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    Novel Strategy Enabled by a Photo-cleavable Surfactant for Extracellular Vesicle Proteomics
    1.
    发明申请
    Novel Strategy Enabled by a Photo-cleavable Surfactant for Extracellular Vesicle Proteomics 有权

    公开(公告)号：US20230138788A1

    公开(公告)日：2023-05-04

    申请号：US17978793

    申请日：2022-11-01

    申请人： Wisconsin Alumni Research Foundation

    发明人： Ying GE ,  Song JIN ,  Kyle BROWN ,  Kevin BUCK

    IPC分类号： G01N33/92 ,  C11D1/14 ,  G01N21/33 ,  G01N33/52

    摘要： Exosomes are a small type of extracellular vesicles containing nucleic acids, lipids, and proteins that are implicated in tumorigenesis, metastasis, and cardiac regeneration, and therefore serve as potentially useful biomarkers from fluids or as vehicles for drug delivery. Global bottom-up mass spectrometry-based proteomics has been previously used to profile exosome cargo for diagnostic purposes. However, the current protocols for MS analysis of extracellular vesicles and exosome proteomics are challenging due to labor-intensive sample preparation, including lengthy digestion times and removal of MS incompatible reagents, and the need for high sensitivity. To address these challenges, the present invention provides a novel, high-throughput strategy for extracellular vesicle analysis and exosome proteomics using a photo-cleavable, anionic surfactant, preferably 4-hexylphenylazosulfonate (Azo). These photo-cleavable, anionic surfactants are able to facilitate high-throughput digestion with minimal sample cleanup for quantitative and highly reproducible analysis.

    Phenyl based compounds substituted with aldehyde moieties and their use in perfumery
    7.
    再颁专利
    Phenyl based compounds substituted with aldehyde moieties and their use in perfumery 有权

    公开(公告)号：USRE49502E1

    公开(公告)日：2023-04-25

    申请号：US16922570

    申请日：2020-07-07

    申请人： GIVAUDAN SA

    发明人： Corinne Baumgartner ,  Yue Zou

    IPC分类号： C11B9/00 ,  C07C47/228 ,  C11D3/50

    摘要： A compound represented by the formula 1 wherein R1 is H, or when R2 and R3 is H, then R1 is CHR5CHR6CHO, CR5═CR6CHO or C(CH3)CHO, wherein R5, R6 each independently may represent H or methyl; R2 is H, or when R1 and R3 is H, then R2 is CHR5CHR6CHO, CR5═CR6CHO or C(CH3)CHO, wherein R5, R6 each independently may represent H or methyl; R3 is H, or when R1 and R2 is H, then R3 is CHR5CHR6CHO, CR5═CR6CHO or C(CH3)CHO, wherein R5, R6 each independently may represent H or methyl; and R4 is methyl or a branched or linear, saturated or unsaturated, unsubstituted or substituted (optionally with cyclopropyl groups), C2-C7 alkyl or alkenyl residue, preferentially isobutyl, isoamyl. Said compounds are useful as perfume ingredients in personal care and household care products.