公开(公告)号：US20240360177A1

公开(公告)日：2024-10-31

申请号：US18687807

申请日：2022-09-01

申请人： AimMax Therapeutics, Inc.

发明人： Laurene Wang ,  David E. Pereira ,  Dale J. . Christensen ,  Kara S. Keedy ,  Gregory J. Pacofsky ,  Derek J. Nunez

IPC分类号： C07K7/08 ,  A61K38/00 ,  A61P31/04 ,  A61P31/10 ,  C07K7/06

CPC分类号： C07K7/08 ,  A61P31/04 ,  A61P31/10 ,  C07K7/06 ,  A61K38/00

摘要： The disclosure includes peptides of Formula (I): S1-[block-1]m-x-[block-2]n-y-[block-3]o-z-[block-4]p-S2. Also included are pharmaceutical compositions containing the peptides and methods of treating microbial infections using the peptides.

公开(公告)号：US12129313B2

公开(公告)日：2024-10-29

申请号：US17350795

申请日：2021-06-17

申请人： ENLITISA (SHANGHAI) PHARMACEUTICAL CO., LTD

发明人： Bengt Ingemar Samuelsson ,  Ming Gu

IPC分类号： A61K38/08 ,  A61K38/00 ,  A61K38/10 ,  A61P17/00 ,  C07K7/06 ,  C07K7/08

CPC分类号： C07K7/06 ,  A61P17/00 ,  A61K38/00

摘要： Provided a peptide of the sequence Ala-Lys-Pro-Ser-Tyr-Hyp-Hyp-Thr-DOPA-Lys or a salt thereof for use in the treatment of inflammation, of an inflammatory disorder and/or of ion thea condition characterized by inflammation, including wounds, burns, psoriasis, acne and atopic dermatitis.

公开(公告)号：US12129312B2

公开(公告)日：2024-10-29

申请号：US16624063

申请日：2018-06-27

申请人： XDCEXPLORER (SHANGHAI) CO., LTD.

发明人： Yan Wang ,  Yvonne Angell ,  Yun Wu ,  Manhua Li ,  Yonghan Hu

IPC分类号： C07K7/06 ,  A61K38/00

CPC分类号： C07K7/06 ,  A61K38/00

摘要： Disclosed in the present invention are a peptide compound, an application thereof, and a composition containing the same. Provided in the present invention are a peptide compound represented by formula I, a pharmaceutically acceptable salt thereof, a tautomer thereof, a solvate thereof, a crystal form thereof, or a prodrug thereof. The compound has good stability and good activity.

公开(公告)号：US20240350677A1

公开(公告)日：2024-10-24

申请号：US18596815

申请日：2024-03-06

申请人： On Target Laboratories, Inc.

发明人： Sumith A. Kularatne

IPC分类号： A61K49/00 ,  A61K49/16 ,  C07D209/20 ,  C07K5/062 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078 ,  C07K5/083 ,  C07K5/087 ,  C07K5/09 ,  C07K5/11 ,  C07K7/02 ,  C07K7/06 ,  G01N21/64 ,  G01N33/574 ,  G01N33/58

CPC分类号： A61K49/0052 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0056 ,  C07D209/20 ,  C07K5/06026 ,  C07K5/0606 ,  C07K5/06078 ,  C07K5/06095 ,  C07K5/06121 ,  C07K5/06147 ,  C07K5/06156 ,  C07K5/0806 ,  C07K5/0812 ,  C07K5/0817 ,  C07K5/1019 ,  C07K7/02 ,  C07K7/06 ,  G01N21/6428 ,  G01N33/57434 ,  G01N33/57492 ,  G01N33/582 ,  A61K49/0017 ,  A61K49/16 ,  C12Y304/17021 ,  G01N2021/6439 ,  G01N2333/948

摘要： The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

公开(公告)号：US12116421B2

公开(公告)日：2024-10-15

申请号：US18021645

申请日：2021-09-02

申请人： KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Charlotte A. E. Hauser ,  Maria Hountondji ,  Manola Moretti ,  Panagiotis Bilalis

IPC分类号： C07K7/06 ,  C12N5/00 ,  C12N5/07

CPC分类号： C07K7/06 ,  C12N5/0062 ,  C12N5/0601 ,  C12N2513/00 ,  C12N2533/50

摘要： The present disclosure relates to Dopa containing ultrashort peptides capable of forming a gel, to a gel comprising a peptide in accordance with the present disclosure, and to a glue comprising a peptide in accordance with the present disclosure. Such gel is adhesive and is biocompatible. The peptides are suitable for building 3D structures, 3D printing, gluing as well as other applications.

公开(公告)号：US12115228B2

公开(公告)日：2024-10-15

申请号：US17189135

申请日：2021-03-01

申请人： Concortis Biosystems, Corp.

发明人： Zhenwei Miao ,  Yufeng Hong ,  Tong Zhu ,  Alexander Wilhelm Chucholowski

IPC分类号： A61K47/68 ,  A61K38/07 ,  C07D207/08 ,  C07D207/09 ,  C07D277/593 ,  C07D401/12 ,  C07D403/12 ,  C07F5/02 ,  C07K5/06 ,  C07K5/062 ,  C07K5/103 ,  C07K7/06

CPC分类号： A61K47/6855 ,  A61K38/07 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6849 ,  A61K47/6889 ,  C07D207/08 ,  C07D207/09 ,  C07D277/593 ,  C07D401/12 ,  C07D403/12 ,  C07F5/025 ,  C07K5/06008 ,  C07K5/06034 ,  C07K5/06052 ,  C07K5/1008 ,  C07K7/06

摘要： In one aspect, an active agent-conjugate, methods of preparing the active agent-conjugate, and uses thereof is provided.

公开(公告)号：US20240327459A1

公开(公告)日：2024-10-03

申请号：US18744868

申请日：2024-06-17

申请人： Follicum AB

发明人： Jan Alenfall ,  Maria Ekblad ,  Pontus Dunér

IPC分类号： C07K7/06 ,  A61K38/00 ,  A61P3/08 ,  C07K7/08

CPC分类号： C07K7/06 ,  A61P3/08 ,  C07K7/08 ,  A61K38/00 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/705

摘要： The present disclosure concerns agents and their use in the treatment of endocrine, nutritional and/or metabolic diseases in a mammal. The disclosure furthermore concerns novel peptide fragments.

公开(公告)号：US12103983B2

公开(公告)日：2024-10-01

申请号：US17299035

申请日：2019-10-31

申请人： HiPep Laboratories

发明人： Kiyoshi Nokihara ,  Yuki Tominaga ,  Atsushi Kitagawa ,  Shun Nokihara

IPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/64

CPC分类号： C07K7/06 ,  C07K7/64 ,  A61K38/00

摘要： Disclosed are a novel compound having a higher angiogenic effect than that of a known peptide-based angiogenic agent, and an angiogenic agent including the novel compound. The compound is represented by the following formula [1]: Cyclic(Cys-O2Oc-SVV(F/Y)GLRG-Cys)-NH2 (wherein the number of oxyethylene units, represented by O2Oc, is within the range of 2 to 6), the following formula [II]: Cyclic(O2Oc-SVV(F/Y)GLRQ)-NH2 [II] (wherein the number of oxyethylene units, represented by O2Oc, is within the range of 2 to 6), or the following formula [III]: O2Oc-SVV(F/Y)GLR-NH2 [III] (wherein the number of oxyethylene units, represented by O2Oc, is within the range of 2 to 6).

公开(公告)号：US12102705B2

公开(公告)日：2024-10-01

申请号：US15734033

申请日：2019-06-11

申请人： AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO—A.C.R.A.F. S.p.A.

发明人： Francesca Mancini ,  Isabel Devesa Giner ,  Antonio Ferrer Montiel ,  Gregorio Fernandez Ballester ,  Giorgina Mangano ,  Cristina Bartella

IPC分类号： A61K8/64 ,  A61K38/00 ,  A61Q15/00 ,  C07K5/117 ,  C07K7/06 ,  C07K7/08

CPC分类号： A61K8/64 ,  A61Q15/00 ,  C07K5/1024 ,  C07K7/06 ,  C07K7/08 ,  A61K38/00

摘要： Peptides able to inhibit the muscarinic receptor M3 activity and to products comprising such peptides, in particular pharmaceutical and cosmetic products useful for ameliorating skin conditions mediated by the muscarinic receptor M3 activity, such as excessive perspiration, inflammation, sebum production, and cell adhesion, motility, growth, differentiation and proliferation.

公开(公告)号：US20240318143A1

公开(公告)日：2024-09-26

申请号：US18611429

申请日：2024-03-20

申请人： Lung Biotechnology PBC

发明人： Victor Hernandez Gordillo ,  Aman Kaur ,  Barbara Nsiah ,  Derek Morris ,  Luis Alvarez

IPC分类号： C12N5/071 ,  C07K1/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00

CPC分类号： C12N5/0688 ,  C07K1/042 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C12N2513/00 ,  C12N2533/50 ,  C12N2537/10

摘要： A method of modifying a surface of a three-dimensional (3D) article includes immersing at least one part of the 3D article in a buffered solution of functionalized peptides, allowing reaction between the functionalized peptides and reactive groups on the surface of the 3D article; and washing the at least one part of the 3D article to remove unreacted functionalized peptides. The surface-modified 3D article includes a plurality of peptides covalently bonded to the surface of the 3D article via a cysteine bridge. The surface-modified 3D article can be used as a scaffold for the formation of biological tissue or bodily implants.