公开(公告)号：US11981723B2

公开(公告)日：2024-05-14

申请号：US16643997

申请日：2018-09-05

申请人： GLADIATOR BIOSCIENCES, INC.

发明人： Terry Hermiston ,  Maxine Bauzon ,  Christopher H. Contag ,  Jonathan Hardy ,  Masamitsu Kanada

IPC分类号： A61K38/36 ,  A61K38/18 ,  A61K38/48 ,  A61K45/06 ,  A61K47/64 ,  A61K49/00 ,  C07K14/745 ,  C12N5/073 ,  C12N5/0789 ,  C12N5/095

CPC分类号： C07K14/745 ,  A61K38/1808 ,  A61K38/36 ,  A61K38/4833 ,  A61K38/4846 ,  A61K38/4866 ,  A61K47/645 ,  A61K49/0043 ,  C12N5/0605 ,  C12N5/0647 ,  C12N5/0695 ,  A61K45/06 ,  C07K2319/035 ,  C07K2319/60

摘要： A method of targeting extracellular vesicles employing a molecule comprising a GLA domain and extracellular vesicles obtained or obtainable from a method are described herein.

公开(公告)号：US11976106B2

公开(公告)日：2024-05-07

申请号：US16317283

申请日：2017-07-11

申请人： OPKO BIOLOGICS LTD.

发明人： Oren Hershkovitz ,  Laura Moschcovich

IPC分类号： A61K38/00 ,  A61K47/64 ,  C07K14/745

CPC分类号： C07K14/745 ,  A61K47/64 ,  A61K38/00

摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the disclosure and methods of using and producing same are also disclosed.

公开(公告)号：US20240132572A1

公开(公告)日：2024-04-25

申请号：US18372942

申请日：2023-09-25

申请人： UBI Pharma Inc. (UBIP)

发明人： Chang-Yi Wang ,  Wen-Jiun Peng ,  Wei-Ting Kao

IPC分类号： C07K14/745 ,  C07K14/505 ,  C07K14/535 ,  C07K14/56 ,  C07K14/565 ,  C07K14/57 ,  C07K19/00

CPC分类号： C07K14/745 ,  C07K14/505 ,  C07K14/535 ,  C07K14/56 ,  C07K14/565 ,  C07K14/57 ,  C07K19/00 ,  C12N9/644

摘要： A fusion protein is disclosed. The fusion protein of the invention comprises an Fc fragment of an immunoglobulin G and a bioactive molecule, wherein the Fc is a single chain Fc. The amino acids in the hinge of the Fc is mutated, substituted, or deleted so that the hinge of Fc cannot form disulfide bonds. Methods for producing and using the fusion protein of the invention are also provided.

公开(公告)号：US20240131193A1

公开(公告)日：2024-04-25

申请号：US18161598

申请日：2023-01-30

申请人： Modema TX, Inc.

发明人： Antonin DE FOUGEROLLES ,  Justin GUILD

IPC分类号： A61K48/00 ,  A61K9/127 ,  A61K9/14 ,  A61K9/51 ,  A61K31/7115 ,  A61K38/17 ,  A61K38/18 ,  A61K38/19 ,  A61K38/21 ,  A61K38/45 ,  A61K38/48 ,  A61K47/54 ,  C07H21/02 ,  C07K14/005 ,  C07K14/435 ,  C07K14/47 ,  C07K14/475 ,  C07K14/485 ,  C07K14/495 ,  C07K14/505 ,  C07K14/515 ,  C07K14/525 ,  C07K14/535 ,  C07K14/54 ,  C07K14/56 ,  C07K14/61 ,  C07K14/62 ,  C07K14/705 ,  C07K14/745 ,  C07K16/00 ,  C07K16/28 ,  C07K16/40 ,  C12N9/00 ,  C12N9/02 ,  C12N9/10 ,  C12N9/12 ,  C12N9/16 ,  C12N9/24 ,  C12N9/42 ,  C12N9/64 ,  C12N9/68 ,  C12N9/88 ,  C12N15/11 ,  C12N15/52 ,  C12N15/85 ,  C12N15/87 ,  C12P13/04 ,  C12P21/00

CPC分类号： A61K48/0066 ,  A61K9/1271 ,  A61K9/145 ,  A61K9/5123 ,  A61K9/5146 ,  A61K9/5153 ,  A61K31/7115 ,  A61K38/17 ,  A61K38/177 ,  A61K38/1816 ,  A61K38/1891 ,  A61K38/191 ,  A61K38/193 ,  A61K38/212 ,  A61K38/45 ,  A61K38/4846 ,  A61K47/543 ,  A61K48/0033 ,  A61K48/005 ,  A61K48/0075 ,  C07H21/02 ,  C07K14/005 ,  C07K14/435 ,  C07K14/43595 ,  C07K14/47 ,  C07K14/4705 ,  C07K14/4713 ,  C07K14/4723 ,  C07K14/4746 ,  C07K14/475 ,  C07K14/485 ,  C07K14/495 ,  C07K14/505 ,  C07K14/515 ,  C07K14/525 ,  C07K14/535 ,  C07K14/5418 ,  C07K14/56 ,  C07K14/61 ,  C07K14/62 ,  C07K14/705 ,  C07K14/745 ,  C07K16/00 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/40 ,  C12N9/0069 ,  C12N9/0091 ,  C12N9/1051 ,  C12N9/1241 ,  C12N9/16 ,  C12N9/2402 ,  C12N9/2445 ,  C12N9/6435 ,  C12N9/6437 ,  C12N9/644 ,  C12N9/6443 ,  C12N9/6451 ,  C12N9/88 ,  C12N9/93 ,  C12N15/11 ,  C12N15/52 ,  C12N15/85 ,  C12N15/87 ,  C12P13/04 ,  C12P21/00 ,  C12P21/005 ,  C12Y603/02019 ,  A61K38/00 ,  Y02A50/30

摘要： The invention relates to compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues, receptor uptake and/or kinetics, cellular access by the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, function, and/or activity.

公开(公告)号：US20240124543A1

公开(公告)日：2024-04-18

申请号：US18497083

申请日：2023-10-30

申请人： HCW Biologics, Inc.

发明人： Hing Wong

IPC分类号： C07K14/54 ,  C07K14/71 ,  C07K14/715 ,  C07K14/745 ,  C07K16/28

CPC分类号： C07K14/5434 ,  C07K14/54 ,  C07K14/5418 ,  C07K14/71 ,  C07K14/7155 ,  C07K14/745 ,  C07K16/283 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/30

摘要： Provided herein are multi-chain chimeric polypeptides that include:



(a) a first chimeric polypeptide including a first target-binding domain, a soluble tissue factor domain, and a first domain of a pair of affinity domains; and (b) a second chimeric polypeptide including a second domain of a pair of affinity domains and a second target-binding domain, where the first chimeric polypeptide and the second chimeric polypeptide associate through the binding of the first domain and the second domain of the pair of affinity domains. Also provided here are methods of using these multi-chain chimeric polypeptides and nucleic acids encoding these multi-chain chimeric polypeptides.

公开(公告)号：US11939363B2

公开(公告)日：2024-03-26

申请号：US17812576

申请日：2022-07-14

申请人： ARCTURUS THERAPEUTICS, INC.

发明人： Pattraranee Limphong ,  Kiyoshi Tachikawa ,  Padmanabh Chivukula ,  Daiki Matsuda ,  Arisa Cale

IPC分类号： C07K14/505 ,  A61K31/7115 ,  A61K38/17 ,  A61K38/18 ,  A61K38/48 ,  C07K14/575 ,  C07K14/745 ,  C07K14/81 ,  A61K38/00 ,  C12Q1/68

CPC分类号： C07K14/505 ,  A61K31/7115 ,  A61K38/1709 ,  A61K38/1816 ,  A61K38/482 ,  A61K38/4846 ,  C07K14/575 ,  C07K14/745 ,  C07K14/81 ,  A61K38/00

摘要： A range of therapeutic mRNA molecules expressible to provide a target polypeptide or protein. The RNA molecules can contain one or more 5-methoxyuridines and 5-methylcytidines. Further provided are DNA templates, which can be transcribed to provide a target mRNA, and can have altered nucleotides, such as reduced deoxyadenosines. Also provided are processes for making the therapeutic mRNA molecules. The RNA molecules can be translated in vitro or in vivo to provide an active polypeptide or protein. The RNA molecules can be included in a composition used for preventing, treating, or ameliorating at least one symptom of a disease or condition in a subject in need thereof.

公开(公告)号：US11913042B2

公开(公告)日：2024-02-27

申请号：US16771700

申请日：2018-08-30

申请人： RUIJIN HOSPITAL SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE ,  Xuefeng Wang ,  Wenman Wu ,  Qiulan Ding

发明人： Xuefeng Wang ,  Wenman Wu ,  Qiulan Ding

IPC分类号： C07K14/745 ,  C12N9/64 ,  A61P7/04 ,  A61K48/00 ,  C12N15/85 ,  A61K38/00

CPC分类号： C12N9/6443 ,  A61K48/005 ,  A61P7/04 ,  C12N15/85 ,  C12Y304/21027 ,  A61K38/00 ,  C12N2800/107

摘要： Methods of preparing and using a highly active blood coagulation factor XI mutant and a gene therapy/editing vector thereof and a recombinant/fusion protein thereof. The nucleotide sequence of the mutant is as shown in SEQ ID NOs: 1-6, and the amino acid sequence is as shown in SEQ ID NO: 7.

公开(公告)号：US11845966B2

公开(公告)日：2023-12-19

申请号：US17196172

申请日：2021-03-09

申请人： Alexion Pharmaceuticals, Inc.

发明人： Mark Karbarz ,  Pamela B. Conley ,  Genmin Lu

IPC分类号： C07K14/745 ,  C12N9/64 ,  C07K1/18 ,  C07K1/20 ,  C07K1/22

CPC分类号： C12N9/6432 ,  C07K1/18 ,  C07K1/20 ,  C07K1/22

摘要： The present disclosure provides methods for manufacturing a fXa derivative protein at large scale leading to high yield of highly pure protein product. The method may include adding a detergent to a sample that contains a polynucleotide construct encoding the protein and purifying the protein through a soybean trypsin inhibitor (STI)-based affinity chromatograph, an ion exchange and mixed mode chromatograph and a hydrophobic interaction.

公开(公告)号：US11820833B2

公开(公告)日：2023-11-21

申请号：US16306920

申请日：2017-06-02

申请人： Tel HaShomer Medical Research Infrastructure and Services Ltd.

发明人： Nicola Maggio ,  Joab Chapman ,  Efrat Shavit Stein

IPC分类号： C07K5/103 ,  C07K5/113 ,  C07K7/06 ,  C07K14/745 ,  C12N9/64 ,  C12N9/74 ,  A61K38/00 ,  A61P37/06 ,  A61P25/00 ,  A61P29/00

CPC分类号： C07K5/1008 ,  A61P25/00 ,  A61P29/00 ,  A61P37/06 ,  C07K5/1021 ,  C07K7/06 ,  C07K14/745 ,  C12N9/644 ,  C12N9/6429 ,  C12N9/6432 ,  C12N9/6437 ,  C12N9/6464 ,  A61K38/00

摘要： An isolated peptide of up to 6 amino acids comprising an amino acid sequence which inhibits binding of an endothelial cell protein C receptor (EPCR) ligand to the EPCR is disclosed. Also disclosed is an isolated peptide comprising an amino acid sequence which inhibits binding of an endothelial cell protein C receptor (EPCR) ligand to the EPCR, wherein the peptide comprises a modification in at least one amino acid. Also disclosed is a molecule comprising an amino acid sequence which inhibits binding of an endothelial cell protein C receptor (EPCR) ligand to the EPCR attached to a heterologous moiety. Pharmaceutical compositions and methods of treatment are also disclosed.

公开(公告)号：US11746140B2

公开(公告)日：2023-09-05

申请号：US16479068

申请日：2019-02-15

申请人： Grifols Diagnostic Solutions Inc.

发明人： Elizabeth Booth ,  Virginia Montanini ,  John A. Hall ,  Jody Berry

IPC分类号： C07K14/705 ,  C07K14/745

CPC分类号： C07K14/745 ,  C07K14/705 ,  C07K2317/92 ,  C07K2319/02 ,  C07K2319/21 ,  C07K2319/30

摘要： Various aspects of the invention relate to recombinant polypeptides that specifically bind human von Willebrand Factor. Such recombinant polypeptides typically include a modified extracellular domain of platelet glycoprotein Ibα that typically comprises at least one mutation selected from G233T, D235V, and K237V, and such recombinant polypeptides optionally include an oligomerization domain.