POLYURETHANE-BASED RADIOPAQUE CROSSLINKED HYDROGELS WITH NON-ISOCYANATE PRECURSOR FOR MEDICAL APPLICATIONS

    公开(公告)号:US20240317944A1

    公开(公告)日:2024-09-26

    申请号:US18615619

    申请日:2024-03-25

    发明人: Yen-Hao Hsu

    摘要: In some aspects, a system for forming a hydrogel composition is described that comprises (a) a multifunctional cyclic carbonate compound and (b) a radiopaque, reactive polymer that comprises a plurality of amino groups that are reactive with the multifunctional cyclic carbonate groups of the multifunctional cyclic carbonate compound. In other aspects, a radiopaque crosslinked hydrogel composition is described that comprises a crosslinked reaction product of a multifunctional cyclic carbonate compound and a radiopaque, reactive polymer that comprises a plurality of amino groups. In further aspects, a method of treatment is described that comprises administering to a subject a mixture that comprises a multifunctional cyclic carbonate compound and a radiopaque, reactive polymer that comprises a plurality of amino groups, wherein the mixture is administered under conditions such that the multifunctional cyclic carbonate compound and the radiopaque, reactive multi-arm polymer crosslink after administration.

    POLYURETHANE COMPOSITION WITH IMPROVED ADHESION ON PAINTED SURFACES

    公开(公告)号:US20230183522A1

    公开(公告)日:2023-06-15

    申请号:US17924078

    申请日:2021-06-04

    摘要: A moisture-curing, one-component polyurethane composition, containing at least one isocyanate group-containing polyether urethane polymer obtained by reacting at least one polyisocyanate with at least one polyether polyol; at least one isocyanurate-containing trimer of 1-isocyanato-3,3,5-trimethyl-5-isocyanatomethyl cyclohexane or 1,6-hexane diisocyanate in a quantity of between 1 and 4 percent by weight in the composition; at least one polyether with blocked hydroxyl groups, which is free of isocyanate groups, as a plasticiser, in a quantity of more than 5 percent by weight in the composition. Where moisture is excluded, the moisture-curing polyurethane composition has good storage stability, good processability and good thermal stability, and surprisingly good adhesive effect on highly scratch-resistant, hydrophobic automotive paints, and no pretreatment with adhesion promoters, primers or activators is needed. It is especially suitable for use as an elastic adhesive in the production of means of transport.