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    Conjugate of minoxidil and peptide
    2.
    发明授权
    Conjugate of minoxidil and peptide 有权

    公开(公告)号：US11617796B2

    公开(公告)日：2023-04-04

    申请号：US16326618

    申请日：2017-08-04

    申请人： CAREGEN CO., LTD.

    发明人： Yong Ji Chung ,  Eun Mi Kim

    IPC分类号： A61K47/64 ,  A61Q7/00 ,  C07K7/08 ,  A61K31/506 ,  C07K7/06 ,  A61K47/50 ,  C07K19/00 ,  A61K8/49 ,  A61P17/14 ,  A61K8/64 ,  A61K9/00 ,  A61K31/513 ,  A61K38/17

    摘要： The present invention relates to a composition for preventing hair loss and, more specifically, to a compound having a structure in which Minoxidil and a peptide are chemically connected, and to a pharmaceutical composition or cosmetic composition for preventing hair loss or promoting hair growth comprising the compound. The compound having a structure in which Minoxidil and a peptide are chemically connected according to the present invention has not only excellent physiological activity such as hair loss reduction, hair growth promotion or cell growth promotion, but also excellent stability in water, and can therefore be useful as a composition for preventing hair loss and promoting hair growth.

    NOVEL CORONAVIRUS S PROTEIN DOUBLE-REGION SUBUNIT NANO-VACCINE BASED ON BACTERIAL COMPLEX
    3.
    发明申请
    NOVEL CORONAVIRUS S PROTEIN DOUBLE-REGION SUBUNIT NANO-VACCINE BASED ON BACTERIAL COMPLEX 有权

    公开(公告)号：US20230090422A1

    公开(公告)日：2023-03-23

    申请号：US17908916

    申请日：2020-03-11

    申请人： SUN YAT-SEN UNIVERSITY

    发明人： Hui ZHANG ,  Xiancai MA ,  Fan ZOU ,  Yaochang YUAN ,  Rong LI ,  Xu ZHANG

    IPC分类号： A61K39/215 ,  A61K39/385 ,  C07K19/00 ,  C12N15/62 ,  C12N15/85

    摘要： The present application is related to a novel coronavirus S protein double-region subunit nano-vaccine based on a bacterial complex. In the present invention, a receptor binding domain (RBD) and a fusion peptide (FP) of a virus are used together as double antigens, and are connected to a bacterial complex (such as PF_Ferritin or Lumazine Synthase (LS)) to form a fusion protein, so as to achieve antigen multimerization; and then expression is performed by using a eukaryotic cell expression system, and a 24-mer nano-antigen or a 60-mer nano-antigen can be formed by means of self-assembly action. The solution can overcome the defect of insufficient immunogenicity of an RBD monomer. The obtained vaccine can significantly increase the level of a neutralizing antibody against a virus in a host, and the resulting antibody has the capability of strongly blocking a virus from invading a target cell.

    MODULATING GAMMA-C-CYTOKINE ACTIVITY
    5.
    发明申请
    MODULATING GAMMA-C-CYTOKINE ACTIVITY 有权

    公开(公告)号：US20230060637A1

    公开(公告)日：2023-03-02

    申请号：US17813304

    申请日：2022-07-18

    申请人： Bioniz, LLC

    发明人： Nazli Azimi

    IPC分类号： A61K38/20 ,  C07K14/54 ,  A61Q7/00 ,  A61K8/64 ,  A61Q3/00 ,  A61Q19/00 ,  A61Q19/08 ,  A61P17/18 ,  A61P31/14 ,  A61P35/00 ,  C07K7/08 ,  C07K14/55 ,  C07K19/00

    摘要： Embodiments relate to peptide antagonists of γc-family cytokines, which is associated with important human diseases, such as leukemia, autoimmune diseases, collagen diseases, diabetes mellitus, skin diseases, degenerative neuronal diseases and graft-versus-host disease (GvHD). Thus, inhibitors of γc-cytokine activity are valuable therapeutic and cosmetic agents as well as research tools. Traditional approaches to inhibiting γc-cytokine activity involve raising neutralizing antibodies against each individual γc-cytokine family member/receptor subunit. However, success has been limited and often multiple γc-cytokine family members co-operate to cause the disease state. Combinatorial use of neutralizing antibodies raised against each factor is impractical and poses an increased risk of adverse immune reactions. The present embodiments overcome these shortcomings by utilizing peptide antagonists based on the consensus γc-subunit binding site to inhibit γc-cytokine activity. Such approach allows for flexibility in antagonist design. In several embodiments, peptides exhibit Simul-Block activity, inhibiting the activity of multiple γc-cytokine family members.

    Cell membrane penetrating conjugates
    8.
    发明授权
    Cell membrane penetrating conjugates 有权

    公开(公告)号：US11583589B2

    公开(公告)日：2023-02-21

    申请号：US16640865

    申请日：2018-08-22

    申请人： Cygenica Limited

    发明人： Nusrat J. M. Sanghamitra

    IPC分类号： A61K47/65 ,  A61K47/62 ,  A61K47/60 ,  C07K19/00

    摘要： A cell penetrating conjugate comprising a recombinant β helical protein linked to a functional molecule wherein the β helical protein length is in the range of from 5 nm to 25 nm, suitably, from 10 nm to 15 nm and width is in the range of from 1 nm to 5 nm, suitably, from 1 nm to 3 nm. Processes for preparing said conjugates and uses thereof are also disclosed.