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1.
公开(公告)号:US20240360481A1
公开(公告)日:2024-10-31
申请号:US18688207
申请日:2022-08-30
CPC分类号: C12P5/007 , C12M23/40 , C12M43/00 , C12N1/12 , C12R2001/89
摘要: Methods and systems that use fluorocarbons for designing scalable living, in-line extraction of heterologous metabolites from microbial cultures are disclosed. The disclosed systems and methods are organism agnostic and be applied to bacteria, yeasts, filamentous microbes, and algae. The disclosed methods and systems use pperfluorocarbon solvent to extract terpenes from engineered microorganisms and allows non-lethal milking of hydrocarbon products from filamentous and single-celled/multicelled microbial cultures. The disclosed process preferably does not use pressure gradients and relies on the physical interaction of microbes with fluorocarbon at satp and standard temperature of microbial cultivation to partition non-native products. The disclosed process and system also allow for increased production of products providing a physical sink which enables the forward reactions to produce more products than in its absence.
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公开(公告)号:US20240360479A1
公开(公告)日:2024-10-31
申请号:US18140097
申请日:2023-04-27
申请人: Zhi-Min Li
发明人: Zhi-Min Li
IPC分类号: C12P3/00 , A61K33/44 , A61K35/741
CPC分类号: C12P3/00 , A61K33/44 , A61K35/741 , A61K2035/115
摘要: A method of making graphene transparent by fermentation contains: a step of preparing prerequisites; a first step in which the graphene mother bacteria, edible powders, powdered sugars, and a warm water and mixed and heated to produce a fermented graphene lump; a second step in which fermented graphene lump is smashed and smoothed out to a holding tray, then the holding tray is dried to form graphene enzyme lump. The method further contains: a third step in which the graphene enzyme lump is refined to graphene enzyme powders by a stirrer; a fourth step in which re-fermenting the graphene enzyme powders of the third step by repeating the first step, the second step and the third step; a fifth step in which the re-fermented graphene powders are soaked to produce edible powders, and the warm water is removed; a step sixth in which a transparent graphene containing probiotics is produced.
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公开(公告)号:US20240360086A1
公开(公告)日:2024-10-31
申请号:US18750537
申请日:2024-06-21
申请人: API CORPORATION
发明人: Tomoko MAEDA , Yasumasa DEKISHIMA , Hiroshi KAWABATA , Masaki NAGAHAMA , Naoyuki WATANABE , Kosuke ITO
IPC分类号: C07D239/42 , C12N9/04 , C12P17/12
CPC分类号: C07D239/42 , C12N9/0006 , C12P17/12 , C12Y101/01184
摘要: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.
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公开(公告)号:US12129300B2
公开(公告)日:2024-10-29
申请号:US18501419
申请日:2023-11-03
发明人: Gregory P. Chang , Ann F. Cheung , Asya Grinberg , William Haney , Bradley M. Lunde , Bianka Prinz
CPC分类号: C07K16/2851 , C07K16/2803 , C07K16/283 , C07K16/32 , C07K2317/31 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要: Antibody heavy chain variable domains that can be paired with antibody light chain variable domains to form an antigen-binding site targeting the NKG2D receptor on natural killer cells are described. Proteins comprising an NKG2D antigen-binding site, pharmaceutical compositions and therapeutic methods thereof, including for the treatment of cancer, are also described.
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公开(公告)号:US12128130B2
公开(公告)日:2024-10-29
申请号:US17352506
申请日:2021-06-21
申请人: KERAMEDIX INC.
发明人: Yu-Shik Hwang , Il-Keun Kwon , So Yeon Kim , Se Young Van
CPC分类号: A61K9/0019 , A61K8/65 , A61K38/01 , A61K38/1748 , A61K47/10 , A61P17/14 , C12P21/06 , C12Y304/21064
摘要: The present invention relates to an injectable pharmaceutical composition containing keratin for preventing hair loss or stimulating hair growth, wherein the composition is excellent in hair follicle generating and hair growth stimulating effects, and thus can be favorably used as a preventive and therapeutic agent for hair loss or a stimulating agent for hair growth.
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公开(公告)号:US12127577B2
公开(公告)日:2024-10-29
申请号:US13695672
申请日:2011-05-03
申请人: Guylaine Lacaze , Isabel Trogh , Bernard Genot , Filip Arnaut
发明人: Guylaine Lacaze , Isabel Trogh , Bernard Genot , Filip Arnaut
CPC分类号: A23L33/22 , A21D2/18 , A21D8/045 , A21D10/002 , A23L7/104 , A23L7/115 , A23L33/10 , C12P19/04
摘要: A method for preparing a liquid composition having a high arabinoxylan oligosaccharides content (AXOS), the product obtained by this method, and its use in food applications, in particular in baked products.
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公开(公告)号:US12127575B2
公开(公告)日:2024-10-29
申请号:US17371745
申请日:2021-07-09
申请人: The Better Meat Co.
发明人: Augustus H. Pattillo
IPC分类号: A23L31/00 , A23J3/04 , A23J3/14 , A23J3/20 , A23J3/22 , A23K10/12 , A23K50/40 , A23L13/40 , C12N1/14 , C12P21/00
CPC分类号: A23L31/00 , A23J3/04 , A23J3/14 , A23J3/20 , A23J3/227 , A23K10/12 , A23K50/40 , A23L13/424 , A23L13/46 , C12N1/14 , C12P21/00
摘要: Provided herein are shelf-stable protein food ingredients, food products comprising the shelf-stable protein food ingredients, methods of their production, and methods of their use. The shelf-stable protein food ingredients comprise cultured fungal biomass and a limited amount of water. Advantageously, the shelf-stable protein food ingredients can be stored, transported, and delivered within the food supply.
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8.
公开(公告)号:US20240352500A1
公开(公告)日:2024-10-24
申请号:US18684500
申请日:2022-08-18
发明人: Markus Landthaler , Ulrike Zinnall , Igor Minia
IPC分类号: C12P21/02 , C07K14/505 , C07K14/565 , C07K14/59 , C07K14/62 , C12N9/22 , C12N15/11 , C12N15/90
CPC分类号: C12P21/02 , C07K14/505 , C07K14/565 , C07K14/59 , C07K14/62 , C12N9/22 , C12N15/11 , C12N15/907 , C07K2319/30 , C12N2310/20
摘要: The invention is related to a method for producing a secreted recombinant protein of interest in a cell, wherein the method comprises artificially co-expressing a protein different from the secreted recombinant protein of interest.
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公开(公告)号:US20240352498A1
公开(公告)日:2024-10-24
申请号:US18751380
申请日:2024-06-24
发明人: Yuzhong Liu , Samantha Aiko Crowe , Jay D. Keasling , Xiaoyue Chen , Graham Arthur Hudson , Fei Gan , Henrik V. Scheller , James Reed , Laetitia Martin
CPC分类号: C12P19/60 , C12N9/0069 , C12N9/0083 , C12N9/1077 , C12N9/1205 , C12N9/1241 , C12N9/88 , C12P5/007 , C12Y113/99001 , C12Y114/99 , C12Y207/01043 , C12Y207/07064 , C12Y402/01076
摘要: The present invention relates inter alia to methods of biosynthetic production of QS-21, precursors and variants thereof, and to related aspects.
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公开(公告)号:US20240352497A1
公开(公告)日:2024-10-24
申请号:US17995816
申请日:2021-04-07
发明人: Thomas F.T. Rexer , Reza Mahour
CPC分类号: C12P19/46 , C12N9/1205 , C12N9/1229 , C12N9/1241 , C12N9/14 , C12N9/88 , C12N9/90 , C12Y207/01048 , C12Y207/04014 , C12Y207/07043 , C12Y306/01001 , C12Y306/01011 , C12Y401/03003 , C12Y501/03008
摘要: The present invention relates to a method for producing cytidine 5′-monophospho-N-acetyl-neuraminic acid (CMP-Neu5Ac, 1) from low-cost substrates N-acetyl-D-glucosamine (GlcNAc), pyruvate, cytidine and polyphosphate in a single reaction mixture with a set of optionally immobilized or optionally co-immobilized enzymes comprising N-acylglucoamine 2-epimerase (AGE), an N-acetylneuraminate lyase (NAL), an N-acylneuraminate cytidylyltransferase (CSS), a uridine kinase (UDK), a uridine monophosphate kinase and a polyphosphate kinase 3 (PPK3). Further, said process may be adapted to produce Neu5Acylated i.e. sialylated biomolecules and biomolecules including a saccharide, a peptide, a protein, a glycopeptide, a glycoprotein, a glycolipid, a glycan, an antibody, and a glycoconjugate, in particular, an antibody drug conjugate, and a carbohydrate conjugate vaccine, or a flavonoid.
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