公开(公告)号：US20240336666A1

公开(公告)日：2024-10-10

申请号：US18578613

申请日：2022-07-28

申请人： Northwestern University

发明人： Shelby Chi YUAN ,  Samuel l. STUPP ,  Nicholas A. SATHER

IPC分类号： C07K14/495 ,  A61K9/51 ,  A61K38/00 ,  A61P21/00

CPC分类号： C07K14/495 ,  A61K9/5161 ,  A61P21/00 ,  A61K38/00

摘要： Provided herein are self-assembling peptide amphiphiles (PAs) comprising a bioactive Transforming growth factor beta 1 (TGF-β1) mimetic epitope, high-aspect-ratio nanostructures of PAs displaying a TGF-β1 mimetic epitope, and methods of enhancing cartilage regeneration/repair and/or treatment of osteoarthritis and other musculoskeletal injuries and diseases.

公开(公告)号：US12065672B2

公开(公告)日：2024-08-20

申请号：US17224047

申请日：2021-04-06

申请人： Wayne State University

发明人： Kang Chen ,  Bo Pei

IPC分类号： C12N5/0781 ,  C07K14/47 ,  C07K14/495 ,  C07K14/54 ,  C07K14/57 ,  C07K14/705 ,  C07K16/06 ,  C12N15/62

CPC分类号： C12N5/0635 ,  C07K14/4702 ,  C07K14/495 ,  C07K14/5406 ,  C07K14/57 ,  C07K14/70578 ,  C07K16/06 ,  C07K16/065 ,  C12N15/62 ,  C07K2317/565 ,  C07K2319/21 ,  C07K2319/41 ,  C07K2319/43 ,  C12N2310/20

摘要： Down-regulating autoimmune regulator (AIRE) function in B cells to produce antibodies is described. The antibodies can be class-switched, high affinity, and neutralizing, and have a high degree of somatic hypermutations, even in the framework region, as compared to antibodies produced in the absence of AIRE downregulation.

公开(公告)号：US12054527B2

公开(公告)日：2024-08-06

申请号：US16620029

申请日：2019-04-08

申请人： Amgen Inc.

发明人： YuMei Xiong ,  Kenneth William Walker ,  Murielle Marie Veniant Ellison

IPC分类号： C07K14/495 ,  A61K38/00

CPC分类号： C07K14/495 ,  A61K38/00 ,  C07K2319/30

摘要： GDF15 molecules are provided herein. In some embodiments, the GDF15 molecule is a GDF15-Fc fusion, in which a GDF15 region is fused to an Fc region. In some embodiments, the GDF15 region is fused to the Fc region via a linker. Also, provided herein are methods for making and using GDF15 molecules.

公开(公告)号：US20240124541A1

公开(公告)日：2024-04-18

申请号：US18286453

申请日：2022-04-12

申请人： University of Florida Research Foundation, Incorprated

发明人： David Hammers ,  Hugh Lee Sweeney

IPC分类号： C07K14/495 ,  A61P3/04 ,  C07K14/47 ,  C12N15/86

CPC分类号： C07K14/495 ,  A61P3/04 ,  C07K14/4716 ,  C12N15/86 ,  C07K2319/01 ,  C12N2750/14143

摘要： The disclosure provides methods of treating obesity, reducing weight, or preventing weight gain using a combination therapy of GDF15 polypeptide and a myostatin inhibitor (e.g., a myostatin propeptide).

公开(公告)号：US11872250B2

公开(公告)日：2024-01-16

申请号：US17150574

申请日：2021-01-15

申请人： Rutgers, The State University of New Jersey

发明人： Yufang Shi ,  Guangwen Ren ,  Liying Zhang

IPC分类号： A61K35/28 ,  A61K38/21 ,  A61K38/20 ,  A61K38/19 ,  A61K38/18 ,  A61P37/04 ,  C12N5/00 ,  C12N5/0775 ,  C12N5/074 ,  A61P37/06 ,  C07K14/50 ,  C07K14/525 ,  C07K14/54 ,  C07K14/56 ,  C07K14/565 ,  C07K14/57 ,  C07K14/52 ,  C07K14/545 ,  A61K35/12 ,  A61K45/06 ,  A61P37/02 ,  C07K14/495

CPC分类号： A61K35/28 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/191 ,  A61K38/20 ,  A61K38/2006 ,  A61K38/212 ,  A61K38/215 ,  A61K38/217 ,  A61P37/04 ,  A61P37/06 ,  C12N5/0018 ,  C12N5/0607 ,  C12N5/0662 ,  C12N5/0663 ,  C12N5/0665 ,  A61K45/06 ,  A61K2035/122 ,  A61P37/02 ,  C07K14/495 ,  C07K14/50 ,  C07K14/52 ,  C07K14/525 ,  C07K14/545 ,  C07K14/56 ,  C07K14/565 ,  C07K14/57 ,  C12N2500/05 ,  C12N2501/10 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2501/2301 ,  C12N2501/2317 ,  C12N2501/24 ,  C12N2501/25 ,  C12N2502/1114 ,  A61K35/28 ,  A61K2300/00 ,  A61K38/191 ,  A61K2300/00 ,  A61K38/2006 ,  A61K2300/00 ,  A61K38/217 ,  A61K2300/00

摘要： The present invention provides methods or kits with inflammatory cytokines to pretreat 1-ISCs to augment their immune modulatory effect, in prevention and treatment of various diseases such as multiple sclerosis, arthritis, lupus, sepsis, hepatitis, cirrhosis, Parkinson's disease, chronic infections, and GvHD. The present invention relates to novel methods for enhancing the immunosuppressive or the immune stimulatory activities of mesenchymal stem cells (JvfSCs).

公开(公告)号：US11827698B2

公开(公告)日：2023-11-28

申请号：US17196256

申请日：2021-03-09

申请人： Scholar Rock, Inc.

发明人： Thomas Schurpf ,  Nagesh K. Mahanthappa ,  Michelle Straub

IPC分类号： C07K16/22 ,  C07K16/00 ,  A61K39/395 ,  C07K14/495 ,  A61K39/00 ,  C07K16/28 ,  C12N15/10 ,  A61K38/00

CPC分类号： C07K16/22 ,  A61K39/001134 ,  A61K39/3955 ,  C07K14/495 ,  C07K16/005 ,  C07K16/28 ,  C07K16/2863 ,  C12N15/1037 ,  A61K38/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/32 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N2333/495 ,  G01N2333/71

摘要： Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-β superfamily of proteins.

公开(公告)号：US20230364248A1

公开(公告)日：2023-11-16

申请号：US18083729

申请日：2022-12-19

申请人： Novo Nordisk A/S

发明人： Xiang Gao ,  Xujia Zhang ,  Hongtao Guan ,  Henning Thoegersen ,  Kristian Sass-oerum ,  Lars Fogh Iversen ,  Per Noergaard ,  Sebastian Beck Joergensen ,  Kristian Tage Hansen ,  Yi Wang ,  Kilian Waldemar Conde Frieboes ,  Birgit Wieczorek

IPC分类号： A61K47/64 ,  A61K38/19 ,  C07K14/475 ,  C07K14/495 ,  A61P3/00 ,  C07K14/52 ,  C07K14/50 ,  G01N33/68 ,  A61K38/00

CPC分类号： A61K47/64 ,  A61K38/19 ,  C07K14/475 ,  C07K14/495 ,  A61P3/00 ,  C07K14/52 ,  C07K14/50 ,  G01N33/68 ,  A61K38/00

摘要： The invention relates to MIC-1 compounds. More specifically it relates to compounds comprising a MIC-1 polypeptide with an N-terminal amino acid extension and a protractor wherein the amino acid extension comprises 3 to 36 amino acid residues and where the MIC-1 polypeptide and the N-terminal amino acid extension together have a calculated pI lower than 6.5. The compounds of the invention have MIC-1 activity. The invention also relates to pharmaceutical compositions comprising such compounds and pharmaceutically acceptable excipients, as well as the medical use of the compounds.

公开(公告)号：US11739131B2

公开(公告)日：2023-08-29

申请号：US16416050

申请日：2019-05-17

申请人： Amgen Inc.

发明人： Yumei Xiong ,  Yi Zhang ,  Jackie Z. Sheng ,  Agnes Eva Hamburger ,  Murielle M. Veniant-Ellison ,  Grant Shimamoto ,  Xiaoshan Min ,  Zhulun Wang ,  Jie Tang ,  Gunasekaran Kannan ,  Kenneth W. Walker ,  Bryan Lemon

IPC分类号： C07K14/475 ,  C07K14/495 ,  C07K14/51 ,  A61K38/16 ,  A61K38/00 ,  A61K38/18 ,  A61K38/17 ,  A61K39/00

CPC分类号： C07K14/475 ,  A61K38/00 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K39/0005 ,  C07K14/495 ,  C07K14/51 ,  A61K2039/6056 ,  C07K2319/30

摘要： GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

公开(公告)号：US20230256025A1

公开(公告)日：2023-08-17

申请号：US18134383

申请日：2023-04-13

申请人： KOLON TISSUEGENE, INC.

发明人： Moon Jong NOH ,  Huan T. Tran

IPC分类号： A61K35/35 ,  A61K35/22 ,  A61K35/36 ,  A61P29/00 ,  C07K14/495

CPC分类号： A61K35/35 ,  A61K35/22 ,  A61K35/36 ,  A61P29/00 ,  C07K14/495

摘要： A method for preventing and treating back pain including discogenic back pain, which includes administering a mixed cell composition containing mammalian connective tissue cells and mammalian cells expressing TGF-β1 into the intervertebral disc defect site.

公开(公告)号：US11648276B2

公开(公告)日：2023-05-16

申请号：US16891841

申请日：2020-06-03

申请人： Immatics Biotechnologies GmbH

发明人： Toni Weinschenk ,  Oliver Schoor ,  Claudia Trautwein ,  Norbert Hilf ,  Steffen Walter ,  Harpreet Singh

IPC分类号： C07K7/06 ,  C07K14/47 ,  C07K14/495 ,  C07K14/725 ,  A61K35/17 ,  C07K7/08 ,  A61K39/00 ,  C07K16/40 ,  C07K19/00 ,  C12N9/02 ,  C12N9/10 ,  C12N5/0783 ,  A61K38/00

CPC分类号： A61K35/17 ,  A61K39/0011 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/495 ,  C07K14/7051 ,  C07K16/40 ,  C07K19/00 ,  C12N5/0638 ,  C12N9/0036 ,  C12N9/13 ,  A61K38/00 ,  A61K2039/5158 ,  A61K2039/572 ,  C07K2317/34 ,  C07K2319/00 ,  C12N2502/1157 ,  C12Y208/02011

摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 11 novel peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.