利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

671 条记录 (耗时 0.06 秒)

    METHOD FOR PRODUCING PEPTIDE COMPOUND, PROTECTIVE GROUP-FORMING REAGENT, AND SUBSTITUTED BENZYL COMPOUND
    2.
    发明公开
    METHOD FOR PRODUCING PEPTIDE COMPOUND, PROTECTIVE GROUP-FORMING REAGENT, AND SUBSTITUTED BENZYL COMPOUND 审中-公开

    公开(公告)号：US20240317796A1

    公开(公告)日：2024-09-26

    申请号：US18735130

    申请日：2024-06-05

    申请人： FUJIFILM Corporation

    发明人： Daisuke NAKAGAWA ,  Hiroaki TSUYAMA ,  Hayato YOSHIDA ,  Takuma MOGI

    IPC分类号： C07K1/06 ,  C07C43/23 ,  C07C217/58 ,  C07C271/16 ,  C07K1/30

    CPC分类号： C07K1/062 ,  C07C43/23 ,  C07C217/58 ,  C07C271/16 ,  C07K1/066 ,  C07K1/30

    摘要： An object of the present invention is to provide a method for producing a peptide compound with an excellent yield, a protective group-forming reagent having an excellent yield, and a novel substituted benzyl compound. According to the present invention, there is provided a method for producing a peptide compound, including a step of using a substituted benzyl compound represented by Formula (1).




    In Formula (1), Y represents —OH, —NHR, —SH, or —X, R represents a hydrogen atom, an alkyl group, an arylalkyl group, a heteroarylalkyl group, or a 9-fluorenylmethoxycarbonyl group, X represents Cl, Br, or I, m represents 1 or 2, n represents an integer of 1 to 5, RB's each independently represent an aliphatic hydrocarbon group, RA, s each independently represent an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, where the number of carbon atoms in at least one aliphatic hydrocarbon group is 12 or more, and a benzene ring in Formula (1) may further have a substituent in addition to RA.

    SEEDED PRECIPITATION OF POLYPEPTIDES
    5.
    发明公开
    SEEDED PRECIPITATION OF POLYPEPTIDES 审中-公开

    公开(公告)号：US20240132539A1

    公开(公告)日：2024-04-25

    申请号：US18278519

    申请日：2022-02-22

    申请人： PreOmics GmbH

    发明人： Nils A. Kulak ,  Sebastian H. Johansson ,  Katrin Hartinger

    IPC分类号： C07K1/30 ,  C07K1/113

    CPC分类号： C07K1/30 ,  C07K1/1136

    摘要： The present invention relates to a method of processing or fractionating a sample comprising proteins, polypeptides and/or peptides, said method comprising (a) changing the physicochemical conditions of said sample; and (b) performing one or both of the following (i) and (ii): (i) adding solid particulate matter to said sample; and (ii) performing said method in a vessel with a rough surface; wherein steps (a) and (b) can be effected concomitantly or in any order; and wherein said processing or fractionating yields one or more first fractions of proteins, polypeptides and/or peptides as a precipitate on said particulate matter and/or said inhomogeneous surface, and a second fraction of proteins, polypeptides and/or peptides remaining in a supernatant.

    Method for enzymatic preparation of glutathione
    9.
    发明授权
    Method for enzymatic preparation of glutathione 有权

    公开(公告)号：US11788110B2

    公开(公告)日：2023-10-17

    申请号：US16622856

    申请日：2018-06-06

    申请人： ANHUI GSH BIO-TECH CO., LTD

    发明人： Shanshan Liu ,  Hui Liu ,  Wenwen Zhou ,  Yongfa Qin

    IPC分类号： C12P21/02 ,  C07K1/30

    CPC分类号： C12P21/02 ,  C07K1/306

    摘要： The present invention relates an enzymatic method for preparing glutathione, comprising the following steps: (1) producing glutathione in a reactor using GshF enzyme, ATP regeneration enzyme and AK enzyme; (2) separating immobilized GshF enzyme, ATP regeneration enzyme and AK enzyme in the reactor, or separating free GshF enzyme using a filtration device; (3) separating the filtrate obtained in step (2) to obtain a crude product GSH and a small amount of ATP, ADP and AMP; and (4) subjecting the GSH obtained in step (3) to concentration, crystallization, and drying to prepare a finished GSH. The described method provides: greatly reduced industrial production costs; faster reaction rate; stable enzyme recovery system that is energy efficient and environmentally friendly; and capability of reusing the byproducts or collecting them for the production of ATP.

    PREPARATION OF CONSERVED HOMOLOGY 1 DOMAINS COMPLEXED TO LIGANDS
    10.
    发明申请
    PREPARATION OF CONSERVED HOMOLOGY 1 DOMAINS COMPLEXED TO LIGANDS 有权

    公开(公告)号：US20230063427A1

    公开(公告)日：2023-03-02

    申请号：US17900740

    申请日：2022-08-31

    申请人： Tatyana I. Igumenova ,  Sachin S. Katti

    发明人： Tatyana I. Igumenova ,  Sachin S. Katti

    IPC分类号： C07K1/30 ,  C30B7/00 ,  C30B29/58

    摘要： A crystallization method for making high-quality molecular crystals containing complexes of diacylglycerol (DAG)-effector proteins and ligands thereof. For example, some of such crystals are of a quality sufficient for crystal-structure determination by X-ray crystallography with a spatial resolution of at least 3.0 Å or, in some cases, of about 1 Å. At least some embodiments of the crystallization method and of the molecular crystals produced thereby can beneficially be used, e.g., to provide high-resolution guides for the design and development of exogenous agonists of DAG-effector proteins of therapeutic interest.