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公开(公告)号：US12071662B2
公开(公告)日：2024-08-27
申请号：US18313227
申请日：2023-05-05
发明人： Elena Cressina , Antoine Francais , Xiaohai Liu
IPC分类号： C12Q1/68 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C07H21/00 , C07H21/04 , C12Q1/6809 , C12Q1/6816 , C12Q1/6869
CPC分类号： C12Q1/6869 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C07H21/00 , C07H21/04 , C12Q1/6809 , C12Q1/6816 , C12Q1/6869 , C12Q2525/117 , C12Q2535/122
摘要： The present disclosure relates to new nucleotide and oligonucleotide compounds and their use in nucleic acid sequencing applications.
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公开(公告)号：US20240174709A1
公开(公告)日：2024-05-30
申请号：US18522886
申请日：2023-11-29
发明人： Ronald Graham , Olga Adelfinskaya , Megha Cila , Rodrigo Rodriguez , Abrehet Abdu , Eli N. Glezer
IPC分类号： C07H19/14 , C07H19/10 , C07H19/20 , C12Q1/6869 , C12Q1/6876
CPC分类号： C07H19/14 , C07H19/10 , C07H19/20 , C12Q1/6869 , C12Q1/6876
摘要： Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
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公开(公告)号：US11958877B2
公开(公告)日：2024-04-16
申请号：US18178802
申请日：2023-03-06
发明人： Ronald Graham , Olga Adelfinskaya , Megha Cila , Rodrigo Rodriguez , Abrehet Abdu , Eli N. Glezer
IPC分类号： C07H19/14 , C07H19/10 , C07H19/20 , C12Q1/6869 , C12Q1/6876
CPC分类号： C07H19/14 , C07H19/10 , C07H19/20 , C12Q1/6869 , C12Q1/6876
摘要： Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
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公开(公告)号：US20230257908A1
公开(公告)日：2023-08-17
申请号：US17913458
申请日：2021-03-25
IPC分类号： C40B40/06 , C07H19/052 , C07H19/14 , C07H19/167 , C07H21/04
CPC分类号： C40B40/06 , C07H19/14 , C07H19/052 , C07H19/167 , C07H21/04
摘要： A compound library may include a plurality of conjugate molecules, said conjugates comprising a small organic molecule covalently coupled to a nucleic acid moiety. The nucleic acid moiety may include or consist of 7-deazapurines and/or 7-deaza-8-azapurines, and, optionally, modified pyrimidine nucleotides and/or unmodified pyrimidine nucleotides. Further, a library for screening compounds binding to a target molecule and methods of synthesizing said library is also disclosed.
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公开(公告)号：US11649260B2
公开(公告)日：2023-05-16
申请号：US17842135
申请日：2022-06-16
发明人： Xiaoyang Guan , David Yu , Ruiming Zou , Xiaoling Zheng , John Liu , Aldrich N. K. Lau , Wing C. Poon , Gang Zhao , Gengyu Du , Yun-Chiao Yao
CPC分类号： C07H19/06 , A61K47/549 , A61K48/0033 , C07H1/00 , C07H19/14
摘要： Embodiments of the present application relate to N-acetylgalactosamine-conjugated nucleosides. In particular, the N-acetylgalactosamine is installed on the nucleobase of the nucleosides through a wide variety of linkers. Methods of making N-acetylgalactosamine-conjugated nucleosides are also disclosed herein. N-acetylgalactosamine is a well-defined liver-targeted moiety and N-acetylgalactosamine-conjugated nucleosides may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
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公开(公告)号：US20230025669A1
公开(公告)日：2023-01-26
申请号：US17856441
申请日：2022-07-01
IPC分类号： C07D417/04 , C07D405/04 , C07D413/04 , C07H19/10 , C07H19/14 , C12Q1/6876
摘要： The present application relates to secondary amine-substituted coumarin compounds and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
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公开(公告)号：US20220411860A1
公开(公告)日：2022-12-29
申请号：US17373295
申请日：2021-07-12
申请人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
发明人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
IPC分类号： C12Q1/6869 , C07H19/10 , C07H19/14 , C07H19/20
摘要： Disclosed herein, inter alfa, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.
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公开(公告)号：US20220233566A1
公开(公告)日：2022-07-28
申请号：US17619379
申请日：2020-06-17
发明人： Hitoshi MIYAKOSHI , Nozomu TANAKA , Yu KOBAYAKAWA
IPC分类号： A61K31/7064 , C07H19/14 , A61P35/00 , A61K31/495 , A61N5/10
摘要： There is provided a novel carbonate compound of a nucleoside having a pyrrolopyrimidine skeleton having an excellent antitumor effect, or a pharmaceutically acceptable salt thereof and a method for preventing and/or treating a tumor in combination with an alkylating agent and/or a radiation therapy. According to one aspect of the present invention, there is provided a compound represented by the following general formula (1): or a pharmaceutically acceptable salt thereof, and a method for preventing and/or treating a tumor in combination with an alkylating agent and/or a radiation therapy.
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公开(公告)号：US11180523B2
公开(公告)日：2021-11-23
申请号：US16396361
申请日：2019-04-26
IPC分类号： C07H19/10 , C12Q1/68 , C07H19/14 , C12Q1/6816 , C07H19/048 , G01N33/58
摘要： Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.
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![Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide and uses thereof](/abs-image/US/2021/09/07/US11111264B2/abs.jpg.150x150.jpg)
公开(公告)号：US11111264B2
公开(公告)日：2021-09-07
申请号：US16645876
申请日：2018-09-21
申请人： Chimerix, Inc.
IPC分类号： C07H19/14
摘要： The present disclosure relates to crystalline morphic forms of 4-amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide. The morphic form can be a stable hemihydrate crystalline form.
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