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    Compositions and methods for activation and overexpression of secondary metabolites in microorganisms
    1.
    发明授权
    Compositions and methods for activation and overexpression of secondary metabolites in microorganisms 有权

    公开(公告)号：US11447742B2

    公开(公告)日：2022-09-20

    申请号：US16059258

    申请日：2018-08-09

    申请人： Prospective Research, Inc.

    发明人： Dakota Benjamin Hamill ,  Jake J. Cotter

    IPC分类号： C12P1/04 ,  C12N1/38 ,  C12N15/80 ,  C12N1/12 ,  C12P17/04 ,  C07D307/33 ,  C12P17/16 ,  C12P1/06

    摘要： Methods and compositions herein provide non-naturally occurring γ-butyrolactones (GBLs) in racemic mixtures that increase efficiency and effectiveness of screening for production of antibiotics, and enhance yields and express silent pathways. Non-naturally occurring GBLs were synthesized and found to stimulate antibiotic production in several different streptomycete strains. Antibiotic production by Streptomyces coelicolor was induced by a racemic mixture of non-cognate stereoisomers of VB-D, seven of which are non-naturally occurring. Further, novel A-factor-type GBL analogs stimulated antibiotic production in S. coelicolor. Synthesis in response to the treatment with the non-cognates GBL was observed for known compounds including undecylprodigiosin, desferrioxamine and streptorubin B, as was synthesis of a compound of unknown structure. A group of 37 additional microbial strains was screened by principal component analysis to determine optimal concentrations of each of a panel of four non-cognate synthetic GBLs for addition to cultures with optimal stimulation of secondary metabolites, and large scale fermentations were analyzed and product enhancement by the GBLs was observed.

    Yeast stage tank incorporated fermentation system and method
    2.
    发明授权
    Yeast stage tank incorporated fermentation system and method 有权

    公开(公告)号：US11427839B2

    公开(公告)日：2022-08-30

    申请号：US17067701

    申请日：2020-10-11

    申请人： Lee Tech LLC.

    发明人： Chie Ying Lee

    IPC分类号： C12P7/14 ,  C12M1/00 ,  C12P1/06 ,  C12P7/00 ,  C12P5/00 ,  C12N1/18 ,  C12R1/85

    摘要： Methods of and system for growing and maintaining an optimized/ideal active yeast solution in the yeast tank and fermenter tank during the fermentation filling cycle are provided. A new yeast stage tank is used between the yeast tank and the fermenter tank allowing yeast to rapidly produce a huge amount of active young yeast cells for a fermenter during the filling period. A measurable and useful controlling factor, % DT/% Yeast by weight ratio (or “food” to yeast ratio), is used (e.g., % DT=glucose), which offers information on the health status of the yeast. The controlling factor is used to control the status of the yeast throughout the entire process.

    Conversion system for biomass
    4.
    发明授权
    Conversion system for biomass 有权
    生物质转化系统

    公开(公告)号：US08399216B1

    公开(公告)日：2013-03-19

    申请号：US13657928

    申请日：2012-10-23

    申请人： Xyleco, Inc.

    发明人： Marshall Medoff

    IPC分类号： C12P1/00 ,  C12P5/00 ,  C12P19/14 ,  C12Q1/34 ,  C12Q1/02 ,  C12P7/16 ,  C12P7/06 ,  C12P7/10 ,  C12P1/02 ,  C12P1/04 ,  C12P1/06

    CPC分类号： C12P7/14 ,  C12P5/00 ,  C12P5/023 ,  C12P7/06 ,  C12P7/10 ,  C12P7/64 ,  C12P13/001 ,  C12P19/34 ,  C12P21/00 ,  C12P33/00 ,  Y02E50/13 ,  Y02E50/16 ,  Y02E50/17 ,  Y02E50/343 ,  Y02P20/136 ,  Y02W30/47

    摘要： The efficient production of ethanol from low-cost biomass (e.g., corn, sugar beets, sugar cane, switchgrass and/or paper) has become increasingly important in making ethanol competitive with gasoline and decreasing the United States' dependence on foreign oil. For example, to reduce the cost of transporting biomass to ethanol production facilities, mobile systems for producing ethanol from biomass are provided. Also provided are small-scale ethanol production facilities. For example, instead of transporting biomass to the production facility, the facility is transported to the biomass or is located nearby the source of the biomass. The ethanol production facilities or components thereof may be transported via land, water, or air. Production of other products, such as hydrocarbons, natural gas, hydrogen gas, plastics, polymers, and proteins, can also be made by the methods and facilities. Any product described herein can be made in finished form or un-finished form and moved, e.g., to a fixed facility, e.g., fixed production facility.

    摘要翻译： 从低成本生物质（例如玉米，甜菜，甘蔗，柳枝稷和/或纸）中有效生产乙醇在使乙醇与汽油竞争并降低美国对外来石油的依赖方面变得越来越重要。 例如，为了降低将生物质运送到乙醇生产设施的成本，提供了从生物质生产乙醇的移动系统。 还提供小型乙醇生产设施。 例如，不是将生物质运送到生产设施，而是将设施运送到生物质或者位于生物质源附近。 乙醇生产设备或其组分可以经陆地，水或空气运输。 生产其他产品，如碳氢化合物，天然气，氢气，塑料，聚合物和蛋白质也可以通过这些方法和设备来制造。 本文描述的任何产品可以以成品形式或未完成的形式制成并移动到例如固定设施，例如固定生产设施。

    Minimal bacterial genome
    5.
    发明申请
    Minimal bacterial genome 审中-公开
    最小细菌基因组

    公开(公告)号：US20070122826A1

    公开(公告)日：2007-05-31

    申请号：US11546364

    申请日：2006-10-12

    申请人： John Glass ,  Hamilton Smith ,  Clyde Hutchison ,  Nina Alperovich ,  Nacyra Assad-Garcia

    发明人： John Glass ,  Hamilton Smith ,  Clyde Hutchison ,  Nina Alperovich ,  Nacyra Assad-Garcia

    IPC分类号： C40B30/06 ,  C40B40/10 ,  C07H21/04 ,  C12P7/06 ,  C12P1/06 ,  C12N9/02 ,  C12N1/21

    CPC分类号： C12N1/20 ,  C07K14/195 ,  C07K14/30 ,  C12N9/16 ,  C12P3/00 ,  C12P7/06 ,  C12R1/35 ,  C12Y301/04046 ,  Y02E50/17

    摘要： The present invention relates, e.g., to a minimal set of protein-coding genes which provides the information required for replication of a free-living organism in a rich bacterial culture medium, wherein (1) the gene set does not comprise the 101 genes listed in Table 2; and/or wherein (2) the gene set comprises the 381 protein-coding genes listed in Table 3 and, optionally, one of more of: a set of three genes encoding ABC transporters for phosphate import (genes MG410, MG411 and MG412; or genes MG289, MG290 and MG291); the lipoprotein-encoding gene MG185 or MG260; and/or the glycerophosphoryl diester phosphodiesterase gene MG293 or MG385.

    摘要翻译： 本发明涉及例如提供在富细菌培养基中复制自由活体的所需信息的蛋白质编码基因的最小集合，其中（1）基因组不包括所列出的101个基因 在表2中; 和/或其中（2）基因组包含表3中列出的381个蛋白质编码基因，以及任选的一个以下的一个：编码用于磷酸酯进口的ABC转运蛋白的三个基因（基因MG410，MG411和MG412;或 基因MG289，MG290和MG291）; 编码脂蛋白的基因MG185或MG260; 和/或甘油磷酸二酯磷酸二酯酶基因MG293或MG385。