5/0783 ,  C07H21/00 ,  C07H21/04 ,  C12N15/63 ,  C12N15/11 ,  C12N15/00 ,  C12N15/10 ,  C12N5/00 ,  C12N15/09 ,  C12N15/79 ,  C12N15/70 ,  C12N15/62 ,  C12N15/85 ,  C12N15/74 ,  C12N5/078 ,  C12N5/071 ,  A61P19/08 ,  A61K48/00 ,  A61P1/18 ,  C12N5/07 ,  C12N5/10 ,  C07H19/06 ,  C07H19/00 ,  C07H19/16

Abstract: Chimeric transmembrane immunoreceptors (CAR) targeted to PSCA are described.

公开(公告)号：US11180524B2

公开(公告)日：2021-11-23

申请号：US16647236

申请日：2018-09-14

Applicant: Janssen BioPharma, Inc.

Inventor： Sergei Gryaznov ,  Jin Hong ,  Vivek Kumar Rajwanshi ,  Leonid Beigelman

IPC: C07H19/10 ,  C07H19/00 ,  C07H19/20 ,  C07H1/00

Abstract: The present disclosure relates to compounds and compositions containing 5′-phosphoramidite nucleoside monomers of formulae (I) and (II), and methods of making and use, wherein the substituents are as defined in the appended claims.

公开(公告)号：US20210179656A1

公开(公告)日：2021-06-17

申请号：US17178151

申请日：2021-02-17

Applicant: Janssen BioPharma, Inc.

Inventor： Leonid BEIGELMAN ,  Guangyi WANG ,  David Bernard SMITH ,  Jerome DEVAL ,  Marija PRHAVC

IPC: C07H19/06 ,  C07H19/207 ,  C07H19/16 ,  A61P31/16 ,  A61K45/06 ,  C07D405/04 ,  C07D405/14 ,  C07D473/18 ,  C07D473/34 ,  C07D487/04 ,  C07D493/04 ,  C07H19/00 ,  C07H19/14 ,  C12N9/12 ,  C07H19/10 ,  C07H19/12 ,  C07H19/20

Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.

公开(公告)号：US11034740B2

公开(公告)日：2021-06-15

申请号：US16778043

申请日：2020-01-31

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services

Inventor： Jeffrey Schlom ,  Claudia M. Palena

IPC: C07H19/00 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C07K14/47 ,  A61K39/00 ,  A61P35/00 ,  A61K9/127 ,  A61K38/17 ,  A61K38/19 ,  A61K45/06 ,  C12N15/86

Abstract: The invention provides Brachyury deletion mutant polypeptides, nucleic acids encoding the polypeptides, non-yeast vectors comprising the nucleic acids, non-yeast cells, and methods of use.

公开(公告)号：US20210139976A1

公开(公告)日：2021-05-13

申请号：US16980708

申请日：2019-03-14

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Jingyue Ju ,  Xiaoxu Li ,  Shiv Kumar ,  Xin Chen ,  James J. Russo ,  Minchen Chien ,  Steffen Jockusch ,  Chuanjuan Tao ,  Xuanting Wang ,  Sergey Kalachikov ,  Irina Morozova ,  Shundi Shi

IPC: C12Q1/6874 ,  C12Q1/6876 ,  C07H21/04 ,  C07H19/00

Abstract: The invention provides various orthogonal nucleotide analogues and methods for using combinations of said various orthogonal nucleotide analogues for sequencing by synthesis.

公开(公告)号：US10947312B2

公开(公告)日：2021-03-16

申请号：US16542013

申请日：2019-08-15

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Susan D. Croll ,  Lynn Macdonald ,  Andrew J. Murphy

IPC: A61K39/395 ,  A61K39/00 ,  C12P21/08 ,  C12N15/00 ,  C12N15/09 ,  C12N15/10 ,  C07H21/04 ,  C07H21/00 ,  C07H19/00 ,  C12P21/00 ,  C12P21/02 ,  C07K16/28 ,  A61K45/06

Abstract: The present invention provides antibodies that bind to human GFRα3 and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human GFRα3. The antibodies of the invention are useful for the treatment of diseases and disorders associated with one or more GFRα3 biological activities, including the treatment of acute or chronic pain conditions, or inflammatory conditions.

公开(公告)号：US10781483B2

公开(公告)日：2020-09-22

申请号：US15357966

申请日：2016-11-21

Applicant: Pacific Biosciences of California, Inc.

Inventor： Lubomir Sebo ,  Gene Shen ,  Stephen Yue ,  Honey Osuna ,  Yuri Lapin ,  Louis Brogley ,  Andrei Fedorov

IPC: C07H19/00 ,  C12Q1/68 ,  C12Q1/6869 ,  C07H19/10 ,  C07H19/207 ,  C09B69/10 ,  C07K19/00

Abstract: Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided. The analogs are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The analogs are detectable with high sensitivity at desirable wavelengths. They contain structural components that modulate the interactions of the analogs with DNA polymerase, thus decreasing photodamage and improving the kinetic and other properties of the analogs in sequencing reactions. Also provided are nucleotide and dye-labeled compounds of the subject analogs, as well as intermediates useful in the preparation of the compounds and analogs. Compositions comprising the compounds, methods of synthesis of the intermediates, compounds, and analogs, and mutant DNA polymerases are also provided.