公开(公告)号：US11479690B2

公开(公告)日：2022-10-25

申请号：US17196937

申请日：2021-03-09

申请人： COVESTRO (NETHERLANDS) B.V.

发明人： Matthias Johannes Cornelis Bos ,  Paulus Franciscus Anna Buijsen ,  Johannes Albertus Hettinga

IPC分类号： C09D167/02 ,  C08G63/20 ,  C09D167/00 ,  C08G63/16 ,  C09D5/03 ,  B05D1/06 ,  B05D1/10 ,  B05D3/02 ,  C09D167/03 ,  C08L67/00 ,  C08L67/02 ,  C08L67/03 ,  C08G63/123 ,  C08G63/02 ,  C08G63/127 ,  C08G63/12 ,  C08G63/00 ,  C08G63/18 ,  C08G63/181 ,  C08G63/183 ,  C08J3/24 ,  C08K5/00 ,  C08K5/1515 ,  C08K5/32

摘要： A branched carboxylic acid functional polyester resin P is described herein along with thermosetting powder coating compositions (PCC A) comprising a binder K, the binder K comprising the polyester resin P and a crosslinker X. The invention further relates to a cured PCC A. In addition, processes for making said PCC A and processes for coating an article with said PCC A are described as well as articles having coated thereon the PCC A and an articles having coated and cured thereon the PCC A.

公开(公告)号：US20220296635A1

公开(公告)日：2022-09-22

申请号：US17691518

申请日：2022-03-10

申请人： Board of Regents, The University of Texas System

发明人： Jian Yang

IPC分类号： A61K31/785 ,  A61K31/765 ,  C08G63/12 ,  C08G63/91 ,  C12N5/077 ,  A61K33/42 ,  C08G81/00 ,  C08L67/04

摘要： In one aspect, methods of promoting bone growth are described herein. In some embodiments, a method of promoting bone growth described herein comprises promoting cell differentiation or phenotype progression in a population of bone cells by providing a citrate-presenting composition to the population of bone cells. In some embodiments, the citrate-presenting composition is provided to the bone cells at a first stage of cell development selected to obtain a first cell differentiation or phenotype progression. Additionally, in some cases, a second citrate-presenting composition is further provided to the bone cells at a second stage of cell development selected to obtain a second cell differentiation or phenotype progression.

公开(公告)号：US11370880B1

公开(公告)日：2022-06-28

申请号：US16668978

申请日：2019-10-30

申请人： FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES

发明人： Yunqing Kang

IPC分类号： C08G63/12 ,  A61K47/59 ,  A61K47/34 ,  A61K38/18 ,  C08G63/78 ,  C08G63/60 ,  C08G63/91

摘要： A novel polymer is provided by polymerization of xylitol and dodecanedioic acid. The polymer, poly(xylitol-dodecanedioic acid) or PXDDA, shows high elasticity. PXDDA significantly improves cell adhesion and promotes cell proliferation compared to an FDA-approved polymer, poly(lactic acid), and tissue-culture plates. PXDDA can be synthesized by a simple melt condensation polymerization without the use of any toxic catalysts.

公开(公告)号：US11318662B2

公开(公告)日：2022-05-03

申请号：US16066212

申请日：2016-12-26

申请人： TOYOBO CO., LTD. ,  Furanix Technologies B.V.

发明人： Jun Inagaki ,  Yukihiro Numata ,  Jesper Gabriel Van Berkel

IPC分类号： B29C55/12 ,  B32B7/035 ,  B32B9/00 ,  B32B9/04 ,  B32B27/36 ,  C08J7/043 ,  C08J7/048 ,  C08G63/123 ,  C08G63/12 ,  C08G63/127 ,  C08G63/18 ,  C08L67/02

摘要： To provide a layered polyester film having excellent mechanical properties, transparency, heat resistance, and in particular excellent gas barrier property. A layered polyester film containing a polyester film and a thin film layer including mainly an inorganic compound, wherein the polyester film is a biaxially oriented polyester film including a dicarboxylic acid component containing mainly a furandicarboxylic acid and a glycol component containing mainly ethylene glycol, the thin film layer is formed on at least one surface of the polyester film, the inorganic compound is at least one of aluminum oxide and silicon oxide, and the layered polyester film has a plane orientation coefficient ΔP of not less than 0.100 and not more than 0.200, a film thickness of not thinner than 1 μm and not thicker than 300 μm, and an oxygen permeability of not less than 0.1 mL/m2/day/MPa and not more than 80 mL/m2/day/MPa under a temperature of 23° C. and a humidity of 65%.

公开(公告)号：US10918729B2

公开(公告)日：2021-02-16

申请号：US16263064

申请日：2019-01-31

申请人： THE SECANT GROUP, LLC

发明人： Jeremy J. Harris ,  Charles Brendan Nicholson ,  Peter D. Gabriele ,  Jared Ely ,  Brian Ginn

IPC分类号： A61L27/18 ,  A61K47/59 ,  A61K47/34 ,  A61L24/06 ,  C08K3/013 ,  C08G63/12 ,  C08J3/12 ,  A61P19/00 ,  C08L67/00 ,  A61L27/48 ,  A61L27/56

摘要： A bone filling composition includes a bone filler. The bone filler includes microparticles of at least one elastomeric material. The at least one elastomeric material includes a poly(glycerol sebacate)-based thermoset. The poly(glycerol sebacate)-based thermoset may be porous thermoset poly(glycerol sebacate) flour, thermoset poly(glycerol sebacate) microspheres, or a combination thereof. In some embodiments, the bone filling composition is a bone filling composite that further includes a carrier material including a poly(glycerol sebacate) resin. A method of forming a bone filling composite includes selecting a bone filler and mixing the bone filler with a carrier material to form the bone filling composite. A method of treating a bony defect includes molding a bone filling composite and placing the bone filling composite in the bony defect. The bone filling composite includes a bone filler mixed with a carrier material.

公开(公告)号：US10822450B2

公开(公告)日：2020-11-03

申请号：US16032733

申请日：2018-07-11

申请人： THE SECANT GROUP, LLC

发明人： Peter D. Gabriele ,  Carissa Smoot ,  Charles Brendan Nicholson ,  Jeremy J. Harris

IPC分类号： C08G63/12 ,  A61K47/55 ,  C08G63/81 ,  C08G63/133 ,  C08G63/123 ,  C08G63/06 ,  C08G63/78 ,  A61K47/59

摘要： A method of preparing a polymeric material includes combining a glycerol-pharmaceutical conjugate, glycerol, and water in a vessel. The glycerol-pharmaceutical conjugate includes a pharmaceutical compound, for example, salicylic acid, having at least one carboxyl group attached to glycerol by an ester bond. The method also includes adding sebacic acid to the vessel and removing water from the vessel and reacting the glycerol, glycerol-pharmaceutical conjugate, and sebacic acid in the vessel at atmospheric pressure in the presence of an inert gas. The method further includes applying a sub-atmospheric pressure to the vessel after the step of reacting, to form the polymeric material in the vessel. The polymeric material includes a polyester copolymer of the sebacic acid and the glycerol and the pharmaceutical compound.

公开(公告)号：US10815404B2

公开(公告)日：2020-10-27

申请号：US15748900

申请日：2016-08-11

申请人： 3M INNOVATIVE PROPERTIES COMPANY

发明人： Richard Y. Liu ,  Jingjing Ma ,  Zhong Chen ,  Victor Ho ,  Nathaniel I. Lehn ,  Harold T. Munson

IPC分类号： C09J167/06 ,  C09J7/38 ,  C09J7/22 ,  C08G63/54 ,  C08G63/676 ,  C09J167/02 ,  C09J201/02 ,  C09J7/25 ,  C08G63/12 ,  C08G63/16 ,  C08G63/52 ,  C08G63/66 ,  C08G63/672

摘要： Polyester pressure-sensitive adhesives are described. The polyester includes at least two different diacid residues and at least two different diol residues. The polyester includes at least one pendant group containing an alkenyl group. A ratio of a total number of the at least one pendant group to the total number of ester groups in the polyester is in a range of 0.001 to 0.1. The polyester has a glass transition temperature in a range of −50° C. to −10° C.

公开(公告)号：US10787546B2

公开(公告)日：2020-09-29

申请号：US15953062

申请日：2018-04-13

申请人： CHINA PETROLEUM & CHEMICAL CORPORATION ,  BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATION

发明人： Jianye Liu ,  Liqiu Chu ,  Yun Lyu ,  Shijun Zhang ,  Liying Zhang ,  Hao Zou ,  Mu Dong ,  Dali Gao ,  Baige Chou ,  Yiqing Bai ,  Jingbo Shao ,  Meng Xu ,  Yihui Xu ,  Ruoshi Chen

IPC分类号： C08J3/14 ,  B29C67/00 ,  C08L67/04 ,  C08J3/21 ,  C08G63/88 ,  B33Y10/00 ,  B33Y70/00 ,  B29C64/153 ,  C08G63/08 ,  C08G63/12 ,  C08J3/09 ,  C08J3/11 ,  B29K67/00

摘要： A method for preparing an aliphatic polyester resin powder includes the steps ofa) heat dissolving a crystalline aliphatic polyester resin in an organic solvent to obtain an aliphatic polyester resin solution;b) cooling the aliphatic polyester resin solution to precipitate a solid, thereby obtaining a solid-liquid mixture;c) optionally adding an adjuvant to the solid-liquid mixture and mixing; andd) conducting solid-liquid separation and drying to obtain an aliphatic polyester resin powder suitable for selective laser sintering.The crystalline aliphatic polyester resin powder obtained has good antioxidant property, good powder flowability, moderate size, smooth surface, suitable bulk density, and suitable dispersibility and particle size distribution. The aliphatic polyester resin powder is particularly suitable for selective laser sintering method.

公开(公告)号：US10703930B2

公开(公告)日：2020-07-07

申请号：US15328622

申请日：2015-07-09

申请人： DSM IP Assets B.V.

发明人： Matthias Johannes Cornelis Bos ,  Paulus Franciscus Anna Buijsen ,  Johannes Albertus Hettinga

IPC分类号： C09D167/02 ,  C08G63/20 ,  C09D167/00 ,  C08G63/16 ,  C09D5/03 ,  B05D1/06 ,  B05D1/10 ,  B05D3/02 ,  C09D167/03 ,  C08L67/00 ,  C08L67/02 ,  C08L67/03 ,  C08G63/123 ,  C08G63/02 ,  C08G63/127 ,  C08G63/12 ,  C08G63/00 ,  C08G63/18 ,  C08G63/181 ,  C08G63/183 ,  C08J3/24 ,  C08K5/00 ,  C08K5/1515 ,  C08K5/32

摘要： The invention relates to a branched carboxylic acid functional polyester resin P1 as described herein. The invention further relates to a thermosetting powder coating composition (PCC A1) comprising a binder K1, said binder K1 comprising the P1 and a crosslinker X1. The invention further relates to a cured PCC A1. The invention further relates to a process for making said PCC A1 and processes for coating an article with said PCC A1. The invention further relates to an article having coated thereon said PCC A1 as well as to an article having coated and cured thereon said PCC A1. The invention further relates to a thermosetting powder coating composition B (PCC B) comprising a physical mixture of the thermosetting powder coating composition A1 (PCC A1) with a separate, distinct thermosetting powder coating composition A (PCC A). The invention further relates to a process for making said thermosetting powder coating composition B and processes for coating an article with said PCC B. The invention further relates to a cured PCC B. The invention further relates to an article having coated thereon said thermosetting powder coating composition B as well as to an article having coated and cured thereon said thermosetting powder coating composition B. The invention further relates to use of: the polyester resin P1, the PCC A1, the cured PCC A1, the PCC B, the cured PCC B, articles coated with the PCC A1, articles coated with the PCC B, articles having coated and cured thereon the PCC A1, articles having coated and cured thereon the PCC B. The invention further relates to the use of the polyester resin P1 for matt powder coatings. The invention further relates to the use of the PCC B for matt powder coatings.

公开(公告)号：US10647876B2

公开(公告)日：2020-05-12

申请号：US15889291

申请日：2018-02-06

申请人： Allnex Netherlands B.V.

发明人： Richard Hendrikus Gerrit Brinkhuis ,  Antonius Johannes Wilhelmus Buser ,  Petrus Johannes Maria David Elfrink ,  Ferry Ludovicus Thys ,  Nicole Mangnus-Verhagen ,  Elwin Aloysius Cornelius Adrianus De Wolf

IPC分类号： C08G63/12 ,  C09D167/00 ,  C08K3/01 ,  C09D175/06 ,  B01J31/02 ,  C08J3/24 ,  C08K5/21 ,  C09D133/14 ,  C08K5/00

摘要： An RMA crosslinkable composition having at least one crosslinkable component including reactive components A and B each including at least 2 reactive groups, the at least 2 reactive groups of component A being acidic protons (C—H) in activated methylene or methine groups and the at least 2 reactive groups of component B are activated unsaturated groups (C═C) and a base catalyst (C) which reactive components A and B crosslink by Real Michael Addition (RMA) reaction under action of the base catalyst, characterised in that the at least one crosslinkable component including reactive components A and B in the composition have a total hydroxy number of less than 60, preferably less than 40 and more preferably less than 20 mg KOH/g solids. Further, specific resins A and B having a low hydroxy number for use in RMA cross-linkable compositions and a process for the manufacture thereof.